"Paragon" Who REALLY wants to try this???
- 09-17-2012, 11:51 AM
"Paragon" Who REALLY wants to try this???
PNI - PARAGON
-The industry's most powerful testosterone booster, via multiple mechanisms.
-Aromatase inhibitor, SHBG inhibitor, and estrogen-receptor antagonist.
-Ideal for PCT use, or as a standalone T-booster and performance enhancer.
NMDAD-Aspartic Acid is incredibly popular as a testosterone booster -- and for good reason, as studies have shown that a dose of 3000mg/day can dramatically increase testosterone levels in men. N-methyl D-Aspartate is simply a more powerful form of DAA: It appears to be 100 times more potent on an equimolar basis (ref), and has a fundamentally-identical mechanism of action. Like DAA, it induces LH release and increases mRNA expression of the steroidogenic acute regulatory protein (StAR) -- a protein which shuttles cholesterol into the mitochondria of steroidogenic cells, and which represents the first rate-limiting step in steroid biosynthesis.
There's no need to reference DAA studies: NMDA itself has been shown to dramatically increase testosterone in animal models. (ref)
Menaquinone-4MK-4 is the most active form of vitamin K, and is found in high concentrations in the testes. Studies in animals have shown that Vitamin K/MK4 deficiency leads to reduced expression of steroidogenic genes and low testosterone levels (ref); another study has shown that MK-4 supplementation can increase testosterone levels via the induction of protein kinase A, CREB, and, most importantly, P450scc. (ref)
• PKA is a multi-functional enzyme which activates steroidogenic transcription factors such as steroidogenic factor 1, GATA-4, and the aforementioned StAR. Like StAR, PKA also directly facilitates cholesterol transport into the mitochondria of leydig cells. (ref) PKA is also a positive regulator of the P450scc enzyme.
• CREB is a upstream regulator of the aforementioned StAR, and increases in CREB expression have been shown to increase StAR promoter activity, StAR mRNA, and StAR protein levels in leydig cells. (ref)
• P450scc is the 'side-chain-cleavage' enzyme which converts cholesterol to pregnenolone -- and after StAR shuttles cholesterol into the mitochondria of steroidogenic cells, this becomes the rate-limiting step in testosterone biosynthesis. If StAR is sufficiently activated, P450scc is the bottleneck. Paragon amplifies P450scc expression with a hefty dose of MK-4 and destroys this bottleneck, allowing for much greater testosterone production.
Vitamin D represents another way to boost testosterone levels. Its mechanism of action has not been entirely elucidated, but seems to involve 17b-HSD induction. (ref, ref) While not a rate-limiting step, increases in 17b-HSD enzyme activity should increase the rate of conversion of DHEA to androstenediol, and therefore speed-up testosterone biosynthesis.
Regardless of mechanism, it's very clear that the stuff works: Vitamin D3 has been shown to increase testosterone levels in healthy adult males (ref), and two recent studies have shown a correlation between serum Vitamin D levels and testosterone levels. (ref, ref) Vitamin D may also improve muscle function (ref, ref) and athletic performance. (ref, ref) Given its many benefits, and its ability to potentially increase testosterone via a seemingly-unique mechanism, its role in Paragon is well warranted.
Forskolin is a potent cAMP-activator which should increase testosterone biosynthesis via a now-familiar mechanism: cAMP activation leads to Protein Kinase A phosphorylation and CREB induction, PKA and CREB both potentiate StAR, which then increases transport of cholesterol into the mitochondria. LH itself works in a nearly identical manner. At the dose contained in Prodigy It has been shown to increase testosterone levels in healthy adult men (ref). It also has beneficial effects where body composition is concerned -- due to increases in testosterone and induction of hormone sensitive lipase (HSL), an enzyme which is usually the rate-limiting step in lipolysis. (ref)
Euonymus Alatus and Prunella Vulgaris extracts
Widely-used as Chinese herbal medicines, Euonymus Alatus and Prunella Vulgaris deliver a one-two punch to estrogen.
Euonymous Alatus extract is a potent aromatase inhibitor with an IC50 of 11μm in Human placental aromatase. Animal studies have shown striking results: Treatment with EA extracts can lead to total estrogen deprivation in normal female rats. What's more, it displays selectivity for certain tissue types, and it may be much more selective and active towards aromatase enzymes expressed in breast tissue. This latter property may make it especially useful to people who are prone to gyno. (ref) It may be the most potent herbal aromatase inhibitor on the market today.
In contrast to Euonymus Alatus, Prunella Vulgaris interferes with estrogen receptor signalling indirectly. An unidentified compound within the extract binds to the aryl hydrocarbon receptor (AHR) as a full agonist, and this ligand-receptor complex seems to degrade the estrogen receptor protein via ubiquitin-mediated mechanisms. It seems to also compete with ER-mediated gene transcription via unknown mechanisms. (ref)
One thing is certain: Estrogen is of no concern to anybody on Paragon!
Urtica Dioica extract
It should be a shame to boost testosterone, only to have it deactivated by SHBG. Urtica Dioica (Stinging Nettle) root extract contains (-)-3,4-divanillyltetrahydrofuran and numerous other inhibitors of SHBG. (ref, ref) We use a full-spectrum aqueous extract, which will help ensure that more of the testosterone you produce is put to good use.
The bottom line: PARAGON strongly targets every pathway to testosterone production, while still paying attention to estrogen, aromatase, and SHBG. There is no better PCT product on the market, and it's extremely potent as a standalone test-booster.
Now that I have your attention.....Who wants to try this???? We are doing some Log Opps for this beast of a product all you need is the following:
18 or over:
Must have good standing and have done previous logs and Link them to me:
Most important, tell me why you want to log this and how detailed you will be:
Since this is a new product I would like someone that can log everyday with updates and before and after pics would be nice as well:
Would Love to pick someone going into pct and someone using it as a stand alone with just the staples:
HUGE opportunity here guys...I can't stress that enough...
- 09-17-2012, 11:59 AM
09-17-2012, 12:23 PM
09-17-2012, 12:48 PM
I would love to do it as a stand alone trial - I dont have any logs but `I will log daily and have before and after pictures as well - I can be very specific with the logs - with food and work out details - thanks!! lets do it!!! IM 42 yrs old 211lbs 18 - 20% bf
09-17-2012, 01:10 PM
Wow you guys outdid it on this one :-)
Purus Labs Anabolic Titan/Rep
Coach AB @ BossBody.net
09-17-2012, 01:17 PM
09-17-2012, 01:20 PM
Haha PNI is generousOriginally Posted by jimbuick
yes I fully agreeOriginally Posted by JonRubio
nice appOriginally Posted by zonpower
yeah even I'm impressed with this plus it will be decently priced I'm sureOriginally Posted by Airborne42
as in? When? How many caps?Originally Posted by Cary K
09-17-2012, 01:25 PM
09-17-2012, 01:32 PM
3 caps together anytime of the day but I prefer the AMOriginally Posted by Cary K
09-17-2012, 02:07 PM
09-17-2012, 05:22 PM
Mmm that cycle sounds juicy!!Originally Posted by Gerbil
09-17-2012, 06:00 PM
09-17-2012, 07:26 PM
Bump for my AM bros
09-17-2012, 08:02 PM
09-17-2012, 08:16 PM
This is pretty impressive if the extracts are extracted properly. Also, I wasn't aware 50% forskolin exists
09-17-2012, 08:21 PM
09-17-2012, 08:27 PM
Very interesting. Great job coming up with this. I am a fan of Intimidate but this has more goodies in it as well.
MY I-FORCE NUTRITION INTIMIDATE/REVERSITOL V2 SPONSORED LOG (PICS)
09-17-2012, 08:28 PM
that stuff sounds delicious. i'd like to see a few logs of it, it'll help my decision for my natural and legal pct support supplements when i come off my cycle.
I'm just a dude chasing a dream
09-17-2012, 08:28 PM
09-17-2012, 08:30 PM
09-17-2012, 08:39 PM
09-17-2012, 08:39 PM
Thanks coop!!! I assure you our formulator is a proOriginally Posted by mr.cooper69
09-17-2012, 10:03 PM
Man I wish I could throw an app in ok this...bad timing to take a daa break!
What do you think the price point will be when it comes out?
09-17-2012, 11:00 PM
Definitely interested in this! I love logging. Try to update every day. If not at least every workout day.
I was getting ready to buy iForce intimidate and run it with but this looks like a better option.
I would probably run it stand alone or with the bottle of FatSmack I'm finishing up. Been using it Long enough to know the effects so it wouldn't skew the log at all...
I've logged a few test boosters and have had a pretty good following actually.
Endosurge/Erase/DAA 8 week Run! First natty stack....
PES meets Purus--a log of Anabeta/AlphaT2/D-Pol ... Summer Shreading take one!
Drizzie's Birthday Havoc Stack + Katanadrol2.0
I can't believe that God put us on this earth to be ordinary. - Lou Holtz
09-18-2012, 12:01 AM
Bump for the late night crew
09-18-2012, 09:12 AM
I would apply but I don't want to have 2 logs that do the same thing. I hopefully will receive the other 2 products in the mail soon! That would not be fair to the others who would like to log this awesome looking product.
After a year off, I'm back
09-18-2012, 10:52 AM
For those who aren't getting it, the "REALLY" in caps translates to:
"SEND NUDES OR GTFO OK!?"
That's if you REALLY want it lol. Now let's see more apps!
>SNS-Glycophase<Serious Nutrition Solutions Rep
09-18-2012, 11:44 AM
I suck at logging but might pick some up after hearing from the diehard guys on this.
"I don't want anything. I don't want anybody. That's the worst part. When the want goes, that's bad."
(Doug Stanhope as Eddie on Louie)
09-18-2012, 12:01 PM
09-18-2012, 01:05 PM
HahaOriginally Posted by Celorza