SPECIAL: The Impact of Prohormones on Your Health - AnabolicMinds.com

SPECIAL: The Impact of Prohormones on Your Health

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    SPECIAL: The Impact of Prohormones on Your Health


    Do prohormones really work?


    We can spend days, months, and years trying to find the latest and greatest form of protein. You've heard them all; whey, casein, soy, cold filtered, cross-flow micro filtered, hydrolysates, protein peptides, nano filtration, super duper super protein! The list goes on! Still at the end of the day when gains are what you want, you turn toprohormones and designer steroids. They are by far and away the most effective legal tool a bodybuilder and physique enthusiast can consume. A 2009 published research paper (1) on anabolic steroid use had the following to say (prohormones and designer steroids are simply pre-cursors to AAS):


    "Controversy raged for decades over the effectiveness of AAS in promoting muscle mass and strength. Despite the admitted illicit use of AAS by athletes, the record breaking in Olympic events, and the obvious appearance in musculature enhancement, the medical and research community disputed and denied the AAS effects [3,4]. After a considerable period of scientific controversy, it is now clear that anabolic-androgenic steroid hormones are effective in increasing both muscle mass and strength [5]."


    Think about the last time you were tossing around weights in the gym and a prototypical gym rat asked you "what are you on?" Sound familiar? Chances are you were actually on a prohormone cycle. Doesn't sound familiar? Well chances are you have yet to experience the unreal results you can get from prohormones. Which is why we exist...we love prohormones!


    What are the negatives of prohormone use?


    We have said enough about the awesome potential of prohormones and designer steroids. And maybe you have not jumped in the prohormone pool of fun simply because you fear the potential negatives, which pre-dominantly occur after your cycle. The giant hurdle that comes after your prohormone cycle is know as Post Cycle Therapy (PCT). On cycle, the additional hormones essentially trigger what is known as the negative feedback loop (more on this later).

    How does your body produce natural testosterone?


    Off cycle your body produces gonadotropin-releasing hormone (GnRH) from the hypothalamus, which tells the pituitary to secrete luteinizing hormone (LH). LH then tells your testicles to spit out some testosterone into your bloodstream. This would all be fine and dandy if your body continued to do this non-stop, but the hypothalamic-pituitary axis essentially monitors free testosterone in your body. If it feels it's getting too high, it shuts off the source (LH), which in turn decreases the testicles output of testosterone. Sperm is produced in a similar manner but through the release of follicle-stimulating hormone (FSH). This is how your body determines your natural testosterone levels.

    What happens to natural testosterone during a prohormone cycle?



    During a prohormone cycle your body recognizes the increased testosterone levels (or a similar effect) from your prohormones and designer steroids. So it becomes reactive quite quickly depending on the compound. The increased levels then "shut down" or more accurately "suppress" the hypothalamic-pituitary axis, which significantly decreases your body's natural testosterone levels. Unfortunately even after you stop the cycle your body doesn't easily go back to producing high levels of natural testosterone. The suppression that follows your cycle can vary by individual as well as severity and duration. In fact one study measured testosterone levels in men from 12 to 43 months after steroid cycles and found that 13 of 15 were in the lower reference ranges for testosterone levels, and 2 of 15 were below the normal range (2)!

    What happens to your gains Post Cycle?


    A 2004 USC study attempted to determine how quickly we lose the strength and muscle gains from a cycle (3). They gave men 20mg's per day of a popular illegal oral steroid known as anavar (which by today's standards is considered a low dose). Over 12 weeks the men gained ~6.6 lbs of lean body mass. They then stopped the cycle, waited 12 weeks, and measured lean body mass again. They found that the men had lost all of their lean body mass gains! They also gained about 8-10% in strength on cycle (based on leg press, chest press, leg extension, and lat pulldowns). By the end of the 12 weeks off cycle they had lost all the strength gains. Later research states this was due to anabolic steroid-induced hypogonadism or low testosterone as a result of the negative feedback loop (1).


    What happens to your liver on cycle?

    There are many different pro hormones and designer steroids, but one thing is for certain, they negatively impact the function of your liver. In fact one man who abused pro hormones (this is why you should cycle them) was checked into the emergency room after reporting acute weakness, fatigue, fever, chills, and high blood press (4). He literally had trouble walking up his stairs. They found his liver enzymes AST and ASL (markers of liver stress) were elevated nearly 34 times normal levels! That may have been unassociated with his prohormone use, but they also found elevated levels of gamma glutamyl transferase, which is just another biomarker used to confirm the suspicion of liver stress and inflammation. Now this is obviously an extreme case, and also a result of abuse, however even with responsible cycles your liver undergoes some level of stress. Of which some are more susceptible than others.

    How do prohormones effect blood pressure?

    A 2010 study published in the Journal of Medicine and Science in Sports and Exercise determined the effect of steroid use on blood pressure (5). They compared a control group (no steroid use) of healthy young men vs. a group that had previously cycled steroids, and was currently using steroids. To no surprise they found that blood pressure was elevated at all time points over 24 hours compared to the control group. They also found it increased muscle sympathetic nerve activity (MSNA) and reduced blood flow to the forearm. MSNA is an independent predictor of heart failure, while reduced forearm blood flow is typically associated with a negative prognosis! They concluded their research with the following statement:

    "These findings suggest that AAS increases susceptibility to cardiovascular disease in humans."
    What can I do to maintain my health and keep my prohormone gains?

    One of the most important things you can do to return to "gainsville" after a prohormone cycle is plan a proper post cycle therapy. This means reversing all those negative effects we previously discussed. The first step is returning your natural testosterone to optimal levels. An important legal supplement to assist with this process is known as d-aspartic acid. D-aspartic acid has been shown to do the following in healthy men (6):


    • Increased LH output 33.3% on average
    • Increased Testosterone 42% on average



    Increasing LH and Testosterone is step #1 in recovering from a prohormone cycle. The faster you do this the faster you will be able to maintain your gains. Natural testosterone suppression is also often associated with a weakened immune system (7). The last thing you want to happen during PCT is getting sick, and being unable to train. Thankfully the combination of Cystine and Theanine (two amino acids) have been shown to improve immune system function in men (8, 9). A final defense towards low testosterone and immune system function is the use of an anti-estrogen. The use of an anti-estrogen in a low testosterone male has previously been shown to increase both sperm density, testosterone, and of course lower estrogen (10). Again the natural compound known as Androst-3,5-dien-7, 17-dione has shown that it's a powerful anti-estrogen both in research and in numerous real world users since it's introduction to the supplement market (11).


    Finally to further promote your immune system and muscle from the catabolic hormone cortisol, the use of an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor is critical. 7-Keto-DHEA and 7-OH-DHEA are both competitive inhibitors of 11β-HSD, and thus reduce cortisol. This keeps you lean, and properly modulates thyroid function (See: ReBoot™ - 7-Keto-DHEA & 7-OH-DHEA). All six (d-aspartic acid, cystine, theanine, Androst-3,5-dien-7, 17-dione, 7-Keto-DHEA, and 7-OH-DHEA) can be found in ForeRunner Labs ReBoot™. Taking ReBoot™ after your prohormone cycle will help optimize your hormone levels and return them to their pre-prohormone levels, ensuring you are able to maintain your mass and strength as well as support your immune system.
    Is ReBoot™ all I need for post cycle therapy (PCT)?

    While ReBoot™ will help your body optimize it's hormone levels and immune system recovery, it does not address the issue of liver stress, or blood pressure previously described above. For this we recommend Advanced Muscle Science's Super Cycle. Super Cycle is a "support" supplement designed to return your health to normal as quickly as possible after a prohormone cycle. Super Cycle contains N-acetyl-l-cysteine (NAC) which is an amino acid bonded to a acetyl group. NAC is actually used to treat non-acetaminophen liver failure. The US Acute Liver Failure Study Group suggested it's use in people with acute liver failure from the use of medications or herbal products (12). In fact the man we previously described with 34 times the normal level of liver enzymes was treated with NAC. Super Cycle also contains milk thistle (80% extract) and zinc aspartate, which are both associated with improved liver health.
    Super Cycle also contains hawthorne berry, which has been used to treat heart conditions since the 1800's. For our purposes it is useful to restore blood pressure to normal levels, and improve other cardiovascular biomarkers. A 2011 analysis assessed the outcomes of human clinical studies involving the use of hawthorne berry on chronic heart failure. The review found that hawthorne berry improved maximal workload, exercise tolerance, weakness, fatigue, and frequency of heart palpitations (14). Finally Super Cycle also contains 6 other ingredients designed to improve your health after a prohormone cycle.

    Can prohormones be used safely?

    The answer to this question is unequivocally YES! By using prohormones in moderation, in responsible doses, and properly planning your recovery period you can safely use prohormones. For a limited time ForeRunner Labs and Advanced Muscle Science have teamed up to offer you this special deal. The Recovery Stack includes 1 bottle of Reboot, and 1 bottle of Super Cycle which both contain 28 days of important post cycle therapy supplements. This is a limited time deal only available at The Lab so act fast!


    Regular Price: $79.78
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    ttt...
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    Bump!!! Great company here!
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    Nice and informative write up. Stuff like this really boost a persons confidence in a supp company.
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    Thanks for the feedback guys.

    I should mention Super Cycle actually contains 60 servings or two months worth of capsules. The article stated it was only a month worth.
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    On the t-nation forums, sponsored new supps like these had heavily moderated threads whereby the mods culled all negative comments. One such discontinued product I remember was the huge yellow tablet Spike, which was just an over-hyped massive dose of a B-vitamin.

    Let the presence of this post be a minor testament to objectivity.
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    Sounds like good stuff. Are these two items necessary when cycling Ostarine MK-2866 with DDA and a AI? Does suppression take place? Should there be a PCT?
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    Quote Originally Posted by omorashi View Post
    On the t-nation forums, sponsored new supps like these had heavily moderated threads whereby the mods culled all negative comments. One such discontinued product I remember was the huge yellow tablet Spike, which was just an over-hyped massive dose of a B-vitamin.

    Let the presence of this post be a minor testament to objectivity.
    Anabolicminds.com is quite different than t-nation. But #coolstorybro

    Quote Originally Posted by Shrine View Post
    Sounds like good stuff. Are these two items necessary when cycling Ostarine MK-2866 with DDA and a AI? Does suppression take place? Should there be a PCT?
    Suppression seems to be dependent on the dose of the sarm. But at bodybuilder doses it is likely mildly suppressive. Still your using DAA with it... So it probably is negligible.

    You can always run a pct to be safe but my guess is you will be fine.
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    Quote Originally Posted by omorashi View Post
    On the t-nation forums, sponsored new supps like these had heavily moderated threads whereby the mods culled all negative comments. One such discontinued product I remember was the huge yellow tablet Spike, which was just an over-hyped massive dose of a B-vitamin.

    Let the presence of this post be a minor testament to objectivity.
    Agree!
    Also a person should be very dumb to use designer steroids (or pro hormones) instead of real hormones.
    Esteroid are in the market for half century, why would someone change that for some crapy PH?

    PH = lots of sides for crappy gains. Thats the true!
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    A very concise post my friend.This is what makes this site great.Reps that actually care about informing and advising.Of course your going to push your products but you guys here do it differently to bb.com and t-nation e.g Lobliner-I drink 1000 scoops of xtend a day because.....

    In regards to the heart health factor exercise really is a saving factor along with sensible dieting on and off cycle.Were the previous users group sloppy with their diet or exercise regime,cardio ect... or were they all in tip top condition.It's worrying really as my blood pressure is normal for someone with low blood pressure but I'm concerned that my Superdrol cycle will change that.

    Thanks!
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    Good info
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    nice post bro
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    Sounds like Super Cycle should be used while on a PH cycle and Reboot after. It states that both should be used after. Blood pressure, liver toxicity would all be important while you are actually using the PH compounds. Super Cycle sounds a lot like CEL CycleAssist.
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    Quote Originally Posted by Roniboney View Post
    A very concise post my friend.This is what makes this site great.Reps that actually care about informing and advising.Of course your going to push your products but you guys here do it differently to bb.com and t-nation e.g Lobliner-I drink 1000 scoops of xtend a day because.....

    In regards to the heart health factor exercise really is a saving factor along with sensible dieting on and off cycle.Were the previous users group sloppy with their diet or exercise regime,cardio ect... or were they all in tip top condition.It's worrying really as my blood pressure is normal for someone with low blood pressure but I'm concerned that my Superdrol cycle will change that.

    Thanks!
    Lol I really like Lobliner :-P

    The blood pressure group consisted of weight trainees. But information beyond that was limited. The questions and answers are all meant to display worst case scenarios since effects seem highly variable depending on the individual.
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    Quote Originally Posted by TShoot View Post
    Sounds like Super Cycle should be used while on a PH cycle and Reboot after. It states that both should be used after. Blood pressure, liver toxicity would all be important while you are actually using the PH compounds. Super Cycle sounds a lot like CEL CycleAssist.
    I tend to see the best value in support supplements during PCT. The reason being that it's like fighting the tide from coming in. The hormones are going to have the impact to some degree with or without support. So just let it happen, and do everything you can to recover your health post cycle.

    I understand some people disagree which is fine of course.
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    Quote Originally Posted by TShoot View Post
    Sounds like Super Cycle should be used while on a PH cycle and Reboot after. It states that both should be used after. Blood pressure, liver toxicity would all be important while you are actually using the PH compounds. Super Cycle sounds a lot like CEL CycleAssist.
    I'd preload super cycle for 2 weeks before cycle, be on for 6-8 weeks and continue taking for 2-4 weeks after cycle. PH's effects on lipids, BP and liver will stick around for a bit after your last dose since the ph takes time to vacate your system completely
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    Quote Originally Posted by cswalczakny View Post
    I'd preload super cycle for 2 weeks before cycle, be on for 6-8 weeks and continue taking for 2-4 weeks after cycle. PH's effects on lipids, BP and liver will stick around for a bit after your last dose since the ph takes time to vacate your system completely
    That's a popular approach.
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    DAA D-Aspartic Acid is so cheap.
    I would be very interested in seeing someone on a straight cycle try taking DAA(testosterone booster) the entire cycle, from day 1 to the end of PCT.

    I know at least for me, during my pulse cycles a dosage of DAA D-Aspartic Acid Daily helps a great deal with lethargy, and also seems to help my joints from poping and hurting so much.
    I feel the DAA D-Aspartic dosage daily helps from getting "shut down" during my pulse cycles. No I have no blood work, but "there not sucked up" so I "feel" there not "shut down" all the way.
    I know with no blood work there's no proof the DAA is doing any good.
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    Good read, thanks.

    Oh, and good price there as well.

    I'll be using both of these products while deployed.
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    Very cool read. Been loving all the articles lately!
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    Sale is still rolling. Thanks for the feedback fellas.
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    Great read, buddy!

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    Quote Originally Posted by Trauma1 View Post
    Great read, buddy!
    Damn you and your avatar!! Goodness sakes alive I've not seen that picture of her and you had to go and put it as your avi....

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    Quote Originally Posted by tattoopierced1 View Post
    Damn you and your avatar!! Goodness sakes alive I've not seen that picture of her and you had to go and put it as your avi....

    I have some great pics for future avatar's too.

    I like the picture of her that's in my profile the best.



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    Quote Originally Posted by tattoopierced1

    Damn you and your avatar!! Goodness sakes alive I've not seen that picture of her and you had to go and put it as your avi....

    I only have my phone so the pic is so small ;(

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    Quote Originally Posted by Trauma1 View Post
    I have some great pics for future avatar's too.

    I like the picture of her that's in my profile the best.



    -T1
    You need to send me the link to a bigger picture of that...
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    Quote Originally Posted by CopyCat View Post
    I only have my phone so the pic is so small ;(

    Sent from my iPhone using Am.com
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    Quote Originally Posted by tattoopierced1 View Post
    You need to send me the link to a bigger picture of that...
    Posted my man. Damn that's a sweet pic....

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    Bump for the sale.

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    Bump!

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