Sodium Ursolic Acetate topical spray

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    Sodium Ursolic Acetate topical spray


    Ur Spray

    Ur Spray contains a soluble derivative of the amazing natural repartitioning compound ursolic acid. By transforming the poorly absorbed parent ursolic acid into its acetic acid ester, and then into the sodium salt of that ester, a form is acquired that can be effectively delivered via topical formulation.
    This allows a much higher percentage of ursolic acid to enter the body than with oral formulations of straight ursolic acid. It also allows for a sustained release effect, so that blood levels of ursolic acid can be maintained throughout the day
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    Any tests so far to prove it works unlike its oral partner?
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    Quote Originally Posted by Celorza View Post
    Any tests so far to prove it works unlike its oral partner?
    no

    but i can take pictures of how the parent compound dissolves in transdermal base and then how this dissolves.

    there is no reason why this formulation should not get a decent amount of ursolic acid into the body. When you figure that the oral bioavailability of ursolic acid is said to be less than 1 percent I dont think there is much to overcome here
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    Quote Originally Posted by Patrick Arnold View Post
    no

    When you figure that the oral bioavailability of ursolic acid is said to be less than 1 percent I dont think there is much to overcome here
    Solid point , lets hope to see this in production soon.
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    Quote Originally Posted by Celorza View Post
    Solid point , lets hope to see this in production soon.
    its available now at prototype nutrition

    www.prototypenutrition.com


    many of the products on prototype are just that - prototypes. Ideas that are put on the market at a very early stage - often before proof of concept has been established. I literally make all those sprays by hand, and in the case of the Ur Spray i made the actual active ingredient (sodium ursolic acetate) by hand starting from Ursolic Acid that was around 95 percent pure
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    very nice. loved the oral form of urso so definitely going to give this a shot
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    There's a sucker born every minute.
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    Quote Originally Posted by thedarce View Post
    There's a sucker born every minute.

    do you have anything intelligent to add?
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    Just picked up two bottles of this and looking forward to giving it a run at some point.

    My wife is pregnant, so of course ill be wearing a t shirt if i decide to utilize the product when i get it, but do you think any negative things could happen if my wife for some reason got in contact with some of the urso? I realize urso isnt hormonal.

    I know this might be a hard question to answer and i know theres no definitive answer, just kind of looking for your opinion so thank you i appreciate your time.
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    Quote Originally Posted by 3clipseGT View Post
    Just picked up two bottles of this and looking forward to giving it a run at some point.

    My wife is pregnant, so of course ill be wearing a t shirt if i decide to utilize the product when i get it, but do you think any negative things could happen if my wife for some reason got in contact with some of the urso? I realize urso isnt hormonal.

    I know this might be a hard question to answer and i know theres no definitive answer, just kind of looking for your opinion so thank you i appreciate your time.

    i cant say for sure but i havent read anything to make me think it would hurt your wifes fertility or harm a fertilized egg
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    Quote Originally Posted by Patrick Arnold View Post
    i cant say for sure but i havent read anything to make me think it would hurt your wifes fertility or harm a fertilized egg
    I didnt think so n from what ive read and seen i havnt noted anything about that. Like i said though i know that area is one thats in the dark simply because of the situation.

    Thanks again for the answer Pat.
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    Quote Originally Posted by thedarce View Post
    There's a sucker born every minute.
    I am a sucker. I bought a bottle. Patrick never makes any big promises or hypes any of his products. HE states what he thinks they will do based on his knowledge, experiences and science, and leaves the rest to consumer. If it doesnt work, it doesnt work. Look at the original urso, he even said it was somewhat lacking or something to that effect and he was trying a new form that should work better. It may suck, who knows. I am willing to try it
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    any truth to This?
    Read this today. Ursolic acid triggers the key anabolic hormones responsible for muscle growth.

    Another key anabolic effect centers around ursolic acid’s effect on molecular signaling molecules. Ursolic acid “switched on” the receptors for IGF-1, Akt and S6K. This molecular signaling activity leads to an increase in protein synthesis and cell proliferation.


    What would be a good stack with this? Anabeta?
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    Quote Originally Posted by djbombsquad View Post
    any truth to This?
    Read this today. Ursolic acid triggers the key anabolic hormones responsible for muscle growth.

    Another key anabolic effect centers around ursolic acid’s effect on molecular signaling molecules. Ursolic acid “switched on” the receptors for IGF-1, Akt and S6K. This molecular signaling activity leads to an increase in protein synthesis and cell proliferation.


    What would be a good stack with this? Anabeta?

    its all lies
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    how long will 1 bottle last?
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    Quote Originally Posted by dlucks View Post
    how long will 1 bottle last?
    all the sprays last around 25-30 days if you spray around 50 sprays once a day
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    Should this be stacked with anything?
    Ageforce rep, Lets patch up those mistakes and stop going oral.
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    Quote Originally Posted by djbombsquad View Post
    Should this be stacked with anything?
    use your imagination

    i cant think of any magic combo off the top of my head

    growth hormone and testosterone cypionate seem to work well with a lot of supps though
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    Growth is just too expensive for my blood, but cyp is covered by my insurance
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    I can say that 8 bottles of Ursobolic didn't do squat for me and I expressed it as well...... But I wouldn't be shy about trying the spray. I'll wait it out for awhile this time and wait for feedback.
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    Quote Originally Posted by Patrick Arnold View Post
    use your imagination

    i cant think of any magic combo off the top of my head

    growth hormone and testosterone cypionate seem to work well with a lot of supps though
    Lol, Pat you drinking?
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    Quote Originally Posted by BPjohn123 View Post
    Lol, Pat you drinking?
    no but i am highly considering starting
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    Quote Originally Posted by Patrick Arnold View Post
    no but i am highly considering starting
    Have fun.
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    He will start drinking when ppl start asking for a suppository of this urso haha
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    Quote Originally Posted by Patrick Arnold View Post
    all the sprays last around 25-30 days if you spray around 50 sprays once a day
    Can I stack with Superdrol and Winny? Will it work better?
    나는 2000년 10월 매들린 올브라이트 전 미 국무장관 매들린 사랑, 그 중 한 뜨거운 젠장!
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    Quote Originally Posted by ax1 View Post
    Can I stack with Superdrol and Winny? Will it work better?
    Add vodka and you have a potent stack.
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    Quote Originally Posted by BPjohn123 View Post
    Add vodka and you have a potent stack.
    If he makes a trandermal Im totally down because I dont drink, not my thing.
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    one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.
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    Quote Originally Posted by EasyEJL View Post
    one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.
    Nice
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    Quote Originally Posted by EasyEJL View Post
    one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.
    Phytomedicine. 2003 Mar;10(2-3):115-21.
    Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension.

    Somova LO, Nadar A, Rammanan P, Shode FO.
    Source

    Department of Human Physiology, University of Durban-Westville, Durban, South Africa. somova@pixie.udw.ac.za

    Abstract

    Cardiovascular (systolic and diastolic blood pressure, heart rate), antihyperlipidemic (tryglycerides, total cholesterol and lipoprotein fractions), antioxidant (glutathione peroxidase--GPx, and superoxide dismutase--SOD), diuretic/saluretic and hypoglycemic activity of 98% pure oleanolic (OA) and ursolic (UA) acid were studied in Dahl salt-sensitive (DSS), insulin resistant rat model of genetic hypertension. Both OA and UA displayed low toxicity, with LC50 0.10 and 0.95 mg/ml, respectively. Although both triterpenoids did not have direct hypotensive effect, after 6-week application in a daily dose 60 mg/kg b.w., i.p., they prevented the development of severe hypertension. The antihypertensive effect was attributed to their potent diuretic-natriuretic-saluretic activity; direct cardiac effect (heart rate decrease by 34% and 32%, respectively); antihyperlipidemic (more than two times decrease of LDL and triglycerides); antioxidant (GPx increase by 12% and 10%, respectively; SOD increase by 12% and 22%, respectively), and hypoglycemic (blood glucose decrease by 20% and 50%, respectively) effects on the DSS rats. Except for the antihyperlipidemic effects, the other described above in vivo antihypertensive effects of OA and UA are reported for the first time and the underlying mechanisms are currently under investigation.

    -----------------

    Phytother Res. 2010 Jun;24 Suppl 2:S220-4.
    Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3.

    Azevedo MF, Camsari C, S CM, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C.
    Source

    CBMA - Centre of Molecular and Environmental Biology/Department of Biology, University of Minho, Campus de Gualtar, Braga, Portugal.

    Erratum in

    • Phytother Res. 2010 Jun;24 Suppl 2:S233-4.

    Abstract

    In the present study, two phytochemicals - ursolic acid (UA) and luteolin-7-glucoside (L7G) - were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of glycogen synthase kinase-3 (GSK3). The increase in glycogen deposition induced by UA (mediated by GSK3) could have contributed to the lower plasma glucose levels observed. Both compounds significantly lowered total plasmacholesterol and low-density lipoprotein levels, and, in addition, UA increased plasma high-density lipoprotein levels. Our results show that UA particularly may be useful in preventable strategies for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition.

    ------------





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    yeah, after getting results from donating I hunted around and saw that. Could prove to be handy as an adjunct to a cycle, to keep lipids from being thrashed as badly.
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    Quote Originally Posted by EasyEJL View Post
    yeah, after getting results from donating I hunted around and saw that. Could prove to be handy as an adjunct to a cycle, to keep lipids from being thrashed as badly.
    its a great benefit, but if i go around touting it as a cholesterol treatment that would piss off the FDA to no end.
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    How were you dosing Eric?
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    Quote Originally Posted by BPjohn123 View Post
    How were you dosing Eric?
    I was taking 4 caps 3x a day
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    Very cool idea, Pat. I'll be looking forward to hearing some more on it. Could be a very fun little product.
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    Quote Originally Posted by MidwestBeast View Post
    Very cool idea, Pat. I'll be looking forward to hearing some more on it. Could be a very fun little product.

    thank you. i think it is a pretty cool idea derivatizing UA as was done and improving the solubiilty so greatly. The guy that made the sucker born every minute comment can bite me. This was an accomplishment of chemistry, not a marketing scam
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    HUNG!

    Looking like a great product concept. I'll go ahead and shoot over an order.
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    I actually am still on UA and take it for the "health" benefits. Kinda like how ppl take milk thistle or NAC. I take UA for that. If I get anymore out of it then omg it's amazing. Perhaps I will pick up the spray too ;D
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    Quote Originally Posted by thedarce View Post
    There's a sucker born every minute.
    It's funny that you did not quote all of Pat's post when you chimed in on the thread on Bodybuilding.Com. In full context Pat goes on to explain himself. See below. As I mentioned over there, Pat is smart enough, and has enough followers that he could BS all day long and make a killing if he wanted to. Instead he's upfront and honest to the consumers, who in reality are gullible and easily taken advantage of. You will be hard pressed to find another formulator in this industry who has a track record of effective, non tainted products as PA.

    Good luck in your 2012 hating goals though.

    Quote Originally Posted by Patrick Arnold View Post
    no

    but i can take pictures of how the parent compound dissolves in transdermal base and then how this dissolves.

    there is no reason why this formulation should not get a decent amount of ursolic acid into the body. When you figure that the oral bioavailability of ursolic acid is said to be less than 1 percent I dont think there is much to overcome here
    Quote Originally Posted by Patrick Arnold View Post
    its available now at prototype nutrition

    www.prototypenutrition.com


    many of the products on prototype are just that - prototypes. Ideas that are put on the market at a very early stage - often before proof of concept has been established. I literally make all those sprays by hand, and in the case of the Ur Spray i made the actual active ingredient (sodium ursolic acetate) by hand starting from Ursolic Acid that was around 95 percent pure
    Quote Originally Posted by howwedo107 View Post
    He will start drinking when ppl start asking for a suppository of this urso haha
    Wait....I thought that's how the original was supposed to be taken.
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    Quote Originally Posted by nimbustim View Post
    It's funny that you did not quote all of Pat's post when you chimed in on the thread on Bodybuilding.Com

    what thread?
    Anabolicminds.com Featured Author
  

  
 

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