[Patrick Arnold]

Ur Spray

Ur Spray contains a soluble derivative of the amazing natural repartitioning compound ursolic acid. By transforming the poorly absorbed parent ursolic acid into its acetic acid ester, and then into the sodium salt of that ester, a form is acquired that can be effectively delivered via topical formulation.
This allows a much higher percentage of ursolic acid to enter the body than with oral formulations of straight ursolic acid. It also allows for a sustained release effect, so that blood levels of ursolic acid can be maintained throughout the day

[Celorza]

Any tests so far to prove it works unlike its oral partner?

[Patrick Arnold]

Any tests so far to prove it works unlike its oral partner?

no

but i can take pictures of how the parent compound dissolves in transdermal base and then how this dissolves.

there is no reason why this formulation should not get a decent amount of ursolic acid into the body. When you figure that the oral bioavailability of ursolic acid is said to be less than 1 percent I dont think there is much to overcome here

[Celorza]

no

When you figure that the oral bioavailability of ursolic acid is said to be less than 1 percent I dont think there is much to overcome here

Solid point , lets hope to see this in production soon.

[Patrick Arnold]

Solid point , lets hope to see this in production soon.

its available now at prototype nutrition

www.prototypenutrition.com


many of the products on prototype are just that - prototypes. Ideas that are put on the market at a very early stage - often before proof of concept has been established. I literally make all those sprays by hand, and in the case of the Ur Spray i made the actual active ingredient (sodium ursolic acetate) by hand starting from Ursolic Acid that was around 95 percent pure

[jwa254]

very nice. loved the oral form of urso so definitely going to give this a shot

[thedarce]

There's a sucker born every minute.

[Patrick Arnold]

There's a sucker born every minute.

do you have anything intelligent to add?

[3clipseGT]

Just picked up two bottles of this and looking forward to giving it a run at some point.

My wife is pregnant, so of course ill be wearing a t shirt if i decide to utilize the product when i get it, but do you think any negative things could happen if my wife for some reason got in contact with some of the urso? I realize urso isnt hormonal.

I know this might be a hard question to answer and i know theres no definitive answer, just kind of looking for your opinion so thank you i appreciate your time.

[Patrick Arnold]

Just picked up two bottles of this and looking forward to giving it a run at some point.

My wife is pregnant, so of course ill be wearing a t shirt if i decide to utilize the product when i get it, but do you think any negative things could happen if my wife for some reason got in contact with some of the urso? I realize urso isnt hormonal.

I know this might be a hard question to answer and i know theres no definitive answer, just kind of looking for your opinion so thank you i appreciate your time.

i cant say for sure but i havent read anything to make me think it would hurt your wifes fertility or harm a fertilized egg

[3clipseGT]

i cant say for sure but i havent read anything to make me think it would hurt your wifes fertility or harm a fertilized egg

I didnt think so n from what ive read and seen i havnt noted anything about that. Like i said though i know that area is one thats in the dark simply because of the situation.

Thanks again for the answer Pat.

[bigbeef]

There's a sucker born every minute.

I am a sucker. I bought a bottle. Patrick never makes any big promises or hypes any of his products. HE states what he thinks they will do based on his knowledge, experiences and science, and leaves the rest to consumer. If it doesnt work, it doesnt work. Look at the original urso, he even said it was somewhat lacking or something to that effect and he was trying a new form that should work better. It may suck, who knows. I am willing to try it

[djbombsquad]

any truth to This?
Read this today. Ursolic acid triggers the key anabolic hormones responsible for muscle growth.

Another key anabolic effect centers around ursolic acid’s effect on molecular signaling molecules. Ursolic acid “switched on” the receptors for IGF-1, Akt and S6K. This molecular signaling activity leads to an increase in protein synthesis and cell proliferation.


What would be a good stack with this? Anabeta?

[Patrick Arnold]

any truth to This?
Read this today. Ursolic acid triggers the key anabolic hormones responsible for muscle growth.

Another key anabolic effect centers around ursolic acid’s effect on molecular signaling molecules. Ursolic acid “switched on” the receptors for IGF-1, Akt and S6K. This molecular signaling activity leads to an increase in protein synthesis and cell proliferation.


What would be a good stack with this? Anabeta?

its all lies

[dlucks]

how long will 1 bottle last?

[Patrick Arnold]

how long will 1 bottle last?

all the sprays last around 25-30 days if you spray around 50 sprays once a day

[djbombsquad]

Should this be stacked with anything?

[Patrick Arnold]

Should this be stacked with anything?

use your imagination

i cant think of any magic combo off the top of my head

growth hormone and testosterone cypionate seem to work well with a lot of supps though

[bigbeef]

Growth is just too expensive for my blood, but cyp is covered by my insurance

[Mission1]

I can say that 8 bottles of Ursobolic didn't do squat for me and I expressed it as well...... But I wouldn't be shy about trying the spray. I'll wait it out for awhile this time and wait for feedback.

[BPjohn123]

use your imagination

i cant think of any magic combo off the top of my head

growth hormone and testosterone cypionate seem to work well with a lot of supps though

Lol, Pat you drinking?

[Patrick Arnold]

Lol, Pat you drinking?

no but i am highly considering starting

[BPjohn123]

no but i am highly considering starting

Have fun.

[howwedo107]

He will start drinking when ppl start asking for a suppository of this urso haha

[ax1]

all the sprays last around 25-30 days if you spray around 50 sprays once a day

Can I stack with Superdrol and Winny? Will it work better?

[BPjohn123]

Can I stack with Superdrol and Winny? Will it work better?

Add vodka and you have a potent stack.

[ax1]

Add vodka and you have a potent stack.

If he makes a trandermal Im totally down because I dont drink, not my thing.

[EasyEJL]

one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.

[BPjohn123]

one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.

Nice

[Patrick Arnold]

one thing I noticed after a few bottles of ursobolic was that when I donated blood, my total cholesterol was the lowest its been in well, probably ever.

Phytomedicine. 2003 Mar;10(2-3):115-21.

Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension.

Somova LO, Nadar A, Rammanan P, Shode FO.
Source

Department of Human Physiology, University of Durban-Westville, Durban, South Africa. [email protected]

Abstract

Cardiovascular (systolic and diastolic blood pressure, heart rate), antihyperlipidemic (tryglycerides, total cholesterol and lipoprotein fractions), antioxidant (glutathione peroxidase--GPx, and superoxide dismutase--SOD), diuretic/saluretic and hypoglycemic activity of 98% pure oleanolic (OA) and ursolic (UA) acid were studied in Dahl salt-sensitive (DSS), insulin resistant rat model of genetic hypertension. Both OA and UA displayed low toxicity, with LC50 0.10 and 0.95 mg/ml, respectively. Although both triterpenoids did not have direct hypotensive effect, after 6-week application in a daily dose 60 mg/kg b.w., i.p., they prevented the development of severe hypertension. The antihypertensive effect was attributed to their potent diuretic-natriuretic-saluretic activity; direct cardiac effect (heart rate decrease by 34% and 32%, respectively); antihyperlipidemic (more than two times decrease of LDL and triglycerides); antioxidant (GPx increase by 12% and 10%, respectively; SOD increase by 12% and 22%, respectively), and hypoglycemic (blood glucose decrease by 20% and 50%, respectively) effects on the DSS rats. Except for the antihyperlipidemic effects, the other described above in vivo antihypertensive effects of OA and UA are reported for the first time and the underlying mechanisms are currently under investigation.

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Phytother Res. 2010 Jun;24 Suppl 2:S220-4.
Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3.

Azevedo MF, Camsari C, Sá CM, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C.
Source

CBMA - Centre of Molecular and Environmental Biology/Department of Biology, University of Minho, Campus de Gualtar, Braga, Portugal.

Erratum in

• Phytother Res. 2010 Jun;24 Suppl 2:S233-4.

Abstract

In the present study, two phytochemicals - ursolic acid (UA) and luteolin-7-glucoside (L7G) - were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of glycogen synthase kinase-3 (GSK3). The increase in glycogen deposition induced by UA (mediated by GSK3) could have contributed to the lower plasma glucose levels observed. Both compounds significantly lowered total plasmacholesterol and low-density lipoprotein levels, and, in addition, UA increased plasma high-density lipoprotein levels. Our results show that UA particularly may be useful in preventable strategies for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition.

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