PES Erase Pro - The Breakdown
- 12-15-2011, 10:08 PM
PES Erase Pro - The Breakdown
After more than a years worth of phenomenal feedback on Erase, we have decided to formulate an all new, full spectrum, hardcore product - Erase Pro.
Erase will not be going anywhere...but you will now have the option to take the Erase experience to a whole new level.
Erase Pro utilizes hormone modulation like never before. With the addition of two new very exciting ingredients users will experience effects they never even imagined possible with an OTC product.
As a standalone, Erase Pro simultaneously has both AI and SERM-like properties. It can act both as an aromatase inhibitor and as an estrogen receptor antagonist.
Aromatase inhibition is sought after due to the fact that by inhibiting the conversion of testosterone to estrogen, T goes up and E goes down.
SERMs are sought after because they block estrogen itself from binding to and activating its receptor. By doing this your body senses a need for more estrogen. Since estrogen comes from testosterone, your body signals for more and more testosterone release. This is why SERMs are used heavily in the underground bodybuilding community.
An ingredient in Erase Pro also has animal data on cortisol reduction. Keep the cortisol spike down. You may choose to take your Erase Pro in the morning, or around your workouts. Times when cortisol is highest...be both anabolic and anti-catabolic.
For users of anabolics, this is the absolute best combination of mechanisms for an over the counter PCT. You can see why, with the combination of both AI and ER inhibition. That is how PCTs are designed.
So what can you expect from Erase Pro over Erase?
Even greater physiological effects. We know because we tested it extensively. We had a number of possible ingredients with possible SERM action, and the one we used clearly stood out to us. We spent the time to find the best extraction and the best dose to combine with the Androsta-3,5-diene-7,17-dione.
We have more experience with the original Erase ingredient than anyone...and there is no doubt Erase Pro's formula took the feel to a new level.
Everyone loves the hardening, drying, lean feeling Erase gives. Expect all that and more from Erase Pro.
The writeup can be viewed on our website, www.pescience.com
- 12-15-2011, 10:09 PM
Boerhaavia diffusa (Root) Extract
Anti-Estrogen via direct Estrogen Receptor Binding
B. diffusa showed potent competitive binding for the estrogen receptor in vitro. The result was less estrogen could bind to the receptor. By preventing E from binding to its receptor it cannot give its undesirable effects on the body.
This is the same mechanism SERMs like Nolva use. As a result your body will signal for more testosterone release in order to hope to also increase estrogen. This is why we included an aromatase inhibitor in Erase Pro.
(Sreekumar Sreeja, Sreeharshan Sreeja; An in vitro study on antiproliferative and antiestrogenic effects of Boerhaavia diffusa L. extracts Journal of Ethnopharmacology, Volume 126, Issue 2, 12 November 2009, Pages 221-225)
Cortisol Modulation in the Animal Model
Data shows that in a stress swim test, animals taking BDE (b. diffusa extract) did not see the significant estrogen spike that control groups saw. The BDE group also had 25% longer swimming times.
Cortisol is the hormone released is stressful situations, especially during physical training. This catabolic hormone has the ability to break down muscle. BDE gives Erase Pro a true anti-catabolic mechanism
(Meera Sumanth and S.S. Mustafa, Antistress, Adaptogenic and Immunopotentiating Activity Roots of Boerhaavia Diffusa in Mice, International Journal of Pharmacology 3 (5): 416-420, 2007)
BDE has also shown to have direct diuretic activity. This fits perfectly in the goal of Erase Pro. Lean...Dry...Hard.
(Gaitonde, B.B., Kulkarni, H.J., and Nabar,S.D. Diuretic activity of punarnava (Boerhaavia diffusa). Bulletins of the Haffkine Institute (Bombay,India) 1974; 2:24)
Alpha-2 Adrenergic Antagonist
You may be familiar with this mechanism if you have real about Alpha-T2, as it is the target pathway in Alpha-T2. Alpha-2 adrenoceptors are receptors in the stomach, love handles, and chest that when turned on are working to STORE fat in those areas. By inhibiting this enzyme you can turn the mechanism off. This is the key pathway to targeted fat loss, most especially belly fat.
(Shigetoshi Kadota et al. Constituents of the Roots of Boerhaavia diffusa L. I. Examination of Sterols and Structures of New Rotenoids, Boerhavinones A and B; Chem Pharm Bull 37(12) 3214-3220 (1989) Vol. 37 No. 12)
12-15-2011, 10:09 PM
Euonymus alatus (Root) Extract
This ingredient caters to those who will be using Erase Pro on cycle and/or PCT. It works under a mechanism known as in-situ inhibition of estrogen. This mechanism is on the forefront of research for developing a way to target estrogen reduction selectively in breast cancer patients.
Those who cycle know that some people are super prone to gyno and seem almost gyno-invincible. The cause of this is some people have more aromatase enzymes in their mammary cells than others.
This ingredient and its mechanism may hold the key to making those who are extremely prone to on-cycle or PCT gyno much less susceptible.
(Lee TK, Kim DI, Han JY, Kim CH. Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells. Immunopharmacol Immunotoxicol. 2004 Aug;26(3):315-27.)
12-15-2011, 10:09 PM
You guys all already know and love this compound so much...the majority of you have used it. We have given this ingredient at the favorite dose after a years worth of feedback - 75mg per capsule.
Once daily dosing is all you need. In fact, if you find Erase Pro is too strong for you then you can even go to once every other day dosing.
This amazing ingredient is a real, synthetic, irreversible aromatase inhibitor. The data shows a Ki value even better than exemestane, and way better than formestane.
Erase, and this ingredient, are both so popular because of one reason...it works...and works extremely well. 1 capsule of Erase Pro is all you need...how's that for potent?
Each of these ingredients are beasts of their own. We have tested the ingredients singularly and in concert with one another. The result is a truly special and cutting edge hardcore formula.
For serious users only...no matter your goals. It is the ultimate hardening, drying, lean formula you will come across. Use it on bulk, cut, or recomp. You will feel the difference.
(Numazawa M, Mutsumi A, Tachibana M, Hoshi K; Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase; J Med Chem. 1994 Jul 8;37(14):2198-2)
12-15-2011, 10:12 PM
Sounds like a solid product. I've only read good things about the original Erase, can't wait to hear more about Pro.
12-15-2011, 10:14 PM
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12-15-2011, 11:40 PM
12-16-2011, 01:04 AM
Alpha 2 adrenergic activity on top or cortisol control, ai, and serm properties. holy ****, this will make a mean fat loss agent
12-16-2011, 01:15 AM
12-16-2011, 01:20 AM
12-16-2011, 02:12 AM
12-16-2011, 04:29 AM
12-16-2011, 04:43 AM
Congrats on the new version Natty!
Quick question (sorry if it has already been discussed on some other 3d): I remember
reading something aboutAndrosta-3,5-diene-7,17-dione stimulating TSH,
since I'm about to try to kickstart my thyroid levels (diet-induced drop)
I'd like to hear your thoughts on this specific (proven?possible?) action of Androsta
BTW just won a PES t-shirt on Fbbbbbbbbbbbb!!
12-16-2011, 04:54 AM
12-16-2011, 05:13 AM
12-16-2011, 05:22 AM
Reading this made me jizz my pants.
SNS - Serious Nutrition Solutions
My advice is exclusively my own and may not correspond with the views of SNS
Questions or concerns? → conny[@]seriousnutritionsolutions.com
12-16-2011, 07:59 AM
Damn! ERASE PRO?!
Just started a log for my 14 week cut! What's a player got to do to log one of these?
12-16-2011, 08:54 AM
I think this will be the product to pop my PES cherry! Haven't used any PES products yet, but I think this may be my first. Sounds right up my ally. I am currently dieting to drop bf.
12-16-2011, 09:01 AM
12-16-2011, 09:53 AM
12-16-2011, 09:59 AM