Trenavar Pre-Sale NOW, Ships by 12/23 only 2000 bottles!!!!

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    Trenavar Pre-Sale NOW, Ships by 12/23 only 2000 bottles!!!!


    trendione is on the banned list so better stock up now, 2000 bottles on pre-sale now ships by 12/23 next batch not available for 6 more weeks..........


    Text of S.4032 as Introduced in Senate: Designer Anabolic Steroid Control Act of 2010 - U.S. Congress - OpenCongress


    even though it was a 2010 bill they are still wanting to ban it


    Nomenclature:


    Estra-4,9,11-triene-3,17-dione



    Synonyms:



    Trenavar, Trendione



    History:



    This is a brand new prohormone from PHF/IBE, never seen before on the prohormone or pharmaceutical market.



    Function:



    This is a prohormone to the veterinary drug and black-market
    bodybuilding steroid trenbolone. Unlike previous "tren" prohormones,
    this one actually converts in the body to trenbolone. Previous "tren"
    PHs converted to the structurally similar - but markedly weaker -
    steroid dienolone.



    Structure:



    This prohormone has the same three conjugated double bonds as
    trenbolone, and differs from it only in that this hormone has a
    17-ketone, where trenbolone has a 17b-hydroxy function. In the body this
    ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase
    type 1 (17b-HSD1) into the active form, trenbolone.



    Effects:



    Conversion to trenbolone should be high, so effects should be identical
    to the injectable form - with the exception of the famed "tren cough".
    Whatever the explanation for "tren cough" (and many have been
    suggested), since it's a reaction to the sudden parenteral introduction
    of some compound directly into the body, it's highly unlikely that any
    orally administered compound will have the same effect.

    Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same - huge strength and size increases, accelerated fat loss, and enhanced vascularity.



    Side Effects:



    Blood pressure is likely to be dose-dependently elevated to a
    significant degree, cholesterol levels and liver function markers are
    likely to be adversely affected, though to what extent remains to be
    seen. Commonly reported trenbolone sides include night-sweats, mood
    swings, androgenic hair loss and/or growth, temporary loss of libido, as
    well as the suppression of endogenous testosterone production, and it
    would be sensible to assume that these may also result from use of Trenavar.





    Metabolism and Bioavailability:



    Warning: if you're not interested in advanced steroid metabolism
    discussion, skip over this section. If you want solid info on how and
    why an oral tren PH should work, read on.



    The anabolic effects of trenbolone are due in part to the enhanced
    androgen receptor binding that the conjugated double bond system causes
    [1], and also because trenbolone is an antagonist of the glucocorticoid
    receptor [2]. The double bonds extending up the backbone of the steroid
    flattens the steroid considerably, which makes it an excellent fit for
    the androgen receptor. It also makes the molecule much more flexible,
    and therefore less receptor-specific [3]. Trenbolone is incapable of
    being affected by 5a-reductase, 5b-reductase, or aromatase. But will it
    work orally?



    The first place to turn to for information on steroids is the seminal
    1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately
    this compound isn't among the 666 compounds discussed there, and there's
    a shortage of information on trenbolone by oral adminstration. I was
    fortunate enough to find a study which compared the anabolic effects of
    oral and subcutaneous application of trenbolone in rats [4], and the
    results were frankly startling. They found that to have a comparable
    anabolic effect, trenbolone needed to be administered orally at 100
    times the dosage as when administered by subcutaneous injection (see
    graph). Sounds pretty bad for a tren PH then, right? Well, the good news
    is we're not rats.





    Trenbolone is metabolised differently in different species - in rats,
    around 40% is excreted as a dione form, as well as several metabolites
    hydroxylated in various positions [5], but in man only one metabolite
    has been identified - the 17a-epimer [6].







    The ratio of excreted trenbolone (17b-trenbolone) to epitrenbolone (17a-trenbolone) is estimated at 1:5 in a 24hr period [7].



    What this means is that although Trenavar
    is a prohormone to trenbolone, it doesn't appear to be a significant
    metabolite in humans. The equilibrium of the reaction between 17-one and
    17b-ol appears to be weighted heavily - in fact pretty much exclusively
    - in favour of the 17b-ol, so Trenavar
    should convert readily to the active form trenbolone. Once converted to
    trenbolone, it will be open to the same metabolism mechanisms as
    injectable tren - conversion via sulfatase to epitrenbolone and
    excretion as glucoronides.



    Of course, this is largely conjecture, since neither trenbolone nor a
    precursor to it has ever been on the supplement market before... or has
    it?

    A few years ago ALRI released an encapsulated product called "Methoxy
    TRN", advertised as containing "17b-methoxytrienbolone". This was
    quickly pulled from the shelves soon after its release, leaving only a
    few highly-collectable bottles and a reputation for tremendous strength
    and size gains and roadmap vascularity. This supplement was tested in
    2008, and the researchers discovered the tell-tale mass spectra of
    trenbolone (and no sign of the advertised methoxy group) [8].



    Detection Limits:



    An anti-doping study from 1996 found that orally administered trenbolone
    was detectable by mass spectrometry for two to four days after a single
    administration, unlike injectable trenbolone, which is detectable for
    much longer [9]. The detection of trenbolone after administration of Trenavar
    is likely to follow similar lines, though detection methods may have
    improved since then. Athletes subjected to doping tests should of course
    avoid this and all other prohibited performance-enhancing products
    altogether.





    Dosages and Cycle Durations:



    Empirical evidence is the only way to determine this; once the product
    has been used by enough people we'll have a better idea of how much, and
    for how long, Trenavar is best used.



    References



    [1] Steroids 74 (2009) 172197



    [2] Acta Endocrinologica, Vol 110, 1 Suppla, S129-S130



    [3] J Steroid Biochem 1979;13:4559.



    [4] Toxicol Sci. 2002;70:202211.



    [5] Xenobiotica. 1981 Jul;11(7):489-500.



    [6] Biol. Mass Spectrom. 20 (1991) 459466.



    [7] Recent advances in doping analysis (2). (1995) 269-274.



    [8] Anal Chim Acta. 2009 Apr 1;637(1-2):92-100.



    [9] Recent advances in doping analysis (3). (1996) 83-94.Share

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    Damn..Gimme
    what is the dose per pill???

    RECOVERBRO


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    Quote Originally Posted by JoHNnyNuTZ
    Damn..Gimme
    what is the dose per pill???
    I think it's 15mg
    "Difficult things take a long time, impossible things take a little longer."
    OG Punjabi Avenger
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    If it's on the ban, why are they selling it or what makes it different?

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