Antaeus Labs ULTRADROL Unleashed on AM!!
- 09-18-2011, 10:55 PM
Antaeus Labs ULTRADROL Unleashed on AM!!
For those of you who haven't seen the logs yet check them out in the cycle info section (under anabolics).
We are giving this away free in two contests, one of which is already running so get in there in the company promo section.
Antaeus Labs Ultradrol - The FASTEST way to build muscle, PERIOD.
Ultradrol is the world's best legal bulking and repartitioning agent. Nothing available can induce changes in strength, muscle mass, and body composition like Ultradrol. None are better. Ne plus ultra.
The active ingredient in Ultradrol is an active and highly orally-bioavailable compound engineered to strongly resist metabolic breakdown on both the A and D rings -- precisely where other active hormonal molecules typically degrade into estrogenic or biologically-inactive metabolites. As a result, Ultradrol has a superior pharmacokinetic profile and exceptional potency. It does not aromatize into any estrogenic compound and has no affinity for the progesterone receptor, so estrogen and progesterone receptor mediated side effects are of no concern.
Δ1-2: Renders the A-ring resistant to reductive metabolism by the 3-hydroxysteroid dehydrogenase enzyme; increases anabolic potency.
2-methyl: Planar 2-methyl group further protects the A-ring from the usual metabolic reduction; modulates the androgenic and anabolic potency of the compound via interfering with receptor binding.
17α-methyl: Inhibits reductive metabolism by the 17-hydroxysteroid dehydrogenase enzyme, thereby increasing oral bioavailablity.
-Active compound. No conversion required.
-Remarkably resistant to metabolic reduction
-High anabolic potency
-Zero conversion to estrogen
Methyl-stenbolone has been 'released' before, but in virtually all instances was simply mis-labelled Superdrol. What we have here is, finally, the real stuff. A rigorous gauntlet of mass-spectrometry tests shall be performed on each batch before they are capped and released. Test results for every single batch will be posted online. We happily give free samples to reputable testing centers and/or professional analytical chemists. We also give cash rewards to people who would like to furnish us with before-and-after blood test results.
Ultradrol Testing Results Explained
Just about every chemical manufacturer that I know of, and certainly every lab that I work with, checks to see if a synthetic reaction is complete via mass spectrometry testing. And we always double-check every Antaeus Lab batch via mass spectrometry at an independent testing center. I want to explain a little bit about our methods here, so that charts we post now & in the future can be understood. (I really feel that "Certificates of analysis" which don't contain mass-spec data are totally useless, and that a good chart is worth a thousand words...)
Mass spectrometry is an analytical method used to measure the molecular mass of a chemical sample. The testing devices typically contain an ionizing unit, a mass anayzer, and a detection/recording unit, which work briefly as follows: A sample is first ionized, in our case typically via electrospray ionization (ESI) or matrix assisted laser desorption ionisation (MALDI). These gaseous ions are seperated by the mass analyzer according to their mass to charge (m/z) ratios. The detector unit monitors the m/z activity, amplifies it, and automatically runs it through some software to create a 'mass spectra' graph which clearly displays the test compound's m/z. (Or that of its fragments, if the compound in question was delicate or unstable & broke apart.)
The m/z of any compound can be expressed as follows:
m/z = [MW+(n*1.0073)]/n
...where 'n' is the number of charges on the ion, and '1.0073' is the approximate weight of the proton (expressed 'H') in daltons. 'n' is typically an unknown quantity, but can be calculated from the m/z chart data.
Salt adducts are ubiquitous in ESI and MALDI mass spectra. Sodium adduct ions, [M+Na]+ in positive ion mode, are particularly common. They occur when the sample chemical is ionized by a sodium cation Na+ instead of a proton H+, and they always result in an observed m/z some 23 daltons higher than one expects.
K+, potassium adduct ions, ~39 daltons heaver than H+, are also common. K+ adducts are frequently spotted along with Na+ adducts.
NH4+ (M+18), H2SO4 and H3PO4 (M+98) are also possible in positive ionization mode. Cl- (M+35) is common in negative ionization mode.
Some compounds lose hydrogen and oxygen atoms during testing; alcohols, in particular, often lose H2O. This affects the m/z as you would expect -- [M-H2O]+, for example, would result in a peak at (M-18). This sort of loss happens frequently with some steroids, especially diols and other compounds with several hydroxyl groups.
...Once you've got a good grasp of the above, which is quite simple, many mass spectra can be read easily and unambiguously.
The methyl-sten results from last week are below. [M+H]+ is at 316.9. A textbook example of [M+Na]+ -- a sodium adduct -- can be seen at 339.0. The peak at 356.9 is due to a small K+ adduct.
The sample we fed into the machine was identified as methyl-sten. Luckily, the chart we have here is very clear & simple, and did not display any significant fragmentation.
We're going to test this batch again at an independent location in the USA within the next few days -- and, when all is said and done, it will almost certainly be tested half a dozen times in total. (If not more.) That Ultradrol is methyl-stenbolone shall be proven beyond all doubt.
...With that out of the way, a few more words about mass spectrometry:
--It is often very simple to identify a chemical sample via mass spectrometry... But it's not perfect. As some of you may have already guessed, MS cannot always distinguish between one compound and another. For one example, 17a-methyl-nandrolone and 7a-methyl-nandrolone (MENT) have identical molecular masses and chemical formulae, and a nearly identical mass-spectra. Without an ironclad standard, it is impossible to use MS to distinguish the one from the other. It is, however, possible via other analytical methods, particularly FT-IR and X-ray crystallography.
--MALDI-MS can analyze compounds over 300,000 Da, and is gentle enough to handle peptides and proteins. It's precise enough to identify the masses of well-known peptides to within 0.01% of their expected molecular weights. It can even be taken a step further: MALDI can be used to figure out the sequences of novel/unidentified peptides... but this requires great skill. Trying to sequence peptides is actually one of the toughest tasks in mass spectrometry. Basically, you'd need to fragment the entire peptide (not all at once!) and measure its individual amino acid constituents in order. For a very large peptide, you can imagine how long this can take, and how easy it can be to make a critical error.
--1 dalton = 1 atomic mass unit = 1.6605 ×10-24 grams. So if you've got a good calculator and a some time on your hands, you can try to figure out approximately how many molecules are in a bottle of any given product.
--Adducts such as the ones I mentioned earlier have absolutely no bearing on the purity of the raw materials being tested. Elemental salts such as sodium are everywhere -- sometimes even in high-grade solvents and matrices. (The sample has to be dissolved in a solvent before ESI and MALDI are possible. Usually organic solvents such as methanol/water or acetonitrile/water are used.) If you keep a chemical in a plastic or glass container, chances are that it has been exposed to enough sodium to form an adduct.
--Take a look at the chart above once more. Notice how the peaks kind of slope downward on the right? These smaller, very close, peaks are due to the presence of some molecules where one 12C atom has been replaced by a 13C atom. 13C is a naturally occurring, but rare, carbon isotope. 13C peaks are usually 1Da higher than the 12C peaks right next to 'em... but this, of course, depends on the charge state of the sample ions. 13C peaks are also usually of very low intensity in organic compounds with numerous carbon atoms.
--ESI and MALDI can create both positively and negatively charged ions -- [M+H]+ and [M-H]-, respectively. We typically measure things in positive ion mode.
- 09-19-2011, 08:36 AM
Nice post, guys. I've seen really great things in all of the Ultradrol logs here on the forum, so far. It looks to be a great compound and sides have seemed to be minimal based on what users are reporting.
09-19-2011, 08:49 AM
Mass specs on each batch. That, I am impressed with. Any chance you'll post COQ's on your website?
~ Nothing can kill the Grimace!!
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