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I'm posting some important MOAs (mechanism of action) of Pink Magic that play a crucial roll in the dieting process...
Pretty simple contest and one entry per person.
Give me 2 scenarios why it would be a perfect addition to a fat loss or muscle building routine..
The best answers will be entered into a lottery. Please think it out and take your time. ideally I would like your answers to educate the audience and please recommend stacking with other supplements, diet and exercise, etc..let the imagination run free!
Winners get!
The Monster Muscle stack!
Pink Magic-PRIME-Super Cissus(for its anabolic actions)-Jack3d Grape bubblegum or flavor of choice-AND-Mystery product-and a Hug from Mulletsoldier and belly rub from Casey.
-Winners chosen Next Friday the 13th--ooooooo!
----------------------Pink Magic Mechanisms of Action contest-------------
Amino & Glucose Transport
In addition to these effects, by inhibiting other subtypes of phosphodiesterase a vasodilatory effect can occur, allowing for increased amino acid and glucose transport to skeletal muscle, as demonstrated in various animal & human studies & review papers (2,14-17).
Pumped To The Gills While Cutting?
In addition, this vasodilatory effect can potentially lead to greater "pumps" and the feeling of fuller muscles, while also potentially increasing lipolysis (2,18).
Keeps Going Like That Bunny
Unlike various nitric oxide (NO) products which can lose their effectiveness over time, these compounds won’t follow in their footsteps.
Synergystic with Nitric Oxide Products?
In fact, as demonstrated in animal models, these compounds may prevent N.O. products from losing their effectiveness in the first place (19-23).
Additionally, these compounds may even increase or potentiate the effects of nitric oxide products(24).
How so, you ask?
Well, to answer that, we must look at how the beloved nitric oxide (N.O.) molecule allows for vasodilation and the subsequent benefits...
N.O. is involved in the NO/guanylyl (guanylate) cyclase/cyclic GMP-dependent cascade...
In effect, it is thought that the N.O. molecule works by binding to and activating soluble guanylyl (guanylate) cyclase, which in turn catalyzes the formation of cGMP from guanosine triphosphate (GTP).
Once the previously mentioned second messenger, cGMP accumulates intracellularly in the given cell/tissue type (in this case smooth muscle), activation of cGMP-dependent protein kinase (protein kinase G or PKG) occurs and eventually leads to vasodilation, in this particular case.
So, again, how might these ingredients prevent N.O. products from losing their effectiveness and possibly even potentiate their effects?
Well, it appears that one mechanism behind the reduction of N.O.'s effectiveness is an increase in the activity of cGMP-phosphodiesterase, which as we discussed earlier, is responsible for degrading cGMP...
Since the body can't stop you from ingesting compounds designed to increase N.O., it does the next best thing by increasing the expression of enzymes designed to reduce the downstream effectiveness of N.O....
In effect, it decreases levels of cGMP and thus reduces the level of vasodilation and other potential benefits...
However, since these compounds have demonstrated the ability to inhibit cGMP phosphodiesterase, this can not only work to prevent the decline ineffectiveness of N.O. products, it may even potentiate the effects of them through the same mechanism...
You'll have that N.O. product working to increase cGMP levels, while the key ingredients in Pink Magic prevent the degradation of cGMP, allowing you to maintain and even increase the beneficial effects seen with NO products!
Yet, unlike most N.O. products, these compounds won't succumb to decreased effectiveness through decreased cGMP levels.
Endurance
If this weren't enough, one may also notice an increase in resistance to fatigue as a result of direct effect upon skeletal muscle (i.e., cAMP accumulation in both type I [slow-twitch] and type II [fast-twitch] can result in a resistance or decrease of fatigue) and the diaphragm; furthermore, by increasing cGMP accumulation in other cell types, one can potentially increase blood flow and the contractility of the heart, also resulting in greater resistance to fatigue as demonstrated in specific animal studies (14,25).
Strong Like Bull
As if all that wasn't enough, as shown in animal models by inhibiting one of the phosphodiesterase subtypes, the contractility of skeletal muscles is increased. It is thought that this is accomplished by increasing the release of acetylcholine at the neuromuscular junction while also sensitizing it to acetylcholine. (26)
Pretty simple contest and one entry per person.
Give me 2 scenarios why it would be a perfect addition to a fat loss or muscle building routine..
The best answers will be entered into a lottery. Please think it out and take your time. ideally I would like your answers to educate the audience and please recommend stacking with other supplements, diet and exercise, etc..let the imagination run free!
Winners get!
The Monster Muscle stack!
Pink Magic-PRIME-Super Cissus(for its anabolic actions)-Jack3d Grape bubblegum or flavor of choice-AND-Mystery product-and a Hug from Mulletsoldier and belly rub from Casey.
-Winners chosen Next Friday the 13th--ooooooo!
----------------------Pink Magic Mechanisms of Action contest-------------
Amino & Glucose Transport
In addition to these effects, by inhibiting other subtypes of phosphodiesterase a vasodilatory effect can occur, allowing for increased amino acid and glucose transport to skeletal muscle, as demonstrated in various animal & human studies & review papers (2,14-17).
Pumped To The Gills While Cutting?
In addition, this vasodilatory effect can potentially lead to greater "pumps" and the feeling of fuller muscles, while also potentially increasing lipolysis (2,18).
Keeps Going Like That Bunny
Unlike various nitric oxide (NO) products which can lose their effectiveness over time, these compounds won’t follow in their footsteps.
Synergystic with Nitric Oxide Products?
In fact, as demonstrated in animal models, these compounds may prevent N.O. products from losing their effectiveness in the first place (19-23).
Additionally, these compounds may even increase or potentiate the effects of nitric oxide products(24).
How so, you ask?
Well, to answer that, we must look at how the beloved nitric oxide (N.O.) molecule allows for vasodilation and the subsequent benefits...
N.O. is involved in the NO/guanylyl (guanylate) cyclase/cyclic GMP-dependent cascade...
In effect, it is thought that the N.O. molecule works by binding to and activating soluble guanylyl (guanylate) cyclase, which in turn catalyzes the formation of cGMP from guanosine triphosphate (GTP).
Once the previously mentioned second messenger, cGMP accumulates intracellularly in the given cell/tissue type (in this case smooth muscle), activation of cGMP-dependent protein kinase (protein kinase G or PKG) occurs and eventually leads to vasodilation, in this particular case.
So, again, how might these ingredients prevent N.O. products from losing their effectiveness and possibly even potentiate their effects?
Well, it appears that one mechanism behind the reduction of N.O.'s effectiveness is an increase in the activity of cGMP-phosphodiesterase, which as we discussed earlier, is responsible for degrading cGMP...
Since the body can't stop you from ingesting compounds designed to increase N.O., it does the next best thing by increasing the expression of enzymes designed to reduce the downstream effectiveness of N.O....
In effect, it decreases levels of cGMP and thus reduces the level of vasodilation and other potential benefits...
However, since these compounds have demonstrated the ability to inhibit cGMP phosphodiesterase, this can not only work to prevent the decline ineffectiveness of N.O. products, it may even potentiate the effects of them through the same mechanism...
You'll have that N.O. product working to increase cGMP levels, while the key ingredients in Pink Magic prevent the degradation of cGMP, allowing you to maintain and even increase the beneficial effects seen with NO products!
Yet, unlike most N.O. products, these compounds won't succumb to decreased effectiveness through decreased cGMP levels.
Endurance
If this weren't enough, one may also notice an increase in resistance to fatigue as a result of direct effect upon skeletal muscle (i.e., cAMP accumulation in both type I [slow-twitch] and type II [fast-twitch] can result in a resistance or decrease of fatigue) and the diaphragm; furthermore, by increasing cGMP accumulation in other cell types, one can potentially increase blood flow and the contractility of the heart, also resulting in greater resistance to fatigue as demonstrated in specific animal studies (14,25).
Strong Like Bull
As if all that wasn't enough, as shown in animal models by inhibiting one of the phosphodiesterase subtypes, the contractility of skeletal muscles is increased. It is thought that this is accomplished by increasing the release of acetylcholine at the neuromuscular junction while also sensitizing it to acetylcholine. (26)