♂♂♂ HGHup♂ by Applied Nutriceuticals: TECH WRITEUP!! ♂♂♂

Page 1 of 3 123 Last
  1. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Thumbs up ♂♂♂ HGHup♂ by Applied Nutriceuticals: TECH WRITEUP!! ♂♂♂


    HGHup♂™ TECHNICAL INFORMATION

    Attached is the Technical Write-Up for APPNUT's newest product HGHup♂™ in two different formats, so that you can all review it.

    ~Rosie
    Team APPNUT
    Attached Images Attached Images
    Attached Files Attached Files
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee

  2. Banned
    Iron Lungz's Avatar
    Join Date
    Apr 2008
    Age
    38
    Posts
    5,785
    Rep Power
    0
    Level
    51
    Lv. Percent
    6.89%
    Achievements Activity ProPosting ProPosting Authority

    L-Dopa...
  3. New Member
    Jeremy Brown's Avatar
    Stats
    5'9"  190 lbs.
    Join Date
    Jun 2008
    Posts
    475
    Rep Power
    317
    Level
    17
    Lv. Percent
    94.76%

    very interesting information, thanks for the post Rosie!
    •   
       

  4. The BPS Rep
    Resolve's Avatar
    Stats
    6'4"  280 lbs.
    Join Date
    Apr 2008
    Posts
    8,062
    Rep Power
    350693
    Level
    59
    Lv. Percent
    84.38%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    Hmmmm...
    Bulk Performance Solutions
    --No Proprietary Blends, All Performance--

    ***NOW @ NP***
  5. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by Jeremy Brown View Post
    very interesting information, thanks for the post Rosie!
    No worries

    ~Rosie
    Team APPNUT
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee
  6. Banned
    Iron Lungz's Avatar
    Join Date
    Apr 2008
    Age
    38
    Posts
    5,785
    Rep Power
    0
    Level
    51
    Lv. Percent
    6.89%
    Achievements Activity ProPosting ProPosting Authority

    So I was right about the L-Carnitine-L-Tartrate, eh?
  7. Elite Member
    SilentBob187's Avatar
    Stats
    5'9"  175 lbs.
    Join Date
    Dec 2007
    Age
    30
    Posts
    7,851
    Rep Power
    11116
    Level
    57
    Lv. Percent
    25.79%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    For those, like me, who don't want to wait to open the file. These are the ingedients that appear to be in HGHup.

    ZMA:
    Vitamin B6
    Magnesium
    Zinc

    Same combo as Powerfull:
    Mucuna Pruriens
    Chlorophytum Borivaillanum (apparently spelled with 1 L)

    Huperzine A
    Green Tea (EGCG)
    L-Carnitine-L-Tartrate
    Selenium


    The bolded ingredients are the ones that seem to be unique to this GH secretagogue.

    Pending an actual ingredient profile or some serious 'synergy,' dosage will either be really high (many pills,) or could potentially be underdosed compared to similar items. Would be a convenient all-in-one I suppose.

    Speculation is like sitting in a rocking chair though, it gives us something to do but doesn't get us anywhere.
    "I am legally blind and if I can Squat,deadlift and over all get myself to the gym then anyone can get their a$$ in gear and get strong!!" - malleus25
    WHITE WHALE!
  8. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Exclamation HGHup♂™ TECHNICAL INFORMATION


    For those who can't be bothered opening the file/s (please note that there are Figures and Graphs in the document; this is just the text).


    HGHup♂™ TECHNICAL INFORMATION


    PRODUCT DESCRIPTION:

    HGHup♂ promotes radical increases in serum HGH and testosterone levels without a prescription. It is the only orally viable compound that is proven to increase HGH AND testosterone in human subjects.


    PRODUCT CHARACTERISTICS:

    • Increases the output of growth hormone and local IGF-1 levels
    • Increases the duration/viability of growth hormone pulse mass
    • Increases androgen receptor structure, function, and number
    • Increases natural production of testosterone


    EFFECTS RELATED TO PHYSIQUE AND LIFE ENHANCEMENT:

    • Greater lean muscle mass
    • Lowered body fat
    • Better skin tone
    • Deeper, more restful sleep
    • Increased strength
    • Faster healing of injuries and better recovery from physical stress/training


    MAIN MECHANISMS OF ACTION:

    Mucuna Pruriens, Vitamin B6 and L-Dopa: Increase Growth Hormone Output and Testosterone Production While Concurrently Decreasing Somatostatin and Prolactin

    • HGHup♂ contains highly concentrated L-Dopa derived from Mucuna Pruriens What is Mucuna Pruriens? (32). L-Dopa has been shown to significantly increase levels of growth hormone in human subjects iwhen administered orally. (1, 2, 3, 33).
    • Oral viability in HGHUP♂ critical for product effectiveness, as growth hormone cannot be absorbed and is rendered ineffective due to the fragility of the ingredients. Several good examples are synthetic growth hormone (see Fig. 1) and growth hormone releasing hormone (GHRH, see Fig. 2). These compounds cannot be administered orally; because of their fragile amino acid sequence is destroyed by stomach acids. This also holds true with the vast majority of the so-called “GH Boosters” and “Peptides” commonly found in sports nutrition products.
    • L-Dopa and Dopamine have also been shown to inhibit prolactin, a hormone that suppresses male testosterone production. Prolactin also has a positive correlation with a second hormone called somatostatin, which decreases the both amount and effectiveness of circulating growth hormone. Therefore, by lowering prolactin (and consequently somatostatin) levels, HGHUP♂ increases both testosterone and GH production; leading to greater recovery and lean body mass (38, 39).
    • Vitamin B6, is included in the formula for HGHUP♂, as it can also help further lower prolactin levels and increase the night-time peak of GH release pulse, while at the same time increasing the rise in GH associated with exercise by as much as 23% (7).

    Huperzine-A: Increasing AChE Inhibition and Mean serum GH by Decreasing Somatostatin

    • Huperzine-A is a strong acetylcholine esterase (AChE) inhibitor. Acetylcholine esterase inhibitors have been shown in numerous scientific studies to inhibit somatostatin via a variety of synergistic biomechanisms; all of which contribute to increased levels of growth hormone (9, 10, 11, 12, 13, 14, 15, 16, 17, 18).
    o Somatostatin is a hormone that exerts effects on anterior pituitary as well as pancreatic, liver and gastrointestinal function (40, 41, 42, 43) .
    o Somatostatin is also important because it directly effects growth hormone release and is the major regulating factor in slowing or even stopping growth hormone output.
    o Somatostatin inhibits GH secretion directly from somatotrophs and antagonizes the GH secretagogue activity of ghrelin. Breifly explain what ghrelin is and its relevance By inhibiting somatostatin, overall mean serum GH will increase (41, 42)..
    o Somatostatin inhibits GH secretion indirectly via antagonizing GHRH secretion (41, 42, 43).
    o It inhibits GH secretion indirectly via inhibiting the secretion of ghrelin from the stomach (42).
    • Therefore, the Huperzine A, in HGHUP♂ increases the length, intensity, duration of growth hormone pulses and increase mean serum GH levels, therefore allowing for more of the positive anabolic and anti-aging benefits associated with GH.(8, 10, 12-17, 19-20).

    Green Tea Extract, and (−)-epigallocatechin-3-O-gallate (EGCG): Increasing Dopa Decarboxylase Inhibition and the AChE-inhibiting Effects of HGHUP♂

    • Dopamine crosses the blood/brain barrier poorly, and cannot exert optimal effects on target receptors unless enough of the compound reaches the brain. L-Dopa is freely absorbed across this barrier, and when L-dopa crosses the barrier readily, growth hormone levels increase. (1-6, 32-33)
    • L-Dopa is most effective when conversion of L-Dopa to dopamine is mediated by a decarboxylase inhibitor What is a decarboxylase inhibitor and what does it do? (2, 3, 4, 5, 19, 20, 37).
    • A decarboxylase inhibitor is generally administered at the same time as L-Dopa / Mucuna in order to reduce conversion of the L-dopa into dopamine in the periphery. (−)-epigallocatechin-3-O-gallate (EGCG), which is found in high amounts in the green tea extract used in HGHUP♂ has been shown in several studies to be irreversible inhibitors of Dopa decarboxylase. Are you saying here that EGCG is a decarboxylase inhibitor? This means that EGCG keeps L-dopa from converting into dopamine and allowing significant levels of L-dopa to reach the brain and increase growth hormone levels (1, 2, 3, 4, 5, 37).
    • EGCG has also been shown to significantly increase the effects of Huperzine A on acetylcholine esterase inhibition by increasing the transport of Hup-A ? by serum albumin. This allows for greater amounts of acetylcholine to be present, therefore allowing for greater mean serum growth hormone. Increased serum GH from HGHUP♂ allows for increased anabolism, better recovery, and increased muscle mass (19, 20).

    HGHUP♂ INCREASES ANDROGEN RECEPTOR QUANTITY AND DENSITY AND CREATES A BETTER BINDING ENVIRONMENT FOR EXISTING ANDROGENS

    L-Carnitine-L-Tartrate and Magnesium: Increasing Androgen Receptor Number and Density, and the Creation of a Better Binding Environment

    • L-Carnitine L-Tartrate is an amino acid that has been shown to increase the number of androgen receptors in skeletal muscle, creating a better binding environment for testosterone and other androgens by allowing for a greater number of intact receptors available for hormonal interactions. (21-23)
    • Magnesium has been shown in more recent studies to inhibit the binding of steroid hormone binding globulin (SHBG) and free testosterone. SHBG binds free testosterone and allows it to be excreted from the body, without binding the androgen receptor. Magnesium keeps this from happening by altering the binding affinity of testosterone to SHBG, and thereby allowing for increased amounts of free testosterone to remain active in the bloodstream. (24)
    • Other human research has shown that supplemental magnesium, when taken along with other ingredients like DHEA and Zinc, can significantly increase free testosterone. (25-27)
    • Therefore, HGHUP♂ allows for greater numbers of androgen receptors and a better binding environment for testosterone in skeletal muscle. This is a new breakthrough in sports supplementation as HGHUP♂ creates a better target for circulating free testosterone, allowing for greater binding of testosterone to the extra receptors which leads to increased protein synthesis, better recovery, and increased muscle mass.

    HGHUP♂ INCREASES TESTOSTERONE

    Mucuna Pruriens, Selenium, and Chlorophytum Borivillanum Ethanolic/Sapogenic Extract: Increasing Testosterone Levels

    • Mucuna Pruriens has been shown in several recent human studies to improve testosterone levels and spermatogenesis in animal studies and humans, via prolactin inhibition. Prolactin, as mentioned earlier, is a hormone that suppresses male testosterone production (30-31, 34-36, 38-39).
    • The ethanolic and sapogenic extracts of Chlorophytum Borivaillanum have also been shown in animal studies to increase testosterone, and anecdotal data from products containing this compound also point to increased testosterone and lean body mass for users of this phyto-androgenic compound. However, the mechanism of action of Chlorophytum is poorly understood. (28- 29)
    • Selenium has been shown in several studies to have direct effects on the biosynthesis pathways of testosterone. Selenium is rate-limiting in testosterone production in men, and if enough selenium (selenium deficiency is very common) is not available, testosterone will not be produced in optimal levels (27).


    Administration, Timing, and Dosing

    • Normal GH pulses (see chart below) occur throughout the day. For a normal male in an average day, there are 10 pulses of GH secretion lasting on average 96.4 mins with 128 mins between each pulse. The largest GH pulse occurs during stages 3 and 4 of the sleep cycle. GH pulses during sleep (see Fig. 5) occur at nearly triple the rate of GH pulses during the day (44-45)
    • Somatostatin release is controlled in large part by the cholinergic system. The cholinergic system is responsible for regulating the amount of acetylcholine found in the body at any given time. Acetylcholine is a neurotransmitter responsible for muscular activation in the peripheral nervous system, and tends to be excitatory in the central nervous system (CNS) (10, 11, 12, 13).
    • The CNS component of acetylcholine mediates the cholinergic system, and this is important because the cholinergic system is responsible for mediating growth hormone response (11, 12, 13, 14, 15).
    • The mechanism through which this is accomplished is simple: by increasing acetylcholine levels, there will be an increase in mean serum GH. HGHUP♂ increases acetylcholine via lowering levels of acetylcholine esterase or AChE (an enzyme that breaks down acetylcholine) (11, 12, 13, 14, 15).
    • Taking an acetylcholine esterase inhibitor (in the case of HGHUP♂, Huperzine-A) before sleep will result in dramatically reduced somatostatin levels and dramatically increase serum GH levels (1-4, 5, 9-17,19, 20, 44, 45).
    • Somatostatin seems to be the major inhibitory factor in sleep-related GH pulses. When AChE is inhibited by pryridostigmine (an AChE inhibitor very similar to Huperzine-A) GH pulse mass is increased, and mean serum GH almost doubled. In terms of potency, Huperzine-A has actually been shown to be more potent than pyridostigmine bromide in terms of AChE inhibition (9-17, 19-20) .
    • There has also been a very popular trend recently of bodybuilders taking Huperzine-A along with injectible synthetic growth hormone, because the compound is so effective at inhibiting somatostatin and increasing serum GH (46)
    • Taking (−)-epigallocatechin-3-O-gallate (EGCG) along with Huperzine-A will increase Hup-A’s effectiveness in inhibiting acetylcholine esterase, and its ability to allow the cholinergic system to suppress somatostatin. This has been verified in several scientific studies (19-20).
    • Taking a supplement containing L-Dopa with a decarboxylase inhibitor before sleep can allow for dramatically increased levels of GH (1-5, 32- 33, 37-39).
    • Hypoglycemia (low blood sugar) can also increase the amount of GH released. Insulin and GH are antagonistic, and the lower the insulin level, the higher the GH level (see chart below, 44-45).
    • Timing of the dose and manipulating insulin levels before sleep is the key getting great results with HGHUP♂ (44-45, 47)
    • Best results occur when a 4-6 capsule dosage is taken on an empty stomach (fasted state) 30 minutes before bedtime (44-45, 47)


    Why Most OTC GH Products Are Ineffective, and How HGHUP♂ Differs

    • Over the last 20 years, a variety of products that claim to boost HGH orally have been promoted in the US sports supplement market. The vast majority of these products have been completely ineffective for several reasons:
    • Growth hormone is a peptide (a long chain amino acid structure), that cannot be taken in an oral form, due to the destruction of the sequence by the acidic environment of the stomach. Any supplement containing “oral growth hormone” is a scam (47).
    • Many products use a combination of amino acids such as arginine and lysine in “kitchen sink” formulas, and claim that their combination is “scientifically proven” to work. Many amino acids boost growth hormone levels, but most of the time, it is only when taken intravenously, or in completely unattainable dosages that would make a normal person extremely sick. And the correct dosage is in gram amounts, not in the milligram range offered in many of these products (47).
    • Even if these products allow for a viable release of GH, there is nothing present to inhibit somatostatin, which has been found to be the biggest factor in controlling GH levels (47)
    • Many of these products are powdered mixes that contain sugar, artificial sweeteners, or other compounds that increase insulin secretion. As discussed above, this will render the product virtually useless due to the antagonism between insulin and growth hormone (47).
    • HGHUP♂ differs from these compounds because of the nature of the formulation. Every compound in the product is designed to work in concert with the other components; no filler or ineffective components are found in this product (47).
    • HGHUP♂ utilizes the latest research on compounds which have been overlooked by other companies. The secret of the product is not necessarily on the newness of the ingredient, more on the complexity, effectiveness and synergism of the blend (1-47).
    • HGHUP♂ also utilizes components that boost androgen levels, increase the number and function of androgen receptors, and create an overall BETTER anabolic environment in which levels of testosterone and GH are optimized, leading to better recovery, increased lean body mass, and lower body fat (1-47).


    Stacks and Tips to Maximize the Product

    • Take Bio-Mend Anti-Oxidant formula
    o High ORAC Value
    o Protects cellular membrane
    o Protects transcriptional factors (mRNA and DNA)
    • In general, maintain a healthy diet and lifestyle:
    o Drink Plenty of water; at least 64 oz. per day
    o Ingest at least 1 gram of protein per lb. of body weight daily
    o Sleep at least 7 hours per night
    o Eat lots of fruits and vegetables
    o Eat lots of complex carbs
    o Eat 5-6 smaller protein and carb-rich meals throughout the day
    o Increase calories to at least 500 Kcal/day over your normal intake
    o BCAAs and Creatine will be helpful
    o Avoid alcohol and tobacco
    o Take HGHUP♂ on an empty stomach before going to sleep, or take it with an all-protein meal. Remember, carbohydrates/insulin decrease the effectiveness of the product.
    o HGHUP♂ can be stacked with synthetic growth hormone and will make it more effective


    In conclusion, HGHUP♂ in the most effective orally administered HGH and Testosterone agonist yet to be offered in the history of sports nutrition. For more information, you can contact Applied Nutriceuticals at info@appliednutriceuticals.com.
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee
  9. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Exclamation Reference List


    Studies and Clinical Info

    1. Hanew, K., Tanaka, A, and Utsumi, A. Plasma GH responses to GHRH, arginine, L-dopa, pyridostigmine, sequential administration of GHRH and combined administration of PD and GHRH in Turner’s syndrome. J. Endocrinol. Invest. 1998. Feb.; 21(2): 72-77.
    2. Schönberger W, Grimm W, Ziegler R. The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature. Eur J Pediatr. 1977 Dec 30;127(1):15-9.
    3. Schönberger W, Ziegler R, Brodt B, Grimm W. HGH secretion after oral application of L-dopa and L-carbidopa. Eur J Pediatr. 1976 Jun 8;122(3):195-200.
    4. Fevang FO, Stoa RF, Thorsen T, Aarskog D. The Effect of L-dopa with and without decarboxylase inhibitor on growth hormone secretion in children with short stature. Acta Paediatr Scand. 1977 Jan; 66(1):81-84
    5. Philippi H, Pohlenz J, Grimm W, Koffler T, Schönberger W. Simultaneous stimulation of growth hormone, adrenocorticotropin, and cortisol with L-dopa, carbidopa, and propranolol in children of short stature. Acta Paediatr, 2000 Apr;89(4):442-446.
    6. Gordon M, Markham J, Hartlein JM, Koller JM, Loftin S, Black KJ. Intravenous levodopa administration in humans based on a two-compartment kinetic model. J. Neurosci Methods, 2007 Jan 30:159(2):300-307. Epub 2006 Aug 24
    7. Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise. 1982 Aug 12;307(7):444-5.
    8. Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects. Boll Soc Ital Biol Sper. 1984 Feb 28;60(2):273-8
    9. Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE, Aisen PS, Doctor BP. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. Chem Biol Interact. 2005 Dec 15;157-158:239-46. Epub 2005 Oct 26.
    10. Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol Sin. 2006 Jan;27(1):1-26
    11. Kelijman M, Frohman LA. The role of the cholinergic pathway in growth hormone feedback. J Clin Endocrinol Metab. 1991 May;72(5):1081-7
    12. Liang YQ, Tang XC. Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats. Acta Pharmacol Sin. 2006 Sep;27(9):1127-36
    13. Giustina A, Bossoni S, Bodini C, Doga M, Girelli A, Buffoli MG, Schettino M, Wehrenberg WB. The role of cholinergic tone in modulating the growth hormone response to growth hormone-releasing hormone in normal man. Metabolism. 1991 May;40(5):519-23
    14. Friend K, Iranmanesh A, Login IS, Veldhuis JD Pyridostigmine treatment selectively amplifies the mass of GH secreted per burst without altering GH burst frequency, half-life, basal GH secretion or the orderliness of GH release. Eur J Endocrinol. 1997 Oct;137(4):377-86
    15. Dinan TG, O'Keane V, Thakore J. Pyridostigmine induced growth hormone release in mania: focus on the cholinergic/somatostatin system. Clin Endocrinol (Oxf). 1994 Jan;40(1):93-6
    16. Thakore JH, Coffey I, Dinan TG. Time dependency of pyridostigmine-induced growth hormone response. J Basic Clin Physiol Pharmacol. 1994 Apr-Jun;5(2):117-2
    17. Li YX, Zhang RQ, Li CR, Jiang XH. Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet. 2007 Oct-Dec;32(4):183-7.
    18. Haigh JR, Johnston SR, Peppernay A, Mattern PJ, Garcia GE, Doctor BP, Gordon RK, Aisen PS. Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. Chem Biol Interact. 2008 Sep 25;175(1-3):380-6.
    19. Xiao J, Chen X, Zhang L, Talbot SG, Li GC, Xu M. Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method. J Agric Food Chem. 2008 Feb. 13:56(3) 910-915.
    20. Zhang L, Cao H, Wen J, Xu M. Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
    21. DI MARZIO L. (1) ; MORETTI S. (2) ; D'ALO S. (1) ; ZAZZERONI F. (1) ; MARCELLINI S. (2) ; SMACCHIA C. (3) ; ALESSE E. (1) ; CIFONE M. G. (1) ; DE SIMONE C. (1) ; Acetyl-l-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects : Correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation.
    22. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exer., 2006 Jul: 38(7): 1288-96.
    23. Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gómez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Häkkinen K. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond. Res. 2003 Aug: 17(3): 455-462,
    24. André C, Berthelot A, Robert JF, Thomassin M, Guillaume YC. Testimony of the correlation between DHEA and bioavailable testosterone using a biochromatographic concept: effect of two salts. J Pharm Biomed An., 2003 Dec 4: 33(5): 911-21.
    25. Excoffon L, Guillaume YC, Woronoff-Lemsi MC, André C. Magnesium effect on testosterone-SHBG association studied by a novel molecular chromatography approach. J Pharm Biomed An. 2009 Feb. 20: 49(2). 175-180.
    26. Age-Related Eye Disease Study Research Group (2001). “A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss. Arch Opthalmology. 119(10): 1417.
    27. Berdanier, Carolyn D.; Dwyer, Johanna T.; Feldman, Elaine B. (2007). Handbook of Nutrition and Food. Boca Raton, Florida: CRC Press.
    28. Thakur M. and Dixit V.K.* EFFECT OF CHLOROPHYTUM BORIVILIANUM ON ANDROGENIC & SEXUAL BEHAVIOR OF MALE RATS Indian Drugs 2006 April 43(4): 300-306
    29. Kothari S.K., Safed Musli (Chlorophytum borivilianum) revisited, Journal of Medicinal and Aromatic Plants. 2004, 26, 60-63.
    30. Saxena S and Dixit V.K: Role of total alkaloids of Mucuna pruriens Baker in spermatogenesis in male rats, Indian Journal of Natural Products. 1987, 3(2), 3-7.
    31. Unnithan A.R. and Tandon V.L: Role of growth hormone in spermatogenesis in male rats. Indian Journal of Experimental Biology. 1982,20,734-737.
    32. Modi KP, Patel NM, Goyal RK. Estimation of L-dopa from Mucuna pruriens LINN and formulations containing M. pruriens by HPTLC method Chem Pharm Bull (Tokyo). 2008 Mar: 56(3): 357-359.
    33. Tharakan B, Dhanasekaran M, Mize-Berge J, Manyam BV. Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage.Phytother Res. 2007 Dec;21(12):1124-6.
    34. Ahmad MK, Mahdi AA, Shukla KK, Islam N, Jaiswar SP, Ahmad S.
    Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men. Fertil Steril. 2008 Sep;90(3):627-35. Epub 2007 Nov 14.
    35. Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP. Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. 2008 Oct 28. [Epub ahead of print]
    36. Shukla KK, Mahdi AA, Ahmad MK, Jaiswar SP, Shankwar SN, Tiwari SC .Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men .Evid Based Complement Alternat Med. 2007 Dec 18. [Epub ahead of print
    37. Bertoldi M, Gonsalvi M, Voltattorni CB. Green Tea polyphenols: Novel irreversible inhibitors of dopa decarboxylase Biochem Biophys Res Commun. 2001 Jun 1;284(1):90-3.
    38. Vaidya RA, Aloorkar SD, Sheth AR, Pandya SK. Activity of bromoergocryptine, Mucuna pruriens and L-dopa in the control of hyperprolactinaemia. Neurol India. 1978 Dec;26(4):179-82.
    39. Vaidya RA, Sheth AR, Aloorkar SD, Rege NR, Bagadia VN, Devi PK, Shah LP. The inhibitory effect of the cowhage plant- mucuna pruriens-and L-dopa on chloropromazine-induced hyperprolactinemia. Neurol India. 1978 Dec;26(4):177-8.
    40. Epelbaum J, Guillou JL, Gastambide F, Hoyer D, Duron E, Viollet Somatostatin, Alzheimer's disease and cognition: An old story coming of age? C. Prog Neurobiol. 2009 Jul 10.
    41. Nikolaeva AA, Koroleva SV, Ashmarin IP. [Research of interactions in the dopamine-serotonin-somatostatin system promises new outlook in fundamental and practical respects] Nikolaeva AA, Koroleva SV, Ashmarin IP. Eksp Klin Farmakol. 2009 Mar-Apr;72(2):60-4. Review
    42. Cordido F, Isidro ML, Nemiña R, Sangiao-Alvarellos S.Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect. Curr Drug Discov Technol. 2009 Mar;6(1):34-42.
    43. Strowski MZ, Blake AD. Function and expression of somatostatin receptors of the endocrine pancreas. Mol Cell Endocrinol. 2008 May 14;286(1-2):169-79.
    44. Haff, G. Lecture Notes for Graduate Study: Hormonal Parameters Relevant to Training. Appalachian State University, 2000.
    45. Khoo, B. and Grossman, A. Normal Physiology of the Hypothalamus and Anterior Pituitary. St. Bartholomew’s Hospital, West Smithfield, London. Neuroendocrinology, Hypothalamus, and Pituitary. 2007 Ch. 1 Lecture.
    46. Various sources. Anecdotal Information concerning the usage of AChE inhibitors with synthetic GH.
    47. Applied Nutriceuticals Research. Unpublished alpha testing for new somatotropin-enhancing sports supplement. Charlotte, NC. 2009
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee
  10. Banned
    jakellpet's Avatar
    Stats
    6'2"  213 lbs.
    Join Date
    Feb 2008
    Age
    40
    Posts
    5,533
    Rep Power
    0
    Level
    50
    Lv. Percent
    1.42%
    Achievements Activity ProPosting ProPosting Authority

    This is what I found on Huperzine A :

    Huperzine A, is a naturally occurring sesquiterpene alkaloid compound found in the plant firmoss Huperzia serrata.[1]

    Huperzine A is an Acetylcholinesterase inhibitor similar to other compounds donepezil, rivastigmine, and galantamine.

    In the US Huperzine A is sold as a dietary supplement for memory support. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Clinical trials in China has shown it to be effective in the treatment of Alzheimer's disease,[2] and has been shown to enhance memory in healthy young students in one study. [3]




    [edit] Pharmacological effects
    Acetylcholinesterase inhibition[4] and NMDA receptor antagonism.[5]

    Huperzine A has also attracted the attention of US medical science. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.[6][7] It has been found to be an inhibitor of the enzyme acetylcholinesterase.[8] The structure of the complex of huperzine A with acetylcholinesterase has been solved by X-ray crystallography (PDB code: 1VOT; see the 3D structure).This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease. Huperzine A is also a NMDA receptor antagonist[citation needed] which protects the brain against glutamate induced damage, and it increases nerve growth factor levels.[citation needed]

    Clinical trials in China have shown that huperzine A is comparably effective to the drugs currently on the market, and may even be a bit safer in terms of side effects.[citation needed] Currently, the National Institute on Aging is conducting a Phase II clinical trial to evaluate the safety and efficiency of huperzine A in the treatment of Alzheimer's disease in a randomized controlled trial of its effect on cognitive function. Recently, it has been investigated for its effectiveness against epilepsy in an initial 20-person clinical study by Harvard University neuroscientists examining its worth and side effects in those who are not satisfactorily treated by existing pharmaceuticals.[citation needed]

    Possible side effects may include breathing problems, tightness in the throat or chest, chest pain, skin hives, rash, itchy or swollen skin, upset stomach, diarrhea, vomiting, hyperactivity and insomnia.[9] Most adverse events were cholinergic in nature and no serious adverse events occurred. Huperzine A is a well-tolerated drug. (Source J Neural Transm. 2009 Apr;116(4):457-65. Epub 2009 Feb 17. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.)
  11. Senior Member
    ambulldog's Avatar
    Stats
    5'10"  205 lbs.
    Join Date
    Aug 2008
    Posts
    1,964
    Rep Power
    8435
    Level
    33
    Lv. Percent
    17.1%
    Achievements Activity ProPosting Pro

    does this make igf2 obsolete?
  12. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by SilentBob187 View Post
    For those, like me, who don't want to wait to open the file. These are the ingedients that appear to be in HGHup.

    ZMA:
    Vitamin B6
    Magnesium
    Zinc

    Same combo as Powerfull:
    Mucuna Pruriens
    Chlorophytum Borivaillanum (apparently spelled with 1 L)

    Huperzine A
    Green Tea (EGCG)
    L-Carnitine-L-Tartrate
    Selenium


    The bolded ingredients are the ones that seem to be unique to this GH secretagogue.

    Pending an actual ingredient profile or some serious 'synergy,' dosage will either be really high (many pills,) or could potentially be underdosed compared to similar items. Would be a convenient all-in-one I suppose.

    Speculation is like sitting in a rocking chair though, it gives us something to do but doesn't get us anywhere.
    You would be wrong in regard to the Chlorophytum being the same as in PowerFull. The Chlorophytum found in HGH Up is The Chlorophytum Borivilianum Santander Ethanolic Extract. Big difference. The ingredient is novel and unique to HGH Up. The only other product containing it that I know of is Alpha-X (A European product made by AN).

    Cheers!
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  13. Banned
    jakellpet's Avatar
    Stats
    6'2"  213 lbs.
    Join Date
    Feb 2008
    Age
    40
    Posts
    5,533
    Rep Power
    0
    Level
    50
    Lv. Percent
    1.42%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by ambulldog View Post
    does this make igf2 obsolete?
    bump for an interesting question
  14. Diamond Member
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,014
    Rep Power
    33560
    Level
    62
    Lv. Percent
    82.03%
    Achievements Activity AuthorityActivity ProPosting ProPosting AuthorityPosting Veteran

    very nice write up and studies. oral gh products are ineffective the write up states.

    after researching growth hormone for ghenerate I was thinking sublingual is the way to go with hgh products. nice studies as well. This product looks like who ever formulated it put a good amount of research and work into it. it looks solid. and me wants some =)
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness
  15. Elite Member
    bioman's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Sep 2003
    Age
    42
    Posts
    7,714
    Rep Power
    513546
    Level
    59
    Lv. Percent
    89.71%
    Achievements Activity ProActivity AuthorityPosting ProPosting Authority

    I'd say no. IGF-2 is better to take pre-bedtime IMO, but HGHup feels quite a bit stronger.
  16. New Member
    Psychabinol's Avatar
    Join Date
    Sep 2009
    Posts
    380
    Rep Power
    254
    Level
    15
    Lv. Percent
    95.09%

    ive speculated that huperzine-a increases growth hormone for a while.

    Through acetycholine receptors, Alpha-GPC and nicotine do this as well.
  17. Board Sponsor
    Urban Monk's Avatar
    Stats
    6'0"  180 lbs.
    Join Date
    Jul 2007
    Posts
    1,462
    Rep Power
    14388
    Level
    29
    Lv. Percent
    8.01%
    Achievements Posting Pro

    Can IGF-2 and HGHup be taken together in a stack, or does one supercede the other?
  18. New Member
    Psychabinol's Avatar
    Join Date
    Sep 2009
    Posts
    380
    Rep Power
    254
    Level
    15
    Lv. Percent
    95.09%

    Quote Originally Posted by Urban Monk View Post
    Can IGF-2 and HGHup be taken together in a stack, or does one supercede the other?
    I would think HGHup is the evolution of IGF-2, it would seem silly to stack them. There are better stacking optionsm

    well igf-2 has safed musli, rhodilea rosea, and dodder seed which are some beneficial herbs, probally rhodilea the most beneficial, but that does not effect growth hormone.
  19. Elite Member
    andrew732's Avatar
    Join Date
    Jun 2008
    Posts
    5,751
    Rep Power
    781737
    Level
    58
    Lv. Percent
    7.57%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Honestly this is an IDEAL supplement, stack it with some testofen and KABOOM, good job AN, I feel this is the replacement of IGF-2. I will be purchasing, this is POTENT for SURE.
    doing my own thang!
  20. New Member
    KDLMaj's Avatar
    Stats
    5'7"  166 lbs.
    Join Date
    Jul 2009
    Age
    33
    Posts
    110
    Rep Power
    121
    Level
    9
    Lv. Percent
    66.92%

    Looks interesting- I will definitely be trying this. A few questions:

    1. If taken with 2nd Gear, would this give enough of a test boost to serve as a proper PCT?

    2. How much of a test boost does this give? More or less than Drive?

    3. How much lean muscle are testers gaining and over what time frame?

    4. Can this be stacked with Lipo-PM?
    Should it be?

    5. Does this need to be cycled in the same way IGF-2 does?

    6. Can this be stacked with The One for the added androgen receptor increase?
  21. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by KDLMaj View Post
    Looks interesting- I will definitely be trying this. A few questions:

    1. If taken with 2nd Gear, would this give enough of a test boost to serve as a proper PCT?

    2. How much of a test boost does this give? More or less than Drive?

    3. How much lean muscle are testers gaining and over what time frame?

    4. Can this be stacked with Lipo-PM?
    Should it be?

    5. Does this need to be cycled in the same way IGF-2 does?

    6. Can this be stacked with The One for the added androgen receptor increase?
    1) Me personally...Your PCT should be 2nd Gear, DRIVE, and HGH Up.

    2) Honestly...The Chlorophytum Borivillanum Sapogenic and Ethanolic Extracts are pretty damn potent. In regard to herbs that increase test...everyone responds differently to different compounds. However, I believe HGH Up will give you a greater increase over DRIVE. However, you could stack HGH up with DRIVE. . That by itself is sweet stack.

    3) This is too subjective of a question to answer...it depends on too many variables and every individual is different. To get the most out of HGH Up in regard to the test boosting effects...I would supplement with HGH Up for at the minimum 6 weeks, preferably 8 weeks. You would yield some pretty sick results if you are dedicated with your diet and training.

    4) There is no need to stack with Lipo-PM and furthermore...I always advise to not stack any two products both containing L-Dopa. Too much L-Dopa can have some undesirable side effects.

    5) I would never go longer than 12 weeks running this consecutively. Everyone does things differently, but I believe the best results would be obtained running HGH Up for 10-12 weeks and then at least one month off. Note: That is my personal opinion...not AN's official stance.

    6) Simple answer...yes.

    Cheers!

    -Sean-

    Team APPNUT
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  22. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by bioman View Post
    I'd say no. IGF-2 is better to take pre-bedtime IMO, but HGHup feels quite a bit stronger.
    You have to play around with the doses with HGH Up, but when you find the sweet spot pre-bed it knocks you out...better than IGF-2. What I noticed that I like better than IGF-2 is that I don't have the groggy effect upon waking as I do with IGF-2.

    Quote Originally Posted by ambulldog View Post
    does this make igf2 obsolete?
    No.

    Quote Originally Posted by Urban Monk View Post
    Can IGF-2 and HGHup be taken together in a stack, or does one supercede the other?
    I wouldn't do it. No two products containing L-Dopa should be taken together and if they are the doses of both products would have to be lowered. Research side effects of L-Dopa and you'll understand why.

    Quote Originally Posted by Psychabinol View Post
    I would think HGHup is the evolution of IGF-2, it would seem silly to stack them. There are better stacking optionsm

    well igf-2 has safed musli, rhodilea rosea, and dodder seed which are some beneficial herbs, probally rhodilea the most beneficial, but that does not effect growth hormone.
    I agree it would be silly to stack the two, but HGH Up is not necessarily the evolution of IGF-2...it is a different animal altogether.


    Quote Originally Posted by andrew732 View Post
    Honestly this is an IDEAL supplement, stack it with some testofen and KABOOM, good job AN, I feel this is the replacement of IGF-2. I will be purchasing, this is POTENT for SURE.
    Testofen is good stuff, but stacking with DRIVE is more ideal...Icariin and forslean together with the chlorophytum borivillanum sapogenic ethanolic extract yield some nice strength gains, a great libido boost, hardening and recomping effects, and an awesome sense of well-being.

    Cheers!

    -Sean-

    Team APPNUT
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  23. Elite Member
    andrew732's Avatar
    Join Date
    Jun 2008
    Posts
    5,751
    Rep Power
    781737
    Level
    58
    Lv. Percent
    7.57%
    Achievements Activity AuthorityActivity ProPosting ProPosting Authority

    Quote Originally Posted by SamBoz19 View Post
    You have to play around with the doses with HGH Up, but when you find the sweet spot pre-bed it knocks you out...better than IGF-2. What I noticed that I like better than IGF-2 is that I don't have the groggy effect upon waking as I do with IGF-2.



    No.



    I wouldn't do it. No two products containing L-Dopa should be taken together and if they are the doses of both products would have to be lowered. Research side effects of L-Dopa and you'll understand why.



    I agree it would be silly to stack the two, but HGH Up is not necessarily the evolution of IGF-2...it is a different animal altogether.




    Testofen is good stuff, but stacking with DRIVE is more ideal...Icariin and forslean together with the chlorophytum borivillanum santander ethanolic extract yield some nice strength gains, a great libido boost, hardening and recomping effects, and an awesome sense of well-being.

    Cheers!

    -Sean-

    Team APPNUT
    I was referring to freeing test, in my opinion nothing beats a combo of testofen and divanil for freeing test, not a fan of forslean in this department. Although some icarrin is always fun
    doing my own thang!
  24. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by andrew732 View Post
    I was referring to freeing test, in my opinion nothing beats a combo of testofen and divanil for freeing test, not a fan of forslean in this department. Although some icarrin is always fun
    I am a big fan of Divanil...had great success with it. Actually...ActiVate Xtreme stacked with DRIVE and IGF-2 was one of my favorite stacks ever. Testofen does work, but for me I had to dose it on the higher side...regardless it still worked.

    Cheers!

    -Sean-

    Team APPNUT
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  25. Diamond Member
    DreamWeaver's Avatar
    Stats
    5'11"  200 lbs.
    Join Date
    Nov 2002
    Age
    56
    Posts
    20,809
    Rep Power
    789766
    Level
    84
    Lv. Percent
    39.47%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    So even running this 5 on and 2 off you would only run it 10-12 weeks. I am no expert but have had a lot of success with PGH, with this kind of protocol as a staple, I take a week off every couple months but most benefits are long term. It has been my experience that most benefits are long term using products like this. I can see 12 weeks on 2 off maybe using it 5 and 2. Maybe my current regime of 8 weeks on and one off would work also.
    LG Sciences sponsored athlete
    Mind and Muscle Board Representative
  26. Advanced Member
    ticco's Avatar
    Stats
    6'1"  270 lbs.
    Join Date
    Jan 2008
    Age
    29
    Posts
    649
    Rep Power
    419
    Level
    20
    Lv. Percent
    17.98%

    seems interesting...when will the pricing and release date information be available?
  27. New Member
    WilteredFire's Avatar
    Stats
    5'10"  164 lbs.
    Join Date
    Feb 2008
    Posts
    488
    Rep Power
    330
    Level
    18
    Lv. Percent
    7.87%

    Thanks for the write up, much appreciated. Having taken IGF-2 stacked with Drive im very much looking forward to this. Will most definately be stacking this will drive and taking it solo too. Sweet
  28. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by DreamWeaver View Post
    So even running this 5 on and 2 off you would only run it 10-12 weeks. I am no expert but have had a lot of success with PGH, with this kind of protocol as a staple, I take a week off every couple months but most benefits are long term. It has been my experience that most benefits are long term using products like this. I can see 12 weeks on 2 off maybe using it 5 and 2. Maybe my current regime of 8 weeks on and one off would work also.
    Your protocol might work as well. I say might because I think everyone has to find a different protocol to follow individually. I cannot claim to be an expert either. I have toyed around with these different dosing protocols too, but I have found I get better results with how I do it. I mean to each their own obviously. The key is knowing your body and knowing what works for you and what doesn't. Who knows...maybe I'll give your idea a shot in the near future. Your a wise man and have years of experience on me and I respect that. With age comes more wisdom and I just try to take it all in and arm myself with more knowledge.

    Cheers bud!

    -Sean-

    Team APPNUT
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  29. Board Sponsor
    Rodja's Avatar
    Stats
    5'10"  230 lbs.
    Join Date
    Jan 2006
    Age
    30
    Posts
    23,735
    Rep Power
    1317328
    Level
    94
    Lv. Percent
    29.35%
    Achievements Activity RoyaltyActivity VeteranActivity ProActivity AuthorityPosting Pro

    When is the label/pricing info going to be avaiable?
    M.Ed. Ex Phys
    Performax Labs Product Specialist

  30. Diamond Member
    DreamWeaver's Avatar
    Stats
    5'11"  200 lbs.
    Join Date
    Nov 2002
    Age
    56
    Posts
    20,809
    Rep Power
    789766
    Level
    84
    Lv. Percent
    39.47%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by SamBoz19 View Post
    Your protocol might work as well. I say might because I think everyone has to find a different protocol to follow individually. I cannot claim to be an expert either. I have toyed around with these different dosing protocols too, but I have found I get better results with how I do it. I mean to each their own obviously. The key is knowing your body and knowing what works for you and what doesn't. Who knows...maybe I'll give your idea a shot in the near future. Your a wise man and have years of experience on me and I respect that. With age comes more wisdom and I just try to take it all in and arm myself with more knowledge.

    Cheers bud!

    -Sean-

    Team APPNUT

    Thanks I appreciate that.. I am a little weak in the scientific department though so I need to sound my ideas off those that have more knowledge in that department so I can make a more informed descision. Bottom line for me is the main thing I am looking at is skin elasticity (me being an old fugger) and these types of products have a pronounced effect on your body type over extended periods .. meaning your metabolism seems to speed up and you seem to become more meso... These kinds of changes pay off big time over the long haul. I am intrigued by some of the more immediate benefits too, I just feel the real benefits are the lasting ones.
    LG Sciences sponsored athlete
    Mind and Muscle Board Representative
  31. Senior Member
    SamBoz19's Avatar
    Stats
    6'4"  285 lbs.
    Join Date
    Sep 2007
    Age
    31
    Posts
    2,691
    Rep Power
    35302
    Level
    37
    Lv. Percent
    63.66%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by Rodja View Post
    When is the label/pricing info going to be avaiable?
    TBD...if I knew I would have announced it already. I would assume that information will be coming along shortly now. As soon as I hear anything...AM will know first.

    Cheers!

    -Sean-

    Team APPNUT
    "Never trust a b*tch because b*tches be crazy, now get out there and go crush some P***Y!" - Jerry Stiller.
  32. Professional Member
    hardknock's Avatar
    Stats
    5'10"  198 lbs.
    Join Date
    Jan 2004
    Posts
    3,214
    Rep Power
    18674
    Level
    40
    Lv. Percent
    37.61%
    Achievements Activity ProPosting Pro

    Isn't chlorophytum borivilianum a version of safed musli?

    On another note

    Wasn't exactly what I thought it would be but hopefully this works for those that are able to handle the extra l-dopa
  33. Board Sponsor
    Rodja's Avatar
    Stats
    5'10"  230 lbs.
    Join Date
    Jan 2006
    Age
    30
    Posts
    23,735
    Rep Power
    1317328
    Level
    94
    Lv. Percent
    29.35%
    Achievements Activity RoyaltyActivity VeteranActivity ProActivity AuthorityPosting Pro

    Quote Originally Posted by hardknock View Post
    Isn't chlorophytum borivilianum a version of safed musli?

    On another note

    Wasn't exactly what I thought it would be but hopefully this works for those that are able to handle the extra l-dopa
    Yes. I'm a huge fan of safed musli and it's vastly underrated.
    M.Ed. Ex Phys
    Performax Labs Product Specialist

  34. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122082
    Level
    55
    Lv. Percent
    25.35%
    Achievements Activity ProPosting ProPosting Authority

    When is out?
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  35. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by ambulldog View Post
    does this make igf2 obsolete?
    No, it does not make IGF-2 obsolete. Although both IGF-2 and HGHup♂ are natural Growth Hormone products, they are two DIFFERENT products.


    Quote Originally Posted by Urban Monk View Post
    Can IGF-2 and HGHup be taken together in a stack, or does one supercede the other?
    I would not recommned stacking them together; use either one or the other. And no, one does not supercede the other.


    Quote Originally Posted by DreamWeaver View Post
    So even running this 5 on and 2 off you would only run it 10-12 weeks. I am no expert but have had a lot of success with PGH, with this kind of protocol as a staple, I take a week off every couple months but most benefits are long term. It has been my experience that most benefits are long term using products like this. I can see 12 weeks on 2 off maybe using it 5 and 2. Maybe my current regime of 8 weeks on and one off would work also.
    Each to their own.


    Quote Originally Posted by ticco View Post
    seems interesting...when will the pricing and release date information be available?
    Pricing to be advised...Release date is counting down to on the AN site.


    Quote Originally Posted by Rodja View Post
    When is the label/pricing info going to be avaiable?
    Soon.


    Quote Originally Posted by hardknock View Post
    Isn't chlorophytum borivilianum a version of safed musli?
    It's not "a verion of"; it IS Sfaed Musli.


    Quote Originally Posted by MAxximal View Post
    When is out?
    9 days and 12 hours.

    ~Rosie
    Team APPNUT
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee
  36. Senior Member
    Liftingstud's Avatar
    Join Date
    May 2005
    Age
    34
    Posts
    2,075
    Rep Power
    1184
    Level
    34
    Lv. Percent
    19.58%
    Achievements Activity ProPosting Pro

    You must have been reading my thoughts cause I have been using IGF2 3 caps 3x day and recently with the night and morning dose I have taking with bulk powerfull powder (USPowders) with glycobol, Stoked and testopro and liked the combo so fair... love to switch to this stuff. I think IGF2 is a vastly underrated and when I added the bulk 1-c I was blowen away. GF says I am out like I am dead every night and never move. I wake up rested and ready to rock each day.

    I think the combo of a test booster + AI + nutrient partioner + GH supplement is the way to go. I am becoming a quick believer.

    Nothing against Drive, loved it when I used it but wanted to try testopro. May switch back to Drive and Activate and see which I like better.

    Looks like a solid product.
  37. New Member
    sillycibin's Avatar
    Join Date
    Sep 2006
    Posts
    8
    Rep Power
    348
    Level
    2
    Lv. Percent
    79.95%

    The green tea extract makes a lot of sense since it is acting as a decarboxylase inhibitor and will make more L-dopa available to cross the blood-brain barrier, but the vitamin b6 seems at odds with that since research with parkinsons patients shows that it increases the break down of l-dopa. I guess its all about which one is winning between the green tea and b-6.
  38. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122082
    Level
    55
    Lv. Percent
    25.35%
    Achievements Activity ProPosting ProPosting Authority

    I waiting this stuff....what is the price range?
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  39. Board Sponsor
    rms80's Avatar
    Stats
    6'2"  215 lbs.
    Join Date
    Jan 2007
    Posts
    4,224
    Rep Power
    241543
    Level
    47
    Lv. Percent
    35.57%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by sillycibin View Post
    The green tea extract makes a lot of sense since it is acting as a decarboxylase inhibitor and will make more L-dopa available to cross the blood-brain barrier, but the vitamin b6 seems at odds with that since research with parkinsons patients shows that it increases the break down of l-dopa. I guess its all about which one is winning between the green tea and b-6.
    I posted this on another board:
    "the explanation of this can get a little confusing: B-6 is a co-factor in Dopa Decarboxylase (DDC) synthesis. In this case, this seems counterproductive, because we are trying to lower DDC and prevent the conversion of L-Dopa to dopamine by using a DDCI, at least peripherally, because dopamine has a hard time crossing the blood brain barrier. However, administration of a DDCI with L-Dopa can cause a deficiency in pyroxidine (B-6), and this can significantly lower the effectiveness of the L-Dopa, in that L-Dopa still must be converted to dopamine once it crosses the BBB anyway to exert its effects, and pyroxidine is necessary as a cofactor for this to occur. So the B-6 is included as a co-factor/preventative measure..... "

    The dose of B-6 per 5 capsules of HGH-Up is 2 mg- fairly low, but a decent dose for usage as a co-factor.........
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
  40. The Female Terminator
    Rosie Chee's Avatar
    Stats
    5'1"  116 lbs.
    Join Date
    Mar 2008
    Age
    30
    Posts
    16,186
    Rep Power
    493835
    Level
    76
    Lv. Percent
    53.4%
    Achievements Activity VeteranActivity ProActivity AuthorityPosting ProPosting Authority

    Quote Originally Posted by MAxximal View Post
    I waiting this stuff....what is the price range?
    As mentioned above, price still to be advised...

    ~Rosie
    Team APPNUT
    Contact Me for INDIVIDUALIZED TRAINING AND NUTRITION

    "Think like a Champion. Train like a Warrior. Live with a Purpose." - Rosie Chee
  

  
 

Similar Forum Threads

  1. Pmiller's HGHup♂ Sponsored Log
    By pmiller383 in forum Supplement Logs
    Replies: 61
    Last Post: 12-03-2009, 02:02 AM
  2. Chan is movin' on up♂!
    By CHANcore in forum Supplement Logs
    Replies: 1
    Last Post: 11-04-2009, 09:30 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in