What is EndoAmp Max
? EndoAmp Max
is a naturally occurring phospholipid complex, designed to minimize the cortisol increase after exercise while amplifying the testosterone and growth hormone (GH) response.
As a mild "nutty" tasting powder, EndoAmp Max can be taken by itself or mixed with a beverage. Each dose includes 800mg of pure phosphatidylserine and 600mg of alpha-glycerylphosphorylcholine (A-GPC). At the recommended dose, EndoAmp Max will last 29 days.
EndoAmp Max is known as an "endocrine amplifier" because it can amplify the beneficial hormones such as testosterone & GH while preventing the unwanted spike in cortisol associated with exercise, so you can begin making progress towards building a harder, more masculine physique. How does EndoAmp Max
EndoAmp Max works by supplying the body with vital phospholipids and neurotransmitters, thus reducing the requirement for cortisol following strenuous physical or mental activity and supporting higher testosterone and GH output. (11,21,37,38)
Increased GH and testosterone levels help promote faster recovery, increased muscle growth and enhanced
fat loss. (36) How does EndoAmp Max
Support Testosterone production?
The active ingredient phosphatidylserine (PS) prevents the exercise induced cortisol spike, and is a vital nutrient that supports testicular function and testosterone production. (11,37) Each serving of EndoAmp Max includes a clinically proven dose of 800mg of PS.
A recent study examined the effects of 10 days of 600mg/day PS supplementation on testosterone and cortisol during and after exercise. (37) The researchers found that PS supplementation increased testosterone 78% over the placebo group, while completely blunting the cortisol response to exercise. When analyzed for the testosterone to cortisol (T:C) ratio and compared to placebo, the PS group had a 3,354% higher T:C!
In another human study, hormone levels where examined during two weeks of intense
weight training. The group receiving the 800mg of PS had higher testosterone levels and lower cortisol levels, compared to the group receiving the placebo. (11) Another study showed that 800mg of PS reduced cortisol levels 30% (compared to the placebo group) after intense cycling exercise. (21)
It’s been hypothesized that PS supplementation minimizes cortisol secretion by providing the necessary phospholipids required for cellular membrane structure and regulatory functions, thus reducing the requirement for bodily breakdown and nutrient displacement. (17,25,36,40)
Research also suggests that PS supports testosterone production by increasing the testes sensitivity to luteinizing hormone (LH) and increases testicular steroidogenesis - aka the creation of testosterone. (1-11, 19-26)
Take this quote from Cooke et al (1989) about the important role of PS in the testes –
"The requirement for specific phospholipid configurations for optimal steroidogenic activity suggests a regulatory role for these membrane components. It is possible that certain phospholipids [phosphatidylserine] may possess the most suitable configuration and charge distribution to optimize the binding of the steroid substrate to the active site of the enzyme. Alternatively, they may assist the catalysis by providing a more suitable microenvironment or electrochemical gradient for proton transfer between enzyme and steroid."¯
In other words, EndoAmp Max creates a more conducive environment for testosterone synthesis in the testes by mitigating the damaging effects from cortisol and supplying the testes with the necessary phospholipids for testicular function. How does EndoAmp Max support Growth Hormone (GH) production?
The active ingredient alpha-glycerylphosphorylcholine (A-GPC) increases the synthesis and release of an important neurotransmitter known as acetylcholine which enhances GH production following exercise. (38-43) Each serving of EndoAmp Max provides a scientifically proven dose of A-GPC.
A recent study examined GH release in resistance trained men after supplementation with a single 600mg dose of A-GPC. When supplemented with A-GPC, GH levels peaked 68% higher than placebo following exercise. The peak bench press force was also 14% greater with A-GPC than placebo. (38)
Similar results have been found in another human study with young and elderly subjects. In the young subjects (30-34 yrs), A-GPC lead to a 40% higher increase in GH over the non-A-GPC group. In the elderly subjects (80-82 yrs.), A-GPC caused a 140% higher increase in GH over the non-A-GPC group. (39)
The research suggests that A-GPC amplifies the release of GH following growth-hormone-releasing-hormone (GHRH) stimulation. It was proposed that A-GPC supplementation increases acetylcholine levels in the brain, thus enhancing pituitary sensitivity and amplifying the release of GH from GHRH stimulation. (39)
Another mechanism by which A-GPC may increase GH secretion is by improving the fluidity of pituitary membranes, thus increasing signal transduction at the pituitary level. (39-41)
In laymen’s terms, EndoAmp Max increases the amount of GH secreted from exercise. What sort of effects should I expect from EndoAmp Max?
Human research shows that EndoAmp Max can offer the following benefits –
Improve the testosterone to cortisol ratio (11,21)
Amplify GH levels following exercise (38,39)
Increase resistance to stress & fatigue (19-23)
Increase exercise capacity (22, 38)
Speed recovery & reduce muscle soreness (23,24)
Enhanced sense of well-being (19,23)
Note: Although PS and A-GPC are naturally present in animal meat, most Americans are probably getting less than 120mg/day of PS & A-GPC combined through a Western diet (17,18,44). Therefore, supplementing with EndoAmp Max will ensure you get a sufficient amount of these highly valuable nutrients for the clinically proven benefits. What are some signs that my cortisol is too high?
Excess fat distribution around the face and/or abdominal area (16)
Low Libido (33,34)
Low Testosterone* (2,3,10)
Low GH (Growth Hormone) (12-14)
Decreased insulin sensitivity (15)
Suppressed immune system (12, 15)
Mental depression (34)
Easily fatigued or exhausted (34,35)
Prolonged recovery from exercise (35)
*Cortisol dominance is a primary cause of hypogonadism and male impotence.
Keep in mind, it is normal and healthy to have elevated cortisol prior to waking from a night's rest, which is part of the body's natural regeneration process. However, it is not healthy to maintain elevated cortisol levels throughout the day. What if I already have low cortisol? Will EndoAmp Max still benefit me?
Although seemingly contradictory, the answer is yes. Fortifying the body with the vital phospholipids and nutrients contained in EndoAmp Max will support the proper physiological structure & function of the body.
Remember, insufficient cortisol production is generally brought upon by adrenal fatigue which generally originates from over production of cortisol. In order to revive the adrenal glands and restore
normal cortisol secretion, you must remove the hyper-cortisol stimulus, and reduce the requirement for cortisol by providing the body with proper nutrition.
What does it mean to “reduce the requirement for cortisol”?
Cortisol is a catabolic hormone produced by the body to breakdown bodily tissue and free up vital nutrients for the repair and maintenance of the body. (12) Cortisol Secretion
1. When the brain senses a low availability of vital nutrients (e.g., glucose, phospholipids, etc.), it releases adrenocorticotropic hormone (ACTH) which travels down to the adrenal glands.
2. Once ACTH reaches the adrenal glands (above the kidneys), it stimulates the release of cortisol to begin breaking down bodily tissue. (12)
When muscle tissue is damaged during intense exercise it creates a high demand for nutrients (e.g., amino acids and phospholipids) for the structural repair of muscle tissue. Therefore, if the body is not supplied with sufficient nutrition to repair and rebuild the damaged cellular tissue, it will release cortisol to breakdown other areas of the body for the nutrients it needs.
Aside from breaking down muscle tissue for glucose and amino acids, research shows that cortisol also breaks down testicular tissue and reduces the body’s ability to produce testosterone, perhaps as a mechanism to free up phospholipid stores within the testes. (2-10)
Research with over-trained and/or malnourished athletes has clearly shown that high cortisol levels are associated with low testosterone levels. This is known as a low testosterone to cortisol ratio and is highly correlated with decreased performance, slow recovery and inability to gain lean body mass. (45,46)
Therefore, when the body is supplied with ample nutrients to repair itself, it reduces the requirement for cortisol. Can I stack EndoAmp Max with other testosterone support supplements?
Yes, EndoAmp Max can enhance the effectiveness of other testosterone boosting supplements by amplifying the testes ability to produce testosterone.
This synergistic effect makes EndoAmp Max an important addition to our Testosterone Recovery Stack. It also makes EndoAmp Max a vital part of post cycle therapy (PCT), when preserving muscle mass
and restoring natural testosterone production is of the utmost importance. Supplement Facts
Serving Size 2200mg (one scoop)
Servings Per Container 29
Amount Per Serving %DV
----- Phosphatidylserine 800mg*
----- Phosphatidylcholine 154mg*
----- Phosphatidylethanolamine 128mg*
----- Phosphatidylinositol 68mg*
AlphaSize (A-GPC) 600mg*
*Daily Value not established Buy it, Here!: EndoAmp Max
1. Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitro
Biol Reprod, Sep 1989; 41: 438 - 445.
2. Testosterone levels during systemic and inhaled corticosteroid therapy.
D Morrison, et al.
Respir Med, October 1, 1994; 88(9): 659-63.
3. Testicular function during prolonged corticotherapy
JM Kuhn, et al.
Presse Med, March 22, 1986; 15(12): 559-62.
4. Glucocorticoid Induces Apoptosis in Rat Leydig Cells
Hui-Bao Gao, et al.
Endocrinology, Jan 2002; 143: 130.
5. Role of glucocorticoid in the stress-induced suppression of testicular steroidogenesis in adult male rats.
Orr TE, Mann DR 1992
Horm Behav 26:350 – 363
6. Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro.
Gao HB, Shan LX, Monder C, Hardy MP 1996
Endocrinology 137:1714 – 1718
7. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion
DR Mann, et al.
Endocrinology, Apr 1987; 120: 1542.
8. Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: evidence for a mediating role of testicular 11ĆŸ-hydroxysteroid dehydrogenase.
Monder C, et al.
Endocrinology 134:1193 – 1198
9. The effect of stress-induced ligands on testosterone formation in Leydig cells.
Cooke BA, et al. 1992
West AP, eds. Stress and reproduction. New York: Raven Press; 135 – 144
10. Acute suppression of circulating testosterone levels by cortisol in men.
Cumming D, Quigley ME, Yen SSC 1983
J Clin Endocrinol Metab 57:671 – 673
11. HORMONAL EFFECTS OF PHOSPHATIDYLSERINE DURING 2-WKS OF INTENSE WEIGHT TRAINING
[Annual Meeting Abstracts]
Fahey, T. D.; Pearl, M.
California State University, Chico
12. Association of 24-Hour Cortisol Production Rates, Cortisol-Binding Globulin, and Plasma-Free Cortisol Levels with Body Composition, Leptin Levels, and Aging in Adult Men and Women
Jonathan Q. et al.
J. Clin. Endocrinol. Metab., Jan 2004; 89: 281 - 287.
13. Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormone release from cultured sheep pituitary cells
JL Sartin, et al.
J. Endocrinol., Jun 1994; 141: 517 - 525.
14. Lowering cortisol enhances growth hormone response to growth hormone releasing hormone in healthy subjects.
TG Dinan, J Thakore, and V O'Keane
Acta Physiol Scand, July 1, 1994; 151(3): 413-6.
15. Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities
Roland Rosmond, Mary F. Dallman, and Per Bjorntorp
J. Clin. Endocrinol. Metab., Jun 1998; 83: 1853 - 1859.
16. Visceral obesity: a "civilization syndrome".
Obes Res. 1993 May;1(3):206-22.
17. Brain caphalin, a mixture of phosphatides. Separation from it of phosphatidyl serine
, phosphatidyl ethanolamine, and a fraction containing an inositol phophatide.
Folch J et al.
J Biol Chem 1942 146(1):35-44
18. Food composition and nutritional tables.
Souci et al.
Medpharm Scientific Publishers; 200
19. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor.
Benton D et al.
Nutr Neurosci 2001, 4(3):169-178
20. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
Monteleone et al.
Neuroendocrinology 1990, 52(3):243-248
21. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
Monteleone et al.
Eur J Clin Pharmacol 1992, 42(4):385-388
22. Effects of phosphatidylserine on exercise capacity during cycling in active males.
Kingsley et al.
Med Sci Sports Exerc 2006, 38(I):64-71
23. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of weight training-induced over-training.
Fayey TD, et al.
Biol Sport 1998, 15(2): 135-144
24. The effects of phosphatidyl serine on markers of muscular stress in endurance
Fernholz et al.
Med Sci Sports Exerc 2000, 32(5):S321
25. Phospholipids and sports performance.
R Jager, et al.
J Int Soc Sports Nutr, Jan 2007; 4: 5
26. Effects of Phosphatidylserine on oxidative stress following intermittent running.
Kingsley M et al.
Med Sci Sports Exerc 2005 37(8):1300-1306
27. The effect of phosphatidylserine on golf performance.
Ralf Jager et al.
J Int Soc Sports Nutr. 2007; 4:23
28. Changes in Financial Strain Over Three Years, Ambulatory Blood Pressure, and Cortisol Responses to Awakening
Andrew Steptoe, Lena Brydon, and Sabine Kunz-Ebrecht
Psychosom Med, Mar 2005; 67: 281 - 287.
29. Perfectionism and the Cortisol Response to Psychosocial Stress in Men
Petra H. Wirtz, et al.
Psychosom Med, Apr 2007; 69: 249 - 255.
30. Influence of dietary protein, energy and corticosteroids on protein turnover, proteoglycan sulphation and growth of long bone and skeletal muscle in the rat.
ZA Yahya, et al
Clin Sci (Lond), Nov
1994; 87(5): 607-18.
31. Cortisol, testosterone, and free testosterone in athletes performing a marathon at 4,000 m altitude.
Marinelli et al.
Horm Res., 41(5-6), 225-229, 1994
32. Usefullness of free testosterone/cortisol ratio during a season of elite speed skating athletes.
Banfi et al.
Int J Sports Med., 14(7), 373-379, 1993.
33. Corticosterone Can Act at the Posterior Paraventricular Thalamus to Inhibit Hypothalamic-Pituitary-Adrenal Activity in Animals that Habituate to Repeated Stress
Azra Jaferi and Seema Bhatnagar
Endocrinology, Oct 2006; 147: 4917 – 4930
34. Steroids and depression
Alexander Mitchell and Veronica O'Keane
BMJ, Jan 1998; 316: 244
35. Biological Markers of overtraining
Fahey et al.
Biol Sport 1997, 14:1-19
36. Amino acids and proteins for the athlete.
CRC Press, 2007, Pg 309
37. The effects of soy phosphatidylserine on cortisol, growth hormone and testosterone response to moderate intensity exercise.
Starks, et al.
University of Mississippi
38. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to and peak force production during resistance exercise
Ziegenfuss et al.
J Int Soc Sports Nutr, Jun 2008 5(Suppl 1): P15
39. Alpha-Glycerylphosphorylcholine administration increases the GH response to GHRH of young and elderly subjects.
Ceda et al.
Horm Metab Res, Mar 1992; 24(3): 119-21.
40. Phospholipids as dynamic participants in biological processes.
Hanahan et al.
J lipid Res 1984, 25:1528-1535
41. Biosynthesis of phospholipids
Kennedy at al.
Fed, Proc 16: 847-853 (1957)
42. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia.
R Di Perri, G Coppola, LA Ambrosio, A Grasso, FM Puca, and M Rizzo
J Int Med Res, July 1, 1991; 19(4): 330-41.
43. Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat.
F Drago, F Mauceri, L Nardo, C Valerio, N Lauria, L Rampello, and G Guidi
Pharmacol Biochem Behav, February 1, 1992; 41(2): 445-8.
44. L--Glycerophosphocholine Contributes to Meat's Enhancement of Nonheme Iron Absorption
Charlotte N. Armah, Paul Sharp, Fred A. Mellon, Sandra Pariagh, Elizabeth K. Lund, Jack R. Dainty, Birgit Teucher, and Susan J. Fairweather-Tait
J. Nutr., May 2008; 138: 873 - 877.
45. Overtraining and elite athletes: Review and directions for the future.
Kuipers et al.
Sports Med. 1988, 6:79-92
46. Resistance exercise overtraining and overreaching neuroendocrine responses .
Kraemer et al.
Spots Med. 1997, 23(2):106-129