Primordial Performance presents: EndoAmp Max!

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    Lightbulb Primordial Performance presents: EndoAmp Max!






    What is EndoAmp Max
    ?


    EndoAmp Max is a naturally occurring phospholipid complex, designed to minimize the cortisol increase after exercise while amplifying the testosterone and growth hormone (GH) response.

    As a mild "nutty" tasting powder, EndoAmp Max can be taken by itself or mixed with a beverage. Each dose includes 800mg of pure phosphatidylserine and 600mg of alpha-glycerylphosphorylcholine (A-GPC). At the recommended dose, EndoAmp Max will last 29 days.

    EndoAmp Max is known as an "endocrine amplifier" because it can amplify the beneficial hormones such as testosterone & GH while preventing the unwanted spike in cortisol associated with exercise, so you can begin making progress towards building a harder, more masculine physique.


    How does EndoAmp Max
    work?


    EndoAmp Max works by supplying the body with vital phospholipids and neurotransmitters, thus reducing the requirement for cortisol following strenuous physical or mental activity and supporting higher testosterone and GH output. (11,21,37,38)

    Increased GH and testosterone levels help promote faster recovery, increased muscle growth and enhanced fat loss. (36)


    How does EndoAmp Max
    Support Testosterone production?


    The active ingredient phosphatidylserine (PS) prevents the exercise induced cortisol spike, and is a vital nutrient that supports testicular function and testosterone production. (11,37) Each serving of EndoAmp Max includes a clinically proven dose of 800mg of PS.

    A recent study examined the effects of 10 days of 600mg/day PS supplementation on testosterone and cortisol during and after exercise. (37) The researchers found that PS supplementation increased testosterone 78% over the placebo group, while completely blunting the cortisol response to exercise. When analyzed for the testosterone to cortisol (T:C) ratio and compared to placebo, the PS group had a 3,354% higher T:C!






    In another human study, hormone levels where examined during two weeks of intense weight training. The group receiving the 800mg of PS had higher testosterone levels and lower cortisol levels, compared to the group receiving the placebo. (11) Another study showed that 800mg of PS reduced cortisol levels 30% (compared to the placebo group) after intense cycling exercise. (21)

    It’s been hypothesized that PS supplementation minimizes cortisol secretion by providing the necessary phospholipids required for cellular membrane structure and regulatory functions, thus reducing the requirement for bodily breakdown and nutrient displacement. (17,25,36,40)

    Research also suggests that PS supports testosterone production by increasing the testes sensitivity to luteinizing hormone (LH) and increases testicular steroidogenesis - aka the creation of testosterone. (1-11, 19-26)

    Take this quote from Cooke et al (1989) about the important role of PS in the testes –

    "The requirement for specific phospholipid configurations for optimal steroidogenic activity suggests a regulatory role for these membrane components. It is possible that certain phospholipids [phosphatidylserine] may possess the most suitable configuration and charge distribution to optimize the binding of the steroid substrate to the active site of the enzyme. Alternatively, they may assist the catalysis by providing a more suitable microenvironment or electrochemical gradient for proton transfer between enzyme and steroid."Ě

    In other words, EndoAmp Max creates a more conducive environment for testosterone synthesis in the testes by mitigating the damaging effects from cortisol and supplying the testes with the necessary phospholipids for testicular function.


    How does EndoAmp Max support Growth Hormone (GH) production?

    The active ingredient alpha-glycerylphosphorylcholine (A-GPC) increases the synthesis and release of an important neurotransmitter known as acetylcholine which enhances GH production following exercise. (38-43) Each serving of EndoAmp Max provides a scientifically proven dose of A-GPC.

    A recent study examined GH release in resistance trained men after supplementation with a single 600mg dose of A-GPC. When supplemented with A-GPC, GH levels peaked 68% higher than placebo following exercise. The peak bench press force was also 14% greater with A-GPC than placebo. (38)

    Similar results have been found in another human study with young and elderly subjects. In the young subjects (30-34 yrs), A-GPC lead to a 40% higher increase in GH over the non-A-GPC group. In the elderly subjects (80-82 yrs.), A-GPC caused a 140% higher increase in GH over the non-A-GPC group. (39)

    The research suggests that A-GPC amplifies the release of GH following growth-hormone-releasing-hormone (GHRH) stimulation. It was proposed that A-GPC supplementation increases acetylcholine levels in the brain, thus enhancing pituitary sensitivity and amplifying the release of GH from GHRH stimulation. (39)

    Another mechanism by which A-GPC may increase GH secretion is by improving the fluidity of pituitary membranes, thus increasing signal transduction at the pituitary level. (39-41)

    In laymen’s terms, EndoAmp Max increases the amount of GH secreted from exercise.


    What sort of effects should I expect from EndoAmp Max?

    Human research shows that EndoAmp Max can offer the following benefits –

    Improve the testosterone to cortisol ratio (11,21)
    Amplify GH levels following exercise (38,39)
    Increase resistance to stress & fatigue (19-23)
    Increase exercise capacity (22, 38)
    Speed recovery & reduce muscle soreness (23,24)
    Enhanced sense of well-being (19,23)
    Note: Although PS and A-GPC are naturally present in animal meat, most Americans are probably getting less than 120mg/day of PS & A-GPC combined through a Western diet (17,18,44). Therefore, supplementing with EndoAmp Max will ensure you get a sufficient amount of these highly valuable nutrients for the clinically proven benefits.


    What are some signs that my cortisol is too high?

    Excess fat distribution around the face and/or abdominal area (16)
    Low Libido (33,34)
    Low Testosterone* (2,3,10)
    Low GH (Growth Hormone) (12-14)
    Decreased insulin sensitivity (15)
    Suppressed immune system (12, 15)
    Mental depression (34)
    Easily fatigued or exhausted (34,35)
    Prolonged recovery from exercise (35)
    *Cortisol dominance is a primary cause of hypogonadism and male impotence.

    Keep in mind, it is normal and healthy to have elevated cortisol prior to waking from a night's rest, which is part of the body's natural regeneration process. However, it is not healthy to maintain elevated cortisol levels throughout the day.


    What if I already have low cortisol? Will EndoAmp Max still benefit me?

    Although seemingly contradictory, the answer is yes. Fortifying the body with the vital phospholipids and nutrients contained in EndoAmp Max will support the proper physiological structure & function of the body.

    Remember, insufficient cortisol production is generally brought upon by adrenal fatigue which generally originates from over production of cortisol. In order to revive the adrenal glands and restore normal cortisol secretion, you must remove the hyper-cortisol stimulus, and reduce the requirement for cortisol by providing the body with proper nutrition.

    What does it mean to “reduce the requirement for cortisol”?

    Cortisol is a catabolic hormone produced by the body to breakdown bodily tissue and free up vital nutrients for the repair and maintenance of the body. (12)


    Cortisol Secretion

    1. When the brain senses a low availability of vital nutrients (e.g., glucose, phospholipids, etc.), it releases adrenocorticotropic hormone (ACTH) which travels down to the adrenal glands.

    2. Once ACTH reaches the adrenal glands (above the kidneys), it stimulates the release of cortisol to begin breaking down bodily tissue. (12)



    When muscle tissue is damaged during intense exercise it creates a high demand for nutrients (e.g., amino acids and phospholipids) for the structural repair of muscle tissue. Therefore, if the body is not supplied with sufficient nutrition to repair and rebuild the damaged cellular tissue, it will release cortisol to breakdown other areas of the body for the nutrients it needs.

    Aside from breaking down muscle tissue for glucose and amino acids, research shows that cortisol also breaks down testicular tissue and reduces the body’s ability to produce testosterone, perhaps as a mechanism to free up phospholipid stores within the testes. (2-10)

    Research with over-trained and/or malnourished athletes has clearly shown that high cortisol levels are associated with low testosterone levels. This is known as a low testosterone to cortisol ratio and is highly correlated with decreased performance, slow recovery and inability to gain lean body mass. (45,46)

    Therefore, when the body is supplied with ample nutrients to repair itself, it reduces the requirement for cortisol.


    Can I stack EndoAmp Max with other testosterone support supplements?

    Yes, EndoAmp Max can enhance the effectiveness of other testosterone boosting supplements by amplifying the testes ability to produce testosterone.

    This synergistic effect makes EndoAmp Max an important addition to our Testosterone Recovery Stack. It also makes EndoAmp Max a vital part of post cycle therapy (PCT), when preserving muscle mass and restoring natural testosterone production is of the utmost importance.









    Supplement Facts
    Serving Size 2200mg (one scoop)
    Servings Per Container 29
    Amount Per Serving %DV
    ----------------------------------------
    SerinAid 1600mg*
    ----- Phosphatidylserine 800mg*
    ----- Phosphatidylcholine 154mg*
    ----- Phosphatidylethanolamine 128mg*
    ----- Phosphatidylinositol 68mg*
    AlphaSize (A-GPC) 600mg*
    (alpha-glycerylphosphorylcholine)

    --------------------------------------

    *Daily Value not established






    Buy it, Here!: EndoAmp Max





    References –

    1. Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitro
    GM Cooke
    Biol Reprod, Sep 1989; 41: 438 - 445.

    2. Testosterone levels during systemic and inhaled corticosteroid therapy.
    D Morrison, et al.
    Respir Med, October 1, 1994; 88(9): 659-63.

    3. Testicular function during prolonged corticotherapy
    JM Kuhn, et al.
    Presse Med, March 22, 1986; 15(12): 559-62.

    4. Glucocorticoid Induces Apoptosis in Rat Leydig Cells
    Hui-Bao Gao, et al.
    Endocrinology, Jan 2002; 143: 130.

    5. Role of glucocorticoid in the stress-induced suppression of testicular steroidogenesis in adult male rats.
    Orr TE, Mann DR 1992
    Horm Behav 26:350 – 363

    6. Suppression of endogenous corticosterone levels in vivo increases the steroidogenic capacity of purified rat Leydig cells in vitro.
    Gao HB, Shan LX, Monder C, Hardy MP 1996
    Endocrinology 137:1714 – 1718

    7. Mutually independent effects of adrenocorticotropin on luteinizing hormone and testosterone secretion
    DR Mann, et al.
    Endocrinology, Apr 1987; 120: 1542.

    8. Reciprocal changes in plasma corticosterone and testosterone in stressed male rats maintained in a visible burrow system: evidence for a mediating role of testicular 11√Ÿ-hydroxysteroid dehydrogenase.
    Monder C, et al.
    Endocrinology 134:1193 – 1198

    9. The effect of stress-induced ligands on testosterone formation in Leydig cells.
    Cooke BA, et al. 1992
    West AP, eds. Stress and reproduction. New York: Raven Press; 135 – 144

    10. Acute suppression of circulating testosterone levels by cortisol in men.
    Cumming D, Quigley ME, Yen SSC 1983
    J Clin Endocrinol Metab 57:671 – 673

    11. HORMONAL EFFECTS OF PHOSPHATIDYLSERINE DURING 2-WKS OF INTENSE WEIGHT TRAINING
    [Annual Meeting Abstracts]
    Fahey, T. D.; Pearl, M.
    California State University, Chico

    12. Association of 24-Hour Cortisol Production Rates, Cortisol-Binding Globulin, and Plasma-Free Cortisol Levels with Body Composition, Leptin Levels, and Aging in Adult Men and Women
    Jonathan Q. et al.
    J. Clin. Endocrinol. Metab., Jan 2004; 89: 281 - 287.

    13. Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormone release from cultured sheep pituitary cells
    JL Sartin, et al.
    J. Endocrinol., Jun 1994; 141: 517 - 525.

    14. Lowering cortisol enhances growth hormone response to growth hormone releasing hormone in healthy subjects.
    TG Dinan, J Thakore, and V O'Keane
    Acta Physiol Scand, July 1, 1994; 151(3): 413-6.

    15. Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities
    Roland Rosmond, Mary F. Dallman, and Per Bjorntorp
    J. Clin. Endocrinol. Metab., Jun 1998; 83: 1853 - 1859.

    16. Visceral obesity: a "civilization syndrome".
    Bjorntorp P
    Obes Res. 1993 May;1(3):206-22.

    17. Brain caphalin, a mixture of phosphatides. Separation from it of phosphatidyl serine, phosphatidyl ethanolamine, and a fraction containing an inositol phophatide.
    Folch J et al.
    J Biol Chem 1942 146(1):35-44

    18. Food composition and nutritional tables.
    Souci et al.
    Medpharm Scientific Publishers; 200

    19. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor.
    Benton D et al.
    Nutr Neurosci 2001, 4(3):169-178

    20. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
    Monteleone et al.
    Neuroendocrinology 1990, 52(3):243-248

    21. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men.
    Monteleone et al.
    Eur J Clin Pharmacol 1992, 42(4):385-388

    22. Effects of phosphatidylserine on exercise capacity during cycling in active males.
    Kingsley et al.
    Med Sci Sports Exerc 2006, 38(I):64-71

    23. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of weight training-induced over-training.
    Fayey TD, et al.
    Biol Sport 1998, 15(2): 135-144

    24. The effects of phosphatidyl serine on markers of muscular stress in endurance runners.
    Fernholz et al.
    Med Sci Sports Exerc 2000, 32(5):S321

    25. Phospholipids and sports performance.
    R Jager, et al.
    J Int Soc Sports Nutr, Jan 2007; 4: 5

    26. Effects of Phosphatidylserine on oxidative stress following intermittent running.
    Kingsley M et al.
    Med Sci Sports Exerc 2005 37(8):1300-1306

    27. The effect of phosphatidylserine on golf performance.
    Ralf Jager et al.
    J Int Soc Sports Nutr. 2007; 4:23

    28. Changes in Financial Strain Over Three Years, Ambulatory Blood Pressure, and Cortisol Responses to Awakening
    Andrew Steptoe, Lena Brydon, and Sabine Kunz-Ebrecht
    Psychosom Med, Mar 2005; 67: 281 - 287.

    29. Perfectionism and the Cortisol Response to Psychosocial Stress in Men
    Petra H. Wirtz, et al.
    Psychosom Med, Apr 2007; 69: 249 - 255.

    30. Influence of dietary protein, energy and corticosteroids on protein turnover, proteoglycan sulphation and growth of long bone and skeletal muscle in the rat.
    ZA Yahya, et al
    Clin Sci (Lond), Nov 1994; 87(5): 607-18.

    31. Cortisol, testosterone, and free testosterone in athletes performing a marathon at 4,000 m altitude.
    Marinelli et al.
    Horm Res., 41(5-6), 225-229, 1994

    32. Usefullness of free testosterone/cortisol ratio during a season of elite speed skating athletes.
    Banfi et al.
    Int J Sports Med., 14(7), 373-379, 1993.

    33. Corticosterone Can Act at the Posterior Paraventricular Thalamus to Inhibit Hypothalamic-Pituitary-Adrenal Activity in Animals that Habituate to Repeated Stress
    Azra Jaferi and Seema Bhatnagar
    Endocrinology, Oct 2006; 147: 4917 – 4930

    34. Steroids and depression
    Alexander Mitchell and Veronica O'Keane
    BMJ, Jan 1998; 316: 244

    35. Biological Markers of overtraining
    Fahey et al.
    Biol Sport 1997, 14:1-19

    36. Amino acids and proteins for the athlete.
    Di Pasquale
    CRC Press, 2007, Pg 309

    37. The effects of soy phosphatidylserine on cortisol, growth hormone and testosterone response to moderate intensity exercise.
    Starks, et al.
    University of Mississippi

    38. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to and peak force production during resistance exercise
    Ziegenfuss et al.
    J Int Soc Sports Nutr, Jun 2008 5(Suppl 1): P15

    39. Alpha-Glycerylphosphorylcholine administration increases the GH response to GHRH of young and elderly subjects.
    Ceda et al.
    Horm Metab Res, Mar 1992; 24(3): 119-21.

    40. Phospholipids as dynamic participants in biological processes.
    Hanahan et al.
    J lipid Res 1984, 25:1528-1535

    41. Biosynthesis of phospholipids
    Kennedy at al.
    Fed, Proc 16: 847-853 (1957)

    42. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia.
    R Di Perri, G Coppola, LA Ambrosio, A Grasso, FM Puca, and M Rizzo
    J Int Med Res, July 1, 1991; 19(4): 330-41.

    43. Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat.
    F Drago, F Mauceri, L Nardo, C Valerio, N Lauria, L Rampello, and G Guidi
    Pharmacol Biochem Behav, February 1, 1992; 41(2): 445-8.

    44. L--Glycerophosphocholine Contributes to Meat's Enhancement of Nonheme Iron Absorption
    Charlotte N. Armah, Paul Sharp, Fred A. Mellon, Sandra Pariagh, Elizabeth K. Lund, Jack R. Dainty, Birgit Teucher, and Susan J. Fairweather-Tait
    J. Nutr., May 2008; 138: 873 - 877.

    45. Overtraining and elite athletes: Review and directions for the future.
    Kuipers et al.
    Sports Med. 1988, 6:79-92

    46. Resistance exercise overtraining and overreaching neuroendocrine responses .
    Kraemer et al.
    Spots Med. 1997, 23(2):106-129

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    impressive write-up! very professional looking sourcing the studies.
    i'm not too familiar with alpha-glycerylphosphorylcholine but it looks like a great addition.
    i'll have to check out some of thosee studies run on it.
    i loved the old endo amp so i'm sure i'll like max!
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    is endo amp max going to replace endo amp? or are you planning on selling both?
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    Quote Originally Posted by Hank Vangut View Post
    is endo amp max going to replace endo amp? or are you planning on selling both?
    Replacement. Old EA is gone from their site , we should get it at NP with our next shipment. Good timing too; I'm just running low on the EndoAmp
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    Quote Originally Posted by Hank Vangut View Post
    is endo amp max going to replace endo amp? or are you planning on selling both?
    This will replace the our original EndoAmp. Get you some, hank!

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    Quote Originally Posted by Trauma1 View Post
    This will replace the our original EndoAmp. Get you some, hank!
    don't worry, i'll probably pick this up once it's out. i'm a for PS.
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    Quote Originally Posted by Hank Vangut View Post
    don't worry, i'll probably pick this up once it's out. i'm a for PS.
    Lol!


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    Quote Originally Posted by Steveoph View Post
    Replacement. Old EA is gone from their site , we should get it at NP with our next shipment. Good timing too; I'm just running low on the EndoAmp
    So Steveo when we order the Testosterone Recovery stack from NP doe sit now come with the Endoamp Max?
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    Quote Originally Posted by Mr.50 View Post
    So Steveo when we order the Testosterone Recovery stack from NP doe sit now come with the Endoamp Max?
    test recovery stack currently is shipped with endo amp until NP's stock is cleared.
    not sure what will change yet once EAM is stocked. i guess we'll wait to hear from PP on if the price will increase.
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    Quote Originally Posted by Hank Vangut View Post
    test recovery stack currently is shipped with endo amp until NP's stock is cleared.
    not sure what will change yet once EAM is stocked. i guess we'll wait to hear from PP on if the price will increase.
    The price of our EndoAmp Max as of current is $52.95. A minor increase in price, but an absolute steal for what you're getting here in terms of product. Use the coupon code: SPONSOR10 to get 10% off that.

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    Awesome. I know it is usually run pct, but it has done great for me during my currrent cycle. Looking forward to the new version.
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    EndoAmp Max is perfection! Great job!

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    Interesting i was looking at some endoamp before...so now i will look at this even more...
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    Quote Originally Posted by strategicmove View Post
    EndoAmp Max is perfection! Great job!

    I'd still love them to try and improve on perfection down the road
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    Quote Originally Posted by Steveoph View Post
    I'd still love them to try and improve on perfection down the road
    As long as you do not mean incremental improvements. The power of EndoAmp Max is entirely in its simplicity. Sometimes I have the impression that certain advanced compounds involved in choline/phosphatidylcholine synthesis such as Alpha-GPC and CDP-Choline (cytidine 5’-diphosphocholine) do not get the attention they deserve in supplements geared toward cognitive enhancement, dopamine signalling, acetylcholine receptor stimulation, and cholinergic regulation of growth-hormone synthesis. This was the basis for my excitement when I saw the combination of a phosphotidylserine complex with Alpha-GPC in one single matrix.
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    John,

    Can you break down the improvements/comparisons between this and the old product?

    Thanks,

    Monk
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    if taken post workout, wont the gh secretion that alph-gpc induces be blunted by the insulin release from the pwo carbs most people consume? if so are you guys recommending a change in the pwo concontion, dosing before consuming pwo concontion (like intra-workout) or dosing after pwo carbs?
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    Quote Originally Posted by Urban Monk View Post
    John,

    Can you break down the improvements/comparisons between this and the old product?

    Thanks,

    Monk
    The new adds in 600mg of A-GPC and is dicussed in the "How does EndoAmp Max support Growth Hormone (GH) production?" section.
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    How does EndoAmp Max support Growth Hormone (GH) production?

    The active ingredient alpha-glycerylphosphorylcholine (A-GPC) increases the synthesis and release of an important neurotransmitter known as acetylcholine which enhances GH production following exercise. (38-43) Each serving of EndoAmp Max provides a scientifically proven dose of A-GPC.

    A recent study examined GH release in resistance trained men after supplementation with a single 600mg dose of A-GPC. When supplemented with A-GPC, GH levels peaked 68% higher than placebo following exercise. The peak bench press force was also 14% greater with A-GPC than placebo. (38)

    Similar results have been found in another human study with young and elderly subjects. In the young subjects (30-34 yrs), A-GPC lead to a 40% higher increase in GH over the non-A-GPC group. In the elderly subjects (80-82 yrs.), A-GPC caused a 140% higher increase in GH over the non-A-GPC group. (39)

    The research suggests that A-GPC amplifies the release of GH following growth-hormone-releasing-hormone (GHRH) stimulation. It was proposed that A-GPC supplementation increases acetylcholine levels in the brain, thus enhancing pituitary sensitivity and amplifying the release of GH from GHRH stimulation. (39)

    Another mechanism by which A-GPC may increase GH secretion is by improving the fluidity of pituitary membranes, thus increasing signal transduction at the pituitary level. (39-41)

    In laymen’s terms, EndoAmp Max increases the amount of GH secreted from exercise.
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    Primordial Performance seems to just keep producing nothing, but top of the line quality stuff. When I can afford to buy some stuff...I'll definitely be running some of Primordial's products.

    BTW...great post T1.

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    Would this be necessary e/d or can I just use it post w/o?
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    Quote Originally Posted by AZMIDLYF View Post
    Would this be necessary e/d or can I just use it post w/o?
    You can use it everyday. Alpha-GPC is very potent and effective, so try not to overload on other cholinergic agents.

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    I need to pick up some of this!

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    Quote Originally Posted by AZMIDLYF View Post
    Would this be necessary e/d or can I just use it post w/o?
    This is designed to be taken everyday for best overall effects.

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    I added a few things to the write-up, everyone.

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    Quote Originally Posted by rxp1997 View Post
    if taken post workout, wont the gh secretion that alph-gpc induces be blunted by the insulin release from the pwo carbs most people consume? if so are you guys recommending a change in the pwo concontion, dosing before consuming pwo concontion (like intra-workout) or dosing after pwo carbs?
    bump on my question...
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    Will add it to my I want to try it list!
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    so how does this compare to the older version
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    Quote Originally Posted by learn View Post
    so how does this compare to the older version
    Upgrade More GH boosting.
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    Quote Originally Posted by Steveoph View Post
    Upgrade More GH boosting.
    i like
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    Quote Originally Posted by rxp1997 View Post
    bump on my question...

    It's actually related more to actual serum blood sugar levels than insulin. Here is a good read overall:


    Growth Hormone and Blood Sugar

    The most important point in regards to growth hormone (GH) and diet is that "Growth hormone levels increase significantly when insulin levels are low" (Jamieson, p. 85). "More precisely, the cause of growth hormone inhibition is not high insulin levels but rather high blood sugar (which, because insulin is secreted to bring down blood sugar level, overlaps in time with high insulin levels)" (Faigin, p.201).

    To explain further, "… glucose inhibits the secretion of growth hormone by acting on specific areas of the hypothalamus. Consequently, during the day, when food is consumed periodically, growth hormone secretion by the pituitary is suppressed, and insulin release by the pancreas is increased" (Dean).

    But it should be noted that it is not just any food that causes a rise in blood sugar and the consequent insulin release, but primary carbohydrates. And some kinds of carbs cause a greater blood sugar increase than others. This issue is discussed in the article *The Glycemic Index.

    I won't repeat all the details of that article here, but the important point is that low glycemic foods will not increase blood sugar as much as high glycemic foods. And eating a large amount of carbs at once will cause a greater increase in blood sugar levels than eating a small amount of carbs. Also, eating fat with carbs will blunt the rise in blood sugar.

    What this means is, consuming a large amount of high glycemic carbs by themselves could completely halt growth hormone release. Or more generally, a high carbohydrate, low fat diet is absolutely devastating to growth hormone levels. This is one of the reasons why many people trying to lose weight on such a diet "plateau" after a period of time. Their inability to continue to lose weight is partly due to suppressed GH levels.

    Moreover, a study comparing a group of boys consuming meals composed of high-glycemic index (GI) foods verses low GI foods found, "There were higher levels of the hormones insulin, noradrenaline, and cortisol after the high-GI meals" (Brand-Miller, p.230). So a rapid rise in blood sugar and insulin can lead to a rise in cortisol, with its attendant catabolic and lipogenic properties.

    However, "… we need insulin to promote the benefits of growth hormone. Studies show that GH fails to cause growth in animals lacking a pancreas and it also fails if carbohydrates are restricted from the diet" (Jamieson, p.56). The reason for his could be that a strict low carb diet would lead to chronically low insulin levels, and insulin, as indicated above, is needed to drive amino acids into the muscle cells.

    Moreover, IGF-1 is produced in the body through the combined actions of GH and insulin. And IGF-1 "… is at least as powerful an anabolic agent as either of its parents" (Faigin, p. 90). But a low carb diet would lead to a reduction in IGF-1 levels. So a low carb diet is not the answer either. In fact, this relationship of insulin, growth hormone, and IGF-1 is one reason why those following a low carb diet also often plateau after a period of time.

    There is a relationship with thyroid hormone here as well. "Raising GH has a profound effect on normalizing thyroid function … " (Jamieson, p.100). However, "Studies also show that diets that continuously restrict carbohydrate (like the Atkin's diet, for instance) cause a reduction in T3, and that administering carbohydrate can restore T3 levels after they have declined" (Faigin, p.139). This reduction in T3 is another reason people will often plateau on low carb diets.

    So an ideal GH enhancing diet would include some carbs, but not an excessive amount. And the focus would be on low glycemic carbs.


    You could in theory take it either pre or post workout....i would actually suggest in the AM myself. As long as you're allowing for an ample amount of low GI index carbs (to maintain a stable serum glucose level) to help drive this formula into the cells (yet limiting excessive or erratic spikes in insulin release from pancreatic islet cells; suppressing GH effects), you should be made in the shade here.

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    hey t1, i had great results with lean extreme but i had to stop taking because of what it was doing to my joints, very painful effect. will endo amp also have this effect?
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    Quote Originally Posted by thebigt View Post
    hey t1, i had great results with lean extreme but i had to stop taking because of what it was doing to my joints, very painful effect. will endo amp also have this effect?
    the old endo amp did not have that effect on me so I would not think the new 1 would
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    PS and A-GPC is a great combo! I actually have combined these in the past and LOVED it. Now it is one easy powder= awesome.
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    Quote Originally Posted by thebigt View Post
    hey t1, i had great results with lean extreme but i had to stop taking because of what it was doing to my joints, very painful effect. will endo amp also have this effect?
    Not at all, bigt. This product is formulated to modulate/prevent spikes in cortisol throughout the day; it won't destroy your cortisol secretion, but will act to keep it under control at a more therapeutic basal level. Destroying cortisol is not a desired effect we want in general.

    The addition of the A-GPC will also act to increase GH secretion. This should be one hell of an addition to a supplement regimen!

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    Quote Originally Posted by Trauma1 View Post
    Not at all, bigt. This product is formulated to modulate/prevent spikes in cortisol throughout the day; it won't destroy your cortisol secretion, but will act to keep it under control at a more therapeutic basal level. Destroying cortisol is not a desired effect we want in general.

    The addition of the A-GPC will also act to increase GH secretion. This should be one hell of an addition to a supplement regimen!
    think this will go well with somnidren/zmk. i am looking for better health more than a get big or ripped program. at 50 i think increasing gh will help a lot.
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    A-GPC? I am 50 as well...
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    Quote Originally Posted by thebigt View Post
    think this will go well with somnidren/zmk. i am looking for better health more than a get big or ripped program. at 50 i think increasing gh will help a lot.
    I think that would be a great stack.

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    Quote Originally Posted by AZMIDLYF View Post
    A-GPC? I am 50 as well...
    The write-up on page one has a whole paragraph on A-GPC and its effects.

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    Thanks Trauma!!
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