Applied Nutriceuticals on the AIR!
- 10-23-2008, 04:29 PM
Applied Nutriceuticals on the AIR!
Whats up fellow Anabolic Minds members! Applied Nutriceuticals is going to be doing a few sequence interviews on certain products. Alot of good information is going to be given in this thread.
this thread is going to contain the following:
-Articles detailing about certain ingredients in AN products
-Radio broadcast Interviews on AN products
-General Discussions of Any an products
-Questions concerning AN things
- 10-23-2008, 04:32 PM
Interview #1 Osteobolin-C with Dirk Tanis
OSTEOBOLIN-C is a powerful new product that approaches an old but increasingly common problem from a completely new angle. Experienced athletes, weightlifters, bodybuilders, and runners all at one time or another will need to support the health of their joints. Active lifestyles are being prolonged with advancements in our knowledge of fitness and nutrition, and whether it's pounding iron in the gym or pounding pavement around the neighborhood, our muscles, tendons and cartilage all take a beating. The result? Your lean, fit, muscular body has joints that have paid the price! OSTEOBOLIN-C aids in the support of joint, muscle, bone, and connective tissue in a completely different way from traditional joint health supplements. It employs the unique properties of cissus quadrangularis; a unique, versatile herb that has been used in Ayurvedic medicine for thousands of years.
Today, glucosamine sulfate is the most commonly used supplement by those who want to support joint health. It is credited with its ability to help support cartilage in joints by stimulating synovial fluid, which keeps tendons and joints gliding smoothly. However, it often takes as long as two months to produce any noticeable effect and it is extremely expensive; plus only about half of those who take it report any positive effects at all! Fortunately, OSTEOBOLIN-C works though completely different and more reliable mechanisms that are not dependent on an individual's ability to absorb and utilize glucosamine.
Last edited by TexasLifter89; 10-24-2008 at 09:04 PM.
- 10-23-2008, 06:43 PM
Good stuff, Austin. This shall be a VERY INTERESTING thread to follow!
10-23-2008, 06:54 PM
The Osteobolin-C interview went well IMO. A good review on the benefits of Cissus for the initiated, a great primer for those who are not very familiar with it.
10-24-2008, 10:35 AM
10-25-2008, 08:28 PM
Mucuna Pruriens information
Mucuna Pruriens are featured in Applied Nutriceuticals Lipo-AM, Lipo-PM, and Igf-2
Information on Mucuna Pruriens
Anti-Parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage.
Levodopa is considered the 'gold standard' for the treatment of Parkinson's disease. However, a serious concern is dyskinesia and motor fluctuation that occurs after several years of use. In vitro experiments have shown that in the presence of divalent copper ions, levodopa may induce intense DNA damage. Mucuna pruriens cotyledon powder (MPCP) has shown anti-parkinson and neuroprotective effects in animal models of Parkinson's disease that is superior to synthetic levodopa. In the present study two different doses of MPCP protected both plasmid DNA and genomic DNA against levodopa and divalent copper-induced DNA strand scission and damage. It exhibited chelation of divalent copper ions in a dose-dependent manner. The copper chelating property may be one of the mechanisms by which MPCP exerts its protective effects on DNA. Copyright (c) 2007 John Wiley & Sons, Ltd.
MUCUNA PRURIENS (Velvet Bean)
Botanical name: Mucuna Pruriens
Common name: Cowitch, Cowhage, Velvet Bean, Cow-itch, Buffalo bean
Latin name: Mucuna Pruriens
Part used: Seeds, Root, Legumes
Mucuna Pruriens, also known as Cowhage, and velvet bean contains a very powerful neurotransmitter pre-cursor L-Dopa. Mucuna pruriens is a reputed remedy of Ayurveda in nervous and sexual diseases. Traditionally, Mucuna pruriens is commonly used as carminative, hypertensive and hypoglycemic agent. Mucuna pruriens has been found to contain L-DOPA, 40 mg/g of the plant. The plant/seeds contain the bioactive alkaloids mucunine, mucunadine, mucuadinine, pruriendine and nicotine, besides B-sitosterol, glutathione, lecithin, oils, venolic and gallic acids. Studies in experimental model show L-Dopa also helps in the reduction of cholesterol and blood sugar levels.
L-Dopa is an amino acid that converts into dopamine. Dopamine is an essential component of our body and it's required for proper functioning of the brain. Research discovered the body converts the amino acid tyrosine into L-dopa; L-dopa is then converted into dopamine. Without the neurotransmitter dopamine to serve a damping effect on neural transmissions, muscles become tense and tremble.
Benefits of Mucuna Pruriens L-Dopa:
Improved sleep (promotes deep sleep)
Reduced bodyfat & decreased cellulite
Improved skin texture & appearance
Increased bone density and reversal of osteoporosis
Increased lean muscle mass
Improved mood and sense of well-being
Enhanced libido & sexual performance
Increased energy levels
Improved cholestorol profile & regeneration of organs (heart, kidney, liver, lungs)
Dramatically strengthed immune system
Mucuna: Human Growth Hormone
L- Dopa contains natural secretagogues which may support the body's ability to stimulate the natural release of growth hormone. The blood carries the dopamine into the brain, where it naturally increases HGH production from the pituitary gland. The increased dopamine levels also optimize the production of other hormones, including testosterone, leading to increased sex drive and improved sexual performance for both men and women, beneficial in stimulating muscle growth, as well as burning fat from fat cells.
Mucuna and Parkinson
The seed powder of Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinson. L-Dopa significantly affects dopamine metabolism in the striatonigral tract. This ability helps improve Parkinsonian symptoms in humans. The seeds of Mucuna pruriens accumulate 0.2% - 2% L-dopa in their dry weight. Parkinson's disease study group evaluated activity of Mucuna pruriens extract v/s Levodopa/ caebidopa in sixty patients and during their 12 weeks treatment , they proved that the extract was effective with less adverse effects.
In a a randomised, controlled, double blind crossover trial published on Journal of Neurology, Neurosurgery, Psychiatry, the clinical effects of levodopa L-dopa/carbidopa (LD/CD) are compared with two different doses of mucuna preparation. Eight Parkinson's disease patients were given with single doses of 200/50 mg LD/CD, or 15 and 30 g of mucuna preparation in randomised order. Compared with standard LD/CD, the 30 g mucuna preparation led to a considerably faster onset of effect (34.6 v 68.5 min; p = 0.021), Mean on time was 21.9% (37 min) longer, peak L-dopa plasma concentrations were 110% higher and the area under the plasma concentration v time curve (area under curve) was 165.3% larger (p = 0.012). The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of PD.
Mucuna Pruriens Aphrodisiac Effects
Mucuna pruriens can improve sexual behavior, libido, and performance. In an aphrodisiac study done at College of Pharmaceutical Sciences, Manipal, Mucuna Pruriens when administered in a dose of 75 mg/kg body weight daily, increased the sexual activity of male albino rats considerably by stimulating testosterone level. A ten fold increase in the mounting frequency was observed. The research shows that sexually active animals had increased sexual desire and improved sexual performance after 21 to 28 days. However, impotent animals did not derived any benefits.
Another research shows that Mucuna Pruriens heightened arousal and increased sexual activity to a moderate extent but also sustains it for a longer time as indicated by the increase in below Ejaculation Latency and decrease in Post Ejaculatory Interval. Mucuna Prueins is shown to possess central depressant activity. The delay in ejaculation could be due to toning down of hypersensitity of genitals and hyperexcitation of the regulatory centers. This study show that Mucuna Pruriens can be used to improve libido and delay premature ejaculation.
Mucuna pruriens on free radicals and oxidative stress
In a research published on Phytotherapy Research. 2002, in vitro studies with alcohol extract of Mucuna pruriens showed no change on the rate of aerial oxidation of GSH content but it significantly inhibited FeSO(4) induced lipid peroxidation. It also inhibited the specific chemical reactions induced by superoxides and hydroxyl radicals. An in vivo study on albino rats for 30 days showed no toxic effect up to a dose of 600 mg/kg body weight, on oral administration. There was no change in the level of TBA-reactive substances, reduced glutathione content and SOD activity in the liver. The activity of serum GOT, GPT and alkaline phosphatase was also unchanged. Thus it could be concluded that the alcohol extract of the seeds of M. pruriens has an anti-lipid peroxidation property, which is mediated through the removal of superoxides and hydroxyl radicals.
Antidiabetic evaluation of Mucuna pruriens
In normal rabbits, Mucuna Pruriens (0.5, 1 and 2 g/kg) significantly decreased the blood glucose levels while in -diabetic rabbits only 1 and 2 g/kg body weight caused a significant fall. High levels of trace elements like manganese, zinc, and others were found in these seeds. Therefore, it is conceivable that Mucuna pruriens seeds contain hypoglycaemic principles, may be both organic and mineral, which seem to act indirectly by stimulating the release of insulin and/or by a direct insulin-like action.
10-25-2008, 11:16 PM
10-26-2008, 12:49 PM
10-27-2008, 04:25 PM
11-20-2008, 10:26 AM
11-20-2008, 10:43 AM
I simply chose this because of the controversial thoughts of it. I figured I could put out the both good and bad effects of it.To begin, Naringin comes from Grapefruit. It is a flavanoid that gives grapfruit its unique bitter taste. Naringin Contains Positive the following benefits: antioxidant, blood lipid lowering, anticancer activity. Naringin also increases absorption and bio-availability of certain drugs in the intestine. However, it can also inhibit the effects of certain drugs.
Research on Naringin shows the following effects:
1. Protects against toxins in chemotherapy drugs and the environment
2. Enhances lipid metabolism
3. Enhances ethanol metabolism
4. Reduces negative effects of ethanol intake
5. Acts as a free radical scavenger
6. Reduces cytotoxicity
7. Acts as an antioxidant
8. Acts as an anti-apoptotic
9. Protect from carcinogenic matter
10. May reduce risk of atherosclerosis
11. Significantly inhibits LDL oxidation
12. Used in the treatment of gastric lesions
13. Inhibits the Sindbis neurovirulent virus
14. Reduces total cholesterol levels
15. Protects plasma vitamin E levels
16. Prevents hypercholesterolemia
17. Is anti-atherogenic
Pubmed Article 1: Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids.
Dietary flavonoids have been shown to be protective against various types of cancers. Here we studied the effects of 12 different flavonoids and other substances on cell proliferation and VEGF expression in human ovarian cancer cells, OVCAR-3. Cell growth was determined to pinpoint the best time for drug treatment. By LDH assay, no cytotoxicity was observed for OVCAR-3 cells with all 12 chemicals except mevinolin. Six flavonoids, including apigenin, taxifolin, luteolin, quercetin, genistein, and kaempferol, were shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. From both RT-qPCR and ELISA results, all flavonoids have shown varied degrees of inhibition in VEGF expression. Taxifolin and naringin showed the least inhibition effect. They both lack a double bond in the second ring structure that may be important in inhibiting VEGF expression. The rank order of VEGF protein secretion inhibitory potency was genistein > kaempferol > apigenin > quercetin > tocopherol > luteolin > cisplatin > rutin > naringin > taxifolin. Genistein, quercetin, and luteolin have shown strong inhibition to cell proliferation and VEGF expression of human ovarian cancer cells, and they show promising in the prevention of ovarian cancers.
Pubmed Article 2: Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
Significantly, much of the activity of Citrus flavonoids appears to impact blood and microvascular endothelial cells, and it is not surprising that the two main areas of research on the biological actions of Citrus flavonoids have been inflammation and cancer. Epidemiological and animal studies point to a possible protective effect of flavonoids against cardiovascular diseases and some types of cancer. Although flavonoids have been studied for about 50 years, the cellular mechanisms involved in their biological action are still not completely known. Many of the pharmacological properties of Citrus flavonoids can be linked to the abilities of these compounds to inhibit enzymes involved in cell activation. Attempts to control cancer involve a variety of means, including the use of suppressing, blocking, and transforming agents. Suppressing agents prevent the formation of new cancers from procarcinogens, and blocking agents prevent carcinogenic compounds from reaching critical initiation sites, while transformation agents act to facilitate the metabolism of carcinogenic components into less toxic materials or prevent their biological actions. Flavonoids can act as all three types of agent. Many epidemiological studies have shown that regular flavonoid intake is associated with a reduced risk of cardiovascular diseases. In coronary heart disease, the protective effects of flavonoids include mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant. It is suggested that flavonoids decrease the risk of coronary heart disease by three major actions: improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidizing. The anti-inflammatory properties of the Citrus flavonoids have also been studied. Several key studies have shown that the anti-inflammatory properties of Citrus flavonoids are due to its inhibition of the synthesis and biological activities of different pro-inflammatory mediators, mainly the arachidonic acid derivatives, prostaglandins E 2, F 2, and thromboxane A 2. The anti-oxidant and anti-inflammatory properties of Citrus flavonoids can play a key role in their activity against several degenerative diseases and particularly brain diseases. The most abundant Citrus flavonoids are flavanones, such as hesperidin, naringin, or neohesperidin. However, generally, the flavones, such as diosmin, apigenin, or luteolin, exhibit higher biological activity, even though they occur in much lower concentrations. Diosmin and rutin have a demonstrated activity as a venotonic agent and are present in several pharmaceutical products. Apigenin and their glucosides have been shown a good anti-inflammatory activity without the side effects of other anti-inflammatory products. In this paper, we discuss the relation between each structural factor of Citrus flavonoids and the anticancer, anti-inflammatory, and cardiovascular protection activity of Citrus flavonoids and their role in degenerative diseases.
Pub med Article 3:Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model.
Isoflavonoids isolated from plants have been confirmed to fight osteoporosis and promote bone health. However, few studies have been conducted to describe the anti-osteoporosis activity of botanical flavonone. Based on the experimental outcomes, we demonstrated the ability of naringin to fight osteoporosis in vitro. We developed a retinoic acid-induced osteoporosis model of rats to assess whether naringin has similar bioactivity against osteoporosis in vitro. After a 14-day supplement of retinoic acid to induce osteoporosis, SD rats were administered naringin. A blood test showed that naringin-treated rats experienced significantly lower activity of serum alkaline phosphatase and had higher femur bone mineral density, compared to untreated rats. All three dosages of naringin improved the decrease in bone weight coefficient, the length and the diameter of the bone, the content of bone ash, calcium, and phosphorus content induced by retinoic acid. The data of histomorphological metrology of naringin groups showed no difference as compared to normal control rats. These outcomes suggest that naringin offer a potential in the management of osteoporosis in vitro.
Any articles on Naringin you may have whether good or bad. Feel Free to post.
11-24-2008, 07:07 PM
Good to see you doing some research, Austin
So, what's next on your list?
11-24-2008, 07:19 PM
hmmm...I have no clue. give me something rosie . Yeah i learn from it as well as members so its all good
11-24-2008, 10:18 PM
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