Who would be interested in a bulk N-carbamylglutamate (NCG)?

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    Who would be interested in a bulk N-carbamylglutamate (NCG)?


    As you all are aware BSN created a ton of interest in N-carbamylglutamate (NCG) by advertising NCG-CR. There was also a nice article in MD about this compound touting it as "the next big anabolic supplement".

    APS was thinking of making a bulk NCG product containing 250mg/cap at 60 caps per bottle for an unbelievable price. This would give everyone a chance to try this compound without diggng deep into their pockets. Who would be interested. This compound holds on a ton of potential.

    Here is some information.

    NCG: The Ultimate Anabolic Supplement?
    Written by Anssi Manninen, MHS
    Friday, 09 March 2007
    A recent study at Baylor College of Medicine examined the effects of oral N-carbamylglutamate (NCG) supplementation on growth rate in piglets. NCG is an activator of arginine synthesis. Interestingly, the investigators reported that piglets supplementing with NCG gained 28 percent more weight than control pigs over the seven-day period. Protein anabolism rates in longissimus dorsi and gastrocnemius muscles were 30 percent and 21 percent greater, respectively, in NCG-supplemented piglets compared with control pigs.

    Futhermore, piglets treated with NCG had greater blood concentrations of arginine and growth hormone (GH) than control pigs. Thus, the authors concluded that oral NCG supplementation increases blood arginine and GH levels, leading to an increase in growth rate and muscle protein synthesis. While the results of this study are intriguing, it's currently unknown whether NCG supplementation has similar effects in humans.

    The author of this article has no financial relationship with companies producing N-carbamylglutamate.

    Reference: Frank JW, et al. Oral N-carbamylglutamate supplementation increases protein synthesis in skeletal muscle of piglets. J Nut,. 2007 Feb;137(2):315-9.

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    That would def. be interested in some bulk
    N-carbamylglutamate. Its something i've been meaning to do some research on.

    Thumbs up from me!
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    Thanks for the reply. We think it is a very cool item when you can get a month supply fr about $20.00.
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    Quote Originally Posted by apsnutrition View Post
    Thanks for the reply. We think it is a very cool item when you can get a month supply fr about $20.00.
    Sounds like a price that can't be beat!
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    Quote Originally Posted by apsnutrition View Post
    As you all are aware BSN created a ton of interest in N-carbamylglutamate (NCG) by advertising NCG-CR. There was also a nice article in MD about this compound touting it as "the next big anabolic supplement".

    APS was thinking of making a bulk NCG product containing 250mg/cap at 60 caps per bottle for an unbelievable price. This would give everyone a chance to try this compound without diggng deep into their pockets. Who would be interested. This compound holds on a ton of potential.

    Here is some information.

    NCG: The Ultimate Anabolic Supplement?
    Written by Anssi Manninen, MHS
    Friday, 09 March 2007
    A recent study at Baylor College of Medicine examined the effects of oral N-carbamylglutamate (NCG) supplementation on growth rate in piglets. NCG is an activator of arginine synthesis. Interestingly, the investigators reported that piglets supplementing with NCG gained 28 percent more weight than control pigs over the seven-day period. Protein anabolism rates in longissimus dorsi and gastrocnemius muscles were 30 percent and 21 percent greater, respectively, in NCG-supplemented piglets compared with control pigs.

    Futhermore, piglets treated with NCG had greater blood concentrations of arginine and growth hormone (GH) than control pigs. Thus, the authors concluded that oral NCG supplementation increases blood arginine and GH levels, leading to an increase in growth rate and muscle protein synthesis. While the results of this study are intriguing, it's currently unknown whether NCG supplementation has similar effects in humans.

    The author of this article has no financial relationship with companies producing N-carbamylglutamate.

    Reference: Frank JW, et al. Oral N-carbamylglutamate supplementation increases protein synthesis in skeletal muscle of piglets. J Nut,. 2007 Feb;137(2):315-9.
    Awesome!
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    I don't think there are going to be any objections to releasing this in bulk! It sounds great! Now make it happen
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    would def go and get some
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    Yes please. Seems very interesting.
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    Very Interesting!!
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    If we can get just a little more interest we may defintely move forward.
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    Its only been 2 days since thread started.......Im sure alot more people will say "Yes" when they see this thread.

    I mean anything that, increases blood arginine and GH levels, leading to an increase in growth rate and muscle protein synthesis, Is a must try in my opinion!!!!!!!!!!! And everyone elses too!!
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    I am VERY much interested in hearing about this one ! .. at the same time, positively surprised that i've already encountered this ingredient before; Cellucor's N-Zero. .. I've actually spoked with reps of Cellucor before, and they told me that it's one of the reasons for why their formula is so unique in their N-Zero.

    Anyway, I'm looking forward to hearing more about this one .. so 'YES!'
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    Interested.
    Where do I sign? :P
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    sounds great, and at a great price
    ADVANCED MUSCLE SCIENCE STRONGEST ON THE MARKET
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    just curious what BSN product is it in?
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    Welcome APs.=) I'm skeptical as usual. I stick with the basics in till it's really proven
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    i want it NOOOOWWWWW!!!!!!
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    Bring it on. I've been interested in this one. I guess BSN didn't follow through with it?
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    Quote Originally Posted by smeton_yea View Post
    Welcome APs.=) I'm skeptical as usual. I stick with the basics in till it's really proven
    Rightfully so...but we are not named "Advanced" Performance Supplements without a reason. Just kidding. It really is a promising ingredient that we have been testing on people in the local area and it has proven itself effective.
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    Quote Originally Posted by BifWebster View Post
    just curious what BSN product is it in?
    It was going to be in thier NCG-CR. Its also in CMI's Anabolic Signal. Great compound and we can offer it at the best price.
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    Quote Originally Posted by apsnutrition View Post
    It was going to be in thier NCG-CR. Its also in CMI's Anabolic Signal. Great compound and we can offer it at the best price.
    Make it happen!
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    Sounds really interesting
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    im so down!
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    YES!!! definetely. i infact just went searching for cellucor's. couldnt find it
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    Do It, Do It, Do It!!!!!!!! Me Want Now!!!!!!!
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    I'd buy.
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    Well it's unanimous! Let's get shredded!! :bb3:
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    We are also looking at releasing a pure methyl-synephrine product (please do not compare to regular synephrine...M-synephrine is VERY thermogenic), a PEA blend using r-beta
    methylphenylethylamine
    and our new N-Methyl-Beta-Methylphenylethylamine . These are the most highly evolved forms of PEA in one little capsule

    What are your guys thoughts?

    Of course these would be at a unbeleivable price. APS is striving to be your one-stop shop for all your ADVANCED supplement needs.
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    yer sound good, im in
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    I'm in again. How soon would these products be available?
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    lets roll
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    We can have this done in a matter of days. I will speak with the owner of APS today.
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    Nice. Any ideas about pricing
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    just curious, correct me if i am wrong but, in the studies i have seen the pigs were given 50mg per kg of body weight, so how many of your 250 mg pills would you suggest we would have to take for a 220 lb man to equal the results of the studies? 20? every 12 hours? am i figuring this wrong?


    quote from study

    Technical Abstract: Oral supplementation of NCG, an analogue of N-acetylglutamate, increases plasma arginine concentrations and growth rate in sow-reared piglets. To investigate the mechanism involved in this growth response, nursing piglets (n = 18; BW = 3.19 kg) were orally administered 0 or 50 mg/kg BW of NCG twice daily from 9 to 16 d of age. On d 17, piglets were intragastrically fed sow's milk at a rate of 7.5 ml/kg, with the respective NCG treatment at time 0 and 60 min, then given an i.v. flooding dose of [(3)H]phenylalanine to measure protein synthesis. At 90 min, the piglets were euthanized and tissue samples were collected. NCG-treated pigs gained 25% more weight during the 8-d trial than control pigs (1.93 +/- 0.07 vs. 1.55 +/- 0.10 kg, respectively; P<0.01). Tissue mass and protein synthesis rate of longissimus dorsi were 16% and 20% greater respectively, in NCG-treated pigs compared to control pigs; however, these increases did not reach statistical significance. NCG-treated pigs had 29% higher plasma insulin concentrations at 90 min compared to control pigs, but this difference was not statistically significant. Plasma arginine concentrations were 32% higher in NCG-treated pigs compared to control pigs at 90 min (P<0.05). Although the exact mechanism has not been delineated, it appears that oral NCG administration increases plasma arginine levels leading to an increase in growth rate of nursing piglets.
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    Quote Originally Posted by mrbeverage View Post
    just curious, correct me if i am wrong but, in the studies i have seen the pigs were given 50mg per kg of body weight, so how many of your 250 mg pills would you suggest we would have to take for a 220 lb man to equal the results of the studies? 20? every 12 hours? am i figuring this wrong?


    quote from study

    Technical Abstract: Oral supplementation of NCG, an analogue of N-acetylglutamate, increases plasma arginine concentrations and growth rate in sow-reared piglets. To investigate the mechanism involved in this growth response, nursing piglets (n = 18; BW = 3.19 kg) were orally administered 0 or 50 mg/kg BW of NCG twice daily from 9 to 16 d of age. On d 17, piglets were intragastrically fed sow's milk at a rate of 7.5 ml/kg, with the respective NCG treatment at time 0 and 60 min, then given an i.v. flooding dose of [(3)H]phenylalanine to measure protein synthesis. At 90 min, the piglets were euthanized and tissue samples were collected. NCG-treated pigs gained 25% more weight during the 8-d trial than control pigs (1.93 +/- 0.07 vs. 1.55 +/- 0.10 kg, respectively; P<0.01). Tissue mass and protein synthesis rate of longissimus dorsi were 16% and 20% greater respectively, in NCG-treated pigs compared to control pigs; however, these increases did not reach statistical significance. NCG-treated pigs had 29% higher plasma insulin concentrations at 90 min compared to control pigs, but this difference was not statistically significant. Plasma arginine concentrations were 32% higher in NCG-treated pigs compared to control pigs at 90 min (P<0.05). Although the exact mechanism has not been delineated, it appears that oral NCG administration increases plasma arginine levels leading to an increase in growth rate of nursing piglets.
    We are not stating anything to be fact based on the study. We have been trying different dosages and find 1-1,500mg to effective with local trainees.

    We were just thinking of offering it at a very affordable price for those that have been interested in it for quite sometime.
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    still interested!
  

  
 

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