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IBE Epistane™
Finally the PRO-Anabolic, anti-estrogen we have all been waiting for has arrived! Epistane™, exhibits a strong, long lasting anti-estrogen effect that is organ tissue specific. This means it works only where you want it to work. Broad range estrogen blockers and aromatase inhibitors can result in system shut down, aching joints, and decreased IGF-I expression. Epistane™ binds specifically to the 17β-estradiol receptor protein in the target tissues. Because of its long lasting and strong effects on specific tissue, Epistane™ can significantly reduce and reverse the effects of gynocomastia because not only does Epistane™ specifically block estrogen in breast tissue but it induces an estrogen-depleted condition which leads to apoptosis or the death of the breast tissue cells. Studies show that small doses of the parent compound, Epitiostanol, at just 10-20mg/week showed a complete disappearance of the mass and pain in 25% of the male patients in the clinical trail, while the other 75% of the patients showed at least a 50% reduction in the mass and complete loss of pain in just 4-8 weeks. That’s results in 100% of the male users with no side effects. While compounds such as Clomid and Nolvadex also block the 17β-estradiol receptor, they do not elicit the same increase in protein synthesis and strength gains that Epistane can offer.
Epistane™ is more than an anti-estrogen, though, as it also binds to androgen receptors in skeletal muscle. As a PRO-Anabolic compound Epistane™ promotes increases in strength and lean body mass with an anabolic/androgenic value (Q ratio) of 12. With most powerful androgens there is a high risk of the natural suppression of the gonads. Epistane™, unlike other PRO-Anabolic compounds that have recently been released, is relatively mild on the gonads and, due to the anti-estrogenic effects and the fact that Epistane™ keeps LH levels elevated, post cycle therapy becomes a breeze. All effects combined make Epistane™ a great compound to produce dry, lean gains in muscle mass with minimal side effects and suppression of the body’s natural androgen production, while lowering the effects of natural estrogen or combating estrogen from endogenous/exogenous sources. This makes it a powerful tool when combined with “wet” compounds in attempt to increase gains and decrease side effects. One can also not overlook the potential benefit of this compound taken alone, especially when recovering from periods of “wet” compounds. If you don’t want to worry about how your lipid and liver values are doing and whether or not you are going to get gynocomastia or not then get Epistane™, stop worrying, and experience what others are raving about!
FAQ
What can one expect from Epistane™?
• Incredible Strength Gains
• Dry, Lean Mass Gains
• Gynocomastia Protection
• Increased Libido
• Increased Training Intensity and Sense of Well-Being
• In Some, Reductions in Gynocomastia!
Sample Cycles
o Extreme Mass/Hardcore:
Weeks/Dosages/Product
1 40mg (start at 10mg first day and move up 10mg each day) Epistane™
2 40mg Epistane™
3 40mg Epistane™
4 40mg Epistane™
5 150mg X-Lean™ + Favorite PCT SERM
6 100mg X-Lean™ + Favorite PCT SERM
7 50mg X-Lean™ + Favorite PCT SERM
o Minimal Shutdown (take only 3X per week, preferably on lifting days and spread out throughout day up until 6pm, no dosing after):
Weeks/Dosages/Product
1 20-30mg (start at 10mg first day and move up 10mg each day) Epistane™
2 20-30mg Epistane™
3 20-30mg Epistane™
4 20-30mg Epistane™
5 150mg X-Lean™ + Favorite PCT SERM
6 100mg X-Lean™ + Favorite PCT SERM
7 50mg X-Lean™ + Favorite PCT SERM
What is pulse cycling? (Written by Dr.D)
What is "pulse" cycling? Pulsing is a method of dosing a product designed to intentionally avoid potential long term side effects such as HPTA suppression and liver damage. This technique is usually applied as a means of toxicity control when potent corticoids are used on children requiring long term therapy. However, this method can be applied to anyone using any oral steroid with great success and significantly reduced side effects. With pulsing, the serious long term side effects of chronic oral treatment are avoided and short term side effect like acne and mineral retention are much milder that usual. This allows for higher doses to be used since the dosing is less frequent. For example, if you would normally take a product at 30 mg/day, that equals a total intake of 210 mg/week. While pulsing, you might typically take 40 mg on work out days only, 3 times per week. That only comes out to 120 mg/week total! This provides the needed benefits of the product at the most crucial times, which are just before and just after a work out, and offers a means of avoiding the suppression of endogenous steroid production one would expect on a standard, daily dosing cycle. In other words, you can often pulse a compound for 6-8 weeks before you realistically need to start thinking about a conventional post cycle therapy. After a 4 week pulsing cycle, post cycle therapy should not even be required in most cases!
Basically, if you dose every day (ED) in perfectly spaced doses, you will achieve 100% effect, 100% short term side effects, and 100% long term side effects. If you dose every other day (EOD) like the pulse protocol, you still get about 60% effect and 75% short term sides, but only about 40% of the long term sides. That's not a bad trade off and very economical on the body and as well as the wallet! Of course, if you would have gained 10 pounds on a standard 1 month cycle, you will only gain about 6 pounds per month pulsing, but it also means you can do this for twice as long as a standard cycle. That equals about 2 months of worry free dosing, so the net effect is a gain of about 12 pounds over 2 months instead of 10 pounds over 1 month. This structure offers fewer sides and a milder post cycle therapy requirement (if even needed at all) plus the slower gains tend to have a better residual that is more likely to be permanent compared to faster gains. It's a great long term strategy for vets wanting to run 12 weeks, and good for new users too looking to run fast and clean 1 month cycles with no post cycle therapy needed later.
There are three common approaches to pulsing:
1) EOD dosing, so 3-4 times per week.
2) 2 days on / 2 days off
3) 2 weeks on / 2 weeks off (some guys do this and think it's great, I don't practice it but it looks exceptionally safe at least)
Depending on your workout schedule, I would use one of these options for optimal pulsing efficiency. Doses can usually be high (40-60 mg instead of 10-30 mg) but take them close together preferably before 6 pm. It's not crucial you take the last dose before 6 pm, but the earlier the better for avoiding shut down. Take half of the total dose pre work out and half post work out instead of spread out evenly over the whole day like a conventional cycle. If an odd dose is to be used, like 30 mg, take the majority pre work out (so 20 mg pre/10 mg post). However, when pulsing non methylated compounds or fast acting ethers, take the greater dose post work out instead of pre work out. When pulsing, dose at least 3 times per week but not more than 4 times to insure optimal results. 5 doses per week is pushing it and suppression will eventually ensue. If this is attempted, "holidays" of complete non use for up to a week per month may be required to discourage suppression. I do not recommend more than 4.5 doses per week and that is for advanced level only!
Also important to remember is nutrition. Have a good, high carb/calorie post work out meal or shake, and ingest sufficient protein especially on the off days. Off days are also a good time to take a cortisol antagonist or even just low dose DHEA (25-50 mg) if you're a slow healer or hard gainer especially. Cortisol peaks in the morning and again in the mid afternoon so dose at those 2 times minimum. Although pulsing is a great way to avoid suppression, if you're extra sensitive to shut down or using a very suppressive compound, an herbal testosterone booster can be used on the off nights or even included everyday. In fact, running test boosters as the core of your cycle and pulsing a methyl just to augment that is possibly one of the best methods you could employ if not using injectable testosterone. Also, avoid the use of SERMs with long half lives when pulsing. An aromatase inhibitor (AI) or test booster will further punctuate the positive, hormonal "bounce back" effect of pulsing. This bounce back phenomenon is an effect that is often noted when pulsing, so don't be alarmed if your testicular size increases dramatically on the off days. It is not uncommon for testicular volume and testosterone levels to increase above baseline, especially on consecutive off days during the pulse or after the cycle is over. This is like a built in post cycle therapy effect and if you're pulsing properly, you should experiences this to some degree. In pulsing, it is also important to remember that the smaller number of dose exposures means faster liver clearance. Normal safety ancillaries like healthy oils and lipid supplements are always advised on cycle and off, but be modest with liver protectants like Milk Thistle. They are generally counter productive and therefore not suggested when pulsing, except in conjunction with very potent or toxic compounds. If you elect to use liver protectants anyway, I would reserve them for off days only or take them no earlier than 6 hrs after your final dose of anabolics. Cycle safe!
Example of a 3x/wk pulse M,W,F:
Week-Dose(mg)
1 (10,20,30)
2 30
3 30-40
4 30-40
5 30-50
6 30-50
7 30-60
8 30-60
Example of a 4x/wk pulse Sat, Sun, Wed, Thur:
Week-Dose(mg)
1 (10,20,30,30)
2 30
3 30-40
4 30-40
5 30-50
6 30-50
How Epistane™ Works
Battling Gyno
Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ERα and ERβ). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane™ works by binding and deactivating the ERβ so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ERβ is the primary target receptor responsible for growth and proliferation. Epistane™ binds to the ERβ and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ERβ receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane™ has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.
Increasing Lean Body Mass
Epistane™ also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.
Support Supplements
The best overall support supplement in my opinion is Anabolic Innovations Cycle Support. It includes all the necessary ingredients to keep you healthy before/during/after your cycle and includes lipid/liver/heart/prostate support. Since it also blocks 5-AR, your skin will be clearer and if running test. your hair loss will decrease.
Nutraplanet/Supreme Muscle and others carry it.
Cycle Support
Ingredients include:
Red Yeast Rice 1200mg
Silymarin (milk thistle extract) 1000mg
NAC 1200mg
Hawthron Bery 1000mg
Saw Palmetto 300mg
Policosonol 20mg
Celery Seed Extract 150mg
Nettle Root 250mg
Idebenone 100mg
2006 Epi Bloodwork (20-45mg linear ramp):
SuperSoldier & Dr.D
_______________SS_____________________Dr.D
Date: ...1/07.....1/16.....1/26.................1/01.....2/09
AST ......26........32.........41...................24 ........52
ALT ......31........39.........51...................20 ........45
GGT ......09........05.........07...................15 ........21
ALB.......4.0........3.8........3.9............... ..4.5.......4.8
TBIL......1.8........1.1........1.3............... ..0.6.......0.5
DBIL......0.3........0.3........0.2............... ..NA........NA
CHOL.....145.......149.......171.................1 99......208
LDH.......156.......198.......208................. 129......147
HDL........32.........19.........9................ ...30........26
SS only:
26’th E2: 47, Prolactin 16.6
(no baseline on these)
Finally the PRO-Anabolic, anti-estrogen we have all been waiting for has arrived! Epistane™, exhibits a strong, long lasting anti-estrogen effect that is organ tissue specific. This means it works only where you want it to work. Broad range estrogen blockers and aromatase inhibitors can result in system shut down, aching joints, and decreased IGF-I expression. Epistane™ binds specifically to the 17β-estradiol receptor protein in the target tissues. Because of its long lasting and strong effects on specific tissue, Epistane™ can significantly reduce and reverse the effects of gynocomastia because not only does Epistane™ specifically block estrogen in breast tissue but it induces an estrogen-depleted condition which leads to apoptosis or the death of the breast tissue cells. Studies show that small doses of the parent compound, Epitiostanol, at just 10-20mg/week showed a complete disappearance of the mass and pain in 25% of the male patients in the clinical trail, while the other 75% of the patients showed at least a 50% reduction in the mass and complete loss of pain in just 4-8 weeks. That’s results in 100% of the male users with no side effects. While compounds such as Clomid and Nolvadex also block the 17β-estradiol receptor, they do not elicit the same increase in protein synthesis and strength gains that Epistane can offer.
Epistane™ is more than an anti-estrogen, though, as it also binds to androgen receptors in skeletal muscle. As a PRO-Anabolic compound Epistane™ promotes increases in strength and lean body mass with an anabolic/androgenic value (Q ratio) of 12. With most powerful androgens there is a high risk of the natural suppression of the gonads. Epistane™, unlike other PRO-Anabolic compounds that have recently been released, is relatively mild on the gonads and, due to the anti-estrogenic effects and the fact that Epistane™ keeps LH levels elevated, post cycle therapy becomes a breeze. All effects combined make Epistane™ a great compound to produce dry, lean gains in muscle mass with minimal side effects and suppression of the body’s natural androgen production, while lowering the effects of natural estrogen or combating estrogen from endogenous/exogenous sources. This makes it a powerful tool when combined with “wet” compounds in attempt to increase gains and decrease side effects. One can also not overlook the potential benefit of this compound taken alone, especially when recovering from periods of “wet” compounds. If you don’t want to worry about how your lipid and liver values are doing and whether or not you are going to get gynocomastia or not then get Epistane™, stop worrying, and experience what others are raving about!
FAQ
What can one expect from Epistane™?
• Incredible Strength Gains
• Dry, Lean Mass Gains
• Gynocomastia Protection
• Increased Libido
• Increased Training Intensity and Sense of Well-Being
• In Some, Reductions in Gynocomastia!
Sample Cycles
o Extreme Mass/Hardcore:
Weeks/Dosages/Product
1 40mg (start at 10mg first day and move up 10mg each day) Epistane™
2 40mg Epistane™
3 40mg Epistane™
4 40mg Epistane™
5 150mg X-Lean™ + Favorite PCT SERM
6 100mg X-Lean™ + Favorite PCT SERM
7 50mg X-Lean™ + Favorite PCT SERM
o Minimal Shutdown (take only 3X per week, preferably on lifting days and spread out throughout day up until 6pm, no dosing after):
Weeks/Dosages/Product
1 20-30mg (start at 10mg first day and move up 10mg each day) Epistane™
2 20-30mg Epistane™
3 20-30mg Epistane™
4 20-30mg Epistane™
5 150mg X-Lean™ + Favorite PCT SERM
6 100mg X-Lean™ + Favorite PCT SERM
7 50mg X-Lean™ + Favorite PCT SERM
What is pulse cycling? (Written by Dr.D)
What is "pulse" cycling? Pulsing is a method of dosing a product designed to intentionally avoid potential long term side effects such as HPTA suppression and liver damage. This technique is usually applied as a means of toxicity control when potent corticoids are used on children requiring long term therapy. However, this method can be applied to anyone using any oral steroid with great success and significantly reduced side effects. With pulsing, the serious long term side effects of chronic oral treatment are avoided and short term side effect like acne and mineral retention are much milder that usual. This allows for higher doses to be used since the dosing is less frequent. For example, if you would normally take a product at 30 mg/day, that equals a total intake of 210 mg/week. While pulsing, you might typically take 40 mg on work out days only, 3 times per week. That only comes out to 120 mg/week total! This provides the needed benefits of the product at the most crucial times, which are just before and just after a work out, and offers a means of avoiding the suppression of endogenous steroid production one would expect on a standard, daily dosing cycle. In other words, you can often pulse a compound for 6-8 weeks before you realistically need to start thinking about a conventional post cycle therapy. After a 4 week pulsing cycle, post cycle therapy should not even be required in most cases!
Basically, if you dose every day (ED) in perfectly spaced doses, you will achieve 100% effect, 100% short term side effects, and 100% long term side effects. If you dose every other day (EOD) like the pulse protocol, you still get about 60% effect and 75% short term sides, but only about 40% of the long term sides. That's not a bad trade off and very economical on the body and as well as the wallet! Of course, if you would have gained 10 pounds on a standard 1 month cycle, you will only gain about 6 pounds per month pulsing, but it also means you can do this for twice as long as a standard cycle. That equals about 2 months of worry free dosing, so the net effect is a gain of about 12 pounds over 2 months instead of 10 pounds over 1 month. This structure offers fewer sides and a milder post cycle therapy requirement (if even needed at all) plus the slower gains tend to have a better residual that is more likely to be permanent compared to faster gains. It's a great long term strategy for vets wanting to run 12 weeks, and good for new users too looking to run fast and clean 1 month cycles with no post cycle therapy needed later.
There are three common approaches to pulsing:
1) EOD dosing, so 3-4 times per week.
2) 2 days on / 2 days off
3) 2 weeks on / 2 weeks off (some guys do this and think it's great, I don't practice it but it looks exceptionally safe at least)
Depending on your workout schedule, I would use one of these options for optimal pulsing efficiency. Doses can usually be high (40-60 mg instead of 10-30 mg) but take them close together preferably before 6 pm. It's not crucial you take the last dose before 6 pm, but the earlier the better for avoiding shut down. Take half of the total dose pre work out and half post work out instead of spread out evenly over the whole day like a conventional cycle. If an odd dose is to be used, like 30 mg, take the majority pre work out (so 20 mg pre/10 mg post). However, when pulsing non methylated compounds or fast acting ethers, take the greater dose post work out instead of pre work out. When pulsing, dose at least 3 times per week but not more than 4 times to insure optimal results. 5 doses per week is pushing it and suppression will eventually ensue. If this is attempted, "holidays" of complete non use for up to a week per month may be required to discourage suppression. I do not recommend more than 4.5 doses per week and that is for advanced level only!
Also important to remember is nutrition. Have a good, high carb/calorie post work out meal or shake, and ingest sufficient protein especially on the off days. Off days are also a good time to take a cortisol antagonist or even just low dose DHEA (25-50 mg) if you're a slow healer or hard gainer especially. Cortisol peaks in the morning and again in the mid afternoon so dose at those 2 times minimum. Although pulsing is a great way to avoid suppression, if you're extra sensitive to shut down or using a very suppressive compound, an herbal testosterone booster can be used on the off nights or even included everyday. In fact, running test boosters as the core of your cycle and pulsing a methyl just to augment that is possibly one of the best methods you could employ if not using injectable testosterone. Also, avoid the use of SERMs with long half lives when pulsing. An aromatase inhibitor (AI) or test booster will further punctuate the positive, hormonal "bounce back" effect of pulsing. This bounce back phenomenon is an effect that is often noted when pulsing, so don't be alarmed if your testicular size increases dramatically on the off days. It is not uncommon for testicular volume and testosterone levels to increase above baseline, especially on consecutive off days during the pulse or after the cycle is over. This is like a built in post cycle therapy effect and if you're pulsing properly, you should experiences this to some degree. In pulsing, it is also important to remember that the smaller number of dose exposures means faster liver clearance. Normal safety ancillaries like healthy oils and lipid supplements are always advised on cycle and off, but be modest with liver protectants like Milk Thistle. They are generally counter productive and therefore not suggested when pulsing, except in conjunction with very potent or toxic compounds. If you elect to use liver protectants anyway, I would reserve them for off days only or take them no earlier than 6 hrs after your final dose of anabolics. Cycle safe!
Example of a 3x/wk pulse M,W,F:
Week-Dose(mg)
1 (10,20,30)
2 30
3 30-40
4 30-40
5 30-50
6 30-50
7 30-60
8 30-60
Example of a 4x/wk pulse Sat, Sun, Wed, Thur:
Week-Dose(mg)
1 (10,20,30,30)
2 30
3 30-40
4 30-40
5 30-50
6 30-50
How Epistane™ Works
Battling Gyno
Estradiol is the strongest form of estrogen in the human body, effecting several organs. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor (ERα and ERβ). When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Epistane™ works by binding and deactivating the ERβ so that no estrodiol-elicited effects can be carried out in the cell. In the case of breast tissue ERβ is the primary target receptor responsible for growth and proliferation. Epistane™ binds to the ERβ and not only disables the receptor from binding to estradiol, it actually puts the cell in an estrogen deprived state, which decreases the cells viability and leads to a decrease in size and eventual cell death. Other SERMs also block the ERβ receptor and AI’s even block the formation of Estradiol from testosterone conversion. However, the effectiveness at the receptor and long term side effects vary. Epistane™ has been shown to have one of the strongest and longest effects at the binding site, with minimal side effects when compared to other anti-estrogens.
Increasing Lean Body Mass
Epistane™ also binds to androgen receptors located on skeletal muscle cells and muscle stem cells. This then leads to changes in muscle cell function and protein synthesis. In the case of muscle stem cells, they will actually change and fuse with your active adult skeletal muscles increasing the muscles potential for growth and repair. On the opposing side, the presence of androgens actually decreases the ability of stem cells to form new fat cells. So you now have increased stem cell conversion to muscle cells and decreased stem cell conversion to fat cells, giving you more positive effects out of your nutrition and training.
Support Supplements
The best overall support supplement in my opinion is Anabolic Innovations Cycle Support. It includes all the necessary ingredients to keep you healthy before/during/after your cycle and includes lipid/liver/heart/prostate support. Since it also blocks 5-AR, your skin will be clearer and if running test. your hair loss will decrease.
Nutraplanet/Supreme Muscle and others carry it.
Cycle Support
Ingredients include:
Red Yeast Rice 1200mg
Silymarin (milk thistle extract) 1000mg
NAC 1200mg
Hawthron Bery 1000mg
Saw Palmetto 300mg
Policosonol 20mg
Celery Seed Extract 150mg
Nettle Root 250mg
Idebenone 100mg
2006 Epi Bloodwork (20-45mg linear ramp):
SuperSoldier & Dr.D
_______________SS_____________________Dr.D
Date: ...1/07.....1/16.....1/26.................1/01.....2/09
AST ......26........32.........41...................24 ........52
ALT ......31........39.........51...................20 ........45
GGT ......09........05.........07...................15 ........21
ALB.......4.0........3.8........3.9............... ..4.5.......4.8
TBIL......1.8........1.1........1.3............... ..0.6.......0.5
DBIL......0.3........0.3........0.2............... ..NA........NA
CHOL.....145.......149.......171.................1 99......208
LDH.......156.......198.......208................. 129......147
HDL........32.........19.........9................ ...30........26
SS only:
26’th E2: 47, Prolactin 16.6
(no baseline on these)
