[IBE]

trendione is on the banned list so better stock up now, 2000 bottles on pre-sale now ships by 12/23 next batch not available for 6 more weeks..........

Text of S.4032 as Introduced in Senate: Designer Anabolic Steroid Control Act of 2010 - U.S. Congress - OpenCongress


even though it was a 2010 bill they are still wanting to ban it


Nomenclature:


Estra-4,9,11-triene-3,17-dione



Synonyms:



Trenavar, Trendione



History:



This is a brand new prohormone from PHF/IBE, never seen before on the prohormone or pharmaceutical market.



Function:



This is a prohormone to the veterinary drug and black-market
bodybuilding steroid trenbolone. Unlike previous "tren" prohormones,
this one actually converts in the body to trenbolone. Previous "tren"
PHs converted to the structurally similar - but markedly weaker -
steroid dienolone.



Structure:



This prohormone has the same three conjugated double bonds as
trenbolone, and differs from it only in that this hormone has a
17-ketone, where trenbolone has a 17b-hydroxy function. In the body this
ketone will be readily hydrolysed by 17b-hydroxysteroid dehydrogenase
type 1 (17b-HSD1) into the active form, trenbolone.



Effects:



Conversion to trenbolone should be high, so effects should be identical
to the injectable form - with the exception of the famed "tren cough".
Whatever the explanation for "tren cough" (and many have been
suggested), since it's a reaction to the sudden parenteral introduction
of some compound directly into the body, it's highly unlikely that any
orally administered compound will have the same effect.

Trenbolone is one of the strongest injectable steroids on the market, so effects experienced from Trenavar can be expected to be largely the same - huge strength and size increases, accelerated fat loss, and enhanced vascularity.



Side Effects:



Blood pressure is likely to be dose-dependently elevated to a
significant degree, cholesterol levels and liver function markers are
likely to be adversely affected, though to what extent remains to be
seen. Commonly reported trenbolone sides include night-sweats, mood
swings, androgenic hair loss and/or growth, temporary loss of libido, as
well as the suppression of endogenous testosterone production, and it
would be sensible to assume that these may also result from use of Trenavar.





Metabolism and Bioavailability:



Warning: if you're not interested in advanced steroid metabolism
discussion, skip over this section. If you want solid info on how and
why an oral tren PH should work, read on.



The anabolic effects of trenbolone are due in part to the enhanced
androgen receptor binding that the conjugated double bond system causes
[1], and also because trenbolone is an antagonist of the glucocorticoid
receptor [2]. The double bonds extending up the backbone of the steroid
flattens the steroid considerably, which makes it an excellent fit for
the androgen receptor. It also makes the molecule much more flexible,
and therefore less receptor-specific [3]. Trenbolone is incapable of
being affected by 5a-reductase, 5b-reductase, or aromatase. But will it
work orally?



The first place to turn to for information on steroids is the seminal
1969 work Androgens and Anabolic Agents by Julius Vida. Unfortunately
this compound isn't among the 666 compounds discussed there, and there's
a shortage of information on trenbolone by oral adminstration. I was
fortunate enough to find a study which compared the anabolic effects of
oral and subcutaneous application of trenbolone in rats [4], and the
results were frankly startling. They found that to have a comparable
anabolic effect, trenbolone needed to be administered orally at 100
times the dosage as when administered by subcutaneous injection (see
graph). Sounds pretty bad for a tren PH then, right? Well, the good news
is we're not rats.





Trenbolone is metabolised differently in different species - in rats,
around 40% is excreted as a dione form, as well as several metabolites
hydroxylated in various positions [5], but in man only one metabolite
has been identified - the 17a-epimer [6].







The ratio of excreted trenbolone (17b-trenbolone) to epitrenbolone (17a-trenbolone) is estimated at 1:5 in a 24hr period [7].



What this means is that although Trenavar
is a prohormone to trenbolone, it doesn't appear to be a significant
metabolite in humans. The equilibrium of the reaction between 17-one and
17b-ol appears to be weighted heavily - in fact pretty much exclusively
- in favour of the 17b-ol, so Trenavar
should convert readily to the active form trenbolone. Once converted to
trenbolone, it will be open to the same metabolism mechanisms as
injectable tren - conversion via sulfatase to epitrenbolone and
excretion as glucoronides.



Of course, this is largely conjecture, since neither trenbolone nor a
precursor to it has ever been on the supplement market before... or has
it?

A few years ago ALRI released an encapsulated product called "Methoxy
TRN", advertised as containing "17b-methoxytrienbolone". This was
quickly pulled from the shelves soon after its release, leaving only a
few highly-collectable bottles and a reputation for tremendous strength
and size gains and roadmap vascularity. This supplement was tested in
2008, and the researchers discovered the tell-tale mass spectra of
trenbolone (and no sign of the advertised methoxy group) [8].



Detection Limits:



An anti-doping study from 1996 found that orally administered trenbolone
was detectable by mass spectrometry for two to four days after a single
administration, unlike injectable trenbolone, which is detectable for
much longer [9]. The detection of trenbolone after administration of Trenavar
is likely to follow similar lines, though detection methods may have
improved since then. Athletes subjected to doping tests should of course
avoid this and all other prohibited performance-enhancing products
altogether.





Dosages and Cycle Durations:



Empirical evidence is the only way to determine this; once the product
has been used by enough people we'll have a better idea of how much, and
for how long, Trenavar is best used.



References



[1] Steroids 74 (2009) 172–197



[2] Acta Endocrinologica, Vol 110, 1 Suppla, S129-S130



[3] J Steroid Biochem 1979;13:45–59.



[4] Toxicol Sci. 2002;70:202–211.



[5] Xenobiotica. 1981 Jul;11(7):489-500.



[6] Biol. Mass Spectrom. 20 (1991) 459–466.



[7] Recent advances in doping analysis (2). (1995) 269-274.



[8] Anal Chim Acta. 2009 Apr 1;637(1-2):92-100.



[9] Recent advances in doping analysis (3). (1996) 83-94.Share

[fadi]

You guys had beta testers, but I haven't seen results posted anywhere. what were the results and feedback from the beta testers?

[dollar662]

You guys had beta testers, but I haven't seen results posted anywhere. what were the results and feedback from the beta testers?

Heres one I found

http://anabolicminds.com/forum/cycle...ml#post3049390

[fadi]

Heres one I found

http://anabolicminds.com/forum/cycle...ml#post3049390

thanks, I was looking for a log with numbers. I'll wait for the next batch, since I do not plan on running it any time soon. Hopefully more logs will be out around dosing and bloodwork.

[flightposite]

Tren is cool but I want dbol already lol

[Whacked]

1) WHERE do we purchase it?
2) Will it come in caps or liquid form

[RoadBlocK]

1) WHERE do we purchase it?
2) Will it come in caps or liquid form

1-cant say, its against the rules here at am.com
2-caps, unless Im mistaken

[Whacked]

Arrggg
It's NOT on IBE's products site either

1-cant say, its against the rules here at am.com
2-caps, unless Im mistaken

[mugen112]

Plz ibe help.

The product image of the packet says tablets but the facts which show compound and dose say capsules... Which is it tablets or caps?

It says presale 2000 bottles but the picture is of a packet... Which is it bottle or packet??

Hopefully I can get some answers because this information greatly dictates wether or not I will be ordering.

[mh625]

Can someone please pm me as to where I can purchase some. Reps?

[mugen112]

Plz ibe help.

The product image of the packet says tablets but the facts which show compound and dose say capsules... Which is it tablets or caps?

It says presale 2000 bottles but the picture is of a packet... Which is it bottle or packet??

Hopefully I can get some answers because this information greatly dictates wether or not I will be ordering.

No answers?!

[bashman]

Can someone please pm me as to where I can purchase some. Reps?

google trenavar presale

[mh625]

google trenavar presale

Thanks, I googled Trenavar then IBE Trenavar, never even thought of adding in the presale, kinda feel like a dumba$$ now.

[Whacked]

Pretty sure this stuff ids the prohormone to Tren so with adequate dosing, it should feel just like Tren

Anyone - Feel free to jump in here if I am wrong. I thought I read that somewhere!?!?

You guys had beta testers, but I haven't seen results posted anywhere. what were the results and feedback from the beta testers?

[fadi]

There is another thread in the Anabolics section about it. Couple of the testers explained their results.

[brhamilton79]

Just curious but if this on the ban list, why or how are they able to produce and sell it? Or how does it vary from previous tren products that some of us have seen? I LOVE the old TREN, it treats me good

[mugen112]

Plz ibe help.

The product image of the packet says tablets but the facts which show compound and dose say capsules... Which is it tablets or caps?

It says presale 2000 bottles but the picture is of a packet... Which is it bottle or packet??

Hopefully I can get some answers because this information greatly dictates wether or not I will be ordering.

Ibe rep cannot help?

[RoadBlocK]

Ibe rep cannot help?

I'll see what I can find out.

[schwellington]

I'm somewhat skeptical about this. They want to ban it and it's just now released? I dunno. I have used actual trenbolone before stuff made me really strong and really mean lol

[Whacked]

Where are the logs?

[chocolatemilk]

that write up is wrong and IBE/PHF is well aware of that......

trendione is certainly a metabolite of trenbolone and the source epitrenbolone is not sulfoconjugation it is through trenavars direct interaction with 17a-hsd

so fix up the article and let the consumers know that trendione (trenavar) will move forward to some trenbolone, some epitrenbolone, and some won't even go forward with the reaction and stay as trendione

trendione will not go "exclusively" to trenbolone like you are claiming

[Whacked]

Interesting

Thaks Choc

If accurate, what will the NON-tren metabolites do? Are they inert? Do they exert some activity? f so, what?

So what can be expected with this stuff now that it MIGHTR NOT be 'only tren' ?

that write up is wrong and IBE/PHF is well aware of that......

trendione is certainly a metabolite of trenbolone and the source epitrenbolone is not sulfoconjugation it is through trenavars direct interaction with 17a-hsd

so fix up the article and let the consumers know that trendione (trenavar) will move forward to some trenbolone, some epitrenbolone, and some won't even go forward with the reaction and stay as trendione

trendione will not go "exclusively" to trenbolone like you are claiming

[chocolatemilk]

Interesting

Thaks Choc

If accurate, what will the NON-tren metabolites do? Are they inert? Do they exert some activity? f so, what?

So what can be expected with this stuff now that it MIGHTR NOT be 'only tren' ?

the major metabolites will be trenbolone, it's epimer epitrenbolone which is inactive, and you'll also have some fully intact trendione (trenavar) which is also inactive

you can expect to get less trenbolone out of it than what is being claimed

[Whacked]

Thanks Choc

Given the aforementioned info, what do you suggest a decent dosing regimen?

PS: Half life?

[chocolatemilk]

Thanks Choc

Given the aforementioned info, what do you suggest a decent dosing regimen?

PS: Half life?

can't really answer what will be good dosing as there is no information on relative ratios of metabolites at equilibrium

half life should be similar to other orals

if you want in depth information on trenavar here is a good thread but requires some decent understanding of organic chemistry.. if you dont understand something in it i would be happy to explain Trenavar equilibrium