Myostatin Gene?

  1. Myostatin Gene?


    It has been discovered that much of Wheeler's muscular development was aided by a genetic mutation which inhibited the production of myostatin, a key limitor of muscular growth.

    I read this somewhere can't remmeber where... but then I started researching and found this

    The Myostatin Gene

    and

    Genetic mutation turns tot into superboy - Genetics - MSNBC.com
    AEGiS-Chicago Tribune: One Strong Tyke: Gene mutation in muscular boy may hold disease clues


    Interesting...

    this seems to be the genetic disease to have... if you had to have one at all...lol any thoughts on this?


  2. I recently read a write up on Myostatin blockers in MD. A lot of research is being done on myostatin blockers in rats and cows with some success. Increases in both muscle fiber size and number were noted. In the cattle large amounts of muscle mass increases was seen but along with greater muscle damage risk, reduced aerobic capacity, and heart and lung problems. A lot of research still has to be done on it before any human will have the chance to take it imo.

  3. Personally, I can't believe I am saying this, but thats one area that I hope doesn't pan out. If we find something to mildly suppress it that would be cool and would make athletic events a lot more interesting. There is a mighty fine line though, and if there is really no limit to muscle gain, we could all look like those dudes on sythnol (however you spell it) and it would be ridiculous. For the one kid who has it now I feel bad for his pee wee football league lol.
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  4. Thats just freakishly wrong on so many levels.

  5. Quote Originally Posted by OCCFan023 View Post



    Thats just freakishly wrong on so many levels.
    Tasty much?

  6. Yeah i was thinking it would be a bad ass steriod... and hahah yeah sucks to play football wit Hercules but i wasnt shocked to read about flex having it lol

  7. I wonder if the myostatin blockers that had the negative side effects was due to a secondary action from or it if this kid will have those same problems.

  8. there was a report on this. some animals born with this gene activated. but they do not last long. i believe it shortens life due to no control of growth. pressure on bone structure maybe?

  9. I have heard about this as well. Not sure the rationale given, but a much shorter life expectancy. Kinda curious what role it plays on stress for the heart as well
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  10. Yeah I read somewhere it puts extra strain on the respiratory system and cardiovascular system..

  11. Quote Originally Posted by Reaper329 View Post
    I have heard about this as well. Not sure the rationale given, but a much shorter life expectancy. Kinda curious what role it plays on stress for the heart as well
    I don't know about much shorter. I've heard that there is a possibility for a shorter life expectancy, but I don't believe this is always the case. Muscle cramping seems to be a big issue with animals that have been studied that have the myostatin mutation.

    Belgian Blue cattle have this mutation and are specifically bred with two mutated genes in order to get larger quantities of lean meat.

    You guys ever hear of Wendy the Whippet?



    Whippets are a breed of dog that resemble small greyhounds and are bred for speed. National Human Genome Research Institute also did a study on these animals. What scientists have begun to notice is that dogs with one mutated copy are more muscular and significantly leaner, but are also much faster than dogs without a mutated copy. These are the prize whippets that breeders strive for. Whippets that ended up with two mutated copies (biology - we have two copies of each gene; one from the mother and one from the father) were the double-muscled ones. They are HUGE, lean, and not nearly as fast. They're known as "bully whippets". I want one.

    genome.gov | 2007 News Features: NHGRI Researchers Explore Genetics of Canine Speed

    Meet the Incredible Hulk of Hounds | the Daily Mail

    Big Wendy the muscular whippet

    I believe the German kid is said to have one mutated copy, and there's another kid around I was reading about with one mutated copy of his myostatin gene as well. His name is Liam Hoekstra, and at 19 months old they say he's fast as the wind, has the agility of a cat, six pack abs, and has 40% more muscle mass than normal kids his age. The article also said his metabolism is through the roof and he gets hungry for a full meal every hour.

    globeandmail.com: Dad sees a future football star

    Definitely some interesting stuff. I'm always trying to read up for updates on myostatin research. Highly intriguing!

  12. there's a thead in 2004 on a lot of this when i first joined, I remember.

    John hopkin's has done theis to a person with muscle wasting. if a bodybuilder ever gets their hands on this , watch out!

    I tried a myostatin pill called Myo-blast for cps-blast (something like that) four years ago in 04. I think they've been discontinued because it's bunk. At least I didn't show any extraordinary results
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness

  13. that dog is disgusting

  14. Its just so interesting, and i have seen any recent threads on it so i thought i would post about it cuz its so intriguing, and that kid will be a monster.

  15. I'm sure they'll find another mutant dog to breed with it.

    Im all honestly Id rather be the dog with the mutated gene that is faster, lean and huge than the dog that is lean HUGE and not as fast. its interesting none the less. Id rather be faster though and of course muscular and lean.
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness

  16. Quote Originally Posted by smeton_yea View Post
    there's a thead in 2004 on a lot of this when i first joined, I remember.

    John hopkin's has done theis to a person with muscle wasting. if a bodybuilder ever gets their hands on this , watch out!

    I tried a myostatin pill called Myo-blast for cps-blast (something like that) four years ago in 04. I think they've been discontinued because it's bunk. At least I didn't show any extraordinary results
    anyone know what im talking about? Did you try it and how did it work? It was called myoblast

    Bodybuilding.com - Cytodyne Myo-Blast CSP3. they used to advertise it in magazines a few years ago

    Myo Blast CSP3 by Cytodyne - Supplements101.com
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness

  17. Quote Originally Posted by bkoguy07 View Post
    Its just so interesting, and i have seen any recent threads on it so i thought i would post about it cuz its so intriguing, and that kid will be a monster.
    There has to be health issues associated with this (I mean from blocking the gene alone the side effects would make most athletics near impossible between the decrease in aerobic capacity and increase in injury risk.) Plus that kid will be well over the weight limit until high school, but I guess if the health issues don't plague him it will be game on.

  18. That is the most amazing dog I have ever seen.

  19. Its like a roided out pig with long legs (I can't get over how muscular its damn head is.) You show me a Rottweiler with the myostatin gene blocked and Ill show you one dog I'd be down for owning. It'd be like the dogs from I Am Legend only not all shaven and (insert word for can't be in sun light disease here) up. It is more space effective than a rotti though.

  20. Quote Originally Posted by smeton_yea View Post
    anyone know what im talking about? Did you try it and how did it work? It was called myoblast

    Bodybuilding.com - Cytodyne Myo-Blast CSP3. they used to advertise it in magazines a few years ago

    Myo Blast CSP3 by Cytodyne - Supplements101.com
    Yeah man, I remember that stuff. I used to work at GNC when it first came out, and helped myself to about 6 bottles. Didn't do a damn thing for me.

  21. Quote Originally Posted by Mulletsoldier View Post
    That is the most amazing dog I have ever seen.
    Isn't it though?! I totally want one. How cool would it be to have a super-jacked dog that looked like it was on roids! I'd love to see people's reaction when they came over to my house and saw my dog!

  22. Quote Originally Posted by OCCFan023 View Post
    Its like a roided out pig with long legs (I can't get over how muscular its damn head is.) You show me a Rottweiler with the myostatin gene blocked and Ill show you one dog I'd be down for owning. It'd be like the dogs from I Am Legend only not all shaven and (insert word for can't be in sun light disease here) up. It is more space effective than a rotti though.

    lol i feel that... and the fact that it doesnt want to eat you cant be having a dog thats wants to eat any human..

  23. Rather than simply blocking myostatin, upregulating follistatin in muscle for a brief period seems to me to be more advantageous. There is likely more at work than myostatin.

  24. Damn this is interesting. I agree blocking the gene completely seems more dangerous. I nearly shyt myself seeing these pictures! haha

  25. Quote Originally Posted by TheCrownedOne View Post
    Rather than simply blocking myostatin, upregulating follistatin in muscle for a brief period seems to me to be more advantageous. There is likely more at work than myostatin.
    got any research on this?

    have you ever used..what results did u get
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness

  26. Quote Originally Posted by smeton_yea View Post
    got any research on this?

    have you ever used..what results did u get


    yeah im interested in it as well

  27. I can't cite any research off the top of my head. From what I've casually read and seen (such as the mouse pictures below), results from simply blocking myostatin do not produce the levels of muscle hypertrophy/hyperplasia seen with administration/upregulation of muscle follistatin. Researchers have noted that there seems to be more at work than myostatin and have posited that perhaps follistatin blocks or downregulates these unknown factors. Moreover, myostatin plays a large role in the strength, flexibility and utility of tendons and/or ligaments. A generalized negation of myostatin would not seem to serve us well with regard to our oft-injured connective tissue.
    In addition, there is a wide variety of Histone Deacetylase (HDAC) inhibitors found in our diet, such as butyrate, allyl mercaptan (from garlic) and sulphoraphane (crucifers like broccoli sprouts/florets), and HDAC inhibitors have been shown to upregulate muscle specific follistatin. Trichostatin A seems to be the hot one at the moment, but its cost is prohibitory.



    See also:

    'Mighty Mice' Made Mightier

  28. Quote Originally Posted by bkoguy07 View Post
    It has been discovered that much of Wheeler's muscular development was aided by a genetic mutation which inhibited the production of myostatin, a key limitor of muscular growth.

    I read this somewhere can't remmeber where... but then I started researching and found this

    The Myostatin Gene

    and

    Genetic mutation turns tot into superboy - Genetics - MSNBC.com
    AEGiS-Chicago Tribune: One Strong Tyke: Gene mutation in muscular boy may hold disease clues


    Interesting...

    this seems to be the genetic disease to have... if you had to have one at all...lol any thoughts on this?
    http://www.musclephotos.com/myogene.html

    Considering the author of the letter, there has been much speculation that the intention of the letter was to come up with a reason (other than drugs) for Flex's development. In other words...not true. Who knows?

  29. Quote Originally Posted by mmorpheuss View Post
    http://www.musclephotos.com/myogene.html

    Considering the author of the letter, there has been much speculation that the intention of the letter was to come up with a reason (other than drugs) for Flex's development. In other words...not true. Who knows?
    yeah, but from the avatar you got, looks like you might wanna get checked for a myostatin deficiency as well lol freakin jacked

  30. Quote Originally Posted by bkoguy07 View Post
    yeah, but from the avatar you got, looks like you might wanna get checked for a myostatin deficiency as well lol freakin jacked

  31. Quote Originally Posted by bkoguy07 View Post
    yeah, but from the avatar you got, looks like you might wanna get checked for a myostatin deficiency as well lol freakin jacked
    That's Dexter Jackson.

  32. Quote Originally Posted by mmorpheuss View Post
    That's Dexter Jackson.
    MD just lost him but got Lee Priest back.I personally love Lee,his physique and his attitude,advice,and all.So I'm happy to see him back.
  

  
 

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