- 04-20-2008, 09:36 PM
It has been discovered that much of Wheeler's muscular development was aided by a genetic mutation which inhibited the production of myostatin, a key limitor of muscular growth.
I read this somewhere can't remmeber where... but then I started researching and found this
The Myostatin Gene
Genetic mutation turns tot into superboy - Genetics - MSNBC.com
AEGiS-Chicago Tribune: One Strong Tyke: Gene mutation in muscular boy may hold disease clues
this seems to be the genetic disease to have... if you had to have one at all...lol any thoughts on this?
- 04-20-2008, 10:10 PM
I recently read a write up on Myostatin blockers in MD. A lot of research is being done on myostatin blockers in rats and cows with some success. Increases in both muscle fiber size and number were noted. In the cattle large amounts of muscle mass increases was seen but along with greater muscle damage risk, reduced aerobic capacity, and heart and lung problems. A lot of research still has to be done on it before any human will have the chance to take it imo.
04-20-2008, 10:20 PM
Personally, I can't believe I am saying this, but thats one area that I hope doesn't pan out. If we find something to mildly suppress it that would be cool and would make athletic events a lot more interesting. There is a mighty fine line though, and if there is really no limit to muscle gain, we could all look like those dudes on sythnol (however you spell it) and it would be ridiculous. For the one kid who has it now I feel bad for his pee wee football league lol.
Muscle Pharm Rep
04-20-2008, 10:29 PM
04-20-2008, 10:47 PM
04-21-2008, 01:26 AM
Yeah i was thinking it would be a bad ass steriod... and hahah yeah sucks to play football wit Hercules but i wasnt shocked to read about flex having it lol
04-21-2008, 09:07 AM
I wonder if the myostatin blockers that had the negative side effects was due to a secondary action from or it if this kid will have those same problems.
04-21-2008, 09:39 AM
there was a report on this. some animals born with this gene activated. but they do not last long. i believe it shortens life due to no control of growth. pressure on bone structure maybe?
04-21-2008, 12:24 PM
I have heard about this as well. Not sure the rationale given, but a much shorter life expectancy. Kinda curious what role it plays on stress for the heart as well
04-21-2008, 12:58 PM
04-21-2008, 05:48 PM
Belgian Blue cattle have this mutation and are specifically bred with two mutated genes in order to get larger quantities of lean meat.
You guys ever hear of Wendy the Whippet?
Whippets are a breed of dog that resemble small greyhounds and are bred for speed. National Human Genome Research Institute also did a study on these animals. What scientists have begun to notice is that dogs with one mutated copy are more muscular and significantly leaner, but are also much faster than dogs without a mutated copy. These are the prize whippets that breeders strive for. Whippets that ended up with two mutated copies (biology - we have two copies of each gene; one from the mother and one from the father) were the double-muscled ones. They are HUGE, lean, and not nearly as fast. They're known as "bully whippets". I want one.
genome.gov | 2007 News Features: NHGRI Researchers Explore Genetics of Canine Speed
Meet the Incredible Hulk of Hounds | the Daily Mail
Big Wendy the muscular whippet
I believe the German kid is said to have one mutated copy, and there's another kid around I was reading about with one mutated copy of his myostatin gene as well. His name is Liam Hoekstra, and at 19 months old they say he's fast as the wind, has the agility of a cat, six pack abs, and has 40% more muscle mass than normal kids his age. The article also said his metabolism is through the roof and he gets hungry for a full meal every hour.
globeandmail.com: Dad sees a future football star
Definitely some interesting stuff. I'm always trying to read up for updates on myostatin research. Highly intriguing!
04-21-2008, 06:45 PM
there's a thead in 2004 on a lot of this when i first joined, I remember.
John hopkin's has done theis to a person with muscle wasting. if a bodybuilder ever gets their hands on this , watch out!
I tried a myostatin pill called Myo-blast for cps-blast (something like that) four years ago in 04. I think they've been discontinued because it's bunk. At least I didn't show any extraordinary results
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04-21-2008, 06:47 PM
04-21-2008, 11:37 PM
Its just so interesting, and i have seen any recent threads on it so i thought i would post about it cuz its so intriguing, and that kid will be a monster.
04-21-2008, 11:46 PM
I'm sure they'll find another mutant dog to breed with it.
Im all honestly Id rather be the dog with the mutated gene that is faster, lean and huge than the dog that is lean HUGE and not as fast. its interesting none the less. Id rather be faster though and of course muscular and lean.
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04-21-2008, 11:47 PM
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04-21-2008, 11:51 PM
04-21-2008, 11:52 PM
04-22-2008, 12:02 AM
Its like a roided out pig with long legs (I can't get over how muscular its damn head is.) You show me a Rottweiler with the myostatin gene blocked and Ill show you one dog I'd be down for owning. It'd be like the dogs from I Am Legend only not all shaven and (insert word for can't be in sun light disease here) up. It is more space effective than a rotti though.
04-22-2008, 01:03 AM
04-22-2008, 01:08 AM
04-22-2008, 01:52 AM
04-22-2008, 09:04 AM
Rather than simply blocking myostatin, upregulating follistatin in muscle for a brief period seems to me to be more advantageous. There is likely more at work than myostatin.
04-22-2008, 09:50 AM
Damn this is interesting. I agree blocking the gene completely seems more dangerous. I nearly shyt myself seeing these pictures! haha
04-22-2008, 05:25 PM
04-22-2008, 05:54 PM
04-23-2008, 10:14 PM
I can't cite any research off the top of my head. From what I've casually read and seen (such as the mouse pictures below), results from simply blocking myostatin do not produce the levels of muscle hypertrophy/hyperplasia seen with administration/upregulation of muscle follistatin. Researchers have noted that there seems to be more at work than myostatin and have posited that perhaps follistatin blocks or downregulates these unknown factors. Moreover, myostatin plays a large role in the strength, flexibility and utility of tendons and/or ligaments. A generalized negation of myostatin would not seem to serve us well with regard to our oft-injured connective tissue.
In addition, there is a wide variety of Histone Deacetylase (HDAC) inhibitors found in our diet, such as butyrate, allyl mercaptan (from garlic) and sulphoraphane (crucifers like broccoli sprouts/florets), and HDAC inhibitors have been shown to upregulate muscle specific follistatin. Trichostatin A seems to be the hot one at the moment, but its cost is prohibitory.
'Mighty Mice' Made Mightier
04-23-2008, 11:28 PM
Considering the author of the letter, there has been much speculation that the intention of the letter was to come up with a reason (other than drugs) for Flex's development. In other words...not true. Who knows?
04-23-2008, 11:58 PM
04-24-2008, 12:08 AM
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