Here's what cutting edge says about it!
6 pumps=1ml about an hour before bed!
It does make me drowsy,which is great because I've had a hard time sleeping because I'm so jacked up.
When I wake up I can eat, eat, eat!!!
Ketotifen Fumarate is here!
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Ketotifen Fumarate is here!
Ketotifen is perhaps best known for its ability to inhibit the down regulation of beta receptors caused by drugs like clenbuterol and Albuterol. clenbuterol and its sister drug Albuterol are typically cycled on and off because they desensitize the very receptors they act on to produce their fat mobilizing effect. Ketotifen used in conjunction with either would allow the use of these fat burning drugs for much longer periods. This is convenient if, for example, a person is wishes to do a T3 cycle for a month or six weeks and use Albuterol to ehnance T3's fat burning. Adding Ketotifen would allow that person to use the Albuterol throughout the entire T3 cycle.
Ketotifen is also recognized for its ability to lower levels of the catabolic cytokine Tumor Necrosis Factor-alpha (TNF-alpha). It is used by people suffering from AIDS or cancer to prevent muscle wasting caused to a large extent by TNF-alpha. In one study involving AIDS patients, combining Ketotifen and oxymetholone showed that 18 out of 22 patients gained an average of 11.4 pounds after treatment of an average of 3.9 weeks (1).
There is a large body of research showing TNF-alpha lowers both testosterone and IGF-1 levels quite significantly (2,3). What's relevant to bodybuilders and other athletes is that strenuous exercise elevates TNF-alpha levels (4).
TNF-alpha has also been implicated in insulin resistance, the condition in which muscle uptake of glucose is hindered. Ketotifen then could potentially improve insulin sensitivity in muscle. (R-ALA is so popular because it too improves insulin sensitivity.)
Besides blocking TNF-alpha, Ketotifen is a potent appetite stimulant. This is an aded bonus for someone with a wasting condition, or someone on a bulking cycle. This almost certainly contributed in part to the weight gain cited in the study above. When cutting using clenbuterol or Albuterol, this is obviously going to force one to exercise more will power when it comes to dieting.
Recent research has shown that hypogonadism (low testosterone) is also associated with elevated TNF-alpha (5). Testosterone replacement reduces these high levels of TNF-alpha. After a cycle of anabolic steroids, a person is essentially in a hypogonadal state, with elevated TNF-alpha. This could be a possible factor in the loss of muscle mass that is normally seen after a cycle. Adding Ketotifen to a typical post cycle therapy (PCT) regimen would likely help stave off this loss of muscle until testosterone levels return to normal, or until beginning the next cycle.
So whether cutting or bulking, or as part of PCT Ketotifen has a valuable place in bodybuilding and exercise recovery.
(1) Smart T. GMHC Treat Issues. 1995 May;9(5):7-8, 12.
(2) Mauduit C, et.al Endocrinology 1998 Jun;139(6):2863-8
(3) Lang CH et.al Growth Horm IGF Res 2001 Aug;11(4):250-60
(4) Pedersen BK et. al. Exerc Immunol Rev 2001;7:18-31
(5) Malkin CJ et.al. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-[/font][font=verdana, arial, helvetica]
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Are you tired at all? I think I'm going to order some so I can cycle my ant-histamine, Calrritan seems to work less effective after a week or so. Calaritan still works after one week but not as good as the first week. Any other side effects? Whats your dosage? I assume its oral administration?
