This concept is what weight watchers is based upon and is also why it is flawed. Total energy intake accounts for weight loss and gain but ignoring the downstream metabolic consequences macronutrients have leads to weight loss but also adipose gain. This is the "skinny fat" body type that is becoming ever so prevelant today.
That said, in the bulking sense considering he is taking in a caloric surplus, it is probably something that isn't if much importance. The determining factor is how fast he is looking to grow vs. How much adipose gain he is willing to have happen.
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I'm responding to a woman interested in bulking, who will be lifting and will be creating a favorable insulin response to handle the posted ratios.
I don't know why you insist on pulling comments out of context to argue them.
I should end my reply there but following your rabbit hole and generally speaking:
Caloric intake is
the key factor for the vast majority of people interested in manipulating weight, period. I realize macros can be manipulated and have said so (in context), multiple times in multiple conversations you've been a part, though we were discussing protein specifically.
Big picture, considering her training and diet, the downstream metabolic factors of her diet will have limited if any negative effect and she shouldn't get caught up on super technical bull**** unless she decides to hit either a level of muscle or leanness that simple caloric manipulation can't help her achieve. 95% of lifters really don't need to concern themselves with this however. Caloric management and proper training will create a beach body with room for macro flexibility within a caloric umbrella.
Athletes manipulating their bodies for quick weight loss to hit a weight class, bodybuilders getting as lean and dry as possible et cetera genuinly benefit from technical manipulations.
Can the average joe looking for a six pack and biceps manipulate macros to isolate physiological responses taking advantage of glycolysis, lypolysis et cetera and see results? Yes. Is it necessary? Absolutely not.
And FTR, nobody is discussing untrained people.