I started at about the same weight you are at (352 was my peak) and am currently (297) about halfway to my goal (240). I'd offer this advice based on my own experience and reading what you've got.
1. Your weight is at a crisis level (as mine was and to a lesser extent is). I would suggest that you cut hard to 300, then consider a more balanced approach after that.
2. ECA and Clen are the most commonly recommended supplements for weight loss, but I would recommend holding off on those until you hit a plateau. I've started an ECA cycle because I've been stuck at 297 for 14 days despite large caloric deficits and a lot of exercise. Clen is more difficult to obtain and, from what I understand, more expensive. An ECA stack can be picked up for ~20-30 per month at a drugstore in most states.
3. Get yourself a fitday.com account and log your foods. It takes 10-12 minutes per day, and is really eye opening about what foods will spike your caloric intake for little in the way of satisfaction or nutrition. It will also help you keep track of what size caloric deficit you need to run to achieve your goals.
4. Weight loss is probably 70-90% diet and 30-10% exercise, but you can't neglect it. Most recommend either long, low-intensity cardio or HIIT cardio. I prefer HIIT because I don't really have the time/patience for an hour long, low-intensity workout and I think the results are better. Compound-movement weightlifting is also important, although my recovery has been terrible with deep squats and deadlifts.
5. The only way that I'm aware that one can lose weight and build muscle simultaneously is on a carb-cycling diet. Few have the time or discipline to implement this diet, and from what I understand most people lose 1-2 pounds per week on this; my guess is you want more weight loss than that.
6. Consider having your thyroid and testosterone levels checked. Even if both are off it wouldn't be the whole story, but it could help.
7. Consider starting with a ketosis diet like Atkins. My guess is that your blood sugar levels are all over the place, and this can have disastrous effects on appetite. Going on something like Atkins (impossibly boring as it may be) for about a month will probably shed a half a pound per day or so, will force you to discipline yourself in terms of what you eat, and will sort out blood sugar issues. All of this will make your future weight loss - which will ultimately have to be centered around moderate calorie restriction - easier.
8. Green tea is often recommended as a weight loss supplement. It has no known negative side effects and probably has a lot of positive ones.
Hope this helps