Enhancing Your Napalm: Anyone clen do it!
01-21-2008 04:01 PM
I'm saying albuterol has a shorter duration of activity than clen. Period. If using the same route of administration for both, regardless of what route that is, albuterol is a shorter acting compound than clenbuterol.
01-21-2008 04:59 PM
Chemical Name: Albuterol Sulfate
Drug Class: Beta-Agonist
Albuterol is very closely related to Clenbuterol (often simply called “Clen”), which has been a drug athletes have been using for literally decades to lose fat. Although it’s typically thought of as only a shorter acting version of Clenbuterol, that’s not 100% correct, and Albuterol actually has some benefits that Clen doesn’tJust like Clen, Albuterol binds to the beta 2 adrenergic receptors. Beta 2 receptor stimulation is a very potent mechanism for initiating fat loss. Stimulating the beta-2 receptors found in fat cells activates hormone sensitive lipase, to break up stored fat into free fatty acids which are then used as fuel by the body (1). Once those fatty acids are broken up, Albuterol then has the added effect of elevating your metabolism, which helps you use the free fatty acids that it has broken up. It’s a very potent fat burner, as a result of both being able to break up stored fat and make it available as energy, as well as increasing the rate at which this energy is used.
Interestingly, while Clenbuterol increases both muscle size and strength in animal studies (2), the same thing isn’t necessarily true in humans, and if it is, actual studies proving so are nearly impossible to find. It’s suspected to possibly do this, but there’s really no hard evidence of it. And since it’s not approved by the FDA for use in humans, non-anecdotal data proving that Clen actually builds muscle or increases performance is scarce. Since it’s approved by the FDA for use in asthmatics, studies on humans and Albuterol, regarding exercise performance are more plentiful. In multiple studies, it has been suggested strongly that it increases strength as well as endurance in humans (3,4). Clen, on the other hand, has anecdotally been reported to reduce endurance in athletes who use it.
In addition, Albuterol may even help the lipid profile (cholesterol)(5), which is definitely something that steroid using athletes may want to consider, when deciding whether or not to include Albuterol in a cutting cycle. In fact, a small dose of it might be useful on nearly any cycle, because of this characteristic.
The main difference between Albuterol and Clen is that Albuterol has a significantly shorter half life than Clen. If Clenbuterol happens to give you insomnia, then Albuterol is a much better alternative, because it’s not going to build up in your system to the same degree that Clen can.
I’m typically much more confident recommending Albuterol to athletes instead of Clen, because stimulant induced anxiety and insomnia seem to be much less likely. Also, due to the shorter half life, there’s probably a much lower level of beta-2 receptor downgrade, but the trade off is more frequent dosing. Two to four milligrams, three to four times a day is usually sufficient for an anabolic as well as fat burning effect.
1. Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans.
2. Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E775-82. Epub 2003 Jun 24.
3. J Appl Physiol. 2001 Nov;91(5):2064-70
4. Med Sci Sports Exerc. 2000 Jul;32(7):1300-6. Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men. van Baak MA, Mayer LH, Kempinski RE, Hartgens F.
5. Aviat Space Environ Med. 2004 Jun;75(6):505-11 Albuterol helps resistance exercise attenuate unloading-induced knee extensor losses. Caruso JF, Hamill JL, Yamauchi M, Mercado DR, Cook TD, Keller CP, Montgomery AG, Elias J.
6. Metabolism. 1996 Jun;45(6):712-7 Effects of oral albuterol on serum lipids and carbohydrate metabolism in healthy men. Maki KC, Skorodin MS, Jessen JH, Laghi F.
01-21-2008 06:57 PM
On my grind
E-Pharm Rep... PM me with any questions or concerns
01-21-2008 07:02 PM
hmm albuterol FTW it would seem in a transdermal.
01-21-2008 08:49 PM
hmmmm...i definetly wanna try this
01-21-2008 08:50 PM
Only if dosing the transdermal 3x/day though.
01-21-2008 08:57 PM
Running with the Big Boys
It's only recommended to dose our topicals 2x/day with about 12 hours in between each application.
01-21-2008 09:01 PM
For clen. But we're now talking albuterol. Somehow.
Originally Posted by rpen22
01-21-2008 09:21 PM
half the point of transdermals is that they release slowly. when you take a tablet of albuterol, the entire __ mg goes into your digestive system at once. with the transdermal, it slowly gets absorbed through the skin.
01-21-2008 09:21 PM
Running with the Big Boys
Actually, I just meant for Avant topicals in general, not what would be optimal for Albuterol administration.
Originally Posted by N4cer
01-21-2008 09:26 PM
And 3/4 the problem with them is you'd have to be a vegetable to not wear it all off or you'd have to be comfortable being a freak with Saran Wrap on you all day. The real deal is it'd be easier to just take the Napalm topically and the albuterol orally and call it a day probably.
Originally Posted by EasyEJL
01-21-2008 09:28 PM
There is a shorter half live in albuterol than clenbuterol but this may not be a clear disadvantage:
"Albuterol, like its closely related chemical cousin clenbuterol, is an asthma medication that has been adopted by athletes and bodybuilders as an ergogenic aid. Like clenbuterol, albuterol binds to the so called beta 2 adrenergic receptors found on cells throughout the body. The beta 2 receptors on fat cells activate an enzyme called hormone sensitive lipase. This breaks up stored fat into free fatty acids that are able to then leave the fat cell and serve as a fuel source in other tissues. In athletes the primary target of these fatty acids is working muscle. This is the familiar process we know as lipolysis. Albuterol, like clen, is a potent lipolytic agent. But simply freeing up fat is not enough. Unless the body can burn the extra FFA they will simply be reincorporated into fat. Albuterol has the ability to elevate a person's metabolic rate so these FFA can be utilized for fuel. Numerous animal studies have shown that clenbuterol increases both muscle size and strength; data supporting these effects in humans are sparse. Albuterol on the the other hand has been shown to significantly increase both strength and endurance in humans (1,2). As an added benfit, albuterol lowers LDL and total cholesterol, while at the same time elevating HDL, the "good cholesterol": "Significant alterations (P < or = .02) were observed in total cholesterol ([TC] -9.1% +/- 2.5%), low-density lipoprotein cholesterol ([LDL-C] - 15.0% +/- 2.9%), and high-density lipoprotein cholesterol ([HDL-C] +10.4% +/- 3.2%) concentrations, as well as the TC/HDL-C (-17.4% +/- 2.6%) and LDL-C/HDL-C (-22.9% +/- 2.4%) ratios." (3) 4 mg of albuterol taken approximately 1 to 2 hours before a workout allows for peak plasma levels to be reached during the training session. Additionally the much shorter half life of albuterol compared to clenbuterol allows one to benefit from its ergogenic effects during a training session but not suffer the sleeplessness that many clenbuterol users experience. Moreover, the short half life leads to much less beta 2 receptor downregulation than with clenbuterol, allowing one to use the drug daily for longer periods of time. On the other hand, if one is primarily interested in fat loss rather than performance enhancement, one could take 3 or 4 multiple doses of albuterol throughout the day, always of course cutting back if clenbuterol-like side effects are felt. 1 Bottle Of CEM Laboratories Liquid USP Albuterol Sulfate is 30 ML at 4 MG/ML. (1) Med Sci Sports Exerc. 2000 Jul;32(7):1300-6. Effect of salbutamol on muscle strength and endurance performance in nonasthmatic men. van Baak MA, Mayer LH, Kempinski RE, Hartgens F. (2) Aviat Space Environ Med. 2004 Jun;75(6):505-11 Albuterol helps resistance exercise attenuate unloading-induced knee extensor losses. Caruso JF, Hamill JL, Yamauchi M, Mercado DR, Cook TD, Keller CP, Montgomery AG, Elias J. (3) Metabolism. 1996 Jun;45(6):712-7 Effects of oral albuterol on serum lipids and carbohydrate metabolism in healthy men.
Maki KC, Skorodin MS, Jessen JH, Laghi F."
I've noticed that with albuterol the increase in heart rate is there, but since the half life is short, you don't notice the effect nearly as much as with clen. This is probably because I use it prior to a workout when my heart rate is up anyway. With clen, I notice it when I'm trying to get to sleep, for example.
The stimulation of the heart is a result of the fact that neither clenbuterol nor albuterol are completely selective for beta-2 receptors. They still act on beta-1 receptors to some degree, and these are the receptors that are primarily responsible for the cardiac effects. Ephedrine is nonselective, and that's probably why many people say they get better fat burning effects with an EC or ECA stack than with clen: the increase in heart rate is contributing to the calorigenic effect more than is the case with clen or albuterol. But it also has more side effects.
As far as the enantiomers go, albuterol contains an equal mixture of the R/S enantiomers, Xopenex consists of the R enantiomer. From the discussion above you can see that both enantiomers contribute to the calorigenic effect. The S form present in albuterol contributes to beta-1 activity, which increases heart contractility contributing to a portion of the calorigenic effect. Beta-1 receptors also contribute to lipolysis in fat cells.
In humans both beta-1 and beta-2 receptors contribute to thermogenesis, with there being conflicting data about the contribution from beta-3 receptors. See (1) for example. So some degree of beta 1 stimulation is desirable.
Both the R and S enantiomers of albuterol contribute to thermogensis by activating both the beta-1 and beta-2 (and probably beta-3 as well) receptors. Xopenex would likely be a much less effective thermogenic than albuterol because of its lack of beta-1 stimulation.
(1) Am J Physiol. 1993 Jan;264(1 Pt 1):E11-7.
Role of alpha- and beta-adrenoceptors in sympathetically mediated thermogenesis.
Blaak EE, van Baak MA, Kempen KP, Saris WH
01-21-2008 09:29 PM
true enough at least scent wise i know transdermals seem to stick around for hours
01-21-2008 09:36 PM
So at 4mg/ml how many ml would we want to be adding to a 120ml topical like Napalm or Lipo-U?
Right now the recommendation is 30ml of 100mcg/ml to 120ml of topical Napalm and Lipo-U
01-21-2008 09:37 PM
I think I just want to find some albuterol tablets
01-21-2008 09:41 PM
They are both b1 receptor agonists which have impact on cardiovascular health when taken orally. The one, albuterol has a shorter half life, yet still the b1 receptor aganist just the same.
01-21-2008 09:53 PM
i just want to not be fat dad, why do you have to keep crushing my dreams of magic pills?
01-21-2008 09:57 PM
Oh, I am not intending to crush your anti-fat dreams. But even when using clenbuterol I would only use it in this transdermal application to avoid systemic administration that will be potential cardiovascular risk. Albuterol has the same risk for shorter durations due to the shorter half life. But this can mean twice or more the dosing frequency. Risk all the same. Of course you can find albuterol for oral consumption if one choses to go that route
01-21-2008 11:56 PM
Avant Research Guru
Yes, but the problem is simply that your just saying it, without provide anything to support it.
Originally Posted by N4cer
The parent drug doesn't just disappear as one may easily infer from the above comment. Drug half life is very complex, and often non-linear.
Have a look here to get a better idea. Pharmacokinetic parameters such as clearance, volume of distribution, metabolism and dose are all paramount when determining the half life in vivo. For this reason I asked for the source of your claims and if you were aware of a particular mechanism unique to the biological processes inherent to albuterol metabolism.
While the reading above was educational, a distinct metabolic element for albuterol removal at the level of the adipocyte has yet to be discussed. To that effect, it appear that albuterol clears faster in obese subjects, suggesting it's poor distribution into lipophylic regions.
In light of all this, it should be obvious that BOTH can be acceptable in a topical solution. However,
I feel that albuterol is ideal for oral dosing, while the clenbuterol is better suited for topical solutions. The former strategy allows athletes to increase their basal metabolism and avoid insomnia, while the latter buffers the deleterious effects of clen on cardiovascular tissue.
01-22-2008 12:01 AM
Avant Research Guru
And to speak more generally to the entire topic:
It should be very clear now that albuterol is acceptable in a topical solution like Napalm, but is likely more effective taken orally (to boost metabolism and avoid insomnia).
All things considered, both will be very effective in a topical regardless.
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