~ATHLETIC EDGE NUTRITION-IntraXCell-FAQ-The Beta-Alanine Carnosine thread!~
- 03-27-2007, 12:15 AM
~ATHLETIC EDGE NUTRITION-IntraXCell-FAQ-The Beta-Alanine Carnosine thread!~
The World’s First Beta-Alanine, Carnosine Boosting Formula in convenient capsule form.
When You Think of Beta-Alanine, We Dare You Not to Think of IntraXCell!
Boost Strength and Increase Lean Muscle Gains with IntraXCell!
Athletic Edge Nutrition, The Nutrient Timing Specialists, is pleased to introduce IntraXCell, the biggest scientific breakthrough in physique enhancement and athletic performance since creatine. We have scientifically formulated precise doses of four key ingredients to create a product that will work synergistically to increase intramuscular Carnosine and Glutathione levels, which boosts strength, lean muscle mass and fights muscular fatigue at the cellular level.
The Result: Explosive Strength and Endurance, forcing lean muscle gains, physique improvements and muscular GROWTH!
IntraXCell is scientifically formulated to:
• Boost Explosive Muscular Strength and Endurance, Forcing
Lean Muscle Gains.
• Increase Intracellular Carnosine Levels and Fight Muscular
Fatigue & Metabolic Acidosis.
• Extreme Muscle Fullness and Vascularity.
• Naturally Boost the Power Antioxidant Glutathione and Fight
History is about to be made once again!
Until now, creatine, with numerous research studies to support its effectiveness, was the leading supplement for improving exercise and muscular performance. Since creatine exploded into the sports nutrition world in the early 90’s, our understanding of exercise physiology and sports nutrition has evolved exponentially. Exciting new research has given rise to another breakthrough, one that could change the direction of the industry like creatine did so many years ago..
Hydrogen ions are released during exercise, causing performance to plummet.
When we exercise, especially when it’s high intensity exercise, our bodies accumulate a large amount of hydrogen ions (H+), causing our muscles’ pH to drop (become more acidic). This process is occurring whether you feel a burn or not.
The breakdown of ATP and the subsequent rise in H+ concentrations occur in all of our energy systems but H+ buildup is most prevalent in an energy system called glycolysis, which also produces lactic acid. At physiological pH, lactic acid dissociates H+ and is the primary source of released H+ ions during exercise, causing pH to drop. It is the released H+ from lactic acid that causes muscular performance problems, not the leftover lactate ions as many incorrectly believe. While lactic acid is the primary source of released H+, it is not the only source. H+ ions are also being released at a rapid rate when you break down the high energy compound ATP during exercise. With the presence of many sources during energy production releasing H+, pH quickly drops as does muscular performance, slowing progress and lean muscle gains.
While muscle acidity has certainly proven to decrease strength and contribute to muscular fatigue, new research is now showing that exercise-induced intracellular free radical production is another source of muscular fatigue. The combination of muscular acidity and increased free radical production greatly diminishes your performance during exercise, stopping your workouts cold and interfering with lean muscle gains.
Fortunately, Athletic Edge Nutrition has developed a tool you can use to combat intracellular acidity and free radical production, pushing your performance, physique and results to the next level.
Q: How does IntraXCell combat H+ accumulation and free radical production to boosts my strength, fight cellular fatigue and increase my lean muscle gains?
Much of IntraXCell’s benefits come through its key ingredeint, Beta-Alanine. Beta-Alanine effects are realized through its ability to boost the synthesis of a powerful intramuscular buffer called carnosine. Carnosine is a naturally occurring di-peptide that has been consistently and scientifically proven to DRAMATICALLY affect athletic performance when increased above normal baseline levels. How much, can Beta-Alanine increase carnosine concentraions you ask? Daily supplementation with extra Beta-Alanine, can increase muscle carnosine concentrations by as much as 80% after 10-12 weeks
Due to the dramatic boost in our muscles buffering capacity, through supplementing with IntraXCell, you can expect BIG GAINS in strength, lean muscle and muscular endurance.
- 03-27-2007, 12:19 AM
Q: How does the rest of IntraXCell’s formula fit in with Beta-Alanine?
IntraXCell is more than just a carnosine booster designed to increase strength, lean muscle and endurance. IntraXCell also contains ingredients that work synergistically with each other and with carnosine. These ingredients act as direct precursors to the powerful antioxidant, glutathione.
1. N-Acetyl-L-Cysteine (NAC) - increases glutathione levels inside the cell which is a power antioxidant that fights cellular fatigue. Interestingly Beta-Alanine has now been shown to increase the synthesis of glutathione by increasing the availability of its precursor cysteine. Beta-Alanine and NAC work perfectly together.
2.Vitamin E – Vitamin E has been shown to increase carnosine levels more than carnosine alone. Carnosine has been shown to increases Vitamin E antioxidant ability. These two operate hand in hand.
3. Alpha-Lipoic-Acid – Finalizing this HIGHLY synergistic formula, alpha-lipoic-acid is utilized as a highly versatile antioxidant that boosts other antioxidants like Vitamin E and Glutathione.
These three ingredients combined with Beta-Alanine make IntraXCell an extremely powerful and versatile weapon in your quest for greater strength, lean muscle mass and super-charged endurance.
Q: Who can benefit from IntraXCell?
•Individuals participating in weight training looking to gain lean muscle mass and increase strength.
•Any individual involved in athletic activities where strength, power and muscular endurance are needed.
•Active individuals who have reached a training plateau and are looking for something to take them to the next level.
Q: How long will it take for me to start noticing benefits?
Performance benefits typically start occurring in as little as two weeks, although some individuals will notice benefits within one week. As carnosine levels continue to increase, so will the benefits. The most dramatic results are generally experienced within the 3-4 week range, but they don’t stop there. Recent research is now showing carnosine levels continue to increase up to at least 12 weeks, so the benefits just keep on getting better which is why we recommend to continuously stay on IntraXCell for at least 3 months to optimize your carnosine levels.
Immediate benefits: Many users experience intense vasodilatation/pumps from the very first time they take their first does of IntraXCell. The reason this occurs is because Beta-Alanine increases carnosine and carnosine is a powerful precursor in generating nitric oxide synthase (NOS). NOS are a group of enzymes necessary for making the powerful vasodilator nitric oxide. Take IntraXCell with SteelEdge prior to exercise and let us know your experience. We are confident that you will be very pleased pumps/vasodilatation from your very first workout.
Q: At what point during my set will IntraXCell have its strongest effects?
IntraXCell, unlike creatine, is effective at all points during your set whether you’re lifting heavy or doing endurance work. Your body uses three energy systems to perform work: the ATP-PC system, which is primarily used during heavy lifting and for sets in the 5-6 rep range; the glycolytic system, which is predominantly used roughly within the 7-15 rep range; and the oxidative/fat system which is used primarily in endurance training. Our energy systems are simultaneously utilized but depending on the level of intensity or duration, certain energy system will become more dominant. Anybody that trains with weights will use the first two systems predominantly and, in both cases, the result of the build-up of hydrogen ions will contribute to fatigue in both systems, especially glycolysis. This is where creatine falls a little short. It’s mostly effective in the ATP-PC system which relies on ATP and phosphocreatine (PC) for intense, high-energy contractions. Taking creatine will help your explosive and maximal strength but it won’t help you much in that 7-15 rep range. As anyone trying to build bigger muscles knows, you must train in both heavy and moderate (7-15 reps) ranges to gain lean mass. Only IntraXCell can fight the H+ build-up that occurs in both these ranges, allowing you to train at high levels regardless of your goals or your training intensity.
A recent study, in fact, showed that Beta-Alanine significantly outperformed creatine in decreasing cellular fatigue, giving it yet another advantage over what has been considered the most effective sport supplement of the last decade. With Beta-Alanine yielding impressive results in university-sponsored performance studies, creatine’s days at the top may be numbered.
Q: Does Beta-Alanine replace creatine?
Beta-Alanine does not replace creatine. As shown above, they work differently and creatine is still effective for increasing maximal strength and power. If anything, they should be taken together as the ultimate one-two punch.
03-27-2007, 12:23 AM
Q: How should I take IntraXCell?
Take two servings daily. IntraXCell may be taken with or without food, but we recommend it be taken with food as food may dampen the prickling sensation that some individuals experience from the Beta-Alanine content.
On Training days: Take one serving 15-20 minutes prior to exercise (can be conveniently taken with our Pre-Workout formula SteelEdge) and take one serving post workout. This protocol serves two purposes. One, it takes advantage the pre-workout timing benefits of increased blood flow driving Beta-Alanine into the working muscles. Two, the carbohydrate content in SteelEdge speeds up how quickly Beta-Alanine increases its performance benefits and there may also be synergy with the caffeine content in SteelEdge.
On Non-training days: Continue to take two servings daily with food.
For best results, use IntraXCell daily for a minimum of one month to optimize intracellular muscle carnosine levels. Performance benefits from IntraXCell will become noticeable in your workouts withing 1-2 weeks, and will continue to become stronger for the first three months as intracellualr carnosine levels continue to increase.
Q: How much Beta-Alanine is needed to cause performance increases?
Research has shown that you can take an amount between 3.2 grams and 6.4 grams per day to significantly boost carnosine levels and improve performance. The most recent research, now using 4-5 grams a day, is showing comparable carnosine concentration and performance improvements to those using 6.4 g daily.
Q: How long will a bottle of IntraXCell last me?
There are 60 servings in a bottle of IntraXCell. Two serving daily gives you exactly one month worth of product at 4 grams of Beta-Alanine per day, plus the highly beneficial NAC/ALA and Vitamin E.
Q: If one of the building blocks of carnosine is histidine, wouldn't it be beneficial to include it with beta-alanine to further boost muscle carnosine levels?
No, it wouldn't. Histidine is already present in high concentrations in muscle, while beta-alanine is present only in small amounts. Scientists have determined and demonstrated that it is beta-alanine that drives the intra-muscular synthesis of carnosine, not histidine.
Q: What other supplements do you recommend to maximize the results when taking IntraXCell?
•We recommend our Full Spectrum Pre-Workout Formula, SteelEdge. SteelEdge contains many ingredients that may work synergistically with IntraXCell. On training days, take IntraXCell with SteelEdge to amplify the benefits of each product.
•Creatine is another supplement that may work synergistically with IntraXCell and they can certainly be stacked together.
Q: Are there any methods that may increase Beta-Alanine’s ability to increase Carnosine levels?
Yes. A recent study showed that a group of subjects taking Beta-Alanine with carbohydrates increased performance gains in half the time of the group taking an equal amount of Beta-Alanine without carbohydrates. Carbohydrates spike insulin and one of insulin’s effects is to increase amino acid (such as Beta-Alanine) transport into our cells.
Q: What is the prickling I feel when I first take IntraXCell?
The prickling - called parathesia - is caused by Beta-Alanine binding to nerve receptors, activating them and causing them to discharge/fire. Many of these nerves are below the skin, giving a prickling/pins-and-needles sensation. This sensation begins approximately 15-20 minutes after ingesting Beta-Alanine and usually continues for 1-1.5 hours. The intensity varies depending on dosing, individual sensitivity and potentially from activators of Ca2+ channels, such as caffeine.
This sensation, though generally enjoyed, often subsides over a few weeks of continued use. Carbohydrates/food may also blunt the prickling effect from Beta-Alanine.
Q: Are their any stimulants in IntraXCell that would prevent me from taking it for a late night training session?
03-27-2007, 01:08 AM
Anyone, please feel free to jump in and ask Q's. We really enjoy interacting with enthusiasts and love the opportunity and format to be able to explain our products in full detail.
03-27-2007, 10:56 AM
03-27-2007, 01:51 PM
03-27-2007, 07:12 PM
For the guy in the gym, what this means is, more weight, for more reps, with less rest time between sets= overloading the muscle and Greater lean muscle mass.
Than there is the whole, antioxidant angle of IntraXCell, which is often overlooked. The ingredients in IntraXCell, not only boost carnosine levels, which has antioxidant effects, but IntraXCell also boosts glutathione, which is another powerful way to fight cellular fatigue caused by intracellular free radicals. This is an emerging area of interest in exercise physiology research and just another way IntraXCell boosts performance over just Beta-Alanine.
For athletes,such as strongmen competitors,MMA fighters, hockey, soccer and other sports that are predominantly performed in our energy system, called glycolysis, well there probably isn't a more specific supplement that will help them more than IntraXCell/ Beta-Alanine.
We currently sell through one of AM's board sponsors, Planetary Nutrition,.
03-27-2007, 07:51 PM
03-27-2007, 09:31 PM
03-28-2007, 12:11 AM
This video is of a young gentleman that was in one of our early rounds of IntraXCell/SteelEdge testers.
He is aspiring to become a strongman one day and was kind of enough to make this video for us on his own accord and post it in his log. Everytime I watch it, it gets me motivated.
Turn up the volume and enjoy.
[nomedia="http://youtube.com/watch?v=gJbzyUL8xos"]YouTube - Broadcast Yourself.[/nomedia]
03-29-2007, 01:25 PM
When most of us think about IntraXCell/Beta-Alanine, hopefully at this point we think of much of its performance benefits occurring from increasing CARN concentrations in term increasing our buffering capacity, neutralizing more H+ and controlling ph.
While this is the focus of the current research and most understood mechanism of action on how BA a acts as a performance enhancer, there are other ways it works as well.
Some are related again to increased CARNs concentrations and its effects on pH, while others are working independently of CARNs pH effects.
Some of these include:
1. Quenching intracellular free radicals and their connection to cellular fatigue i.e. potentially interfering with calcium uptake necessary for muscle contraction…ect
2. Regulation/activation of Ca2+ from the sarcoplasmic reticulum(SR)…crucial to the muscular contraction process and also ties in with the potential synergy of CARN and caffeine.
3. An enzyme regulator and activator within the various energy systems, this one I find particularly fascinating.
4. Decreases in pH interfering with ATP production and myosin-actin affinity (contractile components of muscle fibers).
5. CARNS connection with NOS/vasodilatation.
These are just a few of the directions I will try and take this thread in and hope others will jump in with there own input and experiences with Beta-Alanine supplementation!
Hopefully we can compile a solid base of info over here, giving AM readers a much more thorough understanding of IXL/BA’s effects beyond H+ buffering.
03-31-2007, 06:09 PM
As I said before, I hope to take this thread in some interesting directions and get into the nitty gritty of how BA supplementation works as a whole. When I first started seeing random threads on the forums about BA, it was simply looked at as a Lactic acid buffer. For some strange reason, BA was looked at as an aerobic/endurance supplement, eventhough all the research until recently shows BA performance affects work on anaerobic/strength/power/muscular endurance tests.
Only recently, does it seem that people are understanding the H+ connection and how it is the H+ that are causing fatigue through lowering pH, not intact lactic acid. As I've mentioned before, lactic acid does contribute to fatigue, but it contribution comes from the H+ is dissociates, NOT the left over lactate ion.
And even before lactic acid is significantly building up in glycolysis, H+ are getting produced much sooner in the ATP-PC system, causing pH to drop and strength to decrease and fatigue to set in
Aside from all the cool pH related research on Beta-Alanine, there are other potential ways BA may affect fatigue, not related to pH. One of them being Beta-Alanine boosts Carnosine and carnosine is a intracellular antioxidant as well as buffer.
Below is a summery of what I will touch on relating carnosine's antioxidant role and how it may fight fatigue.
• Quenching intracellular free radicals, often referred to as reactive oxygen species (ROS) and their connection to cellular fatigue i.e. potentially interfering with calcium uptake necessary for muscle contraction
The above sentence is one area that CARN is thought, though not proven to effect performance, separate from its buffering of H+. Aside from BA/CARN antioxidant connection, I thought it would also be interesting to look at the overall antioxidant aspect of IntraXCell, as IntraXCell is more than just Beta-Alanine. It contains NAC, ALA and E. All four ingredients in IntraXCell work as antioxidants fighting free radicals that cause cellular fatigue. Beta-Alanine antioxidant effects come through boosting CARN. NAC and ALA through boosting glutathione levels. vitamin E works synergisticly with carnosine antioxidant abilities and ALA comes back into the picture with its ability to boost vitamin E and glutathione levels.
(Some of the below is taken from a paper I wrote a while ago)
One of the main sites where ROS are thought to effect fatigue is the calcium storage sites known as the sarcoplasmic reticulum (SR).
The SR is located within a portion of the cell membrane called the sarcolemma, which surrounds a muscle cell. Once the muscle cell is initially stimulated by acetylcholine, this stimulation or excitation travels deep into the muscle cell and reaches the SR. When the SR is stimulated, it releases calcium ion(Ca2+), allowing the two protein filaments myosin and actin to interact and shorten, causing a muscle contraction. This whole sequence of events, though highly summarized, beginning from the nerve impulse to the actual shortening of the muscle cell, is called “excitation-contraction coupling.”
Research shows that tissue damaging, ROS are increased during exercise. While free radicals are a necessary process of physiology, they also contribute to muscular fatigue. One theory suggests that free radicals contribute to fatigue by damaging the SR, causing less Ca2+ to be released and hindering the muscular contraction process as a result. Low pH from H+ accumulation, may also negatively impact Ca2+ in many other ways, but the end result being, less forceful contractions, hurting performance
IntraXCell's formula of pH buffers and antioxidants, performs double duty in maintaining forceful contractions, by fighting ROS and buffering H+ accumulation.
Anyone feel free to jump in and add your thoughts/idea's..
03-31-2007, 06:38 PM
Looks interesting although I really couldn't read through all your posts. The scientific stuff gets really boring after awhile....You say to take it for at least 12 weeks to evaluate it. Thats a pretty long time, maybe it should be cheaper or some with more servings per bottle so its more cost effective?. I would try it because I just tried Green Mag and it has beta alanine in it. I have got great results from it, so I think it might be something elese in the product besides the Creatine because I don't respond to creatine at all. I like to try new creatine products though and see what happens. So I am thinking maybe I still don't respond to CEE but I do respond to something elese in that product, particulary the beta-alanine because I did get some nice pumps. I really want something that will help increase my endurance while running though.
03-31-2007, 06:48 PM
No, 1-2 weeks is when you start to get benefits from IntraXCell/Beta-Alanine. I talk about the studies going up to 12 showing performance benefits keep on getting better as BA continues to increase CARN levels.
You do NOT need 12 weeks to evaluate it. One bottle of IntraXCell which is a month, gives users strong gains and is all the time someone needs to know if they like it. Judging by all the MONTH long logs, everyone so far has been VERY pleased with IntraXCell.
GreenMAG does NOT have Beta-Alanine in it, but it does have taurine which has cell volumizing effects which is why you may be experiencing the pumps, aside from the creatines. GreenMAG stacks VERY well with IntraXCell.
03-31-2007, 06:58 PM
Well maybe CEE does actually work for me than. I have no idea. I know Green Mag worked but I stoped taking it because it gave me the runs. I only used it for about two weeks. I just dealt with the sides of running to the bathroom. I tried half dosing it and that didn't work, tried it with solid food and that didn't work. I must have been mistaken about the ingredients, I knew it had something in it that started with a b! - Betaine Anhydrous, I just checked. Anyway, all that aside will this product help with my endurance while doing steady state cardio?. I'm trying to get my endurance up and "train my breathing" so I'm not out of breath so fast. I'm starting to like endurance training a lot more lately.
03-31-2007, 07:03 PM
Yes, IntraXCell will help with your endurance, as a recent aerobic study recently showed. It may also help slow down your breathing rate, though if you were bored with my above explanations, my explanation IXL's effects on breathing rate might put you in the loony bin.
03-31-2007, 07:31 PM
Im looking forward to how intraXcell aids a rugby player like myself. Endurance is important in rugby but theres still plenty of pushing pulling lifting and pain.
03-31-2007, 07:37 PM
04-01-2007, 03:24 PM
Regardless, the players are loving our products and greatly benefiting.
04-01-2007, 03:27 PM
04-01-2007, 11:33 PM
04-01-2007, 11:40 PM
Lots of places to purchase our products, AM's very own sponsor Planetary Nutrition is one such place.
«Discount Bodybuilding Supplements – Discount Nutritional Supplements – Planetary Nutrition
Also, they can check our retailers listing here.
Athletic Edge Nutrition, Inc.
04-04-2007, 06:27 PM
For the most part, people seem to know that the NAC/ALA components of IntraXCell are not only safe, but extremely healthy for you, through boosting the powerful antioxidant glutathione. Both NAC/ALA of course have many other benefits most of us are familiar with by now, so we wont go into them at this time.
However,we do get asked this question very often, as many people are just starting to learn about Beta-Alanine as well as much of the performance/safety studies didn't come out until 2005-06.
Is Beta-Alanine Safe?
The answer to the safety question is a resounding YES. Studies, going up to 12 weeks of continued Beta-Alanine use, have looked at a large array of blood biochemical, hematological and hormonal markers and no negative changes have occurred whatsoever. While it is impossible to say Beta-Alanine is one hundred percent safe until longer term studies are complete, we do know that up to 12 weeks of continued Beta-Alanine supplementation is indeed safe.
04-10-2007, 05:35 PM
04-12-2007, 04:16 PM
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