- 05-04-2007, 05:30 PM
Wow this one is very small but came on Pubmed and well their arent words to describe it
Behavioral treatment of zoophilic exhibitionism.McNally RJ, Lukach BM.
Department of Psychology, Harvard University, Cambridge, MA 02138.
We describe here a case of zoophilic exhibitionism involving a mildly mentally retarded man who masturbated in front of large dogs of either sex. Unlike most exhibitionists, he did not expose himself to women, and unlike most zoophiles, he never desired direct sexual contact with animals. His paraphilia, however, was responsive to a behavioral program comprising masturbatory satiation, covert sensitization, and stimulus control procedures.
PMID: 1823663 [PubMed - indexed for MEDLINE]
- 05-04-2007, 05:31 PM
Imipramine-induced erection, masturbation, and ejaculation in male horses.McDonnell SM, Garcia MC, Kenney RM, Van Arsdalen KN.
Imipramine hydrochloride was administered to five male horses (400-500 kg b.wt.): one experienced young stallion, two mature normal breeding stallions, one 5-year-old stallion with erection and ejaculatory dysfunction, and one long-term castrated male horse. Oral imipramine treatment (100 to 600 mg, twice daily) led to frequent erection and masturbation while at rest in the stall in a nonsexual context. Intravenous imipramine treatment over a range of doses (50 to 1000 mg) similarly induced erection and masturbation in all animals. Erection typically occurred within 10 minutes after injection, and the erection and masturbation continued intermittently for 1 to 2 hours. These erections proceeded as during sexual excitement to a normal firmness and eventual engorgement of the glans penis. Two stallions ejaculated while masturbating. Mild ataxia and drowsiness appeared at the higher doses, but the animals remained responsive to auditory, visual, and tactile stimuli. Erection and masturbation were often interrupted by activities about the barn or the approach of the handler, suggesting cortical inhibitory control of the erection. When tested in a sexual context immediately following IV treatment (500 mg), the two mature breeding stallions bred normally. The 5-year-old stallion, which had not ejaculated over several months of breeding attempts, spontaneously ejaculated following IV imipramine treatment. Subsequently, this stallion has ejaculated during copulation while on low dose oral (100 mg. twice daily) imipramine treatment. Plasma total androgens increased during treatment in these stallions. The long-term castrate showed erection and masturbation following IV imipramine treatment, suggesting that the effect of imipramine is not testosterone dependent.
PMID: 3615542 [PubMed - indexed for MEDLINE]
- 05-04-2007, 05:38 PM
05-04-2007, 06:08 PM
05-04-2007, 06:09 PM
I will pick the winner on Sunday!! Until then, keep them coming!!
Dirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
05-04-2007, 08:45 PM
I just thought the title of this one deserved a look.
Am J Pathol. 2004 January; 164(1): 167–175.
Copyright © American Society for Investigative Pathology
Adult Gonadal Hormones Selectively Regulate Sexually Dimorphic Quantitative Traits Observed in Experimental Allergic Encephalomyelitis
Parley D. Fillmore,* Elizabeth P. Blankenhorn,† James F. Zachary,* and Cory Teuscher‡
From the Department of Veterinary Pathobiology,* University of Illinois at Urbana-Champaign, Urbana, Illinois; the Department of Microbiology and Immunology,† Drexel University College of Medicine, Philadelphia, Pennsylvania; and the Department of Medicine,‡ University of Vermont, Burlington, Vermont
Accepted September 22, 2003.
This article has been cited by other articles in PMC.
Materials and Methods
References AbstractExperimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS) are characterized by strong sexual dimorphisms, many of which may be due to genetically controlled sex hormone effects on the immune system, the central nervous system (CNS), or both. In the present study we used 487 gonadectomized and 376 intact age-matched F2 mice generated through crosses of B10.S/SgMcdJ and SJL/J mice to assess the role of adult gonadal hormones in regulating clinical and histopathological quantitative traits (QT) associated with EAE in the context of genetic heterogeneity. We found that gonadectomy resulted in different effects, depending on the QT and the sex of the mouse. Ovariectomized mice on average had lower cumulative clinical disease scores, shorter duration of clinical signs, and increased peak disease scores. This trend was accompanied by a significant increase in the incidence of acute, progressive EAE which is more frequently seen in intact and orchiectomized males. Although spinal cord (SC) inflammation was the better predictor of clinical signs of EAE in both sexes, ovariectomized females had considerable reductions in nearly all histopathological QT in both the brain and SC. Orchiectomy resulted in modestly significant increases in disease severity and peak score and earlier onset of clinical signs. With the exception of SC demyelination and lesion scores, orchiectomy had no effect on histopathological QT. Importantly, gonadectomy reduced but did not completely abolish any of the sexually dimorphic clinical QT seen in intact mice. It did however, lead to a significant sexual dimorphism in incidence and severity not seen in intact mice. For histopathological QT, no sexual dimorphism was detected for brain lesions in either intact or gonadectomized mice. In contrast, SC histopathological QT exhibited significant sexual dimorphisms, which were impacted by gonadectomy. The results from this study indicate that within the context of genetic heterogeneity, circulating gonadal hormones influence both clinical and histopathological QT in this model of MS, but they do not solely account for the sexual dimorphisms seen in these traits. Thus, additional mechanisms must play a role in regulating gender differences in autoimmune disease of the CNS.
05-04-2007, 08:53 PM
Prestigious Medical Journal Discovers New Use for Duct Tape
Under the category of "strange but true", according to the October 2002 issue of the Archives of Pediatric and Adolescent Medicine, research has shown that duct tape is more effective at removing warts than standard medical treatment. The study was conducted at the Madigan Army Medical Center near Tacoma, Washington. In the research 51 patients with warts between the ages of 3 and 22 were studied. One group received standard medical treatment for warts (cryotherapy) which consisted of liquid nitrogen applied to each wart for 10 seconds every 2-3 weeks for a maximum of 6 treatments. The other group had duct tape applied directly to the wart for a maximum of 2 months.
The results showed that of the 51 patients completing the study, 26 (51%) were treated with duct tape, and 25 (49%) were treated with cryotherapy. Twenty-two patients (85%) in the duct tape group vs 15 patients (60%) enrolled in the cryotherapy group had complete resolution of their warts. The researchers stated the obvious in their conclusion, "Duct tape occlusion therapy was significantly more effective than cryotherapy for treatment of the common wart."
According to lead researcher Dr. Dean "Rick" Focht III of Cincinnati Children's Hospital Medical Center, the duct tape irritated the warts, which apparently caused an immune system reaction that attacked the growths. He said researchers did not test other kinds of tape, and so they cannot say whether there is anything special about the gray, heavy-duty, fabric-backed tape.
The report in the journal did mention that there had been some reports of occlusion therapy (tape) for warts in the past. But there was no mention of why duct tape specifically was chosen for the study. Several comedians including Tim Nyberg, one-half of the comedy duo, "Duct Tape Guys" are having a field day with this latest research. "It's the universal panacea," Nyberg said.
source:Prestigious Medical Journal Discovers New Use for Duct Tape
05-04-2007, 10:33 PM
I nominate myself for the win because "penguin semen" is really near and dear to my heart. That was a study that had to be done for the greater good of mankind. Basically, by me posting it, I have changed the world as we know it.
(Actually, Im freaking addicted to RPM and Im saying its the best supplement Ive ever used and thats after DAY 6, so whether it's free or night, ugab will have a massive stockpile of RPM)
05-05-2007, 03:14 PM
I still havent got my sample but based on the sample of igf I got I am excited to get me some RPM.....or anything from AN
05-05-2007, 04:12 PM
A serological and fecal parasitologic survey of the critically endangered pygmy raccoon (Procyon pygmaeus).McFadden KW, Wade SE, Dubovi EJ, Gompper ME.
Department of Ecology, Evolution and Environmental Biology, Columbia University, 1200 Amsterdam Avenue, MC 5557, New York, NY 10027, USA.
The pygmy raccoon (Procyon pygmaeus) of Cozumel Island, Mexico, is among the most endangered carnivores in the world, and causes of its decline are unclear. During 2002 and 2003, we sampled approximately 10% of the remaining population to survey exposure to viral and parasitic pathogens that may have contributed to population decline. We found evidence of exposure to infectious canine hepatitis, canine distemper, feline panleukopenia virus, and Toxoplasma gondii. The latter is suggestive of spillover from domestic cats, which have only recently been introduced to the island. Additional parasites identified include Eimeria nutalli, Placoconus lotoris, Capillaria procyonis, Physaloptera sp., a mite in the family Listrophoridae, and a trematode in the family Heterophyidae. Several of these are typical of the parasite community of the common raccoon (Procyon lotor).
~ Nothing can kill the Grimace!!
05-05-2007, 04:13 PM
Human papillomavirus infection at the United States-Mexico border Giuliano AR, Papenfuss M, Abrahamsen M, Denman C, de Zapien JG, Henze JL, Ortega L, Brown de Galaz EM, Stephan J, Feng J, Baldwin S, Garcia F, Hatch K.
Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724-5024, USA. firstname.lastname@example.org
The United States-Mexico border is a region comprised of a country with one of the highest rates of invasive cervical cancer (Mexico) and a country with one of the lowest rates (United States). Recent evidence clearly indicates that human papillomavirus (HPV) infection is the cause of cervical cancer. The distribution of specific types of HPV is known to vary in different regions of the world, as do the cofactors that may inhibit or promote HPV carcinogenesis. Estimating the prevalence of oncogenic HPV is needed for guiding vaccine development. The purpose of this study was to determine the prevalence of oncogenic and nononcogenic HPV types and risk factors for HPV among women residing along the United States-Mexico border. A cross-sectional study of 2319 women, ages 15-79 years, self-referring for gynecological care was conducted between 1997 and 1998. HPV was detected by PCR using the PYGMY 09/11 L1 consensus primer, and HPV genotyping was conducted using the reverse line blot method. Overall, the HPV prevalence was 14.4% with no significant differences observed by country after adjustment for age. HPV 16 was the most commonly detected HPV type in both the United States and Mexico. Among women with high-grade squamous intraepithelial lesions, HPV types 58, 45, 51, 31, 35, 55, and 73 were most common in Mexico, and HPV types 18, 31, 35, 51, 52, and 58 were most common in the United States. In both countries, HPV prevalence declined linearly with age from 25% among women ages 15-19 years to 5.3% among women 56-65 years. Factors significantly independently associated with HPV infection were older age [adjusted odds ratio (AOR) = 0.15 for ages 56-65 years compared with those 15-19 years], a marital status other than married (AOR = 1.58-3.29), increased numbers of lifetime male partners (AOR = 3.8 for > or =10 partners compared with 1 partner), concurrent infection with Chlamydia trachomatis (AOR = 1.79), ever use of Norplant (AOR = 2.69), and current use of injectable contraceptives (AOR = 2.29). Risk factors for HPV infection did not differ by country. Results from this study suggest that in addition to HPV 16 and 18, HPV types 31, 45, 51, and 58 should be considered for inclusion in an HPV prevention vaccine for distribution in Mexico.
~ Nothing can kill the Grimace!!
05-06-2007, 10:56 AM
This was a toughy to pick- you guys found some really weird ****!!
Aeternitis for Rooster Related Eye Injuries
KJ Kristion for Percentage by Species of Homosexual Animals
SeanTaylor- Sword Swallowing
BPMartyr- Homosexual Necrophilia in the Mallard Duck
Chemist 2234- Genital Hair Tourniquet
BMW71285 for Dog Bites to Human Genitalia
Winner announced soon!!!
Dirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals
05-06-2007, 11:43 AM
"Sir - we have mutated sea bass" - #2Impact of acute cadmium exposure on the trunk lateral line neuromasts and consequences on the "C-start" response behaviour of the sea bass (Dicentrarchus labrax L.; Teleostei, Moronidae).Faucher K, Fichet D, Miramand P, Lagardere JP.
Centre de Recherche sur les Ecosystemes Marins et Aquacoles, CNRS-Ifremer, BP 5, L'Houmeau, France.
Behavioural responses of sea bass Dicentrarchus labrax were investigated after exposure to cadmium ions in laboratory-controlled conditions. The aim of this study was to discover whether environmental exposure to cadmium ions inactivates fish lateral line system neuromasts, and to determine the behavioural consequences of such a sensory blockage. For this, fish escape behaviour in response to an artificial water jet was recorded using a 25-frames s(-1) analog video camera before and after cadmium exposure. Experimental set up was tested with fish whose lateral line system was artificially inactivated by antibiotics (gentamicin and streptomycin). Histological analyses with scanning electron microscopy showed antibiotic treatment destroyed lateral line system neuromasts. In addition, these fish did not respond to stimulations provoked by the water jet after antibiotic treatment. Fish escape behaviour was then recorded before and after cadmium exposure at two different concentrations. When fish were exposed to the first concentration of cadmium tested (0.5 microg l(-1), which represents the maximal cadmium concentration encountered in contaminated estuaries), no alteration in neuromast tissue was observed. In addition, before cadmium exposure, fish responded positively in 98.41 +/- 4.95% of lateral line system stimulations (escape behaviour in response to the water jet). After cadmium exposure, no behavioural modification could be detected: the fish responded positively in 95.16 +/- 9.79% of stimulations (chi(2) = 2.464, p = 0.116). In contrast, the high cadmium concentration used (5 microg l(-1), which represents 10 times the concentration occurring in highly polluted estuarine areas) involved severe neuromast tissue damage. Just after such cadmium exposure, fish showed only 41.67 +/- 35.36% of positive responses to their lateral line system stimulations, while they responded positively in 95.93 +/- 9.10% of stimulations under control conditions (chi(2) = 24.562, p < 0.0001). Their lateral line system neuromasts seemed to regenerate about 1 month after cadmium exposure. Associated with this regeneration, from the 21st day after cadmium exposure, their escape behaviour had recovered and was not significantly different from that recorded under control conditions (86.74 +/- 20.82%, chi(2) = 2.876, p = 0.090). This study shows that although 5 microg l(-1) cadmium is able to damage lateral line system neuromasts and causes fish behavioural alterations, fish exposed to 0.5 microg l(-1) cadmium displayed neither tissue neuromast nor behavioural modification.
PMID: 16324755 [PubMed - indexed for MEDLINE]
"Are they ill tempered?" - Dr. Evil
05-06-2007, 11:48 AM
05-06-2007, 01:06 PM
05-06-2007, 01:26 PM
my vote is for the homosexual necrophelia in the mallard duck.... that is just akward AND funny as all hell.
05-06-2007, 01:33 PM
05-06-2007, 04:54 PM
05-06-2007, 04:54 PM
MOTIV8 II Challenge
-=The Big Squirrel Nut Swingers=-
05-06-2007, 05:59 PM
Sleep Experts Treat Medical Condition Behind Violent Sleep Sex
STANFORD, Calif. - In a new study, Stanford researchers describe a treatable medical condition which causes people to commit violent sexual acts in their sleep. Referred to as "sleep sex," the nocturnal activities cited in the study range from disruptive moaning to rape-like behavior toward bed partners.
The researchers believe this condition stems from glitches in brain waves during sleep. By bringing attention to the disorder, they hope the health-care community will recognize the problem as medical in origin rather than psychological. "Now doctors might know to ask patients about how they're sleeping," said Christian Guilleminault, MD, professor of psychiatry and behavioral sciences at the Stanford School of Medicine.
Guilleminault's study, released in the March/April issue of the journal Psychosomatic Medicine, outlined 11 patients with symptoms that included loud, disruptive moaning on one end of the scale and sexual assault on the other. Regardless of how unusual or violent the behavior, patients had no memory of the events the next morning.
Guilleminault divided the patients into three groups depending on the severity of their behavior. Those whose disturbances were simply annoying included two women who made sexual moaning sounds during the night. Though relatively harmless, one woman felt embarrassed and guilty that her moaning disturbed her spouse and children.
The second group consisted of a man and a woman whose disturbances placed them at physical risk. They experienced periods of violent masturbation that left bruising or soreness. The man also reported breaking two fingers trying to escape from restraints he had used to prevent the behavior.
The third group included six men and one woman who made unwanted - and sometimes violent - sexual advances on their bed partners while asleep. In one case, the patient tried to strangle his wife. A teenage child in the home heard the disturbance and called the police, eventually leading to a referral to the Stanford Sleep Clinic.
"What was surprising was the duration of the abnormal behavior and the fact that people weren't reporting it," Guilleminault said. One patient in the study had been aware of the unusual behavior for 15 years before talking about it with his doctor. "People have to realize that it's a medical problem and there is a treatment," he said.
Over the past 10 years, researchers have suspected that violent behavior during sleep is a sleep-related disorder, but they didn't have the facts to prove it. Although these cases sound psychological in origin, Guilleminault believes the underlying problem relates to sleep. Rather than quietly passing through the five phases of sleep - each of which has a classic brain-wave pattern - the patients in the study had unusual patterns during one of the sleep phases or short interruptions in their sleep. Sound and video recordings of the patients showed that the sleep-sex behavior took place during these hiccups in the sleep cycle. In addition, seven of the patients had a history of walking in their sleep.
In all cases except one, the sleep disturbances went away with sleep disorder treatments - the same ones that would prevent sleepwalkers from raiding the fridge at night. Therapy includes drugs in the same family as Valium and treatments used for breathing disturbances.
Guilleminault said each of the patients had additional emotional problems that may have altered the form their sleep disturbance took. "What your state of mind is will color the presentation," he said. But even if the patients had no emotional problems, he added, the underlying sleep disorder still would exist, though it may take the form of sleepwalking or talking in sleep.
Guilleminault added that because the sleep disorders were embarrassing, sufferers were less likely to complain and also didn't know where to turn for help with the problem. "The aggressor and the victim are often both in difficult situations and don't know how to express the problem," he said. "They feel that there is nowhere to turn."
---Stanford University Medical Center
05-06-2007, 07:28 PM
05-06-2007, 07:40 PM
Applied Nutriceuticals Representative
Better Results Through Science
Success occurs when everything you have is APPLIED.
Have you heard about N.O. Uptake? ;-)
05-06-2007, 08:44 PM
05-06-2007, 09:05 PM
05-06-2007, 11:10 PM
05-06-2007, 11:51 PM
A case of successful management of recurrent bacterial vaginosis of neovagina after male to female gender reassignment surgery.
* Jain A,
* Bradbeer C.
Department of Genito-Urinary Medicine, Lambeth Wing, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. email@example.com
As sex reassignment surgeries become common and advanced, doctors are more likely to encounter cases with 'different' anatomy. Due to variations in examination and management as compared with non-transsexual patients, these cases generally prove challenging to the physicians. We present a case of recurrent bacterial vaginosis (BV) of neovagina in a transsexual patient successfully managed by using metronidazole gel and occasional douching. This case illustrates the difference in the microscopy of vaginal flora and management of BV in transsexual as compared with non-transsexual women.
PMID: 17331294 [PubMed - in process]
Genital Sensitivity After Sex Reassignment Surgery in Transsexual Patients.
* Selvaggi G,
* Monstrey S,
* Ceulemans P,
* T'sjoen G,
* De Cuypere G,
* Hoebeke P.
From the Departments of *Plastic Surgery, daggerUrology, double daggerEndocrinology, and section signPsychiatry, Ghent University Hospital, Gent, Belgium.
BACKGROUND:: Tactile and erogenous sensitivity in reconstructed genitals is one of the goals in sex reassignment surgery. Since November 1993 until April 2003, a total of 105 phalloplasties with the radial forearm free flap and 127 vaginoclitoridoplasties with the inverted penoscrotal skin flap and the dorsal glans pedicled flap have been performed at Ghent University Hospital. The specific surgical tricks used to preserve genital and tactile sensitivity are presented.In phalloplasty, the dorsal hood of the clitoris is incorporated into the neoscrotum; the clitoris is transposed, buried, and fixed directly below the reconstructed phallic shaft; and the medial and lateral antebrachial nerves are coapted to the inguinal nerve and to one of the 2 dorsal nerves of the clitoris. In vaginoplasty, the clitoris is reconstructed from a part of the glans penis inclusive of a part of the corona, the inner side of the prepuce is used to reconstruct the labia minora, and the penile shaft is inverted to line the vaginal cavity. MATERIAL AND METHODS:: A long-term sensitivity evaluation (performed by the Semmes-Weinstein monofilament and the Vibration tests) of 27 reconstructed phalli and 30 clitorises has been performed. RESULTS:: The average pressure and vibratory thresholds values for the phallus tip were, respectively, 11.1 g/mm and 3 mum. These values have been compared with the ones of the forearm (donor site). The average pressure and vibratory thresholds values for the clitoris were, respectively, 11.1 g/mm and 0.5 mum. These values have been compared with the ones of the normal male glans, taken from the literature.We also asked the examined patients if they experienced orgasm after surgery, during any sexual practice (ie, we considered only patients who attempted to have orgasm): all female-to-male and 85% of the male-to-female patients reported orgasm. CONCLUSION:: With our techniques, the reconstructed genitalia obtain tactile and erogenous sensitivity. To obtain a good tactile sensitivity in the reconstructed phallus, we believe that the coaptation of the cutaneous nerves of the flap with the ilioinguinalis nerve and with one of the 2 nerves of the clitoris is essential in obtaining this result. To obtain orgasm after phalloplasty, we believe that preservation of the clitoris beneath the reconstructed phallus and some preservation of the clitoris hood are essential. To obtain orgasm after a vaginoplasty, the reconstruction of the clitoris from the neurovascular pedicled glans flap is essential.
PMID: 17413887 [PubMed - as supplied by publisher]
05-06-2007, 11:54 PM
Prefabrication of the free fibula osteocutaneous flap to create a functional human penis using a controlled fistula method.
* Chen HC,
* Gedebou TM,
* Yazar S,
* Tang YB.
Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.
Neophalloplasty remains one of the most challenging efforts in plastic and reconstructive surgery. The complex functional and aesthetic requirements are difficult to attain with consistency and safety. The current gold standard technique involves the use of a radial forearm tube-in-tube free flap, which also requires the placement of a stiffening prosthetic device for dual function. We report the safe use of the free fibula osteocutaneous flap to create a functional, cosmetically-acceptable penis utilizing the principles of prefabrication and controlled fistula method in one case of gender dysphoria.
PMID: 17479453 [PubMed - in process]
Neo-phalloplasty with re-innervated latissimus dorsi free flap: a functional study of a novel technique.
* Ranno R,
* Vesely J,
* Hyza P,
* Stupka I,
* Justan I,
* Dvorak Z,
* Monni N,
* Novak P,
* Ranno S.
Clinic of Plastic and Aesthetic Surgery, St. Anna University Hospital, Masaryk University, Brno, Czech Republic. firstname.lastname@example.org
Twenty two patients with gender dysphoria underwent neo-phalloplasties using a novel technique. Latissimus dorsi musculocutaneus re-innervated free flap was used to allow voluntary rigidity of the neo-penis. From the first 22 patients, 18 have obtained motoric function of reconstructed penis; the "paradox erection" was obtained. 14 patients came for examination after a follow-up period of mean 26.4 months. We evaluated the motility and shape changes of neo-phallus measuring its different size and dimension during relax and muscle contraction. The range of neo-phallus length in relaxed position was between 7 and 17 cm (mean 12.2 cm), its circumference in the same position had a range between 13 and 20 cm (mean 13.7 cm). All patients were able to contract the muscle with an average length reduction of 3.08 cm and an average circumference enlargement of 4 cm. In this study, the dimensions and motility were quantified demonstrating the neo-phallus function and size changes during sexual intercourse.
PMID: 17469438 [PubMed - in process]
A case of penile fracture with complete urethral disruption during sexual intercourse: a case report.
* Jagodic K,
* Erklavec M,
* Bizjak I,
* Poteko S,
* Korosec Jagodic H.
ABSTRACT: Penile fracture is a rare condition. Primarily it is a rupture of the corpus cavernosum that occurs when the penis is erect. The rupture can also affect the corpus spongiosum and the urethra. We report a case of a 37 year old man who presented with acute penile pain, penile swelling and the inability to pass urine after a blunt trauma during sexual intercourse. In emergency surgery we found bilateral partial rupture of the corpus cavernosum with complete urethral and corpus spongiosum disruption. In the one year follow up the patient presented with normal erectile and voiding function. Emergency surgical repair in penile fracture can preserve erectile and voiding function.
PMID: 17474981 [PubMed - as supplied by publisher]
05-07-2007, 12:01 AM
Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.
* Nakade Y,
* Mantyh C,
* Pappas TN,
* Takahashi T.
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
BACKGROUND: Fecal pellet output has been assessed as a colonic motor activity because of its simplicity. However, it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output. We examined the causal relationship between colonic transit and fecal pellet output stimulated by the central application of corticotropin-releasing factor (CRF) and restraint stress. METHODS: Immediately after intracisternal injection of CRF, (51)Cr was injected via a catheter positioned in the proximal colon. Ninety minutes after (51)Cr injection, the total number of excreted feces was counted, and then the rats were killed. The radioactivity of each colonic segment was evaluated, and the geometric center (GC) of the distribution of (51)Cr was calculated. For the restraint stress study, after administration of (51)Cr into the proximal colon, rats were submitted to wrapping restraint stress for 90 min. Then they were killed, and GC was calculated. RESULTS: Both restraint stress and CRF significantly accelerated colonic transit. There was a positive correlation observed between fecal pellet output and GC of colonic transit in response to restraint stress, but not CRF, when the number of excreted feces was more than three. In contrast, there was no significant correlation observed between the two in stress and CRF when the number of excreted feces was less than two. CONCLUSIONS: The acceleration of colonic transit in response to restraint stress and central administration of CRF does not always correlate with an increase in fecal pellet output.
PMID: 17464456 [PubMed - in process]
Anal canal anatomy showed by three-dimensional anorectal ultrasonography.
* Regadas FS,
* Murad-Regadas SM,
* Lima DM,
* Silva FR,
* Barreto RG,
* Souza MH,
* Filho FS.
Department of Surgery, Medical School of the Federal University of Ceara and Hospital Sao Carlos, Av Edilson Brasil Soares, 1892. Edson Queiroz, 60834-220, Fortaleza, Ceara, Brazil, email@example.com .br.
BACKGROUND: Demonstrate precisely the anatomic configuration of the anal canal and the length and thickness of the anal sphincters using three-dimensional (3-D) anorectal ultra-sonography in both genders. METHODS: Twelve normal volunteer males and 14 females, with a mean age of 52.4 and 50.3 years, respectively, were prospectively enrolled in this study. All individuals from both groups were submitted to anorectal ultra-sonography. The anal canal was analyzed, measuring the length and thickness of the external anal sphincter (EAE), internal anal sphincter (IAS), puborectalis muscle (PR) and the gap (distance from the anterior EAS to the anorectal junction) in the midline longitudinal (ML) and transverse (MT) planes, and the results were compared between quadrants and genders. RESULTS: The distribution of sphincter muscles is asymmetric in both genders. The anterior upper anal canal is an extension of the rectal wall with all layers clearly identified. The anterior IAS is formed in the distal upper anal canal and is significantly shorter in female than in male in all quadrants. The anterior IAS length is shorter than the posterior and lateral in both genders. The anterior EAS length is significantly shorter (2.2 cm) and the gap is longer (1.2 cm) in female than in male (3.4 cm) (0.7 cm) (p < 0.05), respectively. The posterior and lateral EAS-PR is significant longer in males (3.6 cm) (3.9 cm) than in females (3.2 cm) (3.5 cm) (p < 0.05), respectively. The lateral EAS-PR is significant longer than the posterior part in both genders. The anterior IAS is significantly thicker in males (0.19 cm) than in females (0.12 cm) (p = 0.04). CONCLUSION: 3-D anal endosonography enabled measurement of the different anatomical structures of the anal canal and demonstrated its asymmetrical configuration. The shorter anterior EAS and IAS associated with a longer gap could justify the higher incidence of pelvic floor dysfunction in females, especially fecal incontinence and anorectocele with rectal intussusception.
PMID: 17479327 [PubMed - as supplied by publisher]
Anal Sphincter Laceration at Vaginal Delivery: Is This Event Coded Accurately?
* Brubaker L,
* Bradley CS,
* Handa VL,
* Richter HE,
* Visco A,
* Brown MB,
* Weber AM.
Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa; Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;. and National Institute of Child Health and Human Development, Bethesda, Maryland.
OBJECTIVE: To determine the error rate for discharge coding of anal sphincter laceration at vaginal delivery in a cohort of primiparous women. METHODS: As part of the Childbirth and Pelvic Symptoms study performed by the National Institutes of Health Pelvic Floor Disorders Network, we assessed the relationship between perineal lacerations and corresponding discharge codes in three groups of primiparous women: 393 women with anal sphincter laceration after vaginal delivery, 383 without anal sphincter laceration after vaginal delivery, and 107 after cesarean delivery before labor. Discharge codes for perineal lacerations were compared with data abstracted directly from the medical record shortly after delivery. Patterns of coding and coding error rates were described. RESULTS: The coding error rate varied by delivery group. Of 393 women with clinically recognized and repaired anal sphincter lacerations by medical record documentation, 92 (23.4%) were coded incorrectly (four as first- or second-degree perineal laceration and 88 with no code for perineal diagnosis or procedure). One (0.3%) of the 383 women who delivered vaginally without clinically reported anal sphincter laceration was coded with a sphincter tear. No women in the cesarean delivery group had a perineal laceration diagnostic code. Coding errors were not related to the number of deliveries at each clinical site. CONCLUSION: Discharge coding errors are common after delivery-associated anal sphincter laceration, with omitted codes representing the largest source of errors. Before diagnostic coding can be used as a quality measure of obstetric care, the clinical events of interest must be appropriately defined and accurately coded. LEVEL OF EVIDENCE: II.
PMID: 17470596 [PubMed - as supplied by publisher]
05-07-2007, 12:15 AM
Fertilizability and chromosomal integrity of frozen-thawed Bryde's whale (Balaenoptera edeni) spermatozoa intracytoplasmically injected into mouse oocytes.
* Watanabe H,
* Tateno H,
* Kusakabe H,
* Matsuoka T,
* Kamiguchi Y,
* Fujise Y,
* Ishikawa H,
* Ohsumi S,
* Fukui Y.
Department of Animal Production Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Prior to attempting the in vitro production of embryos in the Bryde's whale (Balaenoputera edeni), we investigated whether spermatozoa can retain the capacity for oocyte activation and pronucleus formation as well as chromosomal integrity under cryopreservation by using intracytoplasmic sperm injection (ICSI) into mouse oocytes. Regardless of motility and viability, whale spermatozoa efficiently led to the activation of mouse oocytes (90.3-97.4%), and sperm nuclei successfully transformed into male pronucleus within activated ooplasm (87.2-93.6%). Chromosome analysis at the first cleavage metaphase (M) of the hybrid zygotes revealed that a majority (95.2%) of motile spermatozoa had the normal chromosome complement, while the percentage of chromosomal normality was significantly reduced to 63.5% in immotile spermatozoa and 50.0% in dead spermatozoa due to the increase in structural chromosome aberrations. This is the first report showing that motile Bryde's whale spermatozoa are competent to support embryonic development.
PMID: 17391541 [PubMed - indexed for MEDLINE]
Semen collection in rhinoceroses (Rhinoceros unicornis, Diceros bicornis, Ceratotherium simum) by electroejaculation with a uniquely designed probe.
* Roth TL,
* Stoops MA,
* Atkinson MW,
* Blumer ES,
* Campbell MK,
* Cameron KN,
* Citino SB,
* Maas AK.
Center for Conservation and Research of Endangered Wildlife, Cincinnati Zoo and Botanical Garden, 3400 Vine Street, Cincinnati, Ohio 45220, USA.
Electroejaculation in rhinoceroses has historically yielded inconsistent results, with the collection of high-quality, sperm-rich samples rare. The goal of this study was to develop a reliable method of electroejaculation in the rhinoceros by designing a rectal probe that appropriately fits the anatomy of this taxon and refining the procedure. A curved probe handle ending in an oblate, ellipsoid head was built using readily available supplies. A combination of rectal massage, penile massage, and electrical stimulation with a specially designed probe was employed in attempts to collect semen on 14 occasions from greater one-horned rhinoceroses (Rhinoceros unicornis; n = 4), black rhinoceroses (Diceros bicornis; n = 2) and a southern white rhinoceros (Ceratotherium simum; n = 1). During 13 of the 14 attempts, ejaculates were collected in multiple fractions. All but one of the ejaculates contained spermatozoa, and seven ejaculates contained good-quality fractions of semen (-60% sperm motility; > or =20 x 106 spermatozoa/ml) suitable for sperm banking and assisted reproduction procedures. Mean (+/-SEM) values for volume, pH, osmolality, and total sperm number for ejaculates containing good-quality fractions (98.2 +/-21.8 ml, 8.5+/-0.1, 290.4+/-6.7 mOsm, and 37.1+/-12.0 x 10(9), respectively) did not differ (P > 0.05) from those containing only poor-quality samples. Urine and/or erythrocyte contamination was not uncommon in fractions of both ejaculate types. Males producing good-quality samples ranged in age from 7 to 34 yr. None of the samples contained > or =75% morphologically normal spermatozoa. Electroejaculation with a uniquely designed probe consistently produced ejaculates in the rhinoceros. However, the production of high-quality samples continued to be challenging, occurring in only 50% of collection attempts. Regardless, the technology has progressed to a stage at which good-quality semen samples can be produced for sperm banking and assisted reproduction, and thereby can be integrated into intensive rhinoceros management strategies for the ultimate survival of this taxon.
PMID: 17312718 [PubMed - indexed for MEDLINE]
05-07-2007, 12:18 AM
Assessment of penile vibratory stimulation as a management strategy in men with secondary retarded orgasm.
* Nelson CJ,
* Ahmed A,
* Valenzuela R,
* Parker M,
* Mulhall JP.
Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA. firstname.lastname@example.org
OBJECTIVES: To evaluate the effectiveness of penile vibratory stimulation for the management of retarded orgasm. Retarded orgasm, a condition characterized by difficulty achieving orgasm and ejaculation, is one of the most recalcitrant of the male sexual dysfunctions. Currently, no evidence-based treatments have been proven to ameliorate this condition. METHODS: Men who had a complete inability to achieve an orgasm during sexual relations in the previous 3 months were instructed in the use of penile vibratory stimulation. The men's responses were measured by self-report of orgasm function and using the orgasm and satisfaction domains of the International Index of Erectile Function. The responses were assessed at baseline (admission into the study) and at 3 and 6 months. RESULTS: A total of 36 men met the inclusion criteria, and 72% reported the restoration of orgasm. These responders reported that orgasm during sexual relations occurred 62% of the time. A statistically and clinically significant increase occurred in the orgasm and satisfaction domains of the International Index of Erectile Function between the baseline visit and the 3-month follow-up visit. These gains were sustained at 6 months. CONCLUSIONS: Penile vibratory stimulation is an effective treatment for retarded orgasm. Penile vibratory stimulation should be integrated into current cognitive-behavioral sex therapy techniques to achieve maximal effectiveness and satisfaction.
PMID: 17382163 [PubMed - indexed for MEDLINE]
[G-spot and female ejaculation: fiction or reality?]
[Article in Hebrew]
* Rabinerson D,
* Horowitz E.
Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva.
The G-spot is an ill-defined region, located on the anterior vaginal wall, in its upper outer third, suggested by Ernst Grafenberg, and commemorates the first letter of his name. This area is sensitive to tactile touch, which, when applied, is claimed to result in an intense female orgasm. The G-spot is thought to be the vaginal part that lies beneath the posterior part of the "female prostatic gland", which, when stimulated, results in female ejaculation during orgasm. G-spot and female ejaculation have been studied intensively during the last 50 years and there is scientific (anatomical and biochemical) evidence for their existence. However, this evidence has been challenged, and the debate regarding the existence of the G-spot and female ejaculation as true clinical entities is still ongoing.
PMID: 17352286 [PubMed - indexed for MEDLINE]
05-07-2007, 12:23 AM
Characteristics of ejaculated rat semen after lesion of scrotal nerves.
* Garcia LI,
* Soto-Cid A,
* Carrillo P,
* Toledo R,
* Hernandez ME,
* Manzo J.
Instituto de Neuroetologia, Universidad Veracruzana, Apartado Postal 566, Xalapa, Ver., 91000, Mexico.
The scrotum, representing the pouch surrounding the testes and their associated structures, plays a significant role in maintaining the gonad at a temperature lower than that of the body. Although thermoregulation of the testes has been ascribed as a main function of the scrotum, here we found that mechanical stimulation of the scrotum is important during mating to facilitate the appropriate expulsion of semen during ejaculation. Previously we showed that the scrotal skin area is innervated by two nerve branches, the proximal (Psb) and distal (Dsb) scrotal branches which supply the proximal or distal half of the scrotum, respectively. The sensory field of each nerve is testosterone-dependent. The decreased androgen levels following castration reduce the sensitive area to mechanical stimuli that can be restored following exogenous administration of the hormone. Here, we tested the effect of scrotal nerve transection on sexual parameters of experienced male rats. Data show that lesion of PSb or DSb alone or combined did not affect the execution of sexual behavior. However, these lesions significantly reduced the proportion of males that expelled semen during ejaculation, with that semen showing a reduced quantity of sperm. Thus, scrotal nerves are important in reproduction not for the appropriate display of sexual behavior, but for the expulsion of a normal quantity of semen and number of sperm during ejaculation. Our suggestion is that scrotal afferents trigger spinal reflexes to activate autonomic efferents supplying the male reproductive tract for the control of seminal emission.
PMID: 17343882 [PubMed - in process]
Involvement of nitric oxide in cocaine-induced erections and ejaculations after paradoxical sleep deprivation.
* Andersen ML,
* Perry JC,
* Antunes IB,
* Tufik S.
Department of Psychobiology - Universidade Federal de Sao Paulo, Escola Paulista de Medicina (UNIFESP/EPM), R. Napoleao de Barros, 925, V. Clementino 04024-002, Sao Paulo, SP, Brazil.
OBJECTIVES: As nitric oxide (NO) is involved in penile erectile (PE) function and also influences the sleep-wake cycle, we speculated that NO could play a role in PE and ejaculation of paradonical sleep deprivation (PSD) rats. METHODS: Animals were pretreated with N(G)-nitro-l-arginine methyl ester (l-NAME, ip) and l-arginine (ip and icv) prior to saline or cocaine injection. RESULTS: Cocaine-induced PE in 90% of PSD rats, 60% of which ejaculated. l-NAME reduced the frequency of erection, but had no effect in the proportion of PSD-cocaine-injected rats displaying this response. l-NAME had no effect in saline groups. l-Arginine in PSD-saline rats reduced the proportion of animals displaying PE at the highest dose and reduced the frequency of PE at all doses in both saline and cocaine groups. The icv administration of l-arginine reduced PE only in PSD-cocaine rats. Results indicate that common to both drugs, whether it was NO synthase (NOS) inhibitor or NO precursor, was their capacity to strongly reduce PE frequency in cocaine-treated rats. Moreover, l-arginine (ip) played a relevant inhibitory role in the erection displayed by PSD rats. CONCLUSIONS: Our findings suggest that the stimulating effects of PSD associated or not with cocaine on erection can be modified by alterations in the NO system.
PMID: 17276569 [PubMed - in process]
Application of 2 vibrators salvages ejaculatory failures to 1 vibrator during penile vibratory stimulation in men with spinal cord injuries.
* Brackett NL,
* Kafetsoulis A,
* Ibrahim E,
* Aballa TC,
* Lynne CM.
Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.
PURPOSE: Penile vibratory stimulation is the treatment of first choice for anejaculation in men with spinal cord injury. Nonresponders to penile vibratory stimulation are usually referred for electroejaculation or surgical sperm retrieval. Compared to penile vibratory stimulation these methods are invasive and usually yield lower total motile sperm, potentially limiting options for assisted reproductive technologies. To avoid these less than ideal options a simple method to salvage penile vibratory stimulation failures would be of benefit to spinal cord injured patients. We investigated the recovery rate when 2 vibrators were used to salvage ejaculatory failures to 1 vibrator in men with spinal cord injury. MATERIALS AND METHODS: A retrospective chart review was performed in 297 spinal cord injured men who underwent a total of 965 trials of penile vibratory stimulation at our center between 1991 and 2006. Only trials with high amplitude vibrators were examined. All men underwent 2 or more penile vibratory stimulation trials using 1 vibrator applied to the dorsum or frenulum of the glans penis. Men failing to ejaculate with 1 vibrator received 1 or more trials in which the glans penis was then sandwiched between 2 vibrators. RESULTS: Of all men 49% and 57% of those whose level of injury was T10 or above responded to penile vibratory stimulation with 1 vibrator. Of failures with 1 vibrator 22% responded to penile vibratory stimulation with 2 vibrators. CONCLUSIONS: Application of 2 vibrators salvaged ejaculatory failures to 1 vibrator during penile vibratory stimulation procedures in men with spinal cord injury. This simple penile vibratory stimulation sandwich method is recommended before referring patients for electroejaculation or surgical sperm retrieval.
PMID: 17222653 [PubMed - indexed for MEDLINE]
05-07-2007, 12:42 AM
The gag reflex and fellatio.
* GIOSCIA N.
PMID: 14783215 [PubMed - indexed for MEDLINE]
Delusion of pregnancy in a male homosexual with an abdominal cancer.
* ARONSON GJ.
PMID: 14944984 [PubMed - indexed for MEDLINE]
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