[rms80]

Originally Posted by xjsynx

Man, I hate to get off track again...But in your Avatar, is that an American Bulldog with it's pup?

Yep Mugsy and Bianca- my two children- they are actually from different breeders- some of the most friendly dogs in the world!!

[rms80]

Originally Posted by ugab37

My lady loves those dogs. I'll definately be suprising her and scoring some major points when I find one at the right price.

ok, back on topic...

I can give you the name of a pretty good breeder- he is down east of Columbia....pretty inexpensive- my brother in law got a white boxer from him, and I got Bianca

[rms80]

Originally Posted by xjsynx

Yeah they can be expensive, but my Bully is the best dog I have ever had.

Agreed- they are sitting here play fighting right now

[tuberman]

Dirk,

Isn't it true that naringin and it's component Naringenin is a pretty damn good to excellent potentiator of many things, not just icariin and caffeine?

When I get my samples (tommorrow, I hope), I intend to give RPM an extra tough test. First time, I'll test it with weight training, perhaps deadlifts. But then, I'll see if it will potentiate my endurance stack (second test). The endurance test will be tough, as RPM is not primarily designed for that, and I have a great endurace stack already. I use beta alanine, citrulline malate, plcar, some caffeine and a decent quality cordyceps for my endurace stack which has been super, and I mean really super. Yet I figure if I go for intensity, I can probably up it one more notch with RPM (smashing the pedals in mountain climbing gears on the bike).

I'll be very happy with just the extra intensity for weight training. I'd like to add another 50-60 pounds to my deadlift in the next few months. Bonus endurance would be a gift that goes beyond my expectations.

[determination]

I have tried rpm three times now and it is a great pre workout supplement. It gave me great energy, focus and pumps. What I really noticed was a very noticable increase in alpha-male mentality. I think I will be buying a bottle of this. I also had a great mood and felt like getting things done when I took it. I dosed it 4,4,3. I got 11 caps. 10 good ones and one broken one. the powder from the broken one tasted horrible.

[rms80]

Originally Posted by tuberman

Dirk,

Isn't it true that naringin and it's component Naringenin is a pretty damn good to excellent potentiator of many things, not just icariin and caffeine?

When I get my samples (tommorrow, I hope), I intend to give RPM an extra tough test. First time, I'll test it with weight training, perhaps deadlifts. But then, I'll see if it will potentiate my endurance stack (second test). The endurance test will be tough, as RPM is not primarily designed for that, and I have a great endurace stack already. I use beta alanine, citrulline malate, plcar, some caffeine and a decent quality cordyceps for my endurace stack which has been super, and I mean really super. Yet I figure if I go for intensity, I can probably up it one more notch with RPM (smashing the pedals in mountain climbing gears on the bike).

I'll be very happy with just the extra intensity for weight training. I'd like to add another 50-60 pounds to my deadlift in the next few months. Bonus endurance would be a gift that goes beyond my expectations.

Si Senor!!

Contraception. 1996 Jan;53(1):41-7. Links
Can grapefruit juice influence ethinylestradiol bioavailability?Weber A, Jager R, Borner A, Klinger G, Vollanth R, Matthey K, Balogh A.
Department of Clinical Pharmacology, Friedrich Schiller University of Jena, Germany.

The effects of grapefruit juice on the bioavailability of 17 alpha-ethinylestradiol (EE2) after a single oral administration of 50 micrograms EE2 have been investigated. The pharmacokinetics of EE2 were studied in an open, randomized, cross-over study in which 13 healthy volunteers were administered the drug with herbal tea or grapefruit juice (naringin, 887 mg/ml). In contrast to herbal tea, grapefruit juice increased the peak plasma concentration (Cmax) significantly to 137% (mean; range 64% to 214%, p = 0.0088) and increased the area under plasma concentration-time curve from 0 to 8 hours (AUC0-8) to 128% (mean; range 81% to 180%, p = 0.0186). This study shows that grapefruit juice increases the bioavailable amount of EE2. A possible explanation may be that grapefruit juice inhibits the metabolic degradation of EE2. Whether the increased bioavailability of EE2 following grapefruit juice administration is of clinical importance should be investigated in long-term studies.

Drug Metab Dispos. 2006 Apr;34(4):521-3. Epub 2006 Jan 13. Links
Inhibitory effects of fruit juices on CYP3A activity.Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH.
Department of Pharmacology, Inje University College of Medicine, # 633-165, Gaegum-Dong, Jin-Gu, Busan 614-735, South Korea.

There have been very limited reports on the effects of commercial fruit juices on human CYP3A activity. Therefore, the inhibitory effects of readily available commercial fruit juices on midazolam 1'-hydroxylase activity, a marker of CYP3A, were evaluated in pooled human liver microsomes. The fruit juices investigated were black raspberry, black mulberry, plum, and wild grape. White grapefruit, pomegranate, and orange juice were used as positive and negative controls. The black mulberry juice showed the most potent inhibition of CYP3A except for grapefruit juice. The inhibition depended on the amount of a fruit juice added to the incubation mixture. The inhibitory potential of human CYP3A was in the order: grapefruit > black mulberry > wild grape > pomegranate > black raspberry. The IC(50) values of all fruit juices tested were reduced after preincubation with microsomes in the presence of the NADPH-generating system, suggesting that a mechanism-based inhibitory component was present in these fruit juices, as in the case of grapefruit. The results suggest that, like grapefruit juice, commercial fruit juices also have the potential to inhibit CYP3A-catalzyed midazolam 1'-hydroxylation. Therefore, in vivo studies investigating the interactions between fruit juices such as black mulberry and wild grape and CYP3A substrates are necessary to determine whether inhibition of CYP3A activity by fruit juices is clinically relevant.




Biol Pharm Bull. 2003 Sep;26(9):1371-3. Links
Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans.Fujita K, Hidaka M, Takamura N, Yamasaki K, Iwakiri T, Okumura M, Kodama H, Yamaguchi M, Ikenoue T, Arimori K.
Department of Pharmacy, Miyazaki Medical College Hospital, Miyazaki-gun, Japan. kfujita@post.miyazaki-med.ac.jp

The capacities of citrus fruits to inhibit midazolam 1'-hydroxylase activity of cytochrome P450 3A (CYP3A) expressed in human liver microsomes were evaluated. Eight citrus fruits such as ama-natsu, banpeiyu, Dekopon, hassaku, hyuga-natsu, completely matured kinkan (Tamatama), takaoka-buntan and unshu-mikan were tested. We also examined the inhibition of CYP3A activity by grapefruit (white) and grapefruit juice (white, Tropicana-Kirin). The addition of a fruit juice prepared from banpeiyu, hassaku, takaoka-buntan or Tamatama caused the inhibition of the microsomal CYP3A activity. The inhibition depended on the amount of a fruit juice added to the incubation mixture (2.5 and 5.0%, v/v). The fruit juice from banpeiyu showed the most potent inhibition of CYP3A. The addition of a banpeiyu juice (5.0%, v/v) resulted in the inhibition of midazolam 1'-hydroxylase activity to about 20% of control without a fruit juice. The elongation of the preincubation period of a fruit juice from banpeiyu (5.0%, v/v) with the microsomal fraction (5 to 15 min) led to the enhancement of the CYP3A inhibition (5% of control). Thus, we discovered ingredients of banpeiyu to be inhibitor(s) or mechanism-based inhibitor(s) of human CYP3A activity, but the inhibitory effects of them were somewhat lower than those of grapefruit.




Clin Pharmacol Ther. 2002 Jan;71(1):21-9. Links
Comment in:
Clin Pharmacol Ther. 2005 Oct;78(4):441-3.
Effects of grapefruit juice on the pharmacokinetics of sildenafil.Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, Hering U, Bulitta J, Schreiner P, Sorgel F, Fuhr U.
Institute for Pharmacology, Clinical Pharmacology, University of Koln, Germany. alexander.jetter@medizin.uni-koeln.de

BACKGROUND AND OBJECTIVES: Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N -desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this study we investigated the influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N -desmethylsildenafil. METHODS: In a randomized crossover study, 24 healthy white male volunteers received single 50-mg doses of sildenafil. Two doses each of 250 ml grapefruit juice or water, respectively, were administered 1 hour before and together with the drug. Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). RESULTS: Grapefruit juice changed the area under the sildenafil plasma concentration-time curve from time zero to infinity [AUC(0-infinity) from 620 [1.53] ng/ml x h to 761 [1.58] ng/ml x h (geometric mean with geometric standard deviation), corresponding to a 23% increase (90% confidence interval, 13%-33%). N-Desmethyl sildenafil AUC(0-infinity) increased by 24% (90% confidence interval, 17%-32%). Maximum plasma concentrations (C(max)) of sildenafil and N -desmethylsildenafil were essentially unchanged. There was a trend toward a prolonged time to reach C(max) during the grapefruit juice period (from a median of 0.75 hour to a median of 1.13 hours), corresponding to an increase by 0.25 hour (90% confidence interval, 0-0.63 hour). Interindividual variability was pronounced in both periods. CONCLUSIONS: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.

[rms80]

Originally Posted by tuberman

Dirk,

Isn't it true that naringin and it's component Naringenin is a pretty damn good to excellent potentiator of many things, not just icariin and caffeine?

When I get my samples (tommorrow, I hope), I intend to give RPM an extra tough test. First time, I'll test it with weight training, perhaps deadlifts. But then, I'll see if it will potentiate my endurance stack (second test). The endurance test will be tough, as RPM is not primarily designed for that, and I have a great endurace stack already. I use beta alanine, citrulline malate, plcar, some caffeine and a decent quality cordyceps for my endurace stack which has been super, and I mean really super. Yet I figure if I go for intensity, I can probably up it one more notch with RPM (smashing the pedals in mountain climbing gears on the bike).

I'll be very happy with just the extra intensity for weight training. I'd like to add another 50-60 pounds to my deadlift in the next few months. Bonus endurance would be a gift that goes beyond my expectations.

PS My wife runs marathons and half marathons and is a pretty hardcore endurance trainer- she loves RPM!! Just from what I have seen out on the track and on the basketball court and football field- yes, it will help your endurance quite a bit- as will the stack you are on- but don't take my word for it!!!!

LMK how it turns out!!!

[rms80]

Originally Posted by determination

I have tried rpm three times now and it is a great pre workout supplement. It gave me great energy, focus and pumps. What I really noticed was a very noticable increase in alpha-male mentality. I think I will be buying a bottle of this. I also had a great mood and felt like getting things done when I took it. I dosed it 4,4,3. I got 11 caps. 10 good ones and one broken one. the powder from the broken one tasted horrible.

Yeah- the RPM powder is not the most fun thing in the world to work with- but there are some worse things- tribulus is probably my least favorite!!!

[Lanbane]

What makes Trib bad?

[ugab37]

Originally Posted by rms80

I can give you the name of a pretty good breeder- he is down east of Columbia....pretty inexpensive- my brother in law got a white boxer from him, and I got Bianca

Yeah man, PM me the contact info if ya dont mind. As you know, Columbia's really close to me. I can probably get there in under 45 minutes, so Ill definately make the trip for a good deal.

[WannaBeHulk]

i did 4 caps at about noon today and had a solid leg day. strength was difficult to measure because i reversed my typical leg routine and started with isolation movements and ended with compounds just to throw a curve ball into my routine. i experienced the mood lift yet again so i would say this is a conclusive effect. then again, maybe i was just excited to use leave time off from work honestly though, i liked 3 caps better than 4. i know most people think more is better but i actually like less.

good call on the free samples! without this trial, i highly doubt that i would purchase this supplement initially but now im anxiously waiting for its availability. great promotion, it should pay off

[rms80]

Originally Posted by Lanbane

What makes Trib bad?

Very sticky, even at low relative humidity- tends to stick to capsule mold, plus it does not get along well with our dust filtration system, or our air scrubbers....ok if run in limited batches- 20K capsules per run (usual is 70K)

[rms80]

Originally Posted by ugab37

Yeah man, PM me the contact info if ya dont mind. As you know, Columbia's really close to me. I can probably get there in under 45 minutes, so Ill definately make the trip for a good deal.

Will do- I will talk to my wife when she gets home from work- it is on the other side of Columbia- out towards O'burg...

[rms80]

Originally Posted by WannaBeHulk

i did 4 caps at about noon today and had a solid leg day. strength was difficult to measure because i reversed my typical leg routine and started with isolation movements and ended with compounds just to throw a curve ball into my routine. i experienced the mood lift yet again so i would say this is a conclusive effect. then again, maybe i was just excited to use leave time off from work honestly though, i liked 3 caps better than 4. i know most people think more is better but i actually like less.

good call on the free samples! without this trial, i highly doubt that i would purchase this supplement initially but now im anxiously waiting for its availability. great promotion, it should pay off

WBH-
Excellent feedback- I have heard some like less, some like more, so I split the difference- trying to be diplomatic

The strength effects get better over time, as well as the hardening and vasularity- and you don't really attenuate to the stim. component either- I have been on something similar as far as the stims for over a year- and it still does the same thing (clear focus, no jitters, endless energy) it did when I started, at the same dose