- 11-01-2010, 06:39 PM
The SAM-e / methylation pathway is responsible for a variety of different biochemical reactions in the body. The pathway is also responsible for the formation of dopamine and norepinepherine plus the formation of H²S, all of which allow for greater NMDA receptor activity, greater NO activity and ultimately greater initiation of steroidogenesis.
SAM-e is a combination of ATP and methionine, and has some pronounced effects in several different areas relevant to increased product effectiveness:
· SAM-e also exerts strong effects on increasing Hydrogen Sulfide (H²S) Production, which increases NMDA receptor activity and has been shown to be synergistic with Nitric Oxide (NO) in terms of vasodilation. A great deal of the most recent research on erectile dysfunction drugs is focusing on this pathway.
· The compound has strong mood-enhancing effects via increasing serotonin and dopamine in the brain
SAM-e has been shown to have some very positive effects on joint health and regeneration
Trimethylglycine (also known as Betaine), ATP, and SAM-e directly function within the SAM-e pathway, albeit in different segments and capacities; each of which add to product effectiveness. TMG has been shown have positive effects on muscular strength, as well as having the ability to form sarcosine (an NMDA receptor co-agonist) and act as a methyl donor to fuel SAM-e formation. TMG acts in the following fashion as a methyl donor and in the SAM-e pathway (50-54,64-68,118):
TMG donates a methyl group during the formation of SAM-e, and becomes DMG (N-N-dimethylglycine).
· The donated methyl group can then form SAM-e, or be used for the production of neurotransmitters, the production of DNA, or the metabolism of fats
· The remaining DMG is then converted readily by the liver to the NR-1 agonist N-Methyl Glycine via glycine N-methyltransferase☣☣☣☣Hi-Tech Pharmaceuticals Representative☣☣☣☣
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- 11-01-2010, 08:43 PM
That is an excellent explanation! Definitely has shed new light to why SAM-e is included. Previously i knew that SAM-e was used in the treatment of depression, osteo-athritis, liver problems....etc etc but never thought of it in the mechanism explained above.
Exciting stuff.DISCLAIMER: Anything that I post on this forum should not be taken as medical advice. Consult your doctor before starting new diets, supplements, training protocols, and/or if you have any concerns about your health.
11-01-2010, 08:58 PM
is this something that should be taken daily even if you don't work out? I am curious since the 3 grams of DAA have to build up in your body in order to increase testosterone. I am reading the ingredients right? If I take the max dose at 3 scoops a day that would put me at over 9 grams of DAA right?
12-15-2010, 03:47 PM
01-03-2011, 01:40 PM
01-16-2011, 11:35 AM
Perhaps, but he has every right in his view/statement/discussion as one of the claims in the write up says "Dramatically Increases Testosterone to Foster an Environment Favorable for Substantial, Long-term Increases in Lean Body Mass & Fat Reduction.", assumingly from the DAA. So has DAA been shown to do this in women, as he was discussing or not?
01-16-2011, 11:49 AM
01-16-2011, 05:06 PM
01-16-2011, 05:28 PM
01-20-2011, 09:14 PM
01-20-2011, 11:32 PM
01-21-2011, 08:38 AM
01-21-2011, 08:45 AM
I would think you'd be better off not "wasting" the Lit Up, and pick up some bulk DAA to use off days.
01-21-2011, 09:28 AM
01-21-2011, 09:25 PM