IGF 2 tiredness and gyno

[Garyboy]

It may have made you feel 'sleepy' due to the growth hormone release.

Yes, excellent product ("underrated" as you out it). My personal favourite though (the other is Lipotrophin-PM (also very underrated IMO), and that gives deeper, more restful sleep, if you're looking for a supplement that can give better quality sleep).

Thanks for the recommendation. Would you say the sleep on Lipotrophin-PM is just as deep as on IGF-2? Thanks.

[EasyEJL]

depending on details, sometimes its even better. pretty close either way

[Rosie Chee]

Thanks for the recommendation. Would you say the sleep on Lipotrophin-PM is just as deep as on IGF-2? Thanks.

BETTER, actually. I have used Lipotrophin-PM as a standalone and my sleep was noticeably different in only a couple of days; the stuff is honestly worth its weight in gold to me.

[Chub]

I'm on day 5 of IGF-2 now and i've noticed better sleep already, plus more dreaming too!

[Skeetopunk01]

Wrong. I also got a lump in mu left nipple while on IGF-2. It went away shortly after I finished the bottle. My strength gains were awesome though.

[Rosie Chee]

I'm on day 5 of IGF-2 now and i've noticed better sleep already, plus more dreaming too!

Yep, you start noticing results re sleep and recovery (and muscle hardness) in a few days of using it

[Mulletsoldier]

Mucuna Pruriens contains highly active amounts of L-DOPA [levodopa], a direct amino-acid derivative of L-Tyrosine, and the body's direct precursor to Dopamine synthesis. This is important to the discussion as L-DOPA displays a marked ability to increase Testosterone and LH in healthy, normal males, through the inhibition of PRL [prolactin]; it does so by increasing Dopamine production in the hypothalamus. In turn, Dopamine site-binds to D2 [dopamine] receptors found on the anterior pituitary cells responsible for PRL secretion, "lactotropes". This direct site-binding by Dopamine alters Ca2+ currents in the lactotropes, and also promotes a reorganization of protein lines responsible for cell structure. In combination, this inhibits PRL secretion and promotes healthy LH, and Testosterone synthesis.

Now, I say this because PRL is also known to increase the expression of ER-A [estrogen receptor alpha], the estrogen receptor sub-type responsible for the proliferation of breast-cancer cells. The selective modulation of this receptor is the target of certain drugs in the drug-class SERMs [selective estrogen receptor modulator]. The inhibition of PRL, therefore, has been demonstrated to decrease ER-A sensitivity to estradiol [estrogen] and decrease ER-A related gene expression. In concert, these inhibitory effects on PRL would most likely attenuate breast-glandular expansion [i.e., development of breast tissue associated with gynecomastia].

In simpler terms, Mucuna is highly unlikely to promote gynecomastia, and it all likelihood works to decrease factors that promote it.

[TexasLifter89]

Mucuna Pruriens contains highly active amounts of L-DOPA [levodopa], a direct amino-acid derivative of L-Tyrosine, and the body's direct precursor to Dopamine synthesis. This is important to the discussion as L-DOPA displays a marked ability to increase Testosterone and LH in healthy, normal males, through the inhibition of PRL [prolactin]; it does so by increasing Dopamine production in the hypothalamus. In turn, Dopamine site-binds to D2 [dopamine] receptors found on the anterior pituitary cells responsible for PRL secretion, "lactotropes". This direct site-binding by Dopamine alters Ca2+ currents in the lactotropes, and also promotes a reorganization of protein lines responsible for cell structure. In combination, this inhibits PRL secretion and promotes healthy LH, and Testosterone synthesis.

Now, I say this because PRL is also known to increase the expression of ER-A [estrogen receptor alpha], the estrogen receptor sub-type responsible for the proliferation of breast-cancer cells. The selective modulation of this receptor is the target of certain drugs in the drug-class SERMs [selective estrogen receptor modulator]. The inhibition of PRL, therefore, has been demonstrated to decrease ER-A sensitivity to estradiol [estrogen] and decrease ER-A related gene expression. In concert, these inhibitory effects on PRL would most likely attenuate breast-glandular expansion [i.e., development of breast tissue associated with gynecomastia].

In simpler terms, Mucuna is highly unlikely to promote gynecomastia, and it all likelihood works to decrease factors that promote it.

yes sir! That is why I don't understand how they could have received gyno from igf-2. If anything it would reduce it....

[Mulletsoldier]

yes sir! That is why I don't understand how they could have received gyno from igf-2. If anything it would reduce it....

I agree it's very unlikely anybody would suffer gynecomastia directly from Mucuna, but the biochemistry of predisposed users may be easily offset! In an individual with pubertal gynecomastia or a history of steroid-induced gynecomastia, the promotion of testosterone by Mucuna [shown to be substantial even in non-pathological states] could lead to a rise in estradiol - coupled with extremely sensitive receptors, gynecomastia could erupt. This would most definitely take a confluence of a wide-range of gynecomastia-attractive factors, though; factors which aren't at play in the general pop.

[EasyEJL]

Yah, that was the only way I could see it happening too, and it just seems farfetched. Literally if you were that sensitive a change in your saturated fats dietary intake could bring on a gyno "attack", or taking 50mg DHEA a day

[Garyboy]

BETTER, actually. I have used Lipotrophin-PM as a standalone and my sleep was noticeably different in only a couple of days; the stuff is honestly worth its weight in gold to me.

Thanks. I'll give it a shot.

[SamBoz19]

Thanks. I'll give it a shot.

Let us know how it works out for you.

Cheers!