I know AST and ALT are the major markers for damage to the liver. But my AST level was at 50 and the range is 15-37 and I told my retarded doctor AST is in the heart and the muscles and if I am exercising a lot it can show in my liver but the true marker is ALT and it was fine and I take Milk Thistle and LiverCare by himalaya! Should I er on the side of caution and discontinue HRT like he said or continue and he is going to check again in 6 weeks so he isn't to worried I feel like. I am going to continue because my HRT is all most up any who. Please Reply! With thoughts!