Either way is fine Mike. Some complain about stomach discomfort on these sups, so if that occurs, dose with food. In about a week, all stomach issues should clear up.
Jim got you covered nicely here. The effects are from Forslean that some feel the discomfort from and both products contain Forslean. The nice thing is, once you build some tolerance, it will last for quite a while even after you discontinue the first product.
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