Study: Statins inhibit pro-inflammatory peptides.

  1. Study: Statins inhibit pro-inflammatory peptides.

    As many of you know Life Support contains Red Yeast Rice, a known statin. Many of you will probably wonder why I felt this study was significant but I will try and explain. This study explains the effects of statins on the inhibition of neurogenic inflammation. Neurogenic inflammation is the main factor in causing things such as fibromyalgia, asthma, eczema, and most importantly migraine headaches. In fact the most important study right now is the effect of calcitonin gene related peptide on migraine headaches.

    Statins Decrease Expression of the Proinflammatory Neuropeptides Calcitonin Gene-Related Peptide and Substance P in Sensory Neurons
    Robert C. Bucelli, Eugene A. Gonsiorek, Woo-Yang Kim, Donald Bruun, Richard A. Rabin, Dennis Higgins1, and Pamela J. Lein

    Department of Pharmacology and Toxicology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York (R.C.B., E.A.G., W.-Y.K., R.A.R., D.H.); and Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, Oregon (D.B., P.J.L.)

    Clinical and experimental observations suggest that statins may be useful for treating diseases presenting with predominant neurogenic inflammation, but the mechanism(s) mediating this potential therapeutic effect are poorly understood. In this study, we tested the hypothesis that statins act directly on sensory neurons to decrease expression of proinflammatory neuropeptides that trigger neurogenic inflammation, specifically calcitonin gene-related peptide (CGRP) and substance P. Reverse transcriptase-polymerase chain reaction, radioimmunoassay, and immunocytochemistry were used to quantify CGRP and substance P expression in dorsal root ganglia (DRG) harvested from adult male rats and in primary cultures of sensory neurons derived from embryonic rat DRG. Systemic administration of statins at pharmacologically relevant doses significantly reduced CGRP and substance P levels in DRG in vivo. In cultured sensory neurons, statins blocked bone morphogenetic protein (BMP)-induced CGRP and substance P expression and decreased expression of these neuropeptides in sensory neurons pretreated with BMPs. These effects were concentration-dependent and occurred independent of effects on cell survival or axon growth. Statin inhibition of neuropeptide expression was reversed by supplementation with mevalonate and cholesterol, but not isoprenoid precursors. BMPs signal via Smad activation, and cholesterol depletion by statins inhibited Smad1 phosphorylation and nuclear translocation. These findings identify a novel action of statins involving down-regulation of proinflammatory neuropeptide expression in sensory ganglia via cholesterol depletion and decreased Smad1 activation and suggest that statins may be effective in attenuating neurogenic inflammation.

  2. Very interesting. Thanks for posting this Lake!

    (For those that may not know, Lake was the one who created Cycle Support for Anabolic Innovations)

  3. Nice! This is good info ... Thanks!

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