HyperTrop-X - New Formula!

  1. Arrow HyperTrop-X - New Formula!


    Advanced Muscle Science introduces a new line of thinking when it comes to muscle energy and workout performance. Hypertrop-X utilizes a targeted approach that incorporates three unique pathways in the form of a Pre-Workout Energizer, Muscle Endurance Enhancer and Muscle Protein Stimulator, in this unique and surprisingly powerful blend. Taken prior to workouts, your muscles will never feel so energized not just from the onset of training but throughout the entire workout. This is not your ordinary pre-workout supplement. Let’s explain why…

    Leucine and Beta-Alanine

    The key to Hypertrop-X is the combination of key ingredients in precise quantities. The formulation foundation begins with the proprietary MRA (Muscle Recovery Accelerator) combination, which is a precise blend of two compounds, beta alanine and leucine, which are backed by decades of performance documenting research. Leucine has recently become very well known for its effects in stimulating the mTOR and other protein synthesis pathways. These pathways signify that protein synthesis and the machinery behind the formulation of new skeletal tissue can be enhanced via the administration of leucine. Aside from research on the metabolic pathways behind leucine’s effects, research is also plentiful on the performance enhancing effects of leucine. For example, Crowe et al, 2006 investigated the effects of leucine on plasma concentrations of leucine, measures of body power, work and time to exhaustion. Results from this study showed significant increases in plasma leucine and additional increases in total power and time to exhaustion.

    Beta alanine is another must-have, pre-workout supplement included in Hypetrop-X. It’s one thing to get stimulated and energized prior to exercise but if you’re muscles can’t buffer all of the metabolites that are generated during the exercise bout, performance will degrade rapidly and you won’t maximize your training session. In order for maximum performance to continue, the body must rid itself of various metabolic byproducts that can quickly be generated during workouts. The byproducts, particularly hydrogen ions and lactic acid, are some of the culprits that want to end your workout prematurely. You see, the energy or ATP-producing reactions create these metabolites, and the more energy output there is, the more these metabolites are generated. That’s why we’ve added copious amounts of beta alanine to allow workout performance to be extended by aiding the body in buffering these. Beta alanine along with the amino acid histidine, form a compound known as carnosine. Carnosine is responsible for these beneficial effects. Supplementation though with beta alanine has been shown to be the key at increasing muscle carnosine concentration.

    Some recent clinical trials have documented these effects. One such study showed total work increased by 13% in a cycle capacity test and muscle carnosine concentrations were increased by 58.8% and 80.1% at 4 and 10 weeks (Hill et al, 2007). Derave et al, 2007 showed total increases in muscle carnosine of 47% greater in the soleus and 37% in the gastrocnemius, whereas placebo groups showed little change. In addition, total torque during a dynamic knee extension was significantly increased with the use of ß -alanine.

    Peak ATP and Yohimbine

    Aside from aiding in buffering performance degrading metabolites and stimulating protein synthesis, any pre-workout product wouldn’t be complete unless you have compounds that enhance energy. When formulating Hypertrop-X though, we didn’t want to just add a run-of-the-mill stimulant like caffeine. While we think these sorts of stimulants have their purpose, what we were seeking was enhancing not only the “feelable” effect but also the real effect of energy production at the cellular level. Thus, we used a combination of the patented Peak ATP product and yohimbine. ATP or adenosine triphophate is the energy source that powers our bodies. Research on ATP is backed by dozens of clinical trials. Much of this research has been conducted by Dr. Eliezer Rapaport, a widely recognized expert in adenosine nucleotides and the inventor of the patented Peak ATP product. Research on ATP is vast and shows numerous beneficial effects. After administration of Peak ATP, extracellular ATP in the body can be increased for approximately 6 hours. Of particular interest to those intensely training, ATP supplementation may first and foremost support increases in ATP levels of the blood and tissues along with increasing circulation. This is particularly important for 1) enhancing and maintaining energy levels during workouts 2) reducing fatigue 3) enhancing nutrient delivery to tissues and removal of catabolic waste products such as lactic acid for optimal recovery. One unpublished study on ATP showed that people who supplemented with ATP could do 18.5% more reps and lifting volume was increased by 28.2% over the course of a two week period, while supplementing with high doses of ATP. ATP has also shown to enhance the delivery of glucose, nutrients and oxygen to working and recovering muscles.

    Finally, we added in yohimbine. If you’re a fan of achieving a lean chiseled physique like we are, you may recall some science on alpha and beta receptors, particularly as they relate to fat loss. Both of these receptors are present on adipose tissue. Generally speaking, beta enhances lipolysis and alpha inhibits it. Yohimbine may help to block the alpha – 2 receptor which tries to shut off lipolysis. In doing so we may allow to keep the lipolytic pathway continuing. One study further demonstrated yohimbine increased weight loss and supported increases in exercise energy expenditure (along with accompanying the parameters of lipolysis). Results from many studies conclude that the primary lipid-mobilizing effect of yohimbine is a direct effect of stimulating the sympathetic nervous system. Thus yohimbine is added to the Hypertrop-X formulation, not only to help support enhanced energy and sympathetic nervous system stimulation, but to assist in mobilizing fatty acids to be utilized as a fuel substrate during exercise.

    Hyper Trop-X was designed with one thing in mind – HYPERTROPHY: The formation of new skeletal tissue. No fluff, just a straight-up, scientific approach to enhancing your workouts through well-researched, science-based compounds. If you’re looking for an A-typical formulation to support enhanced muscle recovery, ATP, muscle buffering and protein synthesis, then Hypetrop-X is for you. We guarantee you won’t be disappointed.


    Galitzky J, Taouis M, Berlan M, Riviere D, et al. a 2-Antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect oral yohimbine in healthy male volunteers. Eur J Clin Invest 1988; 18:587-594.

    Galitzky j, Riviere D, Tran MA, Montastruc JL, Berlan M. Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers. Eur J Clin Pharmacol 1990; 39:447-451.

    Begum G, Cunliffe a, Leveritt M. Physiological role of carnosine in contracting muscle. Int J Sport Nutr Exerc Metab. 2005 Oct;15(5):493-514. Review.

    Derave W, Ozdemir MS, Harris R et al. Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol. 2007

    Hill CA, Harris RC, Kim HJ et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids. 2007 Feb;32(2):225-33

    Anthony JC, YoshizawaF, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucinestimulates translation initiation in skeletal muscle of postabsorptiverats via a rapamycin-sensitive pathway. J Nutr, 130: 2413-2419. 2000.

    Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucinestimulates protein synthesis in skeletal muscle of postabsorptiverats in association with increased eIF4F formation. J Nutr, 130: 139-145. 2000.

    Crowe MJ, Weatherson JN, Bowden BF. Effects of dietary leucine supplementation on exercise performance. Eur J Appl Physiol, 97: 664–672. 2006.

    Coburn JW, Housh DJ, Malek MH, Beck TW, Cramer JT, Johnson GO, Donlin PE. Effects of leucine and whey protein supplementation during eight weeks of unilateral resistance training. J Strength Cond Res, 20(2): 284–291. 2006.

    Norton LE, Layman DK. Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after Exercise. J Nutrition, 136: 533-537. 2006.


    Balage M., Dardevet D., 2010. Long-term effect of leucine supplementation on body composition. Curr. Opin. Clin. Nutr. Metab. Care. [Epub ahead of print].

    Norton, LE., layman, Dk., Bunpo, P., Anthony TG., Brana, DV., Garlick, PJ., 2009. The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats. J. Nutr. 139(6):1103-9.

    Forrester T, Harper AM, Mackenzie ET, Thompson EM. Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism. J Physiol. 1979; 296:343-355

    Rosenmeier JB, Hansen J, Gonsalez-Alonso J. Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J. Physiol. 2004; 558:351-365


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  2. Odd combo.

    L-Leucine --> raise insulin --> halt yohimbine --> blunt it's lipid mobilizing effects

  3. Quote Originally Posted by Cerberus View Post
    Odd combo.

    L-Leucine --> raise insulin --> halt yohimbine --> blunt it's lipid mobilizing effects
    You're correct but it's an effective CNS stimulant and essentially what you really want ramped up pre-wo.
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  4. Quote Originally Posted by Cerberus View Post
    Odd combo.

    L-Leucine --> raise insulin --> halt yohimbine --> blunt it's lipid mobilizing effects
    I sent this question to the formulator just to follow up. Here was his response:

    I'd have him give this a read before he comes to that conclusion. On the surface yes insulin may be negative for fat loss, however you have to look at several things. First and foremost is what is the concentration and it's effects on insulin. Leucine's effects on insulin is pretty controversial at best. Look at Anthony's data 2000 showing no effect. Later Anthony came back and postulated that the leucine may only acutely and transiently increase insulin. However, what we do know is the Leucine has tremendous effects on downstream insulin related pathways, i.e. mTOR, etc...upregulating machinery behind protein synthesis, etc..Protein synthesis machinery is very ATP demanding and substrates would be required for this to happen, hence why it is postulated leucine to be beneficial in fat loss. I know its a bit counterintuitive but I would not hesitate for a second to put leucine with yohimbine...I could go further as well to argue half life's of each of the compounds, etc... but I don't think I need to.
    The read he is referring to is the following reference:

    Potential Importance of Leucine in Treatment of Obesity and the
    Metabolic Syndrome1–3
    Donald K. Layman*y4 and Denise A. Walkery
    *Department of Food Science and Human Nutrition and yDivision of Nutritional Sciences,
    University of Illinois, Urbana, IL 16801
    ABSTRACT Diets with total protein intake .1.5 gkg1d1 and carbohydrate intake ,150 g/d are effective for
    treatment of obesity, type 2 diabetes, and the Metabolic Syndrome. These diets improve body composition and
    enhance glycemic control. During weight loss, protein-rich diets reduce loss of lean tissue and increase loss of body
    fat. Specific mechanisms to explain each of these clinical outcomes remain to be fully elucidated. We propose that
    keys to understanding the relationship between dietary protein and carbohydrates are the relationships between the
    branched-chain amino acid leucine and insulin and glucose metabolism. Leucine is known to interact with the insulin
    signaling pathway to stimulate downstream signal control of protein synthesis, resulting in maintenance of muscle
    protein during periods of restricted energy intake. Leucine also appears to modulate insulin signaling and glucose use
    by skeletal muscle. Whereas total protein is important in providing substrates for gluconeogenesis, leucine appears
    to regulate oxidative use of glucose by skeletal muscle through stimulation of glucose recycling via the glucosealanine
    cycle. These mechanisms produce protein sparing and provide a stable glucose environment with low insulin
    responses during energy-restricted periods. J. Nutr. 136: 319S–323S, 2006.
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