2,17α-dimethyl-17β-hydroxy-5α-androst-2-ene

Page 1 of 2 12 Last
  1. 2,17α-dimethyl-17β-hydroxy-5α-androst-2-ene


    Very excited about the news of this compound ,upcoming in a new iron legion product.would love to know more about it anything .It seems like it has the potential to be a monstrous gainer surpassing m1t this would be an amazing new supplement love to also know how anyone thinks real world results will play out.


  2. It's been out for many many years. It's called methyl sten... or even more widely known to the forum bros as Mass Tabs.
    It's not better for 'gains' than M1T.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.
    •   
       


  3. Ehh methylstenbolone is 2,17a-methyl-5a-androsta-1-en-17b-ol-3-one this compound while similar, dons a 17beta hydroxy function and 2-ene bond
    It's called dimethandrostenol ,completley different beast this could be considered desoxymethasterone

  4. this looks pretty powerful according to vida. 10 times methyltest. I hope they test it to validate it. The stuff could also be referred to as 2-methyl DMT (2-methyl madol)
    Anabolicminds.com Featured Author

  5. Quote Originally Posted by Anabolimac View Post
    Ehh methylstenbolone is 2,17a-methyl-5a-androsta-1-en-17b-ol-3-one this compound while similar, dons a 17beta hydroxy function and 2-ene bond
    It's called dimethandrostenol ,completley different beast this could be considered desoxymethasterone
    ****, I missed 3-keto group not being posted... I need to stop reading so late at night and stick to watching stupid videos. Looks interesting though.

    I think there's a protocol where you can burn down a ketone to an alkene; makes me wonder if you can make it from SD if you can get the elimination to happen at the more substituted side.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.
    •   
       


  6. Quote Originally Posted by Beejis60 View Post
    ****, I missed 3-keto group not being posted... I need to stop reading so late at night and stick to watching stupid videos. Looks interesting though.

    I think there's a protocol where you can burn down a ketone to an alkene; makes me wonder if you can make it from SD if you can get the elimination to happen at the more substituted side.
    you would need to protect the 17b-OH as a ketal or something. then reduce C3 to OH. then p-toluenesulfonylchloride to make pTSA ester. Then boil in collidine and you will have your 2 ene. The workup of the collidine reaction mix is often done with sulfuric acid so that may deprotect 17bOH
    Anabolicminds.com Featured Author
  7. AnabolicMinds Site Rep
    Spaniard's Avatar

    Quote Originally Posted by Patrick Arnold View Post
    this looks pretty powerful according to vida. 10 times methyltest. I hope they test it to validate it. The stuff could also be referred to as 2-methyl DMT (2-methyl madol)
    Methyl DMT holy ****ing ****
    Founder & Owner
    Aspire. Train. Perform. Nutrition
    "More than a supplement company."

  8. SO no one sells this yet, its just going to potentially hit the market soon?

  9. Quote Originally Posted by Patrick Arnold View Post
    you would need to protect the 17b-OH as a ketal or something. then reduce C3 to OH. then p-toluenesulfonylchloride to make pTSA ester. Then boil in collidine and you will have your 2 ene. The workup of the collidine reaction mix is often done with sulfuric acid so that may deprotect 17bOH
    Wut? Isn't collidine too sterically hindered to eliminate from the 2-position due to the methyl group there? I would think it would rather eliminate from the 4-position giving an a,b unsaturation. But I meant like a one step procedure. I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  10. Quote Originally Posted by GigaPaladin View Post
    SO no one sells this yet, its just going to potentially hit the market soon?
    Only post itt I understood outside maybe the OP

  11. Original DMT Was shown in a study to enlarge the heart. Strong possibility this may have an even stronger effect on the heart?
  12. AnabolicMinds Site Rep
    Spaniard's Avatar

    Quote Originally Posted by Duywayne View Post
    Original DMT Was shown in a study to enlarge the heart. Strong possibility this may have an even stronger effect on the heart?
    Original DMT was icing dudes... I don't know if I'd go after this white buffalo...
    Founder & Owner
    Aspire. Train. Perform. Nutrition
    "More than a supplement company."

  13. Quote Originally Posted by Spaniard View Post
    Original DMT was icing dudes... I don't know if I'd go after this white buffalo...
    Yes but methylating a compound can completely change its properties unless I am missing something here.

  14. Quote Originally Posted by CATdiesel76 View Post
    Yes but methylating a compound can completely change its properties
    this is correct
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  15. Quote Originally Posted by Beejis60 View Post
    Wut? Isn't collidine too sterically hindered to eliminate from the 2-position due to the methyl group there? I would think it would rather eliminate from the 4-position giving an a,b unsaturation. But I meant like a one step procedure. I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.

    i dont think you can directly remove a ketone without it going through an OH

    i cant answer your question about the collidine but i picture the mechanism with the collidine coming from the other side, so a 2a-methyl would in fact encourage formation of 2-ene (plus it would be the thermodynamically favored product)
    Anabolicminds.com Featured Author

  16. Quote Originally Posted by Patrick Arnold View Post
    i dont think you can directly remove a ketone without it going through an OHi cant answer your question about the collidine but i picture the mechanism with the collidine coming from the other side, so a 2a-methyl would in fact encourage formation of 2-ene (plus it would be the thermodynamically favored product)
    The reaction I was talking about is kinda like a tandem Wolff-Kishner/Sn2' reaction.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  17. Quote Originally Posted by Beejis60 View Post
    The reaction I was talking about is kinda like a tandem Wolff-Kishner/Sn2' reaction.

    oh yeah, thru a hydrazone intermediate. does that leave a double bond though?
    Anabolicminds.com Featured Author

  18. Quote Originally Posted by Patrick Arnold View Post
    oh yeah, thru a hydrazone intermediate. does that leave a double bond though?
    Vinyl iodide son. So yes.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  19. Quote Originally Posted by Beejis60 View Post
    Vinyl iodide son. So yes.

    not sure what u are referring to
    Anabolicminds.com Featured Author

  20. Quote Originally Posted by Patrick Arnold View Post
    not sure what u are referring to
    reed below

    Quote Originally Posted by Beejis60 View Post
    I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  21. You two make me miss organic chem so bad. I need to freshen up on my nomenclature and rxn mechanisms. Fascinating stuff.

  22. Quote Originally Posted by Kinggrommet View Post
    You two make me miss organic chem so bad. I need to freshen up on my nomenclature and rxn mechanisms. Fascinating stuff.
    Superdrol + Zn + TMSCl at room temp OR make the tosyl hydrazone, then subject to LiH in refluxing toluene yields the title compound. Both are high-yielding procedures.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  23. Quote Originally Posted by Beejis60 View Post
    Superdrol + Zn + TMSCl at room temp OR make the tosyl hydrazone, then subject to LiH in refluxing toluene yields the title compound. Both are high-yielding procedures.

    I dont know the mechanism but would this affect the 17b-OH group?
    Anabolicminds.com Featured Author

  24. Quote Originally Posted by Patrick Arnold View Post
    I dont know the mechanism but would this affect the 17b-OH group?
    Nope. Only 3-oxo selective. The one paper has 6, 7, and 20-oxo diones and only the 3-keto group is removed.
    TMS coordination to carbonyl O, Zn oxidative addition to carbonyl C, reduction to Zn carbenoid, pinacol-type rearrangement... or like a 1,2-hydride shift.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  25. Quote Originally Posted by Beejis60 View Post
    Nope. Only 3-oxo selective. The one paper has 6, 7, and 20-oxo diones and only the 3-keto group is removed.
    TMS coordination to carbonyl O, Zn oxidative addition to carbonyl C, reduction to Zn carbenoid, pinacol-type rearrangement... or like a 1,2-hydride shift.
    cool

    please email me the paper thanks
    Anabolicminds.com Featured Author

  26. Quote Originally Posted by Patrick Arnold View Post
    coolplease email me the paper thanks
    They're two early 70s and mid 70s RSC papers, so no mechanism published though they discuss it. Yields kinda suck actually; the book I found it in though, Comprehensive Org. Synthesis said 95%... spoke too soon. The tosylhydrazone reaction is better; I've never made tosylhydrazones but free hydrazones and azines preps are balls simple and high-yielding, and the following LiH redox protocol is mid 90% yields.
    E-Pharm Nutrition Representative
    WARNING: I tend to speak my mind and will verbally assault you if you are a tool. My words do not necessarily represent the official opinion of E-Pharm, but most likely, they do.

  27. while the compound looks interesting, I just would like to know, what level of schooling would I need to be, in order to be up to par with you guys?
    Rejoice not against me, O mine enemy: when I fall, I shall arise; when I sit in darkness, the LORD shall be a light unto me. Micah 7:8

  28. Quote Originally Posted by tilldeath View Post
    while the compound looks interesting, I just would like to know, what level of schooling would I need to be, in order to be up to par with you guys?

    years of graduate school and years of experience in the lab
    Anabolicminds.com Featured Author

  29. i wish i knew what you guys were talking about

  30. Quote Originally Posted by Patrick Arnold View Post
    years of graduate school and years of experience in the lab
    well, I'm currently about to start my Labtech program and will have a medical lab tech certification and BA in applied science. That said I haven't worked in a lab so not really sure what to except as far a a learning curve. I suspect though I would like to get into research field at some point.
    Rejoice not against me, O mine enemy: when I fall, I shall arise; when I sit in darkness, the LORD shall be a light unto me. Micah 7:8
  •   

      
     

Similar Forum Threads

  1. Replies: 15
    Last Post: 12-08-2012, 10:21 AM
  2. Replies: 7
    Last Post: 02-03-2009, 11:10 PM
  3. 17 Hydroxy-Mesterone. WTF!?
    By freaky in forum Anabolics
    Replies: 38
    Last Post: 07-26-2007, 05:37 PM
  4. 17-Hydroxy-Mesterone
    By fritzer in forum Anabolics
    Replies: 1
    Last Post: 04-30-2006, 03:17 AM
Log in
Log in