Ellagic acid as a SERM?

  1. Ellagic acid as a SERM?

    i read that this might be useful as a SERM. your thoughts on this?

  2. Quote Originally Posted by bossman523 View Post
    i read that this might be useful as a SERM. your thoughts on this?
    not familiar sorry
    Anabolicminds.com Featured Author

  3. Selective estrogen receptor modulators (SERMs) are estrogen receptor (ER) ligands exhibiting tissue-specific agonistic or antagonistic biocharacter and are used in the hormonal therapy for estrogen-dependent breast cancers. Pomegranate fruit has been shown to exert antiproliferative effects on human breast cancer cells in vitro. In this study, we investigated the tissue-specific estrogenic/antiestrogenic activity of methanol extract of pericarp of pomegranate (PME). PME was evaluated for antiproliferative activity at 20–320 μg/ml on human breast (MCF-7, MDA MB-231) endometrial (HEC-1A), cervical (SiHa, HeLa), ovarian (SKOV3) carcinoma and normal breast fibroblast (MCF-10A) cells. Competitive radioactive binding studies were carried out to ascertain whether PME interacts with ER. The reporter gene assay measured the estrogenic/antiestrogenic activity of PME in MCF-7 and MDA MB-231 cells transiently transfected with plasmids coding estrogen response elements with a reporter gene (pG5-ERE-luc) and wild-type ERα (hEG0-ER). PME inhibited the binding of [3H] estradiol to ER and suppressed the growth and proliferation of ER-positive breast cancer cells. PME binds ER and down-regulated the transcription of estrogen-responsive reporter gene transfected into breast cancer cells. The expressions of selected estrogen-responsive genes were down-regulated by PME. Unlike 17β−estradiol [1 mg/kg body weight (BW)] and tamoxifen (10 mg/kg BW), PME (50 and 100 mg/kg BW) did not increase the uterine weight and proliferation in ovariectomized mice and its cardioprotective effects were comparable to that of 17β-estradiol. In conclusion, our findings suggest that PME displays a SERM profile and may have the potential for prevention of estrogen-dependent breast cancers with beneficial effects in other hormone-dependent tissues.

  4. Thats fine but it makes no mention of its activity in the brain - specifically the hypothalamus - so we cant make any predictions on what its influence on LH and testosterone would be
    Anabolicminds.com Featured Author

  5. if i only had a brain....



Similar Forum Threads

    By samva777 in forum Anabolics
    Replies: 11
    Last Post: 03-19-2009, 10:03 AM
  2. Ellagic Acid in T-911
    By chainsaw in forum LG Sciences
    Replies: 3
    Last Post: 01-25-2009, 06:19 PM
  3. Ginko as a SERM
    By jasonschaffin in forum Supplements
    Replies: 21
    Last Post: 12-27-2007, 10:58 PM
  4. Replies: 8
    Last Post: 05-25-2007, 09:23 PM
Log in
Log in