- 06-16-2012, 10:51 PM
What do you think about this compound? It is suppose to be the next anti aging compound?
Cycloastragenol extends T cell proliferation by increasing telomerase activity Hector F. Valenzuela1, Thomas Fuller1, Jim Edwards2, Danielle Finger1 and Brenda Molgora11 Biology 2 Biochemistry, Whittier College, Whittier, CA
All normal human somatic cells have a finite number of times that they can divide and when this limit is reached cells are described as cellular senescent. Telomere shortening has been attributed as a main mechanism for cellular aging and for the lack of cellular functions associated with aging. Unlike what is seen in most somatic cells, in activated T cells telomerase activity is upregulated, resulting in increased telomere length. However, this brief period of telomerase induction only delays cellular senescence. Naturally, there is a great deal of interest in finding inducers of telomerase that may help delay the onset of cellular aging. There are various nutraceuticals that claim to both increase the health of individuals and delay the onset of cellular aging. We tested the nutraceuticals resveratrol and cycloastragenol for their ability to enhance T cell functions in vitro. In this study we evaluated the effect of these compounds on cellular proliferative capacity, levels of telomerase activity, surface markers and cytokine secretion of human CD4 and CD8 T cells. Our results show that cycloastragenol moderately increase telomerase activity and proliferative capacity of both CD4 and CD8 T cells. These preliminary results suggest that nutraceuticals inhibit the onset of CD4 and CD8 cellular senescence.
- 06-17-2012, 11:12 AM
that stuff is sold as part of a special astralagus extract under some name and costs about 500 dolllars for 30 days. i think its ridiculous people pay that for something that really has just shown to increase telemorase activity in-vitro. it could be that there are dozens of cheaper compounds that do the same thing but have just not been tested. and it could be that this approach of taking a compound that increases telomerase in-vitro has no effect on health or longevity in living animals
its a testament to the money to be made by the rich baby boomers that are growing old and afraid of deathAnabolicminds.com Featured Author
06-17-2012, 05:48 PM
06-17-2012, 09:15 PM
06-18-2012, 05:22 AM
Here's a good read by Vincent Giuliano with reasons for and against supplementing telomerase activators. TA-65 I think is the most widely known, as well as another supplement called Compound B. I believe their induction value is .2. Sierra sciences supposedly has a new activator with a value of 6 but they are keeping a tight lid on it right now.