my thyroid crapped out on me. Put my heart rate to 252 and I spent a week in icu. Then the weight gain started and it has been impossible to get a grip on, the best I can do is maintain, but not lose. I was on 50mcg a day for three years and the weight gain continued and I felt like crap but doc would not increase my med and my tsh stayed anywhere from 3-4.5. My doc died and I started a new one last month. He immediately upped my dose and I feel really good. I am supplementing with vitD, kelp, calcium, magnesium, vit B complex, fish oil and q10 and flouride free tooth paste. I am having my next blood panel in a week. Will probably start ursobolic then if things are looking good. According to the pamplet in the synthroid box, the dose should be 1.7mcg per pound. that would put me over 400mcg a day. Doc said if things did not improve at this dose he would start adding in some t3