Piperine - dangerous?

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    tangozero's Avatar
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    Piperine - dangerous?


    Anyone concernced about piperine? It's in a lot of supps (piperine/bioperine) - am I reading these studies right? In one of the studies piperine is shown to have 'in vivo anti-androgenic activity' and another 'decreased intratesticular testosterone'. However in the third it shows an increase in testosterone.
    Anyone have any insight or opinions on this? Doc H included. In the one rat study a 10mg dose was used which caused seminal/testicular disturbance.




    Effects of piperine on testis of albino rats. [J Ethnopharmacol. 1999] - PubMed - NCBI
    Testosterone 5alpha-reductase inhibitory act... [Biol Pharm Bull. 2007] - PubMed - NCBI

    Piperine, an active principle... [J Basic Clin Physiol Pharmacol. 2006] - PubMed - NCBI

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    haven't seen anything about that. I been using 10mg to help with curcumin and trans-resveratrol, would be interested in hearing what dinoiii may have to say.

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