Sir whats your thoughs on this? I didn't write this I just found this.
Curcumin, the herbal clenbuterol
Curcumin, the yellow colour [see structure below] in turmeric – Curcuma longa – turns out to be even more interesting for athletes than we thought, according to an animal study done by gerontologists at Tufts University. Curcumin inhibits the growth of fat tissue and stimulates fat burning in the body.
Curcumin is an anti-catabolic: in muscle cells it inhibits NFkB, a molecular regulator. By doing this curcumin inhibits the proteasome and the calpain proteins, two systems that the muscle cells use to break down proteins. High doses of curcumin prevent rats from breaking down muscles if they have serious blood poisoning. And, we hope, the same mechanism could help athletes to reduce the breakdown of muscles through training.
All old news for alert readers of this no-tech web magazine. But researchers at Tufts University have now published an article in the Journal of Nutrition describing a study in which they gave mice a high-fat diet for a period of twelve weeks. One group of mice was given food supplemented with half a gram of curcumin per kilogram. As you can see in the figure below, the curcumin reduces weight gain.
But, the addition of curcumin does not just inhibit the production of fat tissue, as you can see in the table below. The amount of free fatty acids, triglycerides and cholesterol in the animals’ blood indicates that curcumin also accelerates fat metabolism.
The table below shows what curcumin does to the fat tissue at cell level. The calorie-rich diet leads to an increase in the manufacture of VEGF, a hormone that stimulates cells to form blood vessels – essential for the growth of tissue. Curcumin reduces the amount of vessels that are laid down in the fat tissue, however, and therefore inhibits the growth of fat layers.
Curcumin also inhibits the production of PPAR-gamma, the sensor that alerts fat cells to the presence of fat. If the sensor works less well, fat cells absorb less fat.
Then the production of the enzyme carnitinepalmitoyltransferase-1 (CPT-1) rises. This enzyme attaches carnitine to fatty acids so that they are absorbed by the mitochondria, the energy generators in the cell.
Curcumin probably helps the cells to attach more phosphorus groups to the signal molecule AMPK. And this activates AMPK, an enzyme that recharges exhausted AMP energy molecules. The cell also uses the enzyme as a measure of the amount of energy. If AMPK becomes more active, the cells starts to work harder to provide more energy. Fat cells discharge their content into the blood; muscles absorb more glucose and burn more fatty acids. The figure below shows that curcumin increases the concentration of AMPK in the mice’s fat tissues.
More fat burning and anti-catabolic. Hmm. What does that remind us of?
Turmeric – clenbuterol in the kitchen cupboard.
J Nutr. 2009 Mar 18. [Epub ahead of print].