Thanks doc!
So something like Pure T2 from taurus (which is just 3,5 diiodo) or TT-33 from Iforce (which is a combo of 3,3 and 3,5) should be fine to take?
I was only concerned since within the advertisement for alpha T2 (which is just 3,3) they sad said that 3,5 was suppressive and more dangerous and 3,3 being the better option.
Glad to hear this isnt true. Thanks for clearing it all up doc!
The combo products are "interesting" as the entire rationale for using them in this fashion is to avoid potential suppression and yet still they put the 3,5 variant in coupled with the 3,3'.
Let's back up for a second and understand how this whole 3,5-T2 = suppresion / 3,3'-T2 = non-suppression thing shapes up...
T3 and 3,5-T2 are very similar in their effect on TSH with suppression at about 75% in RODENTS (mice or rats; I don't recall exactly nor do I have the citation). Similar studies with the 3,3'-T2 variant have comparably shown no suppression, however, one must consider the 3,5 is STRICTLY thyromimetic, which can NOT be said about the 3,3'.
For those looking at
quick cycles (your guess at a definition for this term is as good as mine); I am uncertain the level of suppression that would be seen with even the 3,5-T2 because there is an exponential impact when considering iodination cascades and susbequent feed into the HPTA. What I can say is that 3,5-T2 has actually increased basal metabolic rate (as measured gas analysis through either direct or indirect calorimetry as well as through calculation of the RQ for an individual). 3,5-T2 also has a MUCH better effect on GH secretion, increasing it about 5-fold.
How to summarize my aforementioned jibberish...
(1) I am not chastizing those that use both, BUT the reason to use both is NOT to avoid suppression.
(2) Suppression by way of 3,5-T2 can be avoided by short cycles, though we've never understood well what truly constitues "short."
(3) There is an exponential effect seen with T2/T3 and TSH and this allows us "rough predictability" of how long it would take to see effect on the HPTA, but nothing more (and I don't care if the best advertised supplement manufacturer suggests the contrary).
(4) Additional hormone alteration - like that of a 5-fold increase in GH - is seen with the 3,5-T2 and NOT the 3,3'-T2.
(5) I cannot speak for Taurus Nutrition's or IForce's products as no one outside of SAN has proven good sourcing in my estimation (not that I have asked said groups...but SAN is the only one I could verify). Given this is a VERY HARD item to source; I am gathering it is exceedingly easy to get screwed in this market if trying these products and a "buyer beware" effort should be used.
D_