Me too, I've been doing a lot of reading on the topic and it seems to have some solid science backing its effects on glucose.Originally Posted by Frank Reynolds
Always willing to learn :D
Na-R-Ala is the effective isomer and it is highly soluble so I'm sure he's going to pick Na-R-Ala .
WE SHALL SEE!!!Originally Posted by mr.cooper69
Always willing to learn :D
What do you think about recompadrol?
I eat very low carb and when I eat a meal with 10-20g carbs I usually have 1 cap of recompadrol prior.
I saw your post about refeeds and stopped taking it when i have my refeeds now
VS in rats is shown to increase leptin sensitivy when leptin is injected into them.
your able to kind of offset some of the fat gain via ACL inhibiton and PPARy down regulation along with increased glycogenolysis.
the insulin increase will still occur you just may need more to get the same responce which is fine if doing a refeed. general refeeds for a 180-185 lb individual (as per dan duchaines kg x 16) is about 1250-1440 carbs in the 2 days. Im sorry but im not doing that wityout a saftey net. Dan duchaine also advocates things like VS for refeeds as well as phenformin OR metformin (which berberine works very similar to show in human studies at 1500mg per day i believe)
also if your having a **** meal and not a real refeed you want to down regulate gene expression associated with fat gain.
Whoa! This is another thread that has gotten a lot of response; but unfortunately it will take me some time to wade through all the posts to give any kind of educated responses. I will likely have some time to offer much more with the holiday weekend.
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ALA on a cheat meal or refeed , after reading this i dont think so!!!!
dont want to inhibit secrection unless leptin resistant in which case its a golden supplement.
this also says it doesnt activate the insulin pathway...
i need full article.
- Lipoic acid;
- Sp1 transcription factor
Scope: Lipoic acid (LA) is an antioxidant with therapeutic potential on several diseases such as diabetes and obesity. Hyperleptinemia and oxidative stress play a major role in the development of obesity-linked diseases. The aim of this study was to examine in vivo and in vitro the effects of LA on leptin production, as well as to elucidate the mechanisms and signalling pathways involved in LA actions.
Methods and results: Dietary supplementation with LA decreased both circulating leptin, and adipose tissue leptin mRNA in rats. Treatment of 3T3-L1 adipocytes with LA caused a concentration-dependent inhibition of leptin secretion and gene expression. Moreover, LA stimulated the anaerobic utilization of glucose to lactate, which negatively correlated with leptin secretion. Furthermore, LA enhanced phosphorylation of Sp1 and inhibited Sp1 transcriptional activity in 3T3-L1 adipocytes. Moreover, LA inhibited Akt phosphorylation, a downstream target of phosphatidylinositol 3-kinase (PI3K). Treatment with the PI3K inhibitor LY294002 mimicked LA actions, dramatically inhibiting both leptin secretion and gene expression and stimulating Sp1 phosphorylation.
Conclusion: All of these data suggest that the phosphorylation of Sp1 and the accompanying reduced DNA-binding activity are likely to be involved in the inhibition of leptin induced by LA, which could be mediated in part by the abrogation of the PI3K/Akt pathway.
Dang this is horrible. Any idea how relevant/significant this study was? I mean there is so much more saying that ALA is a wonder supplement. I dont know if I'd toss it out because of this one study.
AK- wouldnt matter while dieting, it would just make it less time to do a refeed
for example every 5 instead of 7 or something like that i would assume.
i only use it on refeed. and a lot of it. i saw no difference... however....... i havent taken it in almost 2 weeks. and im leaner now then i was. at prolly same caloric intake.
Sometimes I'm under the impression that we simply know very lil about what really happens inside our bodies,
every other day there is a study coming out stating completely the opposite of the one before, and different from
the one that will come.
Bah, I'll start to really cut *a lot* of stuff that I use to take, stick to the basics,
few good product that I know they work on me, good prewo and that's it.
Diet and kick ass training will do the rest
Haha. Yup.Originally Posted by AutoKal47
ALA is amazing, i wont cut it out. i simply just dose higher.
I dose ala pretty high as well. But mainly for overall health. Not just for gdaOriginally Posted by ssbackwards
Omfg. That's one hell of a nutrient partitioner. Yg is great!!Originally Posted by ssbackwards
I am not sure if this was asked/answered yet but someone who has taken GDAs can chime in...I am going to start my first GDA got glyocobol on sale so that is going to be my first go. Do you have to cycle off GDAs or is it a supplement you can consider a staple?