Glucose Disposal Agents - Q&A with Dr. Dana Houser

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  1. Quote Originally Posted by AutoKal47 View Post
    Is coconut flour gonna be as good as coco oil? Because I have hard time finding the first one in shops here

    As for the carbs, I don't know if there is a medical condition for such thing, but I know for sure
    after several attempt that carbs do make me feel bad, it has nothing to do with appearance (i don't check myself out
    the day of the refeed or something) my stomach gets bloated, ridiculous amount of air in it and most important
    the next day I feel lethargic and I am objectively weaker, it's a fact I can repeat the experiment 10 times,
    and it gives me the same result.

    I'll try with MCTs then, I was about to anyway
    typically the bloat comes from an allergy.

    now. think of it this way, you may be gluten sensitive or have a gluten allergy. Now if thats the case, AVENIN from oats is similar to that.

    So it can cause issues, hell i cant eat oatmeal. I suggest you try jasmine rice on refeed. replace oats with that. or rice krispies. or some sort of rice related product thats got no whole wheat.

    Even amaranth, or quinoa. you will see a difference. Trust me. The avenin plus fiber may be too much for you,


  2. Quote Originally Posted by ssbackwards View Post
    typically the bloat comes from an allergy.

    now. think of it this way, you may be gluten sensitive or have a gluten allergy. Now if thats the case, AVENIN from oats is similar to that.

    So it can cause issues, hell i cant eat oatmeal. I suggest you try jasmine rice on refeed. replace oats with that. or rice krispies. or some sort of rice related product thats got no whole wheat.

    Even amaranth, or quinoa. you will see a difference. Trust me. The avenin plus fiber may be too much for you,
    Gluten kills me, but other carbs work well. Well basically ONLY sweet potato.
    RecoverBro ELITE
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  3. Quote Originally Posted by ssbackwards View Post
    typically the bloat comes from an allergy.

    now. think of it this way, you may be gluten sensitive or have a gluten allergy. Now if thats the case, AVENIN from oats is similar to that.

    So it can cause issues, hell i cant eat oatmeal. I suggest you try jasmine rice on refeed. replace oats with that. or rice krispies. or some sort of rice related product thats got no whole wheat.

    Even amaranth, or quinoa. you will see a difference. Trust me. The avenin plus fiber may be too much for you,
    I know potatoes do the same, rice I have no idea, it's something like 8 years that i haven't touched it

    'bout the coconut oil vs flour? I checked facts and I'm pretty sure is not the same right?
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  4. Coconut flour, I have some....Its mostly fats and protein. But its the chewy portion of the nut so its mostly all fiber.
    RecoverBro ELITE

  5. Quote Originally Posted by ssbackwards View Post
    typically the bloat comes from an allergy.

    now. think of it this way, you may be gluten sensitive or have a gluten allergy. Now if thats the case, AVENIN from oats is similar to that.

    So it can cause issues, hell i cant eat oatmeal. I suggest you try jasmine rice on refeed. replace oats with that. or rice krispies. or some sort of rice related product thats got no whole wheat.

    Even amaranth, or quinoa. you will see a difference. Trust me. The avenin plus fiber may be too much for you,
    That is what I am driving at in regards to a "medical" condition.

    It is not normal to be a bloated mess, from 45g of oats.
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  6. Quote Originally Posted by Frank Reynolds View Post
    That is what I am driving at in regards to a "medical" condition.

    It is not normal to be a bloated mess, from 45g of oats.
    or 60gr of potatoes.. I know right?

    I mean, I don't really care since I hate oats, rice, potatoes, bread etc..
    so mentally is all good, I crave protein all the time, beef, eggs, chicken turkey
    that's heaven for me but the whole metabolism thing bothers me
    because I'm sure i'm leaving gains on the table, gains that I could get
    - slowly sure, but I'm not aiming at getting 300lbs or even 200lbs -
    while staying lean :/
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  7. Quote Originally Posted by AutoKal47 View Post
    or 60gr of potatoes.. I know right?

    I mean, I don't really care since I hate oats, rice, potatoes, bread etc..
    so mentally is all good, I crave protein all the time, beef, eggs, chicken turkey
    that's heaven for me but the whole metabolism thing bothers me
    because I'm sure i'm leaving gains on the table, gains that I could get
    - slowly sure, but I'm not aiming at getting 300lbs or even 200lbs -
    while staying lean :/
    broski just eat a FULL box of gushers fruit snacks, its 240g carb for the whole box no high fructose corn sysrup.

    start there, 1 time wont kill you.

  8. I am telling you right now.. This stuff is anabolic..



  9. mmmmmhh Strawberry and Green Apple, man that'd be awesome
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  10. I usually eat a natty PB and banana sandwich tasty
    Always willing to learn :D

  11. Quote Originally Posted by Frank Reynolds View Post
    Great thread!

    So what is your recommended dose of R-ala or Na-rala in terms of a lower carb meal for ex. 50g or less, and a larger carb meal of say 100-200g?
    I would love to hear your thoughts on this. As well as your preference between ALA, R-ALA, and NA-RALA

  12. Quote Originally Posted by Frank Reynolds

    I would love to hear your thoughts on this. As well as your preference between ALA, R-ALA, and NA-RALA
    Me too, I've been doing a lot of reading on the topic and it seems to have some solid science backing its effects on glucose.
    Always willing to learn :D

  13. Na-R-Ala is the effective isomer and it is highly soluble so I'm sure he's going to pick Na-R-Ala .

  14. Quote Originally Posted by mr.cooper69
    Na-R-Ala is the effective isomer and it is highly soluble so I'm sure he's going to pick Na-R-Ala .
    WE SHALL SEE!!!
    Always willing to learn :D

  15. What do you think about recompadrol?

    I eat very low carb and when I eat a meal with 10-20g carbs I usually have 1 cap of recompadrol prior.

    I saw your post about refeeds and stopped taking it when i have my refeeds now

  16. Quote Originally Posted by RawStrength View Post
    What do you think about recompadrol?

    I eat very low carb and when I eat a meal with 10-20g carbs I usually have 1 cap of recompadrol prior.

    I saw your post about refeeds and stopped taking it when i have my refeeds now
    this comes to an individuality.

    VS in rats is shown to increase leptin sensitivy when leptin is injected into them.

    your able to kind of offset some of the fat gain via ACL inhibiton and PPARy down regulation along with increased glycogenolysis.

    the insulin increase will still occur you just may need more to get the same responce which is fine if doing a refeed. general refeeds for a 180-185 lb individual (as per dan duchaines kg x 16) is about 1250-1440 carbs in the 2 days. Im sorry but im not doing that wityout a saftey net. Dan duchaine also advocates things like VS for refeeds as well as phenformin OR metformin (which berberine works very similar to show in human studies at 1500mg per day i believe)

    also if your having a **** meal and not a real refeed you want to down regulate gene expression associated with fat gain.

  17. Whoa! This is another thread that has gotten a lot of response; but unfortunately it will take me some time to wade through all the posts to give any kind of educated responses. I will likely have some time to offer much more with the holiday weekend.



    D_
    Anabolicminds.com Featured Author

  18. bump
    iForceHemavol=He-man?-http://anabolicminds.com/forum/supplement-reviews-logs/187487-hemavol-heman-doughs.htmlCompound 20 Beta log-http://anabolicminds.com/forum/supplement-reviews-logs/185396-molding-dough-compound.html

  19. http://onlinelibrary.wiley.com/doi/1...201000534/full

    ALA on a cheat meal or refeed , after reading this i dont think so!!!!

    dont want to inhibit secrection unless leptin resistant in which case its a golden supplement.

    this also says it doesnt activate the insulin pathway...

    i need full article.

    Keywords:

    • Lipoic acid;
    • Leptin;
    • Obesity;
    • PI3K;
    • Sp1 transcription factor

    Abstract

    Scope: Lipoic acid (LA) is an antioxidant with therapeutic potential on several diseases such as diabetes and obesity. Hyperleptinemia and oxidative stress play a major role in the development of obesity-linked diseases. The aim of this study was to examine in vivo and in vitro the effects of LA on leptin production, as well as to elucidate the mechanisms and signalling pathways involved in LA actions.

    Methods and results: Dietary supplementation with LA decreased both circulating leptin, and adipose tissue leptin mRNA in rats. Treatment of 3T3-L1 adipocytes with LA caused a concentration-dependent inhibition of leptin secretion and gene expression. Moreover, LA stimulated the anaerobic utilization of glucose to lactate, which negatively correlated with leptin secretion. Furthermore, LA enhanced phosphorylation of Sp1 and inhibited Sp1 transcriptional activity in 3T3-L1 adipocytes. Moreover, LA inhibited Akt phosphorylation, a downstream target of phosphatidylinositol 3-kinase (PI3K). Treatment with the PI3K inhibitor LY294002 mimicked LA actions, dramatically inhibiting both leptin secretion and gene expression and stimulating Sp1 phosphorylation.

    Conclusion: All of these data suggest that the phosphorylation of Sp1 and the accompanying reduced DNA-binding activity are likely to be involved in the inhibition of leptin induced by LA, which could be mediated in part by the abrogation of the PI3K/Akt pathway.

  20. Quote Originally Posted by ssbackwards View Post
    http://onlinelibrary.wiley.com/doi/1...201000534/full

    ALA on a cheat meal or refeed , after reading this i dont think so!!!!

    dont want to inhibit secrection unless leptin resistant in which case its a golden supplement.

    this also says it doesnt activate the insulin pathway...

    i need full article.

    Keywords:

    • Lipoic acid;
    • Leptin;
    • Obesity;
    • PI3K;
    • Sp1 transcription factor
    Abstract

    Scope: Lipoic acid (LA) is an antioxidant with therapeutic potential on several diseases such as diabetes and obesity. Hyperleptinemia and oxidative stress play a major role in the development of obesity-linked diseases. The aim of this study was to examine in vivo and in vitro the effects of LA on leptin production, as well as to elucidate the mechanisms and signalling pathways involved in LA actions.

    Methods and results: Dietary supplementation with LA decreased both circulating leptin, and adipose tissue leptin mRNA in rats. Treatment of 3T3-L1 adipocytes with LA caused a concentration-dependent inhibition of leptin secretion and gene expression. Moreover, LA stimulated the anaerobic utilization of glucose to lactate, which negatively correlated with leptin secretion. Furthermore, LA enhanced phosphorylation of Sp1 and inhibited Sp1 transcriptional activity in 3T3-L1 adipocytes. Moreover, LA inhibited Akt phosphorylation, a downstream target of phosphatidylinositol 3-kinase (PI3K). Treatment with the PI3K inhibitor LY294002 mimicked LA actions, dramatically inhibiting both leptin secretion and gene expression and stimulating Sp1 phosphorylation.

    Conclusion: All of these data suggest that the phosphorylation of Sp1 and the accompanying reduced DNA-binding activity are likely to be involved in the inhibition of leptin induced by LA, which could be mediated in part by the abrogation of the PI3K/Akt pathway.
    Wow.. that's some news.

    I haven't been using GDAs on refeed day since this 3d, but at this point
    wouldn't be better not to use ALA AT ALL when dieting to avoid further drop of leptin?
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  21. Dang this is horrible. Any idea how relevant/significant this study was? I mean there is so much more saying that ALA is a wonder supplement. I dont know if I'd toss it out because of this one study.
    RecoverBro ELITE

  22. Quote Originally Posted by mattrag View Post
    Dang this is horrible. Any idea how relevant/significant this study was? I mean there is so much more saying that ALA is a wonder supplement. I dont know if I'd toss it out because of this one study.
    cant really know aside from the full study to review it all.

    AK- wouldnt matter while dieting, it would just make it less time to do a refeed

    for example every 5 instead of 7 or something like that i would assume.

    i only use it on refeed. and a lot of it. i saw no difference... however....... i havent taken it in almost 2 weeks. and im leaner now then i was. at prolly same caloric intake.

  23. Sometimes I'm under the impression that we simply know very lil about what really happens inside our bodies,
    every other day there is a study coming out stating completely the opposite of the one before, and different from
    the one that will come.

    Bah, I'll start to really cut *a lot* of stuff that I use to take, stick to the basics,
    few good product that I know they work on me, good prewo and that's it.
    Diet and kick ass training will do the rest
    ..:: ENHANCED BODY FORMULATIONS ::..
    Recompadrol & AAV2 - PM me with any questions


  24. Quote Originally Posted by AutoKal47
    Sometimes I'm under the impression that we simply know very lil about what really happens inside our bodies,
    every other day there is a study coming out stating completely the opposite of the one before, and different from
    the one that will come.

    Bah, I'll start to really cut *a lot* of stuff that I use to take, stick to the basics,
    few good product that I know they work on me, good prewo and that's it.
    Diet and kick ass training will do the rest
    Haha. Yup.
    RecoverBro ELITE

  25. ALA is amazing, i wont cut it out. i simply just dose higher.
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