Fertility

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  1. Quote Originally Posted by lboston View Post
    Doc-

    I am new to anabolic minds and the use of the forums. I hope my question is correctly placed. I am almost 27 years old and my wife and I recently had a baby--she's ten months now. We are wanting to attempt to get pregnant again sometime in the summer of 2012.

    My wife has been pregnant twice--once ending in miscarriage--and each time we "tried" for approximately a month, maybe two. Originally I had the scare of possibly having difficulty getting her pregnant as I am a survivor of pediatric liver cancer.

    My question is, if I were to start a stack of Anabeta, DAA, and Erase would there likely be any negative effects on sperm count or quality? What sort of supplements should I stay away from?

    Many thanks for the information you provide on the forums.
    Well, it is hard to assess. "AnaBeta" is a product featuring Anacyclus pyrethrum DC Extract which in the only rat studies I am aware of were done by one single group (not the best sign); but never evaluated the effects in either humans and never even offered the biochemical analysis (i.e. - serum testosterone, et al...), but instead used the objective measure of sperm count (with no mention of motility) and then behavior characters (i.e. - mount frequency, et al....) which is subjective as hell. There was increase in accessory sex organ volume...and I am uncertain anyone can tell you how this collective data will affect fertility with certainty OR they're lying through their teeth. But, it is possible that anything modulating the HPGA will have impact on what outcomes you see in the fertility arena.

    The authors seem to take a leap of faith saying there is an association between sexual behaviors and spermatogenesis (sperm count and fructose levels in seminal vesicle were markedly increased) AND increased LH/FSH and testosterone, but then didn't provide us with that biochemical analysis which is quintessential to the discussion. Yes, yes...I know; but either motility wasn't mentioned because of sheer lack of funds OR negative results OR fear of results. In any of these scenarios, it is NEEDED to make accurate assessments on a fertility model, which the authors fell well short of discussing and it behooved them to do it in that fashion. Unfortunately, it means I cannot offer a lot of feedback because it would be GUESSING alone here, so I won't.


    With DAA (and hopefully you have opted to use Mucuna); there is accurate biochemical analysis to accompany suggested semen offerings, PLUS not only increased sperm counts BUT also motility (which is unusual) in the setting of any fertility treatment for male factor.


    With "Erase," we're really pushing the envelope to suggest concurrent fertility desires. Androst-3,5-diene-7,17-dione (also known as 3-deoxy-7-oxo-DHEA) WILL impart androgen effect which makes fertility even a more challenging prediction that the previous two. I am not saying you WILL NOT have children on the product (as I have had many also have children on much harsher agents), but there is good possibility - if you are in the majority - that you will potentiate issues should they exist.


    Now - I have had an unusual amount of people using the product "Triazole" from DS and finding their significant others (spouses, girlfriends, mistresses, whatever...) pregnant. This is not to suggest I understand what is happening with it because I DO NOT, nor should it serve as a recommendation; I am just offering you my experience with an agent that you may find useful should AnaBeta and/or Erase not turn out to be for you.


    You mention that you almost thought you were going to have difficulty getting someone pregnant because of pediatric liver cancer; do you feel comfortable expanding upon that? Have you ever had a semen analysis of your own done (usually they are an out-of-pocket expense that can be claimed on taxes as opposed to always covered), as this may give you some data allowing us to offer a better guesstimate as to what these products may do?


    Please keep us abreast of your progress...I think we would all be intrigued to learn of your successes and/or failures with said products. I could only caution against stirring the pot possibly unnecessarily. If you want, maybe use the products for a 1 to 3 month run in the near future and cease all of them with the upcoming spring in preparation for trying once again.



    D_
    Anabolicminds.com Featured Author


  2. Quote Originally Posted by ripped_one View Post
    I need to restate this... my lab tests were in and the nurse said everything looked ok a few days ago, but after the doc let me look at the paperwork today, things are still off a little. This is now 6 months after my last shot.

    Total sperm: 75 million (40-300 is 'normal', but average is usually like 180, so I'm slightly low here)
    Motility: 30% (25 is the minimum normal, so I'm on the low side but still normal)
    Morphology: 4% (4% is minimum to be normal, so I'm definitely on the low side here)

    Now maybe there's a chance that this is how I would have been anyway, but I'm pretty sure it has something to do with the sauce...
    I actually don't care for the motility number at all! We usually like them around 50%.

    Given your number (75 million); it still leaves you with 22.5 million active swimmers; so it isn't horrible from an overt fertility standpoint.

    Are you looking for pregnancy in the near future? Have you had any previous successful pregnancies?


    D_
    Anabolicminds.com Featured Author
    •   
       


  3. Quote Originally Posted by JRC View Post
    Dr. D...wants your thoughts on taking the basic supplements plus creatine, beta alanine, taurine, and a few fat loss supps while trying for a baby? Any complications that you think could happen? Not sure if I should drop any or not. If you require more info I can PM you my whole supplement list. Thanks.
    As for the supplements you mention, there is no data on fertility I am afraid although if not effecting the HPGA, I am going to say likely very little effect. If you use a "fat loss supplement" with thyroidal activity, there is a chance of affecting an alternative axis, but again ... probably very low.

    I could take a look at your entire supplement list if you want, but my answers may be vague as I am almost certain the data won't be there. But like I said, the chances are probably very low.


    D_
    Anabolicminds.com Featured Author

  4. Quote Originally Posted by dinoiii View Post
    I actually don't care for the motility number at all! We usually like them around 50%.

    Given your number (75 million); it still leaves you with 22.5 million active swimmers; so it isn't horrible from an overt fertility standpoint.

    Are you looking for pregnancy in the near future? Have you had any previous successful pregnancies?


    D_
    Couldn't agree more. Did they happen to give you an overall grade of progression? Motility can mean VERY little if you have a low / high grade motility. Often times when I'm performing my IUI's / SA's, if they have a high grade motility, with low concentration, they still often have successful cycles. Much like Dana mentioned, 50% is fine for motility (again the level of progression matters most here), and we have many patients that are teratozoospermic (<4% normal sperm forms) with a chance for potential fertilization to occur.

  5. Can you explain this comment further " With "Erase," we're really pushing the envelope to suggest concurrent fertility desires. Androst-3,5-diene-7,17-dione (also known as 3-deoxy-7-oxo-DHEA) WILL impart androgen effect which makes fertility even a more challenging prediction that the previous two. "
    doing my own thang!
    •   
       


  6. Quote Originally Posted by dinoiii View Post
    I actually don't care for the motility number at all! We usually like them around 50%.

    Given your number (75 million); it still leaves you with 22.5 million active swimmers; so it isn't horrible from an overt fertility standpoint.

    Are you looking for pregnancy in the near future? Have you had any previous successful pregnancies?


    D_
    The motility number was calculated using the 'strict' method, and the average is usually around 8% I think. The lab considers 4% to be normal, as their grading standard is very high. Using the WHO method it would be closer to 40%.

    I don't have any kids, but looking to have some soon.

  7. Quote Originally Posted by ripped_one View Post
    The motility number was calculated using the 'strict' method, and the average is usually around 8% I think. The lab considers 4% to be normal, as their grading standard is very high. Using the WHO method it would be closer to 40%.

    I don't have any kids, but looking to have some soon.
    Using Krugers Strict, WHO, or any other criteria it won't change the % motility you have. Just whether or not you are considered astheno-zoospermic.

  8. Quote Originally Posted by ripped_one View Post
    The motility number was calculated using the 'strict' method, and the average is usually around 8% I think. The lab considers 4% to be normal, as their grading standard is very high. Using the WHO method it would be closer to 40%.

    I don't have any kids, but looking to have some soon.
    I meant to say morphology.... Not motility... way too early haha.

  9. Quote Originally Posted by ripped_one View Post
    I meant to say morphology.... Not motility... way too early haha.
    Ah, same situation though. Their grading methods will not change your actual #'s, just whether or not you set off any panic values according to their guidelines.

  10. Quote Originally Posted by andrew732 View Post
    Can you explain this comment further " With "Erase," we're really pushing the envelope to suggest concurrent fertility desires. Androst-3,5-diene-7,17-dione (also known as 3-deoxy-7-oxo-DHEA) WILL impart androgen effect which makes fertility even a more challenging prediction that the previous two. "
    Sure thing. As the ads would suggest, this product is said to have significant impact on androgens (in particular, it suggests elevating testosterone levels in a pretty significant way; although I will allow 75% of ad copy to account for outlandishness - I see that you are sponsored by the parent company). If testosterone synthesis is supposed to increase the way suggested, it will play into negative feedback systems.

    We do NOT know (hence my comment "challenging prediction") how this product will affect the HPGA and even the company can NOT offer me suggestion to the contrary because the data simply doesn't exist. Now, I am not saying it doesn't do what it says it does - in fact...just the opposite...that if it does, in fact, do what the ads boast, then fertility will subsequently become a question in most men.


    D_
    Anabolicminds.com Featured Author

  11. Quote Originally Posted by dinoiii

    Sure thing. As the ads would suggest, this product is said to have significant impact on androgens (in particular, it suggests elevating testosterone levels in a pretty significant way; although I will allow 75% of ad copy to account for outlandishness - I see that you are sponsored by the parent company). If testosterone synthesis is supposed to increase the way suggested, it will play into negative feedback systems.

    We do NOT know (hence my comment "challenging prediction") how this product will affect the HPGA and even the company can NOT offer me suggestion to the contrary because the data simply doesn't exist. Now, I am not saying it doesn't do what it says it does - in fact...just the opposite...that if it does, in fact, do what the ads boast, then fertility will subsequently become a question in most men.

    D_
    Thank you very much for your time on this topic. With the quality and "health" of sperm in mind, do you happen to know if any of the ingredients/ formula of Universal's Animal Stak and Animal M-Stak could have a negative affect on male fertility and semen quality?

    I just don't want to risk the health of my future children to put on some body mass and with many products there aren't any answers or assumptions to this.

    Are there any natural products that you personally feel are "safe" in this regards and would suggest for use?

  12. Quote Originally Posted by dinoiii View Post
    Sure thing. As the ads would suggest, this product is said to have significant impact on androgens (in particular, it suggests elevating testosterone levels in a pretty significant way; although I will allow 75% of ad copy to account for outlandishness - I see that you are sponsored by the parent company). If testosterone synthesis is supposed to increase the way suggested, it will play into negative feedback systems.

    We do NOT know (hence my comment "challenging prediction") how this product will affect the HPGA and even the company can NOT offer me suggestion to the contrary because the data simply doesn't exist. Now, I am not saying it doesn't do what it says it does - in fact...just the opposite...that if it does, in fact, do what the ads boast, then fertility will subsequently become a question in most men.


    D_
    I see, couldn't it be said the same for exemestane?
    doing my own thang!

  13. Quote Originally Posted by andrew732 View Post
    I see, couldn't it be said the same for exemestane?
    I was going to ask this as well about Formestane; considering the steroidal nature of Formestane would it also suffer from these problems? I understand that too high a dose is literally suppressive to testosterone production and defeats the benefits of the low estrogen negative feedback loop...

    How bout with moderate suggested dosing? would fertility be a concern at these typical doses?
    iForceHemavol=He-man?-http://anabolicminds.com/forum/supplement-reviews-logs/187487-hemavol-heman-doughs.htmlCompound 20 Beta log-http://anabolicminds.com/forum/supplement-reviews-logs/185396-molding-dough-compound.html

  14. Hey Dana, did you happen to go to ASRM this year? One of our doctors is going to be on CBS tonight with 2 of our patients discussing fertility and pregnancy in women over 40 years old.

  15. Quote Originally Posted by lboston View Post
    Thank you very much for your time on this topic. With the quality and "health" of sperm in mind, do you happen to know if any of the ingredients/ formula of Universal's Animal Stak and Animal M-Stak could have a negative affect on male fertility and semen quality?

    I just don't want to risk the health of my future children to put on some body mass and with many products there aren't any answers or assumptions to this.

    Are there any natural products that you personally feel are "safe" in this regards and would suggest for use?

    Do me a favor... please post the ingredient profile that best approximates your products. I ask because Universal is notorious for having multiple versions of products (perhaps unbeknownst to you) and it would be imperative to see the ingredients in question. A good example from the so-called "Methoxy-Stak" -or, more recently- "M-Stak" which has very unusual components dependent upon the version you have... for instance, the "Triboxybol" - part of some older versions is NOT in the newest ones as far as I understand.

    I presume that you mean..."natural products to increase fertility" when you ask what I feel are "safe" in the fertility domain...correct?


    D_
    Anabolicminds.com Featured Author

  16. Quote Originally Posted by andrew732 View Post
    I see, couldn't it be said the same for exemestane?
    Quote Originally Posted by Sourdough View Post
    I was going to ask this as well about Formestane; considering the steroidal nature of Formestane would it also suffer from these problems?
    Yes on both accounts; anything at all that alters the HPGA could - at least theoretically - have an impact on fertility if dosed in an equally efficacious manner to approximate most, if not all, studies performed to show benefit on the testosterone scale. If I could say that something is "better" than another...it might be something that increases T and either increases or keeps the same LH while decreasing FSH. At the same time if both LH and FSH are decreased, I have a much bigger problem with it in this (the fertility one) arena.



    I understand that too high a dose is literally suppressive to testosterone production and defeats the benefits of the low estrogen negative feedback loop...

    How bout with moderate suggested dosing? would fertility be a concern at these typical doses?
    Your definition of "typical" or "moderate" dose and mine may be inherently different, so please be more specific so I know what I am referring to when responding.

    In the estrogen dominant person, some estrogen control is probably going to assist the person in conception as opposed to attenuate it; but the problem is - most men do NOT get baseline lab work before embarking on supplementation and that's one very unfortunate thing. One thing that you must NOT lose sight of is that estrogen is vital to male fertility (usually at the level of ER-alpha) -- specifically to sperm count and quality (its activity is responsible for maintaining epithelial cytoarchitecture in efferent ductules and the reabsorption of fluid for concentrating sperm in the head of the epididymis), so the complete annhilation of estrogen could actually be far worse to the picture in a non-estrogen dominant profile.

    This is a much more complex subject area (Estrogen and fertility) than I think people give credit sometimes.


    D_
    Anabolicminds.com Featured Author

  17. Quote Originally Posted by DaveGabe24 View Post
    Hey Dana, did you happen to go to ASRM this year?
    Unfortunately, I was very limited in my conference attendance this year and did not attend.

    I even missed some of the more prominent meetings I would normally attend: ENDO, ADA, CMHC, ACSM, ISSN, NSCA (just very hard scheduling time this year)


    One of our doctors is going to be on CBS tonight with 2 of our patients discussing fertility and pregnancy in women over 40 years old.
    I don't tend to watch a lot of TV, any follow-up links on-line, etc...


    D_
    Anabolicminds.com Featured Author

  18. Quote Originally Posted by dinoiii View Post
    Do me a favor... please post the ingredient profile that best approximates your products. I ask because Universal is notorious for having multiple versions of products (perhaps unbeknownst to you) and it would be imperative to see the ingredients in question. A good example from the so-called "Methoxy-Stak" -or, more recently- "M-Stak" which has very unusual components dependent upon the version you have... for instance, the "Triboxybol" - part of some older versions is NOT in the newest ones as far as I understand.

    I presume that you mean..."natural products to increase fertility" when you ask what I feel are "safe" in the fertility domain...correct?


    D_
    The ingredients for the Animal M-Stak:

    Amount Per Serving:
    Natural Flavone/Sterone Complex 750mg
    Ecdysterone
    5-Methyl-7-Methoxyisoflavone
    Ajuga Turkestanica Extract (Turkesterone)
    Sitosterol
    Anti-Catabolic Amino Complex 3000mg L-Leucine
    Leucine Alpha Ketoglutarate (AKG)
    Leucine Ethyl Ester
    L-Isoleucine
    L-Valine
    L-Taurine
    Acetyl-L-Carnitine (ALC)

    Anabolic Adaptogen Complex 1000mg
    Muira Puama
    Kudzu Extract (Isoflavones)
    Safed Musli
    Rhodiola Rosea Extract (Rosavins)

    Insulin Potentiating Complex 500mg
    4-Hydroxyisoleucine
    Banana Leaf Extract (1-3% Colosolic Acid)
    Cinnulin PF
    K-R-Alpha Lipoic Acid (K-R-ALA)

    M Factor Complex 500mg
    Ginger Root Extract (Gingerols, Shaogols)
    6,7-Dihydroxybergmottin
    Bioperine

    Energy Complex 500mg
    (as L-valine)
    Methylxanthine Complex (Caffeine, Theobromine, Theophylline)
    Evodiamine

    Other Ingredients:
    Methylxanthine Complex (50% kola nut extract, 22% guarana extract), fenugreek extract, cyanotis vaga extract, evodiae fructus extract, grapefruit extract, cinnamon root extract, gelatin, dicalcium phosphate, whey (milk), microcrystalline cellulose, titanium dioxide, stearic acid, magnesium stearate, FD&C Blue #1, FD&C Red #40.Bioperine is Piper nigrum extract standardized for a minimum of 95% piperine

    The ingredients for the Animal Stak:

    Amount Per Serving:

    Vitamin C: 100mg
    Vitamin B6: 10.5mg
    Magnesium: 450mg
    Zinc: 30mg
    Chromium: 100mcg

    Natural Test Complex:
    longjack extract complex: 250mg
    avena sativa extract: 250mg
    tribulus extract complex: 500mg

    Growth Hormone Secretagogues:
    mucuna pruriens extract: 250mg
    alpha glycerylphosphorylcholine: 50mg

    Vasodilator Complex: 750mg
    arginine alpha-ketoglutarate
    arginine ketoisocaproate

    Aromatase Inhibitors:
    calcium d-glucarate: 100mg
    diindolymethane: 100mg

    DHT Blockers:
    -sitosterol: 250mg
    saw palmetto extract: 200mg
    pygenum africanum: 50mg

    Cortisol Inhibitor Complex: 300mg
    acetyl- l-carnitine
    phosphatidylserine

    Liver Detoxifiers:
    lysophosphatidylcholine: 50mg
    milk thistle extract: 200mg

    Other ingredients:
    Gelatin, dicalcium phosphate, whey, lecithin, microscrystallinr cellulose, stearic acid, and magnesium stearate.

    Longjack Extract Complex is a proprietary blend of Eurycoma Longifolia, including patented LJ100 standardized for 28% bioactive glycopeptide compounds and 40% glycosaponins.

    I am not so much interested in products that "increase fertility", as I do not think that is a problem for myself, but am more concerned about taking any product that would adversely affect male fertility.

    Do you have any recommendations of natural t-boosters that you feel would not adversely affect fertility and are affective for adding lean body mass?

  19. Quote Originally Posted by dinoiii View Post
    As for the supplements you mention, there is no data on fertility I am afraid although if not effecting the HPGA, I am going to say likely very little effect. If you use a "fat loss supplement" with thyroidal activity, there is a chance of affecting an alternative axis, but again ... probably very low.

    I could take a look at your entire supplement list if you want, but my answers may be vague as I am almost certain the data won't be there. But like I said, the chances are probably very low.


    D_
    Thanks Dr. D! Working on my list right now, will send you a PM when finished.

  20. My wife and I went in for Iui today, and my sperm count was 198 million, with 82% motility. Total washed was 34.4 million, with 93% motility and grade 4. Not sure what changed, but I guess the extra 6 weeks helped. Damn near 8 months after finishing a long cycle to get back to normal, even with nolva, letro, and hmg injects. Sheesh.

  21. Remember ... only takes 1 out if those million and wish you guys the best of luck.
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  22. Quote Originally Posted by lboston View Post
    The ingredients for the Animal M-Stak:

    Amount Per Serving:
    Natural Flavone/Sterone Complex 750mg
    Ecdysterone
    5-Methyl-7-Methoxyisoflavone
    Ajuga Turkestanica Extract (Turkesterone)
    Sitosterol
    Anti-Catabolic Amino Complex 3000mg L-Leucine
    Leucine Alpha Ketoglutarate (AKG)
    Leucine Ethyl Ester
    L-Isoleucine
    L-Valine
    L-Taurine
    Acetyl-L-Carnitine (ALC)

    Anabolic Adaptogen Complex 1000mg
    Muira Puama
    Kudzu Extract (Isoflavones)
    Safed Musli
    Rhodiola Rosea Extract (Rosavins)

    Insulin Potentiating Complex 500mg
    4-Hydroxyisoleucine
    Banana Leaf Extract (1-3% Colosolic Acid)
    Cinnulin PF
    K-R-Alpha Lipoic Acid (K-R-ALA)

    M Factor Complex 500mg
    Ginger Root Extract (Gingerols, Shaogols)
    6,7-Dihydroxybergmottin
    Bioperine

    Energy Complex 500mg
    (as L-valine)
    Methylxanthine Complex (Caffeine, Theobromine, Theophylline)
    Evodiamine

    Other Ingredients:
    Methylxanthine Complex (50% kola nut extract, 22% guarana extract), fenugreek extract, cyanotis vaga extract, evodiae fructus extract, grapefruit extract, cinnamon root extract, gelatin, dicalcium phosphate, whey (milk), microcrystalline cellulose, titanium dioxide, stearic acid, magnesium stearate, FD&C Blue #1, FD&C Red #40.Bioperine is Piper nigrum extract standardized for a minimum of 95% piperine

    The ingredients for the Animal Stak:

    Amount Per Serving:

    Vitamin C: 100mg
    Vitamin B6: 10.5mg
    Magnesium: 450mg
    Zinc: 30mg
    Chromium: 100mcg

    Natural Test Complex:
    longjack extract complex: 250mg
    avena sativa extract: 250mg
    tribulus extract complex: 500mg

    Growth Hormone Secretagogues:
    mucuna pruriens extract: 250mg
    alpha glycerylphosphorylcholine: 50mg

    Vasodilator Complex: 750mg
    arginine alpha-ketoglutarate
    arginine ketoisocaproate

    Aromatase Inhibitors:
    calcium d-glucarate: 100mg
    diindolymethane: 100mg

    DHT Blockers:
    -sitosterol: 250mg
    saw palmetto extract: 200mg
    pygenum africanum: 50mg

    Cortisol Inhibitor Complex: 300mg
    acetyl- l-carnitine
    phosphatidylserine

    Liver Detoxifiers:
    lysophosphatidylcholine: 50mg
    milk thistle extract: 200mg

    Other ingredients:
    Gelatin, dicalcium phosphate, whey, lecithin, microscrystallinr cellulose, stearic acid, and magnesium stearate.

    Longjack Extract Complex is a proprietary blend of Eurycoma Longifolia, including patented LJ100 standardized for 28% bioactive glycopeptide compounds and 40% glycosaponins.

    I am not so much interested in products that "increase fertility", as I do not think that is a problem for myself, but am more concerned about taking any product that would adversely affect male fertility.

    Do you have any recommendations of natural t-boosters that you feel would not adversely affect fertility and are affective for adding lean body mass?
    Omigod! There is SO MUCH in these supplements, I would be hard pressed given the degree of interaction with many herbals and semen quality that something doesn't take effect...my only hope is that the quantities are so small because they kitchen-sinked it that it would be no more than wallet-slimming versus anything else.


    D_
    Anabolicminds.com Featured Author

  23. Quote Originally Posted by ripped_one View Post
    My wife and I went in for Iui today, and my sperm count was 198 million, with 82% motility. Total washed was 34.4 million, with 93% motility and grade 4. Not sure what changed, but I guess the extra 6 weeks helped. Damn near 8 months after finishing a long cycle to get back to normal, even with nolva, letro, and hmg injects. Sheesh.
    Wow - interesting that you still went to IUI. What reasoning did you have to not expect spontaneous insemination with these numbers? I don't know that IUI added a lot of value to this equation (compared with spontaneous). Of course, fertility people might tell you different but success rates with IUI are something to yawn at in most instances IMO.

    D_
    Anabolicminds.com Featured Author
  24. Interesting For Motility Woes


    The antioxidant hormone melatonin may play a role in the production of healthy sperm, according to a new study. Previous research has shown that sperm contain melatonin and have melatonin membrane receptors, yet the relationship between melatonin and sperm health had not yet been determined. The American Society for Reproductive Medicine states that one-third of infertility cases among couples are due to male factors.

    In this study, sperm from 52 men with impaired fertility was examined. The sperm was evaluated for concentration, motility and morphology (structure). In addition, the subjects were evaluated for urinary 6-sulfatoxy-melatonin and urinary total antioxidant capacity to determine if there was a correlation between the sperm parameters evaluated and melatonin and antioxidant status. In vitro, the sperm was exposed to melatonin and evaluated for changes in motility.

    The results of the study showed that increased urinary levels of 6-sulfatoxy-melatonin and total antioxidant capacity correlated with increased sperm concentration, motility and improved morphology. In vitro, sperm treated with melatonin for 30 minutes showed increased sperm motility and an increase in the percentage of rapidly swimming cells.

    The study concluded that melatonin improves semen quality. Based on the results of this research, it is likely that this unique antioxidant hormone plays a role in supporting sexual and reproductive health.

    Reference:

    Ortiz A, Espino J, Bejarano I, Lozano GM, Monllor F, García JF, Pariente JA, Rodríguez AB. High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility. J Pineal Res. 2010 Oct 21. Published Online Ahead of Print.



    D_
    Anabolicminds.com Featured Author

  25. Good read. I take melatonin a few times a week to help with sleeping so this is a bonus....especially since me and my wife are looking to have a child next year.

  26. Quote Originally Posted by dinoiii View Post
    Wow - interesting that you still went to IUI. What reasoning did you have to not expect spontaneous insemination with these numbers? I don't know that IUI added a lot of value to this equation (compared with spontaneous). Of course, fertility people might tell you different but success rates with IUI are something to yawn at in most instances IMO.

    D_
    Well, we did the IUI, then had sex a couple of times when we went home, then a couple of times a day for the next two days. Result? No pregnancy. Figured why not try everything, as she has to do injections to grow the egg, and the least we could do was try to maximize the chances.

    We are taking a break this month (holidays, spending a month in Europe for vacation and business, etc), but next month we are going to try again. This time we are goign to try to grow at least 3 eggs instead of 1, so our chances go up.

  27. Quote Originally Posted by dinoiii View Post
    The antioxidant hormone melatonin may play a role in the production of healthy sperm, according to a new study. Previous research has shown that sperm contain melatonin and have melatonin membrane receptors, yet the relationship between melatonin and sperm health had not yet been determined. The American Society for Reproductive Medicine states that one-third of infertility cases among couples are due to male factors.

    In this study, sperm from 52 men with impaired fertility was examined. The sperm was evaluated for concentration, motility and morphology (structure). In addition, the subjects were evaluated for urinary 6-sulfatoxy-melatonin and urinary total antioxidant capacity to determine if there was a correlation between the sperm parameters evaluated and melatonin and antioxidant status. In vitro, the sperm was exposed to melatonin and evaluated for changes in motility.

    The results of the study showed that increased urinary levels of 6-sulfatoxy-melatonin and total antioxidant capacity correlated with increased sperm concentration, motility and improved morphology. In vitro, sperm treated with melatonin for 30 minutes showed increased sperm motility and an increase in the percentage of rapidly swimming cells.

    The study concluded that melatonin improves semen quality. Based on the results of this research, it is likely that this unique antioxidant hormone plays a role in supporting sexual and reproductive health.

    Reference:

    Ortiz A, Espino J, Bejarano I, Lozano GM, Monllor F, García JF, Pariente JA, Rodríguez AB. High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility. J Pineal Res. 2010 Oct 21. Published Online Ahead of Print.



    D_
    I'll get back on that melatonin tonight!

  28. i would like to see a fertility study on something like Sustain alpha + IGF 2 + DAA
    Iron Forged Nutrition Rep

    use code "R1balla" to receive a discount

  29. this site claims that melatonin has the opposite affect

    http://www.melatoninfaq.com/melatonin-side-effects/
    Iron Forged Nutrition Rep

    use code "R1balla" to receive a discount

  30. Hey Doc, I have the go-ahead to submit my first proposal to perform some of my own research in the andrology lab I work at in NJ. I wanted to run by my ideas with you before I submit them, if you have a sec to PM me, and we can discuss them a little, I'd really appreciate it!

    The parameters I'm focusing on will be changes in motility and viability (eosin stains / hypoosmotic swelling test) via reduction of ROS in the microenvironment.
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