I think the possibility of supplemental Omega-3s causing cross-linking and oxidative stress is very real. I know it's been beaten to death, but if you can get n-3s through your diet, do so. If not, there are protective measures that can be taken, e.g. co-ingestion with certain ingredients (not vitamin E, as that has been pretty much proven ineffective for such). For instance, you put ALA in your top 10 supplements. ALA has good data showing it prevents lipid peroxidation.