RNA Drug kills prostate tumor cells

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    Post RNA Drug kills prostate tumor cells


    RNA Drug kills prostate tumor cells

    United Press International

    08-11-06

    DURHAM, N.C., Aug 10, 2006 (UPI via COMTEX) -- U.S. scientists have developed an experimental RNA-based drug -- the first of its kind -- that kills prostate cancer cells, without harming normal cells.

    The drug, developed at Duke University Medical Center, uses a type of genetic material, called targeting RNA, to enter cancer cells, and then another type, called silencing RNA, to stop the expression of a protein that keeps the cells alive.

    In tests in mice with prostate cancer, the drug shrank the size of their tumors by half, while tumors in control mice continued to grow, said study co-author Bruce Sullenger, director of Duke's Translational Research Institute and chief of the Division of Experimental Surgery.

    The mice showed no side effects from the treatment, Sullenger said.

    "This study represents the first step in creating an RNA-based drug for cancer," said lead author James McNamara, a postdoctoral fellow in experimental surgery. "It provides a 'proof of principle' that an entirely RNA-based drug can work with minimal side effects, and it shows it is possible to overcome many of the obstacles that have hampered the development of RNA-based drugs."

    The study is reported in the current issue of Nature Biotechnology.

    URL: www.upi.com

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    Quote Originally Posted by yeahright
    RNA Drug kills prostate tumor cells

    United Press International

    08-11-06

    DURHAM, N.C., Aug 10, 2006 (UPI via COMTEX) -- U.S. scientists have developed an experimental RNA-based drug -- the first of its kind -- that kills prostate cancer cells, without harming normal cells.

    The drug, developed at Duke University Medical Center, uses a type of genetic material, called targeting RNA, to enter cancer cells, and then another type, called silencing RNA, to stop the expression of a protein that keeps the cells alive.

    In tests in mice with prostate cancer, the drug shrank the size of their tumors by half, while tumors in control mice continued to grow, said study co-author Bruce Sullenger, director of Duke's Translational Research Institute and chief of the Division of Experimental Surgery.

    The mice showed no side effects from the treatment, Sullenger said.

    "This study represents the first step in creating an RNA-based drug for cancer," said lead author James McNamara, a postdoctoral fellow in experimental surgery. "It provides a 'proof of principle' that an entirely RNA-based drug can work with minimal side effects, and it shows it is possible to overcome many of the obstacles that have hampered the development of RNA-based drugs."

    The study is reported in the current issue of Nature Biotechnology.

    URL: United Press International - News. Analysis. Insight.
    WOW... just incredible. It's amazing how they can make it target only certain cells and then work its magic.
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    Quote Originally Posted by doom3q
    WOW... just incredible. It's amazing how they can make it target only certain cells and then work its magic.

    I've been reading about different experiments on this approach for years, but they've always failed. Looks like these kids cracked the problem.
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    Thats great news, got to love Duke for their Cancer Research
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    That is terrific news!!! I can't wait to see it developed and put into commercial use!!!!
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    Hell yeah!!!
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