THE END OF OLD AGE......L-carnosine
- 10-27-2011, 07:39 AM
THE END OF OLD AGE......L-carnosine
I'm surprised there not more talk on these forums on l-carnosine. I take ALCAR daily and love it but l-carnosine seems even better and more important to health.
What Is Aging?
The best place to start is at the beginning. What is aging? What makes us age? There are actually many factors that contribute to old age (free radical damage, hormonal changes, etc.), but of all of the things that make us “old,” two things stand out because until now, they have been so untouchable:
The Hayflick Limit
The glycation of proteins
The Hayflick Limit: Cell Life Span
The Hayflick Limit is named after the person who discovered it almost 40 years ago. A quick description is that all cells have only a limited capacity to continue to divide through the course of our lives.
Those numbers are different for each type of cell in our body, and by early adulthood, half of those divisions have been used up. By mid-life, maybe only 20-39% of those divisions are left. At that point, old age starts taking over – then death.
This limited capacity of a cell to perpetuate itself is called the Hayflick Limit. In effect, the Hayflick Limit determines life span at the cellular level. With each division, a cell becomes less likely to divide again, until finally it stops dividing altogether and becomes what we call senescent.
Cell senescence is the final step before cell death. Senescent cells are still alive and metabolically active, but they're no longer capable of dividing. More importantly, though, senescent cells exhibit all of the characteristics that so bother us about old age, such as the difference between the supple skin of a child and the wrinkled skin of the elderly.
How do cells age?
As cells approach the Hayflick Limit, they divide less frequently and become aberrant. They take on wildly irregular forms. They no longer line up in parallel arrays; they assume a granular appearance, and deviate from their normal size and shape. This distorted appearance, called the senescent phenotype, is accompanied by a state of declining functionality that, UNTIL RECENTLY, was thought to be irreversible.
Astounding News: Reverse Aging
As it turns out, not only can we reverse the aging process at the cellular level now, and actually do it quite simply AND QUICKLY – but we can also reverse aging at the system level and the organ level. And for that matter, we can reverse it in terms of how we look and feel – and by that I mean our skin and hair and energy levels. And then, of course, we can even reverse aging in terms of lifespan.
What's the Secret?
The substance I'm talking about is L-carnosine. It's a naturally occurring combination of two amino acids, alanine and histadine, that was discovered in Russia in the early 1900s. Because much of the research was done in Russia, it has been largely unavailable in the United States until recently. Now, though, there have been a number of studies and experiments in other parts of the world verifying everything done in Russia – and more.
Most notably, there were a series of astonishing experiments done in Australia that proved that carnosine rejuvenates cells as they approach senescence. Cells cultured with carnosine lived longer and retained their youthful appearance and growth patterns.
What's probably the most exciting result of the studies is that it was discovered that carnosine can actually REVERSE the signs of aging in senescent cells.
The Reversal of Aging
When the scientists transferred senescent cells to a culture medium containing carnosine, those cells exhibited a rejuvenated appearance and often an enhanced capacity to divide. When they transferred the cells back to a medium lacking carnosine, the signs of senescence quickly reappeared.
As they switched the cells back and forth several times between the culture media, they consistently observed that the carnosine medium restored the juvenile cell phenotype WITHIN DAYS, whereas the standard culture medium brought back the senescent cell phenotype.
Increase Cell Life
In addition, the carnosine medium increased cell life span -- even for old cells. When the researchers took old cells that had already gone through 55 divisions and transferred them to the carnosine medium, they survived up to 70 divisions, compared to only 57 to 61 divisions for the cells that were not transferred.
This represents an increase in the number of cell divisions for each cell of almost 25%.
But in terms of cell life, the increase was an astounding 300%. The cells transferred to the carnosine medium attained a life span of 413 days, compared to just 126 to 139 days for the control cells.
Increase Life Expectancy
This is mind-boggling. But so far, all we've talked about are cells. What does carnosine mean for actual life expectancy.
A new Russian study on mice has shown that mice given carnosine are twice as likely to reach their maximum lifespan as untreated mice. The carnosine also significantly reduced the outward “signs of old age.”
In effect, it made the mice look younger. 44% of the carnosine treated mice had young, glossy coats in old age as opposed to only 5% in the untreated mice. This represents 900% better odds of looking young in old age.
Feel Young Again
Another important difference between the treated and the untreated mice was in their behavior. Only 9% of the untreated mice behaved youthfully in old age, versus 58% of the carnosine treated mice. That's a 600% improvement in how they felt.
Quite simply, carnosine is one of the most powerful antioxidants known. It's a great heavy-metal scavenger. It's a powerful auto-regulator. And it stands alone when it comes to preventing and reversing protein glycation or cross-linking.
Carnosine has the remarkable ability to throttle down bodily processes that are in a state of excess, and to ramp up those that are under expressed.
For example, carnosine thins the blood of people whose blood tends to clot too much and increases the clotting tendency in those with a low clotting index.
Another example is that carnosine suppresses excess immune responses in those who have “hyper” immune systems, whereas it stimulates the immune response in those with weakened immune systems – such as the aged.
And carnosine even seems to have the ability to normalize brain wave functions.
Protein Glycation: Sugar And Aging
Glycation is the uncontrolled reaction of sugars with proteins. It's kind of like what happens to sugars when you heat them and they caramelize. In effect, glycation is what happens when excess sugars caramelize the proteins in your body. It's a major factor in the aging process – and it's particularly devastating to diabetics.
Your body is mostly made up of proteins. In fact, proteins are the substances most responsible for the daily functioning of your body. That's why anything that causes protein deterioration has such a dramatic impact on the body's function and appearance.
Thanks largely to the destructive effect of sugar and aldehydes, the protein in our bodies tends to undergo destructive changes as we age. This destruction is a prime factor, not only in the aging process itself, but also in the familiar signs of aging such as wrinkling skin, cataracts, and the destruction of our nervous system – particularly our brains. Studies show that carnosine is effective against all these forms of protein modification.
Protein Modification for Longevity
As I said, aging is associated with damage to cellular proteins. But carnosine protects cellular proteins from damage in at least two ways.
First, it bonds with the carbonyl (or aldehyde) groups that if left alone will attack and bind with proteins.
Second, it works as an antioxidant to prevent the formation of oxidized sugars, also called Advanced Glycosylation End-products or AGEs for short. That's really the caramelization thing that I mentioned earlier. The bottom line here is that the less AGEs, in your body, the younger you are.
Both of these processes have important implications for anti-aging therapy. The key is that carnosine not only prevents damaging cross-links from forming, it eliminates cross-links that have previously formed in proteins, thus restoring normal membrane function.
Carnosine has been proven to reduce or completely prevent cell damage caused by beta amyloid, one of the prime protein risk factors for Alzheimers. The presence of beta amyloid leads to damage of the nerves and arteries of the brain. Carnosine blocks and inactivates beta amyloid. In effect, it protects neural tissues against dementia.* The key is that carnosine not only prevents damaging cross-links from forming in proteins, it eliminates cross-links that have previously formed in those proteins, thus restoring normal membrane function in cells. This is true not only in the brain, but in all the organs of our body – our skin included. Keep in mind that the damage you see in the skin is not just a cosmetic question. That damage is absolutely an indicator of the kinds of damage happening to every other organ in your body – including your eyes and your brain.
The Reversal of Age
Carnosine levels in our body directly correlate with both the length and quality of our lives. And since carnosine levels decline with age, supplementation with carnosine represents one of the most powerful things you can do to hold back the ravages of old age.
While it is true that many people who supplement with carnosine are going to notice everything from younger looking skin to more energy, the bottom line is that you really shouldn't look for any short term benefits from carnosine supplementation. If any short-term benefits are noticed, you should consider them an added bonus.
The reason you want to supplement with carnosine is for the long term, not for the short-term benefits that you may or may not notice. You supplement with carnosine to protect against the long-term ravages of aging.
Some experts recommend using only 50-100 mg of carnosine a day. Others say that if you don't take 1,000-1,500 mg a day it won't work because your body metabolizes the first 500 mg or so.
The key here is that all of these experts are ignoring the simple fact, that different people need different amounts. For example:
The older you get, the more you need.
If you eat a mostly vegetarian diet, you need more.
If you're diabetic, or just have trouble with blood sugar, you need more.
I think most people will do best on 500-750 mg a day.
If you're young and healthy and include meat in your diet, then 250 mg a day makes sense. As you get older, and if you're starting to show signs of aging or glycation (such as cataracts), then you'd want to think of increasing the dosage up to 1,000 mg a day – maybe even as high as 1,500 mg a day.
In studies, carnosine has been proven safe in amounts as high as 70, 80, or even 100 grams a day, although a small number of people have noticed some minor muscle twitching at doses as small as 1,000 mg. The bottom line is use what you need, and you won't have any problems – only benefits.
As I mentioned earlier, I don't believe in magic bullets. Everything I've ever learned says that you're only as strong as your weakest link. I still believe that improving your entire Baseline of Health® is the key to good health and long life.
But that said, I think that once you actually understand what carnosine does – once you understand the role it plays in preventing and potentially reversing all of the signs of old age in the body (and we're talking about everything from wrinkled skin to cataracts to Alzheimer's) – heck, once you understand the role it plays in extending life itself – then you're left with the unmistakable conclusion that supplementing with carnosine may represent one of the single best things you can do to help "turn back your biological clock."
A Missing Link
As important as carnosine is, there is a "gap" in its usefulness. It's called lipofuscin.
Lipofuscin is the age pigment commonly found in aging brains and in other tissue such as the skin. By itself, it is not dangerous. It is merely a byproduct of harmful reactions that have already taken place. For example, one of the byproducts of free radical damage and protein/aldehyde damage (both conditions that carnosine addresses) is lipofuscin.
Lipofuscin deposits as seen in heart muscle
When you supplement with carnosine, however, something different happens. The carnosine quickly binds with the aldehydes, preventing them from damaging the proteins. The byproduct of this reaction is lipofuscin. So once again you have inactive lipofuscin compounds, but this time as the result of PREVENTING protein damage. In a sense, with carnosine you trade protein damage for lipofuscin.
As I said before, by itself, lipofuscin is not harmful. However, if enough of it accumulates over time (and this process is accelerated when you supplement with carnosine), it can interfere with proper cellular and organ functions. So the bottom line is that however it is produced (as a result of protein damage, or as the result of taking sacrificial carnosine to prevent protein damage), you want to get rid of it.
By any definition, DMAE is the perfect companion to carnosine in an anti-aging formulation. First, it reinforces carnosine's own anti-aging properties. Then, it provides a whole series of complementary benefits of its own.
What Is DMAE?
DMAE is short for (dimethylaminoethanol), a naturally-occurring nutrient that enhances acetylcholine (ACh) synthesis. Adequate levels of ACh are important for proper memory function. Normally found in small amounts in our brains, DMAE has been shown to remarkably enhance brain function when used as a supplement in clinical studies.
DMAE Reinforces Carnosine
One of the prime actions of DMAE is that it flushes accumulated lipofuscin from your body – from the neurons in your brain, from your skin, and from all other organs. It also complements carnosine in that DMAE on its own has been shown to inhibit and reverse the Cross-Linking of proteins and extend lifespan.
Many people have heard of the anti-aging results that Romanian scientist, Ana Aslan, achieved using something called GH3, or procaine. What most people do not know is that GH3 breaks down in the body to form DMAE (after first metabolizing into DEAE) and PABA. In other words, DMAE is the key active component in Ana Aslan's anti-aging formula.
Numerous scientific studies now show that DMAE can help:
Increase Acetylcholine levels and RNA levels in the brain
Stimulate mental activity
Increase attention span
Increase intelligence (especially in children)
Improve learning and memory
Increase energy levels
Provide a mild, safe tonic effect
Stimulate the central nervous system
Elevate mood in general
Alleviate behavioral problems and hyperactivity associated with Attention Deficit Disorder
Increase motivation and reduce apathy in persons suffering from depression
Induce sounder sleep
Over time reduce the amount of sleep required by about 1 hour per night
Intensify dreams tremendously. (Even more so when you take it along with a large dose of phosphatidyl choline -- a key component of
Cause dreams to become more lucid
Decrease the incidence and severity of hangovers in people who consume excessive amounts of Alcohol
DMAE Is Safe
- 10-27-2011, 08:47 AM
10-27-2011, 09:28 AM
10-27-2011, 12:14 PM
10-27-2011, 07:27 PM
10-27-2011, 07:46 PM
beta alanine isnt cheap IMO(and carnatine/carnosine supps really are)... but very effective...
beta alanine is the orally bioavailable way to provide your body with more Alanine to combine with histadine... Its basically the rate limiting factor in your body to naturally produce more carnosine. by increasing the amount of alanine in your body you raise this rate limiting factor therefore raising the amount of carnosine that can be naturally produced...
It does not detract from the benefits one could still get from supplementing with an outside source of carnatine/carnosine and also would be a good thing to take in conjunction with carnatine so that ones body can keep producing at a better rate long after supplementation has been ceased (I recently read a study that the benefits of BA supplementation are exhibited long after stopping use and the better you respond the longer it lasts.... wish I can remember where I read that so I could link it...)
Either way, great article and a great reason to start supplementing carnatine/carnosine if you arent already.
iForceHemavol=He-man?-http://anabolicminds.com/forum/supplement-reviews-logs/187487-hemavol-heman-doughs.htmlCompound 20 Beta log-http://anabolicminds.com/forum/supplement-reviews-logs/185396-molding-dough-compound.html
10-27-2011, 09:48 PM
That is a terrific article, and an important one.
Bulk l-carnosine is not cheap and tends toward the expensive side. Carnatines are cheap in most forms, although I use either PLCAR or better GPLC when they are on sale. Bulk l-carnosine runs 6.5X as much in bulk over beta alanine(by weight comparison), which I can find a 60 day supply of beta alanine for close to $10. It runs just $25 for 500 grams on Nutra in bulk, and you only really need 3 grams a day.
That said it's probably worth my while to pick up some bulk carnosine too, as I'm doing a major rejuvenation program right now. I would like to reverse my aging process by 4-5 years. I look about 10 years younger than I am now, and I'd like to look, and more important, actually physically be, in my mid-to-late-40's in most ways. Insulin resistance is one critical aspect as well as the mentioned glycation process that comes with it.
10-28-2011, 12:54 AM
10-28-2011, 05:21 AM
I did a quick check on a life extension forum about carnosine vs beta alanine. There was a lot of confusion on that forum as to what is best to use, and which one does what. My feeling is that beta alanine is a great sports supplement that buffers H+ ions and increases endurance, but carnosine is probably best for anti-glycation and life extension. There were two guys in their upper 60's who received excellent improvement from carnosine in the age related areas. They were both supplementing a gram per day.
BTW, you can test your long term blood sugar with the HbA1C blood test. If you come in around 4.7 or less you don't have to worry much about glycation, but doctors will often tell you that you are fine at 6.0 or below. They are wrong. Even at my current A1C test results of 5.2, I notice the effects of glycation slowly advancing. My doc thinks my 5.2 is great, and very healthy for my age, but I think it's still bad. Some docs will even tell people they are "not bad" in the low 6's as in 6.2 or 6.3, especially if they have been diagnosed with Type 2. A huge amount of damage is happening at those levels.
10-28-2011, 06:57 AM
iForceHemavol=He-man?-http://anabolicminds.com/forum/supplement-reviews-logs/187487-hemavol-heman-doughs.htmlCompound 20 Beta log-http://anabolicminds.com/forum/supplement-reviews-logs/185396-molding-dough-compound.html
10-28-2011, 07:58 AM
The only thing Carnosine and Carnitine have in common is their latin root, carnis: meat/flesh/body. Think carnal/carnivore in english.
I have been taking 5, size 00 caps of each for at least 5 years and swear by both. The carnosine I take in the form of Beta-Alanine because my body has more than enough Histidine and the Carnosine is 10 times MORE exensive. My best source on Carnosine would be Vitacost but even there it runs about $44 for 90 gms in caps. Here at NP I still buy my bulk B-A for $40 a kilo and my ALCAR for $60 a kilo and cap them myself.
Beta-Alanine is what I combined with 5 caps of Taurine, another potent amino acid for the macula in our eyes, and Astaxanthin 10 mgs, some Zeaxanthin and Lutein 20 mgs to completely heal my eyesight. As I reported here a couple years ago, I went from 3.25 and 3.75 to 1.25 and 1.75 in a year and then to 20 - 20 the second year.
I believe the recent article about the long lasting effects of B-A is "Beta-alanine effective for weeks after end of course" which is on Ergo-Log at http://www.ergo-log.com/betaalaninee...eforweeks.html
Lucly, thanks for adding a great article for our use.
10-28-2011, 04:44 PM
The most interesting part of this article is the addition of extra cell divisions over normal as that requires lengthening of telomeres. The only known substance to do this previously was derived from Astragalus, called TA-65.
10-29-2011, 04:08 AM
Hi to Dutchman,
I've been lurking on the board for a few weeks without posting so I am unable to send PMs at the moment.
I would, however, like to know more about your eye therapy.
My eyes have been going downhill with light tracers, small spots of distorted vision and declining resolution. Not to mention that my glasses are getting worse!
Would you mind PMing me your therapy or pointing me to a thread where you outline your therapy or even pointing me to the source of your supplement choices.
Thanks in advance
10-29-2011, 04:55 PM
I looked into this ages ago and read that Beta-Alanine depletes Taurine but could not find anything specific on dosing the two.
Going to look into your "Astaxanthin, Zeaxanthin and Lutein" suggestion. Do you know of any products that have all 3 ingredients?
10-29-2011, 05:41 PM
They compete for the same receptors, and it is better to take them at separate times.
Although, it's my understanding that unless you take large doses of either one, taking them at the same time should still be effective.
10-29-2011, 06:19 PM
I cap most of my own supplies and buy my bulk products from Nutra Planet. The Taurine andBeta-Alanine cap, after packing, at around 800 mgs per 00 gel cap. I take 5 of each (for 4 gms) although I know others who take more (usually 5 gms). I have always taken them at the same time. There was some mention about taking them together but IIRC that didn't turn out to hold water very well. Certainly not in my personal experience. I used to buy the Lutein from Sam's Club (was the best price around) and use 3(20 mg) caps ED for around 60 total mgs. Now I just get Vitacost’s 20 mg Luteinwith Zeaxanthin and that sems to be enough. Nowadays I stick to only one 20 mg combo cap. I also take one small gel cap of Astaxanthin ED (10mg). The Astaxanthin has so many secondary effects that it is really one of the 3 or 4 most important sups we can take. It even doubles the time I can stay out in the sun without burning. I buy all these from Vitacost.com because I love their products especially their in-house Vitacost brand for its great quality and low, low price. One other element of importance would be that I am a firm believer in megadosing Omega 3s. I use Sam's Club's triple strength Fish Oil (ie 900 mgs of Omega 3)and take 3 caps 2X a day.
You might google these various vitamins and you will usually find some reference to their eyesight properties. I did that and also checked out the most popular brands of eye drops being marketed for tons of dollars. Then I went off and crafted my own. I am still, years later, a very happy puppy! Good luck!Dutch
10-29-2011, 09:09 PM
Good stuff on the eyes. How long had you had less than good vision with your eyes before starting this supplement combo? Was it a long-term decline or relatively new?
10-30-2011, 04:40 AM
Tuberman, I had trouble just reading by the time I hit 40. By 50 I was wearing big, tri-focals. In my early 60s I needed help even when wearing glasses, to see where my golf ball was headed,or landed. I am a committed natural health freak aka as "The Village Shaman" or "The Village Witchdoctor", pick one. I take 70+ pills a day and am in exceptional good health. I had been taking the Beta-Alanine along with my Creatine Mono and the Taurine to help me recover during and after my workouts. I noticed some slight improvement and when I stumbled over Astaxanthin, the chase was on. Some use Bilberry and other things too but this worked out great for me. My Opthamalogists were/are at a loss for words other than to say "You are still 20/20". They claim to have never seen someone over 60 reverse his eyesight problem naturally. Of course, if such info spread, that would not be good for their incomes either. It was this plus similar results for friends and family with other natural health combos for Atrial Fibrulation, Arthritis, Dementia, even slowing my late wife's cancer (prognoses was 3 months but she added almost a year to that) that put me over the top and made me go ape over natural approaches. So now I am certainly old at 70, in the eyes of the AMA and FDA certainly insane and in the eyes of those around me here, the guy they call "the animal" or "ironman" for my strength and health.
10-30-2011, 10:35 AM
Just read up on your recommendation of Axastanthin.....amazing supplement. Thanks again. Do you have any other recommendations for amazing supplements for health, feeling good, looking good, thinking better and clearer etc.
Simply put what would be your top 10 suppliment recommendations. It appears axastanthin and l-carnosine and Alcar would be among them as well as fish oils.
thanks in advance.
10-30-2011, 02:42 PM
I guess I have to cheat and make it my favorite Baker's Dozen. I have spentwith no exaggeration, thousands of hours over the last couple decades trying tounderstand Mother Nature/God's Gifts etc. As a result, this nature loving,ex-seminarian firmly believes that Big Pharma is Bad and only God is Good! Iknow I sound hokey to the youngsters today but c'est la vie! Enjoy!
Dutch’sDirty (Baker’s) Dozen of Vitamins
I take dozens of different things but the followinglist consists of the most important to me. They all have some impact on my physical performance in the gym as theyaffect in some way strength/energy/recovery/metabolism etc. Butthey all make the list because they exert tremendous influence on my health,immune system, brain, heart, eyesight, joints, memory. They do a great job against the greatestthreats we face.
1. Vitamin D3 15,000 IUs
2. Omega 3s 3 – 6 gms
3. Astaxanthin 10 mgs
4. Ubiquinol(CoQH) 100 mgs
5. Curcumin(Turmeric) 1 gm
6. Green Tea Extract 2-3 gms
7. Creatine 4 – 5 gms
8. Beta-Alanine(Carnosine) 4 – 5 gms
9. ALCAR 4 gms
10. ALA 600mgs
11. Coconut Oil 3 tbspns
12. Cissus 1.5 gms @ 10% or 2.5 gms @ 5%
13. Resveritrol (2 glasses of Cab or Merlot)
10-30-2011, 09:41 PM
10-31-2011, 04:44 AM
10-31-2011, 06:24 AM
10-31-2011, 09:57 AM
Carnosine is virtually tasteless (but the half life is SHORT) so buy it in powder form and simply dump into P-shakes and water and anything else to get frequent dosing. Sprinkle it on food (not before cooking) and you will never know the difference.
A-Minds HYPE-SLAYER! All posts & feedback are guaranteed to be unsolicited and legit
"The fear of the LORD is the beginning of knowledge. Fools despise wisdom & instruction" Proverbs 1:7
10-31-2011, 11:07 AM
10-31-2011, 12:20 PM
Here is one of many similar overviews: http://www.betaalanine.info/
10-31-2011, 12:35 PM
I will follow Dutchman's advice and go for beta alanine though!
10-31-2011, 01:20 PM
The following articles may be informative for you. Good luck and God Bless!
Congestive Heart Failure, The Exception to Our Success?
Alleviating Congestive Heart Failure with Coenzyme Q10
AvertingArrhythmias with Omega-3 Fatty Acids
Common Irregular Heartbeats are Completely Normalized by Taurine and Arginine
10-31-2011, 08:07 PM
10-31-2011, 09:45 PM
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