THE END OF OLD AGE......L-carnosine

[luclyluciano]

Definitely going to be looking into that.

Where are you applying the cream?

Second day now that I have noticed improvent. The soreness has actually had me limping in pain and keeping me away from the gym.

I am applying to back and side of my knees and shoulders, chest areas. 1/2 pump twice per day.

I have been reading that progesterone is a great anti-inflammatory and a hood anti-estrogen. Both are evils we want to control. It's a big myth and misconception that it is solely a female hormone. I highly recommend it.

Getting my END OF OLD AGE shipment today. Looking forward to using pregnenolone (mother of all hormones) and astaxanthin!

[luclyluciano]

And my knee ligament keeps getting better everyday

[Sourdough]

Hey... I'm looking for some references on the op's claims...

Where are the studies supporting the defeat of the hayflick limit?

I'd like something to be able to use for citation in a conversation with my friend and father.

Thanks

[luclyluciano]

Hey... I'm looking for some references on the op's claims...

Where are the studies supporting the defeat of the hayflick limit?

I'd like something to be able to use for citation in a conversation with my friend and father.

Thanks

I'm not sure if this is enough for you, but if not, there is plenty of reading on pubmed and through google.





Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?

AuthorsHipkiss AR, et al. Show all Journal
Biogerontology. 2000;1(3):217-23.

Affiliation
Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London EC1 1UL, UK. alan.hipkiss@kcl.ac.uk

Abstract
Carnosine (beta-alanyl-L-histidine) can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts. The mechanisms by which such a simple molecule induces these effects is not known despite carnosine's well documented anti-oxidant and oxygen free-radical scavenging activities. Carbonyl groups are generated on proteins post-synthetically by the action of reactive oxygen species and glycating agents and their accumulation is a major biochemical manifestation of ageing. We suggest that, in addition to the prophylactic actions of carnosine, it may also directly participate in the inactivation/disposal of aged proteins possibly by direct reaction with the carbonyl groups on proteins. The possible fates of these 'carnosinylated' proteins including the formation of inert lipofuscin, proteolysis via the proteasome system and exocytosis following interaction with receptors are also discussed. The proposal may point to a hitherto unrecognised mechanism by which cells/organisms normally defend themselves against protein carbonyls.

[luclyluciano]

Hey... I'm looking for some references on the op's claims...

Where are the studies supporting the defeat of the hayflick limit?

I'd like something to be able to use for citation in a conversation with my friend and father.

Thanks

Pubmed and google. Here is one of a dozen in pubmed.



Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?

AuthorsHipkiss AR, et al. Show all Journal
Biogerontology. 2000;1(3):217-23.

Affiliation
Biomolecular Sciences Division, GKT School of Biomedical Sciences, King's College London, Guy's Campus London Bridge, London EC1 1UL, UK. alan.hipkiss@kcl.ac.uk

Abstract
Carnosine (beta-alanyl-L-histidine) can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts. The mechanisms by which such a simple molecule induces these effects is not known despite carnosine's well documented anti-oxidant and oxygen free-radical scavenging activities. Carbonyl groups are generated on proteins post-synthetically by the action of reactive oxygen species and glycating agents and their accumulation is a major biochemical manifestation of ageing. We suggest that, in addition to the prophylactic actions of carnosine, it may also directly participate in the inactivation/disposal of aged proteins possibly by direct reaction with the carbonyl groups on proteins. The possible fates of these 'carnosinylated' proteins including the formation of inert lipofuscin, proteolysis via the proteasome system and exocytosis following interaction with receptors are also discussed. The proposal may point to a hitherto unrecognised mechanism by which cells/organisms normally defend themselves against protein carbonyls.

[tuberman]

Hey... I'm looking for some references on the op's claims...

Where are the studies supporting the defeat of the hayflick limit?

I'd like something to be able to use for citation in a conversation with my friend and father.

Thanks

I'd seen some earlier studies which suggested that extra cell divisions did not happen with carnosine, but that in other ways it returned the cells to much healthier function, and created a longer time between cell divisions, thus increasing lifespan of the cells, and health of the cells during that lifespan.
This one caught my by surprise. I would need this backed up, but certainly carnosine or beta alanine are remarkable.

[luclyluciano]

Received my shipment.

Been taking,
Pregnonolone
Progrsterone
Beta Alinine
Astaxanthin
L-arginine

Beta Alinine give nice body tingled. Boy oh boy. Really feeling it now!
L-arginine feels nice and warm.
Progesterone is healing my ligaments.
Pregnonlone made me feel smarter for first few days, now nothing.
Astaxanthin, nothing seems hyped.
Hyaloronic acid, nothing much, hyped?

[luclyluciano]

Received my shipment.

Been taking,
Pregnonolone
Progrsterone
Beta Alinine
Astaxanthin
L-arginine

Beta Alinine give nice body tingled. Boy oh boy. Really feeling it now!
L-arginine feels nice and warm.
Progesterone is healing my ligaments.
Pregnonlone made me feel smarter for first few days, now nothing.
Astaxanthin, nothing seems hyped.
Hyaloronic acid, nothing much, hyped?

[tuberman]

Received my shipment.

Been taking,
Pregnonolone
Progrsterone
Beta Alinine
Astaxanthin
L-arginine

Beta Alinine give nice body tingled. Boy oh boy. Really feeling it now!
L-arginine feels nice and warm.
Progesterone is healing my ligaments.
Pregnonlone made me feel smarter for first few days, now nothing.
Astaxanthin, nothing seems hyped.
Hyaloronic acid, nothing much, hyped?

Do you feel anything or get immediate results from fish oil? Not really. Vitamin D3? Only if you take a mega-dose of it, and then you will notice it. Health supplements are subtle, you get the results often from blood tests much later, and a quiet sense of well being. If you stop taking a health supplement that's working well for you, you will notice the lack of it in a fairly short time.

Beta Alanine and to a lesser degree L-arginine are not just health supplements, they are also noticeable as sport supplements for endurance, recovery, and N.O. (arginine) effects. These kick in a few days after starting.

[luclyluciano]

Agreed, Tuberman. I only posted about the possible hype of astaxanthin and hyalauronic acid because of the astonishing reviews and research stating energy increases, decreases in wrinkles, anti inflammatory claims etc etc. These are not subtle claims and noticeable claims. Others have a right to know. If I feel anything positive, I will post it.

I am especially disappointed with astaxanthin as it has been promoted as a miracle supplement. So far nothing.

[Jag]

I am especially disappointed with astaxanthin as it has been promoted as a miracle supplement. So far nothing.

Lucky, which brand of astaxanthin did you get and what doses are you using?

I ordered some on Dutchmans results. Obviously, i read up on it first but couldn't find anything bad on it. Maybe it's one of those supps that works better over the long term.

[tuberman]

Agreed, Tuberman. I only posted about the possible hype of astaxanthin and hyalauronic acid because of the astonishing reviews and research stating energy increases, decreases in wrinkles, anti inflammatory claims etc etc. These are not subtle claims and noticeable claims. Others have a right to know. If I feel anything positive, I will post it.

I am especially disappointed with astaxanthin as it has been promoted as a miracle supplement. So far nothing.

Well, some people do claim to get fantastic results immediately from health supplements, and in most cases I take such claims with a lot of skepticism. You will notice that Dutchman said it took astaxanthin two years to normalize his vision, that is typical of even "miracle" supplements in the health category. Astaxanthin needs to be taken with high-fat meals otherwise absorbtion is minimal or less than 5%. I'm not picking on you here, but I'm saying I have different expectations then you. I feel thateven "miracle" health supps take weeks and even months to show their strength.

[Dutchman]

Good point, in fact I take my Astaxanthin every morning along with 2.7 gms of Omega 3s.

[3whitelights]

Would it be worth purchasing Beta-Alanine w/ L-Histidine?

I found 500g of BA for about $24, or the same amount of a mixture w/~10% L-Histindine for about the same price.

Should I opt for the mixture?

[Jag]

Would it be worth purchasing Beta-Alanine w/ L-Histidine?

I found 500g of BA for about $24, or the same amount of a mixture w/~10% L-Histindine for about the same price.

Should I opt for the mixture?

From what i have read our bodies suplly us with enough Histidine so supplementing with it should not be necessary.

[luclyluciano]

Would it be worth purchasing Beta-Alanine w/ L-Histidine?

I found 500g of BA for about $24, or the same amount of a mixture w/~10% L-Histindine for about the same price.

Should I opt for the mixture?

I too have read our bodies already had l-histidine. Having said that, I would have preferred to have ordered specifically l-carmosine. Simple for the "we do not know what we do not know" factor and the studies are on l-Carnosine not beta Alanine.

[luclyluciano]

Lucky, which brand of astaxanthin did you get and what doses are you using?

I ordered some on Dutchmans results. Obviously, i read up on it first but couldn't find anything bad on it. Maybe it's one of those supps that works better over the long term.

I ordered the healthy origins brand. It had the most positive reviews. I also cut out my fish oil supplementation to see the effects. I will try with fish oil again to see if the the effects are any different.

[Sourdough]

The only thing Carnosine and Carnitine have in common is their latin root, carnis: meat/flesh/body. Think carnal/carnivore in english.

I have been taking 5, size 00 caps of each for at least 5 years and swear by both. The carnosine I take in the form of Beta-Alanine because my body has more than enough Histidine and the Carnosine is 10 times MORE exensive. My best source on Carnosine would be Vitacost but even there it runs about $44 for 90 gms in caps. Here at NP I still buy my bulk B-A for $40 a kilo and my ALCAR for $60 a kilo and cap them myself.

Beta-Alanine is what I combined with 5 caps of Taurine, another potent amino acid for the macula in our eyes, and Astaxanthin 10 mgs, some Zeaxanthin and Lutein 20 mgs to completely heal my eyesight. As I reported here a couple years ago, I went from 3.25 and 3.75 to 1.25 and 1.75 in a year and then to 20 - 20 the second year.

I believe the recent article about the long lasting effects of B-A is "Beta-alanine effective for weeks after end of course" which is on Ergo-Log at http://www.ergo-log.com/betaalaninee...eforweeks.html

Lucly, thanks for adding a great article for our use.

Im very interested in putting your "vision stack" to the test...

Ive had noticeable vision problems since I was 9 when I first had to get glasses... now a month and a half shy of 28 i have -4.00 in each eye as of an exam over a year ago (wouldnt doubt one bit its waned further) and I REALLY am worried about the outcome of my vision by the time im 50, let alone 70...

Lasik is certainly on my list... I want to get it as soon as my health insurance kicks in(should be this next month)... BUT I want to maintain the results and not allow it to continue to decline at a similar rate...

I see in your stack here you mention

• Astaxanthin 10 mgs
• some Zeaxanthin (how much?)
• Lutein 20 mgs
• Taurine (how much for these purposes, as I take 5g-10g every day during cycles)

is this all you would suggest for someone as bad off as im getting?

thanks for any info and your reasoning for use ahead of time

[Dutchman]

Sourdough, the whole gist of this thread was around Beta-Alanine/Carosine. I strongly suggest you add 5 gms of the BA daily to your list as well as taking 5 gms of the Taurine. I'm no Doc. but given your condition as you describe it, I personally would also be taking say 40 or even 60 mgs of the Lutein. If you buy it from Vitacost as I mentioned above, they have it combined with Zeaxanthin. You would then be adding 2 or 3 mgs of the Z which should be enough. Good luck, keep us posted. Oh yeah, I think I also mentioned it somewhere above, make sure you try to get 3 to 5 gms daily of Omega 3s, they are super vision helpers.

[Sourdough]

yup... DHA and EPA are essential for babies to properly develop their eyes and brains... I already supp with those though

thanks for the input.... BA was in my use, but since dropped when I ran out... its currently in my cart at nutra


Ill def report back to this thread/in general after putting this to the test through the next year... may or may not have the surgery by then... would be nice to see some natural progression though.