THE END OF OLD AGE......L-carnosine
- 11-01-2011, 07:20 PM
- 11-02-2011, 08:27 PM
Been reading a lot of fantastic things about Pregnenalone. Felt amazing when I was using Dermacrine which had it as an ingredient.
Pregnenolone – The Mother of all Steroid Hormones!
Pregnenolone is a naturally occurring metabolite that is made in your body. It is often referred to as the ‘mother steroid compound’ because it is the basic raw material for all steroid hormones in the body. This includes cortisone, Progesterone, estrogen, testosterone and DHEA.
Although it’s the precursor of all steroid hormones, Pregnenolone itself is not a steroid hormone. Instead, Pregnenolone is made from cholesterol in the cells of both the adrenal gland and the central nervous system. Inside each cell there are 1000’s of mitochondria (tiny power plants) and it is inside these mitochondria that Pregnenolone is produced.
Pregnenolone has been studied since the 1940’s. Experiments conducted in the 1940's and 1950's found Pregnenolone could not only increase the productivity levels and reduce the stress of factory workers, but was also an excellent anti-inflammatory medication for conditions such as arthritis and allergies.
Research into cortisol at around the same time resulted in Pregnenolone being somewhat over looked by the scientific community. This meant that despite having recognised health benefits, it did not become as popular as it might otherwise have been and its use medically was effectively phased out.
By the 1990’s interest in Pregnenolone had been rekindled when several experiments using mice, indicated that memory and stress might have significant links with the metabolite.
The chemical pathways that use Pregnenolone as the precursor in the production of steroid hormones and, indeed, the interrelationships between these hormones themselves, are complex. Optimal levels of Pregnenolone are important for mental health and ability. Sometimes it is the direct action of Pregnenolone that is beneficial, whereas in other situations the benefits of Pregnenolone flow not from the Pregnenolone itself but from the fact that it is has been used to produce other steroid hormones. Just how much Pregnenolone is used as Pregnenolone or is converted into other hormones depends on a number of factors, not least being your gender. Life-style issues such as diet, stress and exercise, as well as certain diseases and the stage of life that you are at also appear to be determining factors.
Age also plays its part. As we grow older, so the amount of Pregnenolone that we produce reduces. By age 70, Pregnenolone levels have typically declined by as much as 60%. Stress, depression, hypothyroidism and toxin exposure also lead to reduced levels. And with reducing levels, comes the need to supplement the body’s supply.
What is pregnenolone supplementation used for?
Although the actual way Pregnenolone works is not fully understood, using Pregnenolone as a supplement can have a number of effects. Pregnenolone appears to share many of its effects on the body with cortisol in that it can:
Reduce allergic reactions
Act as “a stress buffer”
Lessen arthritis inflammation
However, whereas cortisol can have negative side effects, Pregnenolone is amazingly well tolerated. Pregnenolone is also known to enhance memory and improve mood and energy levels. Below we look at some of the benefits of Pregnenolone supplementation in more detail.
It has long been reported that one of the leading benefits of Pregnenolone supplementation is the enhancement of memory, well in excess of the memory enhancing effects of other substances. Its role in memory enhancement appears to lie in its ability to assist in the acquisition of knowledge and the long term memory of learned behaviour and it does all of this at lower doses than those required by other steroids and steroid precursors such as DHEA. Indeed, in a clinical study carried out in 1995, Pregnenolone was shown to be a potent memory enhancer – possibly 100 times more effective than DHEA.
As far back as the research that was carried out in the 1940’s, Pregnenolone was shown to have fatigue busting capabilities. Even a dose of 1mg a day can improve the quality of sleep and decrease intermittent wakefulness in otherwise healthy young individuals.
Energy levels are also boosted because Pregnenolone protects the energy producing mitochondria in our cells from potentially damaging toxins. This is because Pregnenolone enhances the activity of the cytochrome P450 detoxifying enzymes. These enzymes assist our cells, particularly those in the liver and the brain, to detoxify a whole range of toxins.
Pregnenolone may help to reduce your stress levels as it is thought that Pregnenolone may play a part in the neuro-endocrine response to stress. It may act to reduce the age-increasing effects of cortisol and induce a better state of relaxation.
Certainly clinical studies have shown clearly that Pregnenolone acts as a stress reliever. For example, research carried out in the 1940’s and 1950’s demonstrated that Pregnenolone reduced the stress of factory workers, with the added bonus of increased productivity. A study of aeroplane pilots subjected to stressful situations also revealed that 25mg of Pregnenolone taken twice a day improved performance without causing adverse side effects. In a study of the stress response in rats, the administration of Pregnenolone appeared to increase the animals’ anxiety. While you may think that this is not a good thing, the researchers suggested this was actually a beneficial response during a stressful period and was thought to have been initiated through the nervous system.
Anti Depressant and Mood Enhancer
Research has revealed that people currently suffering from depression or with a history of depression have significantly lower levels of Pregnenolone in the fluid around the brain than those found in healthy people. Indeed, those people with active depression were found to have lower levels of Pregnenolone than those with a history of depression. This shouldn’t be that surprising as steroid hormones (which are synthesized from Pregnenolone) are known to affect mood and behaviour via effects on the nervous system. Pregnenolone has proven itself to be both a mood enhancer and a mild anti-depressant.
Arthritis Treatment and the Treatment of other Rheumatological Diseases
Pregnenolone has been used since the 1940’s as an alternative to mainstream medications for the treatment of arthritis. Indeed, it is almost as synonymous with treating arthritis as cod liver oil.
Many arthritis sufferers find Pregnenolone particularly effective in treating the inflammation in their joints that they experience with the disease. Studies have confirmed the effects of Pregnenolone on arthritis. In one trial 6 out of 11 people suffering from rheumatoid arthritis experienced moderate to marked improvement in joint pain and mobility after receiving intramuscular injections of 50-600mg of Pregnenolone daily. In another study involving 13 osteoarthritis sufferers, Pregnenolone reduced pain and improved mobility in 7 of the patients. The pain reoccurred once the Pregnenolone therapy was stopped. Another study highlighted the substantial benefits of Pregnenolone therapy patients with systemic lupus erythematosus (SLE), psoriasis and scleroderma.
Pregnenolone may offer many post-menopausal women a natural oestrogen replacement therapy. This is because Pregnenolone converts into DHEA which in turn converts into oestrogens. Pregnenolone can also provide a natural source for progesterone, another important hormone for female reproductive health, and one which is particularly useful in controlling PMS. The added advantage of Pregnenolone therapy when compared with DHEA treatment is that there is a reduced risk of experiencing distressing masculinizing side effects such as increasing facial hair because Pregnenolone is less likely to lead to an increase in testosterone levels.
Various parts of nerve cells are insulated by a membrane called the myelin sheath which acts to prevent “short circuiting” or the loss of neural transmission. Research involving mice has demonstrated that either Pregnenolone or progesterone supplementation promotes myelin formation during nerve regeneration. It maybe therefore that Pregnenolone therapy has a place in the treatment of diseases involving demyelination, such as multiple sclerosis.
So although the actions of Pregnenolone are not yet fully understood, it can be seen that its effects are far reaching. For many, the fact that it is a natural substance will be appealing. What is even more exciting is that Pregnenolone does not seem to have any negative side effects.
Dosage is dependent upon the reason for taking Pregnenolone:
For anti- ageing purposes - daily doses of about 25mg (maximum 50mg) are suggested
For arthritis - daily doses should be in the region of 100mg to 300mg
For senile dementia - daily doses of 300mg to 600mg
For mood enhancement and as an anti depressant - daily doses of 50mg to 200mg
For enhancement of detoxifying enzymes - daily doses of 25mg to 200mg per day
Caution and Warnings
Because Pregnenolone has antagonistic effects on what are known as GABA receptors in the central nervous system, Pregnenolone supplementation may cause problems in people with a history of seizures.
Pregnenolone can convert into any number of different metabolites and there isn't at present a definite way of ensuring the precise ones you want. Pregnenolone supplementation may therefore increase the levels of progesterone and DHEA and possibly levels of other hormones such as testosterone and estradiol. In our experience Pregnenolone is less likely to convert directly into testosterone than DHEA. Some testosterone may convert into estrogen. To help prevent this the use of an estrogen detoxification agent such as DIM with regular Pregnenolone use is recommended.
- 11-03-2011, 07:53 AM
11-04-2011, 09:01 AM
11-05-2011, 10:31 AM
Originally Posted by luclyluciano
I have been taking ERASE as a standalone to lower estrogen as I am now 49 years young. I swear my testosterone is increasing. No blood work to prove but much stronger and more defined, better libido etc.
In my research to lower the negative effects of Estrogen in aging males I came across Progesterone. In searching here on AM, I discovered many here feel it promotes Estrogen or femininity as it is a hormone primary taken by women to regulate their cycles and for menopause. Further research has led me many articles such as the following. Could it be that AM has this misunderstood hormone backwards and it actually lowers Estrogen. Everything I am reading indicates yes. Maybe it is only effective in controlling estrogen in aging Males not young males.
Anyone have knowledge or experience here? READ THE FOLLOWING ARTICLE..................
Progesterone: For men?
Not only do men need estrogen, but also progesterone. In fact, progesterone helps counteract the effects of estrogen on the male body. As men age and testosterone levels decline, estrogen levels begin to rise and when they do it's typical for men to deal with weight gain, muscle loss, low libido and fatigue. In a lot of ways progesterone helpsmen maintain their edge.
Progesterone Levels in Men
Why progesterone for men?
When many of us think of progesterone, we think of it as being a hormone strictly for women. However, men need progesterone too. Progesterone helps to counteract the effects of estrogen on the male body. Not only is progesterone found in males, but men rely on the alleged "female hormone" to preserve their masculinity. In fact, progesterone is a precursor to testosterone - the male sex hormone. As men age and testosterone begins to decline, estrogen levels steadily rise. As estrogen levels increase, progesterone levels plummet.
Symptoms of low progesterone in men include:
Impotence· Bone loss
In addition, men with low levels of progesterone have a higher risk of developing health conditions, such as osteoporosis, arthritis, prostatism and prostate cancer.
Estrogen dominance is a term coined by hormones expert Dr. John R. Lee, and it describes a condition where a woman (or in this case, man) has more estrogen than progesterone. Even if a man's estrogen levels are low, it is still possible that he will experience symptoms of estrogen dominance. The main cause of estrogen dominance in men is exposure to xenoestrogens and phytoestrogens? which are hormone-mimicking chemicals found in consumer-based products and even in the air we breathe. In addition to environmental factors, other causes of estrogen dominance in men include alcoholism, obesity, chronic stress and glandular dysfunction.
In addition to testing testosterone levels, men should also consider having other hormones tested to get a clearer picture of what's going inside their bodies. This includes estrogen, progesterone, cortisol, DHEA and thyroid hormones. Hormonal balance is like a jig-saw puzzle - without all of the pieces in place, it just doesn't work.
11-05-2011, 12:07 PM
Lucky, I have been using an all-natural, bio-identical progesterone cream for men for 7 or 8 years at least. I have brought the topic up of how good it is for managing estrogen and preventing prostate cancer both on AM and BB and nicely or not so, been told I was full of it. I stopped talking about it because of people already being omniscient and not needing to hear about new facts. Actually it's probably a pretty well known fact for about a decade by now.
11-05-2011, 02:10 PM
Good to hear I am not going crazy. Sometimes there seems to be too much Bro-science circulating.
I looked at my wife's progesterone cream from NOW and it had a warning that progesterone is known in California to cause cancer and I have read quite the opposite. Any idea why that is?
Also, I tried a dab this morning, felt a sort of alertness. Good feeling.
What exactly do you notice from it and would it not be better to take pregnenolone since it is the mother of all Steroid hormones? Pregnenolone converts into what ever hormone you body is requiring at that time. Said to be safer that a bio-identical or specific hormone treatment. What's your thoughts or experience.
11-05-2011, 05:24 PM
I have a doc appointment next week. My lab work will be in at that time. I hope he hooks me up with the the prego roid but I dont think he will if I'm taking Tess e and deca. This is my first cycle. Hey, what do you think about tren e to add into the mix. I am afraid I am doing to much for the first cycle. But then I don't understand why you shouldn't rip it up!! Anything?
11-05-2011, 07:06 PM
FWIW, several years ago I switched to buying mine at Vitacost and use the "Life-Flo Progest-Care Men's Formula" which costs $18.49 per 3 oz tube and it gives me a measured (10 mg) dose ( ie a little less than half the typical women's dosage) for about 2 months per.
From Dr Lee 10 years ago who really broke this market open, there have been tons of Docs who recommend natural progesterone for men. I like it because it helps me to avoid prostate cancer, helps control my enlarged prostate all by knocking down my Estrogen levels and hence supporting my testosterone level. Between the natural Progesterone, the Test Cyp from my VA DOcs and now also using RS-Transaderm to bump up my DHEA and Pregnenalone, I think I have found the perfect trifecta for my health and my workouts. I am a happy old puppy!
11-05-2011, 07:57 PM
11-06-2011, 04:59 AM
Sounds like there is hope still with the doctors. Do you take anything more then what the doc gives you?
11-06-2011, 06:58 AM
11-06-2011, 01:02 PM
11-07-2011, 11:56 AM
Check out my END OF OLD AGE order.
~beta alanine (dropped l-carnosine, hope works just as good)
~pregnenolone cream and oral
11-07-2011, 12:02 PM
I'm currently spending 6 months on what I call a rejuv (reverse aging) program. I also use a couple of strong endurance supplements as I want to raise that too. I did buy some DMAE, COQ10 cream ($9 at SwansonVitamins) and 50 grams of carnosine along with the 200 grams of beta alanine. I plan to use the carnosine saturated in coconut oil as a skin cream as 3-4 grams goes a long ways. The Japanese make carnosine skin creams at about $60 to $80 per 1.5 ounces. I've never cared about the narcissist looks thing much, but I want to play with this and see what's possible.
The endurance supps I use are cordyceps mushrooms (what the Sherpas use to climb high in the Himalayas without oxygen), and GPLC an amazing form of carnitine that is super for endurance. Both of these actually give you an edge in weigh training too, their effects are so powerful. They really shine with cardio efforts though.
11-07-2011, 12:07 PM
My brother's doc gives him enough injectable test to keep him at the 1150 level. A lot of stuff has happened to me since I was on here before, and I hit a full sized deer with my car while driving home from work on my last drive home before a weeks vacation, on my birthday yet. Oh, well, as the song says, I'll roll with it. But probably using a different car.
11-07-2011, 01:38 PM
Doesn't Carnosine absorb HORRIBLY?? I thought you needed huge amounts to get any decent amount in your blood
11-07-2011, 02:38 PM
11-07-2011, 02:53 PM
11-07-2011, 04:25 PM
DUTCHMAN, don't give up the fight! your wisdom and insight are worth more than you could imagine!As I said, I stopped fighting that war here years ago.
11-07-2011, 05:13 PM
Thanks for providing a list of your natural supplements. Going to definitely look into making my own stack.
And going to definitely try the eyesight improvement nutrients.
Mine comes from having a job being at a PC all day and even breaks still don't stop all of the strain.
On my days off my vision is noticeably better. Trying to get into another type of job.
Anyway, great posts everyone.
I learned a lot. Thanks.
"I don't want anything. I don't want anybody. That's the worst part. When the want goes, that's bad."
(Doug Stanhope as Eddie on Louie)
11-07-2011, 06:47 PM
Great info Dutchman! I just started taking 3.2g of beta-alanine a day and haven't felt the tingling effects at all. The first time I drank the 3.2g in 32fl oz of water in an hour and felt nothing. Now I drink the 3.2g in 64fl oz of water over the course of the day. Am I diluting it too much? I also bought some taurine but I'm not sure on optimal doses. I've been taking (i think) 5g of taurine intra-workout in my intra-shake which has pure karbolyn, protein, leucine, and creatine in it.
11-07-2011, 09:23 PM
aTeam, not everyone gets those tingles and the lower the amount you take the less likely they are. I've been taking a good 4 gms daily for years and now take it twice a day for 8 gms. I also take it all at the same time. If you water it down and spread it out over the day that might just be the reason you don't feel it. What is important to feel is the results in the gym. I love it stacked with my creatine mono. I pump up, recover faster and just seem bigger and stronger. Maybe try taking a little more and all at once? Good Luck.
11-07-2011, 11:27 PM
I'm so glad I found this thread. At 39 I'm glad I see that I can keep building and growing. Thanks to all esp. Dutch ;-) great info
It is not the kind of car you drive. It is whether you can flip it.
11-08-2011, 12:12 AM
I cycle on and off but when i'm on i also use Citrulline Malate with Beta Alanine and start drinking it on the way to the gym and finish about halfway through. Drink plenty of water with it as well.
11-08-2011, 01:04 AM
Thanks for the comments guys. My only concern is it isn't all getting absorbed when I drink it in so much water. I feel like the water just passes through me and I piss it out. Not getting tingles may be related to my ironclad stomach, very few things upset my stomach. I'm sure as I get older that will change, I'm 20. I'll try 3.2g in one 8oz drink and see what happens. Honestly I'm just curious what all this tingle business is about.
11-08-2011, 01:42 AM
BTW people the reason why I use coconut oil like in the Dutchman's supplement list is that it too has many health purposes, but equally important is it sets you up to keep your test levels high. Of all the healthy fats, coconut oil is the best for this, although fish oil and extra virgin olive oil are decent too. Healthy fats lay the foundation for good hormone levels.
Back to the original carnosine post. I intend to try an experiment. I purchased 50 grams of bulk carnosine, and have saturated 3-4 grams of it into 2 ounces of liquid coconut oil. I have a large, deep scar from a major knee surgery in January of this year. I intend to apply this oil with the carnosine powder in it to that scar twice a day for a couple of months as I'm interested in the effect of the carnosine externally. Just curious.
11-08-2011, 07:03 PM
I realize this is off the topic of Carnosine but on topic with END OF OLD AGE. I have been applying NOW progesterone cream for 3 days now and what I have noticed is that the damaged ligament in my knee which I have been living with for 2 months now is feeling better. Upon googling ligaments and progesterone, there seems to be some correlation.
11-08-2011, 11:47 PM
11-09-2011, 02:58 AM
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