Viagra as doping

  1. lutherblsstt
    Guest
    lutherblsstt's Avatar

    Viagra as doping


    A very interesting article appeared in this month's issue of the Journal of Clinical Endocrinology and Metabolism.

    Luigi and colleagues from the University of Rome have been conducting studies investigating the effects of taking Viagra on exercise performance. They have found before that there are not effects on VO2max or anaerobic performance, but in their most recent study, they did find that sex steroid secretion (or at least, circulating levels) is enhanced. Because of that reason, training while on Viagra could potentially lead to a boosted training effect. To be complete, they did not really use Viagra, but Cialis (active ingredient: tadalafil) its longer acting similar component. However, I use the word Viagra because of its similarity and because people are more familiar with this term. One point of caution; cortisol (also a steroid) also increased, and even more so than testosterone. Cortisone though antagonizes some of the effects of testosterone, hence why the ration testosterone to cortisol has been used as an indicator of anabolism or catabolism and overtraining. You want a high ratio when you train hard, and a decreasing ratio (in men) may be being at risk for overtraining. Cortisol though having strong anti-inflammatory potential also has the ability to weaken the muscle.

    Here's the study:

    Di Luigi L, Baldari C, Sgrò P, Emerenziani GP, Gallotta MC, Bianchini S, Romanelli F, Pigozzi F, Lenzi A, Guidetti L.: The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men. J Clin Endocrinol Metab. 93(9):3510-3514, 2008.

    Unit of Endocrinology, Department of Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis, 15, 00194 Rome, Italy. luigi.diluigi@iusm.it

    CONTEXT: Physical exercise-related stress activates hypothalamus-pituitary-adrenal (HPA) axis; nitric oxide is one of the mediators of the HPA axis response to stress, and phosphodiesterase type 5 inhibitors influences nitric oxide-linked biological activities. OBJECTIVE: The objective of the study was to investigate whether a single oral long half-life phosphodiesterase type 5 inhibitor (tadalafil) administration influences the HPA axis response to exercise-related stress. DESIGN: This was a double-blind, cross-over trial. PARTICIPANTS: Participants included nine healthy male athletes. INTERVENTIONS: All subjects performed a maximal exercise test in normoxia, after which they received a single oral administration of tadalafil or placebo. Then after a 2-wk washout period, they were crossed over and repeated the exercise test. Each subject was his own control. Salivary collections, for steroid evaluations [cortisol, dehydroepiandrosterone sulphate (DHEAS), testosterone] and respective ratio calculation (DHEAS to cortisol, testosterone to cortisol, testosterone to DHEAS), were performed before each exercise (Pre-Ex), immediately after (Post-Ex), and at 30 min during recovery. RESULTS: As expected, mean salivary cortisol concentration increased immediately after exercise after both tadalafil and placebo (P = 0.014 and P =0.036 vs. Pre-Ex, respectively); however, the cortisol increase was significantly higher after tadalafil administration (P = 0.034 vs. placebo). Furthermore, an increased salivary testosterone after exercise was observed only after tadalafil administration (P = 0.029 vs. Pre-Ex). No effects of either exercise and/or tadalafil administration on salivary DHEAS concentrations were observed. DHEAS to cortisol and testosterone to cortisol ratios significantly decreased after exercise after tadalafil administration (P = 0.037, and P = 0.02 vs. placebo, respectively). CONCLUSION: Tadalafil administration amplified the salivary cortisol and testosterone responses to a maximal exercise-related stress in healthy trained humans.


    Thus, it will remain to be seen what the end outcome is of all this, but I nevertheless thought it was interesting.

  2. Board Moderator
    Never enough
    EasyEJL's Avatar
    Stats
    5'10"  205 lbs.
    Join Date
    Jun 2007
    Age
    47
    Posts
    31,888
    Rep Power
    852765
    Level
    95
    Lv. Percent
    49.85%
    Achievements Activity VeteranActivity RoyaltyActivity ProActivity AuthorityPosting Pro

    interesting. Cortisol is always higher post workout so that part is ok and if i'm reading right it looks like it increased more in the placebo group than the cialis group.

    But like I could work out with cialis hardon.
  3. lutherblsstt
    Guest
    lutherblsstt's Avatar

    Quote Originally Posted by EasyEJL View Post
    interesting. Cortisol is always higher post workout so that part is ok and if i'm reading right it looks like it increased more in the placebo group than the cialis group.

    But like I could work out with cialis hardon.
    •   
       

  4. New Member
    tremark's Avatar
    Join Date
    Jan 2014
    Posts
    11
    Rep Power
    17
    Level
    2
    Lv. Percent
    89.5%

    .....
  5. Elite Member
    kisaj's Avatar
    Stats
    6'0"  210 lbs.
    Join Date
    Feb 2012
    Age
    40
    Posts
    5,133
    Rep Power
    2178837
    Level
    70
    Lv. Percent
    46.64%
    Achievements Posting AuthorityActivity ProActivity AuthorityPosting Pro

    This was a running joke a few years ago when Brandon Marshall admitted that a lot of the guys in the locker room pop a cialis before games and everybody thought he was insane.
  6. New Member
    rixrix's Avatar
    Stats
    5'3"  177 lbs.
    Join Date
    Sep 2013
    Posts
    58
    Rep Power
    48
    Level
    6
    Lv. Percent
    94.92%

    I do take Cialis and I do feel my workouts are better when I take it. But I don't work out in a place with "distractions".
  

  
 

Similar Forum Threads

  1. the best doping
    By batista19811 in forum Anabolics
    Replies: 32
    Last Post: 01-03-2010, 10:50 AM
  2. Doping officials!! RUN!!!
    By MoTiV in forum News and Articles
    Replies: 2
    Last Post: 05-18-2009, 05:09 PM
  3. Doping for gold
    By tim1985 in forum Anabolics
    Replies: 4
    Last Post: 05-08-2008, 02:24 AM
  4. The Opposite of Doping
    By yeahright in forum News and Articles
    Replies: 0
    Last Post: 02-16-2006, 03:49 PM
  5. doping to win
    By ballzasteel in forum General Chat
    Replies: 1
    Last Post: 08-12-2004, 10:03 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in