Insuligen: New MA Labs Product

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Insuligen

The Industry’s 1st Insulin Secretagogue”



NOW AVAILABLE!!!



Insuligen at a glance…

*The Industry’s 1st Muscle-Building GDA

* Increases Insulin Levels 800% More than the Competition

* Stimulates Muscle Tissue Specific Glucose Transport

* Improves Nutrient Absorption

* Doesn’t Suppress Protein Synthesis via Excessive AMPK Activation (like virtually every other GDA on the market today)

* Initiates Fat Loss via Increased Lipolysis

* Prevents Fat Gain via the Inhibition of Lipogenesis





GDA’s: Sensitizers, Mimetics, and Secretagogues​

Whether we’re talking about sports nutrition stores, online wholesalers, or direct to consumer companies, one thing they all have in common is that they offer a wide variety of products claiming to provide insulin-like effects. Normally referred to as glucose disposal agents, or GDA’s, these products fall into one of three categories: insulin sensitizers, insulin mimetics, and insulin secretagogues. However, for the average consumer, deciphering between this diverse class of supplementation can be difficult and even confusing. Further complicating matters is that these terms are often used interchangeably, leading one to believe that they are one in the same. While there are certainly similarities between them, there are also important differences, with each one producing its own unique effects in the body. Therefore, before we can effectively differentiate MA Labs’ Insuligen from the other GDA’s on the market, we must first possess a basic understanding of the class as a whole, as well as the underlying mechanisms of action for each category.

Keep in mind that the term GDA is somewhat ambiguous, or generic in nature, as it is an umbrella term used to describe the class as a whole. This is because the name itself refers to a singular function applicable to all categories, rather than a trait unique to a particular category. Therefore, the term "GDA” can be applied to any product claiming to provide insulin-like effects. Now that we know what the different categories of GDA’s are, let’s look at the primary differences between them:

Insulin Sensitizers: This category of GDA’s increases our cells’ responsiveness (i.e. sensitivity) to insulin, thereby enabling us to use this hormone more efficiently/effectively.

Insulin Mimetics: This category of GDA’s works by copying (or mimicking) the effects of insulin in one or more ways. For example, one way in which they might mimic insulin is by activating the translocation of Glut-4; a transporter protein utilized in the shuttling of glucose into muscle cells.

Insulin Secretagogues: This category of GDA’s differs from the previously mentioned categories, in that it actually causes the pancreas to secrete insulin into the bloodstream, resulting in greater overall insulin levels.

Although the descriptions I provided above are accurate, the reality is that none of these categories function solely within their respective category. In other words, while an insulin sensitizer may function primarily as a sensitizer, it may also possess some degree of mimetic and/or secretagogue effects, albeit to a lesser degree. The same goes for both mimetics and secretagogues.

While this can sometimes be a good thing (all categories have benefits), neither sensitizers nor mimetics are a replacement for insulin, as they are limited in terms of both functionality and potency. Unfortunately, they simply aren’t capable of replicating insulin’s full range of physiological effects, particularly in those areas responsible for regulating muscle growth. Anyone who is experienced with both insulin and GDA’s will readily attest to this fact, as GDA’s are known more for their fat loss/recomping effects than for stimulating recovery & growth. There are multiple good reasons for this, but there is one main reason. Enter AMPK.



AMPK & GDA’s​

For those of you who are unfamiliar with the term AMPK and what it means to bodybuilders, allow me to give you a brief crash course on this important, yet often misunderstood enzyme. AMPK, otherwise known as adenosine monophosphate-activated protein kinase, is an enzyme involved in regulating energy metabolism. When this enzyme is activated, such as during exercise or starvation (or in this case, when using traditional GDA’s), it can produce a number of beneficial effects, including decreased inflammation, increased fatty acid oxidation (e.g. the burning of fat for fuel) and increased glucose uptake.

Naturally, this would make AMPK activation an enticing target for supplement formulators, so it probably wouldn’t surprise you to learn that today’s GDA’s are comprised almost entirely of these substances. This is an important point to consider, as both insulin sensitizers and mimetics derive the vast majority of their insulin sensitizing effects as a direct result of AMPK activation. In fact, the terms AMPK activator and insulin sensitizer/mimetic have become so closely associated that they are almost synonymous.

Metformin and berberine would be great examples of AMPK activators. Both of these are well known to provide a moderate recomping effect (via fat loss), along with significant improvements in overall metabolic health. With such a large number of potential beneficial effects (from both a cosmetic and health standpoint), it is not unreasonable to assume that more is betterÂ…and thatÂ’s exactly where most supplement companies have erred.



AMPK Activation and Muscle Growth?​


Using a product comprised almost entirely of AMPK activators is a great idea if your primary goals are heath and fat loss oriented, but if muscle growth is at the forefront of your priority list, this is problematic. This is because AMPK activation is antagonistic to mTOR, acting as a negative feedback control to restrain muscle hypertrophy. In other words, AMPK activation directly and strongly inhibits protein synthesis, causing a decrease in muscle growth.
Now, before you start thinking that all AMPK activation is inherently bad for bodybuilders and should therefore be eliminated, think again. The truth is that some degree of AMPK activation is not only essential for our health, but is also necessary for muscle growth. However, excessive activation of this enzyme, especially during times when catabolism is at its peak (i.e. during the training window, for instance), will directly impede your ability to build muscle mass. Therefore, any product which contains copious amounts of sensitizers and/or mimetics should be avoided when muscle growth is the goal, especially at these times.

Unfortunately, nearly every GDA on the market today is loaded to the gills with insulin sensitizers/mimetics. It is no longer uncommon to see GDA’s containing 4, 5, or even more powerful AMPK activators—often at very high dosages—within a single formula. Using a product like this, especially multiple times daily, is the last thing you want to do when trying to grow. You are much better off saving these kinds of products for times when fat loss is the overriding goal, such as during contest prep or simply when trying to get in the best shape possible.



Muscle Building GDA’s vs. Fat-Loss GDA’s.​

Insuligen was formulated specifically to AVOID this modern-day pitfall by relying primarily on insulin itself (via insulin secretagogues) to power it’s unique effects, rather than AMPK activation. Unlike other GDA’s, which aren’t really insulin-like at all (how can a product claim to be “insulin-like” when it not only fails to assist with muscle growth, but actually hinders it?), Insuligen will provide the effects that bodybuilders have been seeking from these products all along—glucose transport in combination with improved recovery and growth. As a side benefit, it will even assist with fat loss/prevent fat gain.

Further improving its effect profile is that Insuligen provides just enough AMPK activation to help maintain insulin sensitivity in the face of elevated insulin levels, allowing the user to reap maximum benefit from the large increase in circulating insulin levels without experiencing the negative effects typically associated with a high insulin environment. In other words, you get the best of both worlds—elevated insulin levels when you need it, but without any of the negative side effects typically associated with a hyperinsulinemic state; all while simultaneously assisting the individual in their health and fat loss goals.

While the idea of formulating a product based solely around insulin secretagogues is a relatively simple concept, Insuligen is the first product to actually do so. Up until now, GDAs have been nothing more than a hodgepodge of randomly selected compounds, focusing solely on glucose disposal and insulin sensitivity without any regard for the detrimental effects they may have on the growth process. This all changes now.



Insuligen: Ingredients

GymnePURE®: Insuligen is the first GDA released within the bodybuilding-fitness industry to contain this novel and costly ingredient. In short, GymnePURE® is the safest, most biologically active and effective Gymnema Sylvestre extract ever developed. This is NOT your typical Gymnema product, which is nothing more than ground up leaf occasionally standardized for gymnemic acids. Rather, GymnePURE® is a unique and innovative multi-patented extract of natural Gymnema Sylvestre Leaf using a scientifically supported extraction process known as OSA™.

When looking at GymnePURE® from a biological standpoint, there are two primary characteristics which differentiate it from traditional gymnema products—potency and safety. Research performed at King’s College in London shows us just how powerful GymnePURE is. When compared directly against multiple other gymnema extracts, just a single 250 mg dose of GymnePURE® elevated insulin levels 600%-1,600% higher than a full 8 capsules (1,000-2,000 mg) of standard gymnema extract, with the average increase being 800% greater. No other Gymnema product on the market even comes close, making GymnePURE® the premier insulin secretagogue available today.

But how does GymnePURE® stack up to the competition from a safety standpoint? This rarely talked about aspect of gymnema usage may be more important than you think, particularly in individuals with compromised beta cell viability or in those who regularly use GDA products. Located in the pancreas, beta cells are the cells responsible for secreting insulin into the bloodstream. When these cells are damaged through chronic/excessive insulin secretion (Type II diabetes, for example) or improper supplementation, they can partially or even totally lose their ability to release insulin into the bloodstream.

The safety difference between GymnePURE® and other gymnema extracts lies in its mechanism of action (M.O.A). Regular gymnema extracts possess a less than ideal M.O.A, as they stimulate insulin secretion by literally breaking down the beta cell walls, causing insulin to leak into the bloodstream. This unnatural method of inducing insulin secretion leads to subsequent beta cell wall exhaustion and eventually, death. You may want to think about this the next time you reach for your gymnema containing GDA product.

In contrast, GymnePURE® works by opening and closing the cell walls in a natural manner, thus preserving their integrity and future ability to perform vital functions. But this is not GymnePURE’s only MOA. It also works through signaling pathways in the presence of Ca and even in the absence of Ca. This three-fold mechanism of action is far superior to anything encountered with normal gymnema extracts, both from an effectiveness and safety standpoint. GymnePURE® accomplishes all this without activating AMPK, so you don’t need to wonder if your muscle building efforts are being compromised.

4-Hydroxyisoleucine: 4-Hydroxyisoleucine, otherwise known as 4-HIL, is a non-protein amino acid isolated from Fenugreek seeds. Although 4-HIL has been known about for some time now, it is almost never included in GDA’s at a meaningful dose (the last time I saw a properly dosed 4-HIL product was 12-15 years ago and it was the only ingredient in the product), and when it is listed on the label, it is always part of an undisclosed (i.e. ineffective) proprietary blend. This is due to its excessive cost, as a single 200 mg dose (the dose found in Insuligen) has a higher production cost than most GDA products do in their entirety. Although highly effective, this makes 4-HIL an impractical addition to many multi-faceted GDA products, unless the company is willing to abandon conventional profit margins in the pursuit of effectiveness.

Like GymnePURE®, 4-HIL does not activate AMPK, but directly activates pancreatic islets, causing insulin to be released into the bloodstream. In addition to its insulin secreting effects, 4-HIL also possess the ability to lower plasma glucose through non-insulin dependent pathways, while simultaneously improving HDL levels and lowering total cholesterol and triglycerides.

Beta-umbelliferone: Beta-umbelliferone, also referred to as 7-hydroxycoumarin, is an interesting compound with a plethora of beneficial effects. Never before used in a GDA product, umbelliferone is the parent compound from which the prescription medication, Warfarin, is derived. However, unlike warfarin, umbelliferone does not have any significant blood thinning properties, but instead acts as an insulin secretagogue, anti-oxidant, and anti-inflammatory agent.

Impressively, umbelliferone has been shown to possess insulinotropic effects comparable to the powerful prescription insulin secretagogue, glibenclamide, but without the AMPK activation that is so prevalent among GDA's in general. That is a very significant finding, as glibenclamide is one of the most effective and long-standing secretagogues used in medicine today. Even better, Umbelliferone does this without any harmful side effects; something that cannot be said of glibenclamide, which has numerous contraindications and potentially serious negative effects on the patientÂ’s health.

As a side benefit, umbelliferone also helps prevent/reverse inflammation induced liver injury, making it a powerful and natural liver protectant. This hepatoprotective effect is largely attributable to umbelliferone’s anti-inflammatory properties, which have been repeatedly demonstrated in clinical studies. Most notably, it has been shown to reduce hepatic TNF-a, IL-1β, and IL-6 levels. These inflammatory cytokines play a critical role in the progression of liver injury by provoking hepatocellular injury and death, while TNF-α and IL-1β act as sensitizing factors, amplifying hepatocyte damage by inciting hepatic leukocyte infiltration.

Ampalaya: More commonly known as Momordica Charantia or bitter pear, Ampalaya is a routinely used oral hypoglycemic agent capable of stimulating glucose uptake through multiple pathways. Acting as an insulin secretagogue, insulin sensitizer, and insulin mimetic, Ampalaya provides a number of benefits not found with secretagogues alone. In addition to its clinical efficacy, Ampalaya was selected for this very reason, as it activates AMPK just enough to provide a potent insulin sensitizing effects, but not so much that it impairs the growth process.

Although there are dozens of hypoglycemic agents found in Ampalaya, the most powerful of these include: charantin, polypeptide-p and to a lesser extent, vicine. Charantin functions as an insulin secretagogue and has been shown in clinical studies to produce a more powerful insulinotropic effect than the prescription secretagogue, tolbutamide. Polypeptide-p functions as a potent insulin mimetic, closely resembling insulin in both structure and effect. So comparable are its physiological effects to insulin that it can even be used as an insulin replacement in Type I diabetics. There are at least a dozen additional hypoglycemic agents found within Ampalaya, all of which contribute to the overall effects of this amazing plant.



Enhanced Bioavailability

When designing an GDA formula, one could decide to include only the most powerful ingredients available, but if they are poorly absorbed due to low bioavailability, it means very little. Therefore, it would behoove any supplement company to make sure that this aspect of product development is not overlooked. In many cases, the simple addition of one or more bioavailability enhancers is all that is required to greatly improve a product’s absorption into the bloodstream, thereby enabling the product to provide the results it was intended to.

For Insuligen, I have chosen to use a combination of 4 different compounds, all of which are backed by a mountain of clinical research. These include BioPerine (a trademarked version of piperine), ginger, cumin seed, and gallic acid. Each of these possesses a different mechanism of action and/or work synergistically with the others to further improve bioavailability. Mechanisms of action include p-glycoprotein inhibition, stimulation of gut amino acid transporters, inhibition of drug metabolizing enzymes, reduced production of intestinal glucuronic acid, and increased bile production and digestive motility.

By optimizing virtually every variable associated with the absorption process, you can rest assured that you are receiving maximum benefit from the compounds within Insuligen.



***IMPORTANT***

Insuligen: Glucose Dependent

When using Insuligen, it is very important to understand that its effects are almost entirely glucose dependent. What does this mean? It means that the substances within Insuligen only stimulate insulin secretion in response to the presence of elevated blood glucose levels…and the greater the elevation, the greater the insulinogenic response. In other words, the more carbs you eat, the better the product works, while those who eat little to no carbs will notice little to no results. Yes, its lipolytic and anti-lipogenic effects will still be present, as will a portion of its insulin sensitizing effects, but without adequate carb intake insulin secretion will be minimal to non-existent. Therefore, low-carb dieters need not apply. Insuligen was designed specifically for those interested in building muscle mass.

Given the fact that Insuligen is glucose-dependent, one should not expect to experience hypoglycemia when using it, regardless of the dose employed, because as soon as Insuligen has done its job (lowered BG levels back down into a normal range), insulin secretion will cease. This self-modulatory effect is exactly what we want out of a secretagogue, as it not only prevents the occurrence of hypoglycemia, but also helps prevent insulin resistance and potential fat gain.



Conclusion

As the 1st product of its kind, Insuligen’s arrival ushers in a new class of GDA’s—the muscle-building GDA. By foregoing AMPK activation as its primary M.O.A., Insuligen takes a step away from the anti-growth approach that typifies most GDA’s and instead chooses to rely on endogenous insulin production to power its effects.

By providing a more muscle-friendly GDA, Insuligen helps fill the gap left by the current roster of GDA products, which are more suited for fat-loss and/or recomping. As always, MA Labs is proud to introduce to you it’s newest release in the MA Labs line-up—Insuligen.



 

Mike Arnold

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Insuligen: Only A Single Run Will Be Produced​





Once this 1st batch is sold out, Insuligen will never be sold again, as the price of one of its ingredients increased by 250% during the production process, putting its production cost way out of range for a product within this product category. Even before the price of this ingedient increased by 250%, its production cost was already at the upper-limit of what is considered reasonable. If I were to make a 2nd run, I would either have to increase the price significantly, or cut my profit margins down to almost nothing (they are already way below average). I am not going to do that, so Insuligen will only be a single run product.

So, get it while you can...because once this batch is gone, it will not be back.
 

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Dare I say this better than the original recompodrol as far potency and weight loss?
 

Mike Arnold

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Dare I say this better than the original recompodrol as far potency and weight loss?
It's a completely differnet kind of GDA. It ushers in a new class of GDA--the muscle building GDA. It is completely differnet than anything that has come before it. You must read the description to understand how it differs from everything else on the market. It is worth the read.
 
Nac

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Could this be used/dosed intermittently and still be effective? Ie if you carb cycle (on high carb days)...when cutting, on high carb days/refeeds...etc
 

Mike Arnold

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Could this be used/dosed intermittently and still be effective? Ie if you carb cycle (on high carb days)...when cutting, on high carb days/refeeds...etc
Yes, it will absolutely still work for that purpose, as it is going to release insulin in response to elevated blood glucose levels, regardless of whether it is a re-feed day, a high-carb day, or a normal cartb meal.

Obviously, if you are using it twice daily, every single day, you are going to experience better muscle building results over the long-run in comparison to someone who only uses it a few times a month, simply because the chronic user would be exposing their body to greater amounts of insulin over time. But...the product will still do exactly what it is supposed to do every single time you eat carbs, regardless of whether it is a re-feed day, high-carb day, etc.

In fact, those who eat carbs infrequently and then load up on carbs during re-feeds or high carb days are likely going to experience superior results on those particular days, in comparison to someone who is just eating one of their normal carb meals. This is because the person who barely eats carbs and then loads up on them is going to be much more insulin senstive in comparison to someone who eats a ton of carbs every day. Therefore, a re-feed or high-carb day is going to make their body respond even better to the Insuligen-mediated increase in insulin levels.
 
Ape McGrapes

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How many servings to a bottle?
 

SpongeTom

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Is there anything to consider if taking this, while on a ketogenic diet?
 
The Solution

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Is there anything to consider if taking this, while on a ketogenic diet?
Mike said this in regards to being low carb:

"but if he is someone who mostly eats low-carbs with occasional re-feeds, it is not the product for him. I clearly state in the product desription that this GDA is not for fat lossor recomping. It is designed SOLELY for those attempting to maximize muscle mass....which is why my product is called "insuligen" Other GDA's are NOTHING like insulin, as they SUPPRESS muscle growth. How can a product claim to be insulin-like when it not only doesn't help muscle growth, but actually hinder it. It can't. Insuligen is the first GDA that actually works primarily via insulin secretion. Insuligen requires one to eat just like if they were using exogensous insulin...if maximum results are desired (i.e. maximim increases in insulin levels). "

It would not be ideal.
 
jameschoi

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Will you offer another GDA or is this it?
 

Mike Arnold

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Mike said this in regards to being low carb:

"but if he is someone who mostly eats low-carbs with occasional re-feeds, it is not the product for him. I clearly state in the product desription that this GDA is not for fat lossor recomping. It is designed SOLELY for those attempting to maximize muscle mass....which is why my product is called "insuligen" Other GDA's are NOTHING like insulin, as they SUPPRESS muscle growth. How can a product claim to be insulin-like when it not only doesn't help muscle growth, but actually hinder it. It can't. Insuligen is the first GDA that actually works primarily via insulin secretion. Insuligen requires one to eat just like if they were using exogensous insulin...if maximum results are desired (i.e. maximim increases in insulin levels). "

It would not be ideal.
Pleased allow me to clarify. Insuligen will still work on re-feed days, high-carb days, etc, as the secretagogues within it will release insulin any time someone consumes carbs. However, if I was going to choose someone to review the product, it would be someone who was able to capitolize on its muscle building effects...not someone who is just looking to occasionally refill glycogen stores on re-feed days.

The secretagogues in Insuligen are glucose dependent (meaning they only secrete insulin in the presence of elevated BG levels) and the more carbs one eats, the greater the insulin reponse will be. Therefore, maxamizing these insulin spikes (thereby maximizing muscle growth) can only be acheived in someone who is consuming significant amounts of carbs on a daily basis.

In conclusion, the prouduct will do what it is supposed to do (release insulin) regardless of whether the person is eating carbs all day long, or only occasionally eats carbs, but the person who eats carbs much more often is going to experince a much greater number of insulin spikes, thereby maximizing the product's potential muscle building results. Obviously, spiking insulin levels 14 times per week is going to provide a more efficacious muscle building effect compared to someone who only spikes levels 2-3 times per week.

This is why I say insuligen is a "muscle building" GDA, as its primary M.O.A (insulin secretion) plays an important role in the recovery & growth process. Insulin enables the individual to increase their growth rate while simultaneously enahncing glucose transport, whereas other GDA's also assist with glucose transport, but they stunt the growth process by reducing protein synthesis via the suppression of mTOR (AMPK activation suppresses mTOR).

Most GDA's today are so loaded with AMPK activators that they are the last thing someone would want to use if they are attempting to maximize muscle growth. They are great for fat loss (AMPK activation stimulates fat loss), but they most certainly aren't growth agents. A little AMPK activation is good and necessary, but the overaction of AMPK, especially at the wrong times (such as during the training window, or at any other time when catabolism is at its peak), facilitates muscle breakdown rather than muscle growth.
 
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My only high carb meals are post work out meal and cheat meals. Breakfast is protein and veggies. Meal 2 and 4 are 30-40 gm carbs. Post workout is 75gm and cheats are 100 plus. How would you use this product with this diet. Basically I have a high carb meals 1x per day, 6-7 days a week
 

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Picked up a couple. Currently in keto, trying to get cut down. Not sure when I’ll use it but sounds intriguing.
 

Mike Arnold

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My only high carb meals are post work out meal and cheat meals. Breakfast is protein and veggies. Meal 2 and 4 are 30-40 gm carbs. Post workout is 75gm and cheats are 100 plus. How would you use this product with this diet. Basically I have a high carb meals 1x per day, 6-7 days a week
You want to use it anytime you consume a significant amount of carbs, so for you it would be about 10 minutes before your once daily high-carb meals and your cheat meals.
 
BigKrabbe

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Good ingredient profile. Nothing special about any of them or unique about this product though.
 
KingErgogenic

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"gymnema extracts possess a less than ideal M.O.A, as they stimulate insulin secretion by literally breaking down the beta cell walls, causing insulin to leak into the bloodstream"

-Are you serious?! I thought it usually helps to regenerate beta cells...?
 
Rostam

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ma70

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Where do I buy this stuff?

EDIT: Wow, it's amazing I didn't look at the link at the bottom....
 

Mike Arnold

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Good ingredient profile. Nothing special about any of them or unique about this product though.
Nothing special? I think the fact that two of Insuligen's ingredients have never been included in a GDA before makes it "special", especially when one of them, (GymnPURE) is 8X more potent as an insulintropic agent than any other gymnema extract. Then again, I'm not sure how you define the word "special". I had mentioned previously that it would have 2 new ingredients and the rest were already in use.
 

Mike Arnold

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"gymnema extracts possess a less than ideal M.O.A, as they stimulate insulin secretion by literally breaking down the beta cell walls, causing insulin to leak into the bloodstream"

-Are you serious?! I thought it usually helps to regenerate beta cells...?
^^^^^ this.
In all the articles I read there is reference to beta cell wall beak down or insuline leakage. They all refer to insuline release and beta cell regeneration.

Here is on article from PubMed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/

and a write up from another site:

https://restorativemedicine.org/library/monographs/gymnema/

And there are many more. Would be good to see where you get this leakage idea from.
I will be posting all the scientific references shortly. There should be around 20 in total. They will be attached to the product desription on the website. I would have done it already, but I didn't want to postpone its release any longer.
 
Rostam

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Thank you. The only reference I’m interested in for the moment is the one related to insulin leakage from beta cells due to break down of the cell wall by gymnema.

If I remember correctly GymnPURE is an extract of gymnema standardized either to 25 or 75% gymnemic acid. How does it differ to other gymnema in regard to insulin leackage due to cell wall break down?
 
Godstrength

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Nothing special? I think the fact that two of Insuligen's ingredients have never been included in a GDA before makes it "special", especially when one of them, (GymnPURE) is 8X more potent as an insulintropic agent than any other gymnema extract. Then again, I'm not sure how you define the word "special". I had mentioned previously that it would have 2 new ingredients and the rest were already in use.
Is that the same stuff thats in redcon1 RPG? I'm using that now
 

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BigKrabbe

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I look forward to seeing said studies disputing hundreds of other studies regarding gymnema.
 
Rostam

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I googled GymnePure and the only info I found in relation to insuline leakage from beta cells is on the write up of the sites and products with financial interest in GymnePure and even then they are talking about studies run at king’s college of London but no reference to the studies. They all repeat the same sentence which is the following (with no actual references to the the studies): According to studies at Kings College in London* GymnePURE is a much safer MOA than standard Gymnema Sylvestre extracts which damage pancreatic beta cell walls by breaking down the cell walls thus a “flooding release of insulin” and causing subsequent exhaustion of cell wall.
 
Rostam

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Nothing special? I think the fact that two of Insuligen's ingredients have never been included in a GDA before makes it "special", especially when one of them, (GymnPURE) is 8X more potent as an insulintropic agent than any other gymnema extract. Then again, I'm not sure how you define the word "special". I had mentioned previously that it would have 2 new ingredients and the rest were already in use.
This is true that GymnePure was not used so far in GDAs however it’s s already sold as a stand-alone (250mg per cap) product.
 
ELROCK

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Is there an AM discount code or no because it’s only a 1 time run?
 

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Insuligen

The Industry’s 1st Insulin Secretagogue”



NOW AVAILABLE!!!



Insuligen at a glance…

*The Industry’s 1st Muscle-Building GDA

* Increases Insulin Levels 800% More than the Competition

* Stimulates Muscle Tissue Specific Glucose Transport

* Improves Nutrient Absorption

* Doesn’t Suppress Protein Synthesis via Excessive AMPK Activation (like virtually every other GDA on the market today)

* Initiates Fat Loss via Increased Lipolysis

* Prevents Fat Gain via the Inhibition of Lipogenesis





GDA’s: Sensitizers, Mimetics, and Secretagogues​

Whether we’re talking about sports nutrition stores, online wholesalers, or direct to consumer companies, one thing they all have in common is that they offer a wide variety of products claiming to provide insulin-like effects. Normally referred to as glucose disposal agents, or GDA’s, these products fall into one of three categories: insulin sensitizers, insulin mimetics, and insulin secretagogues. However, for the average consumer, deciphering between this diverse class of supplementation can be difficult and even confusing. Further complicating matters is that these terms are often used interchangeably, leading one to believe that they are one in the same. While there are certainly similarities between them, there are also important differences, with each one producing its own unique effects in the body. Therefore, before we can effectively differentiate MA Labs’ Insuligen from the other GDA’s on the market, we must first possess a basic understanding of the class as a whole, as well as the underlying mechanisms of action for each category.

Keep in mind that the term GDA is somewhat ambiguous, or generic in nature, as it is an umbrella term used to describe the class as a whole. This is because the name itself refers to a singular function applicable to all categories, rather than a trait unique to a particular category. Therefore, the term "GDA” can be applied to any product claiming to provide insulin-like effects. Now that we know what the different categories of GDA’s are, let’s look at the primary differences between them:

Insulin Sensitizers: This category of GDA’s increases our cells’ responsiveness (i.e. sensitivity) to insulin, thereby enabling us to use this hormone more efficiently/effectively.

Insulin Mimetics: This category of GDA’s works by copying (or mimicking) the effects of insulin in one or more ways. For example, one way in which they might mimic insulin is by activating the translocation of Glut-4; a transporter protein utilized in the shuttling of glucose into muscle cells.

Insulin Secretagogues: This category of GDA’s differs from the previously mentioned categories, in that it actually causes the pancreas to secrete insulin into the bloodstream, resulting in greater overall insulin levels.

Although the descriptions I provided above are accurate, the reality is that none of these categories function solely within their respective category. In other words, while an insulin sensitizer may function primarily as a sensitizer, it may also possess some degree of mimetic and/or secretagogue effects, albeit to a lesser degree. The same goes for both mimetics and secretagogues.

While this can sometimes be a good thing (all categories have benefits), neither sensitizers nor mimetics are a replacement for insulin, as they are limited in terms of both functionality and potency. Unfortunately, they simply aren’t capable of replicating insulin’s full range of physiological effects, particularly in those areas responsible for regulating muscle growth. Anyone who is experienced with both insulin and GDA’s will readily attest to this fact, as GDA’s are known more for their fat loss/recomping effects than for stimulating recovery & growth. There are multiple good reasons for this, but there is one main reason. Enter AMPK.



AMPK & GDA’s​

For those of you who are unfamiliar with the term AMPK and what it means to bodybuilders, allow me to give you a brief crash course on this important, yet often misunderstood enzyme. AMPK, otherwise known as adenosine monophosphate-activated protein kinase, is an enzyme involved in regulating energy metabolism. When this enzyme is activated, such as during exercise or starvation (or in this case, when using traditional GDA’s), it can produce a number of beneficial effects, including decreased inflammation, increased fatty acid oxidation (e.g. the burning of fat for fuel) and increased glucose uptake.

Naturally, this would make AMPK activation an enticing target for supplement formulators, so it probably wouldn’t surprise you to learn that today’s GDA’s are comprised almost entirely of these substances. This is an important point to consider, as both insulin sensitizers and mimetics derive the vast majority of their insulin sensitizing effects as a direct result of AMPK activation. In fact, the terms AMPK activator and insulin sensitizer/mimetic have become so closely associated that they are almost synonymous.

Metformin and berberine would be great examples of AMPK activators. Both of these are well known to provide a moderate recomping effect (via fat loss), along with significant improvements in overall metabolic health. With such a large number of potential beneficial effects (from both a cosmetic and health standpoint), it is not unreasonable to assume that more is betterÂ…and thatÂ’s exactly where most supplement companies have erred.



AMPK Activation and Muscle Growth?​


Using a product comprised almost entirely of AMPK activators is a great idea if your primary goals are heath and fat loss oriented, but if muscle growth is at the forefront of your priority list, this is problematic. This is because AMPK activation is antagonistic to mTOR, acting as a negative feedback control to restrain muscle hypertrophy. In other words, AMPK activation directly and strongly inhibits protein synthesis, causing a decrease in muscle growth.
Now, before you start thinking that all AMPK activation is inherently bad for bodybuilders and should therefore be eliminated, think again. The truth is that some degree of AMPK activation is not only essential for our health, but is also necessary for muscle growth. However, excessive activation of this enzyme, especially during times when catabolism is at its peak (i.e. during the training window, for instance), will directly impede your ability to build muscle mass. Therefore, any product which contains copious amounts of sensitizers and/or mimetics should be avoided when muscle growth is the goal, especially at these times.

Unfortunately, nearly every GDA on the market today is loaded to the gills with insulin sensitizers/mimetics. It is no longer uncommon to see GDA’s containing 4, 5, or even more powerful AMPK activators—often at very high dosages—within a single formula. Using a product like this, especially multiple times daily, is the last thing you want to do when trying to grow. You are much better off saving these kinds of products for times when fat loss is the overriding goal, such as during contest prep or simply when trying to get in the best shape possible.



Muscle Building GDA’s vs. Fat-Loss GDA’s.​

Insuligen was formulated specifically to AVOID this modern-day pitfall by relying primarily on insulin itself (via insulin secretagogues) to power it’s unique effects, rather than AMPK activation. Unlike other GDA’s, which aren’t really insulin-like at all (how can a product claim to be “insulin-like” when it not only fails to assist with muscle growth, but actually hinders it?), Insuligen will provide the effects that bodybuilders have been seeking from these products all along—glucose transport in combination with improved recovery and growth. As a side benefit, it will even assist with fat loss/prevent fat gain.

Further improving its effect profile is that Insuligen provides just enough AMPK activation to help maintain insulin sensitivity in the face of elevated insulin levels, allowing the user to reap maximum benefit from the large increase in circulating insulin levels without experiencing the negative effects typically associated with a high insulin environment. In other words, you get the best of both worlds—elevated insulin levels when you need it, but without any of the negative side effects typically associated with a hyperinsulinemic state; all while simultaneously assisting the individual in their health and fat loss goals.

While the idea of formulating a product based solely around insulin secretagogues is a relatively simple concept, Insuligen is the first product to actually do so. Up until now, GDAs have been nothing more than a hodgepodge of randomly selected compounds, focusing solely on glucose disposal and insulin sensitivity without any regard for the detrimental effects they may have on the growth process. This all changes now.



Insuligen: Ingredients

GymnePURE®: Insuligen is the first GDA released within the bodybuilding-fitness industry to contain this novel and costly ingredient. In short, GymnePURE® is the safest, most biologically active and effective Gymnema Sylvestre extract ever developed. This is NOT your typical Gymnema product, which is nothing more than ground up leaf occasionally standardized for gymnemic acids. Rather, GymnePURE® is a unique and innovative multi-patented extract of natural Gymnema Sylvestre Leaf using a scientifically supported extraction process known as OSA™.

When looking at GymnePURE® from a biological standpoint, there are two primary characteristics which differentiate it from traditional gymnema products—potency and safety. Research performed at King’s College in London shows us just how powerful GymnePURE is. When compared directly against multiple other gymnema extracts, just a single 250 mg dose of GymnePURE® elevated insulin levels 600%-1,600% higher than a full 8 capsules (1,000-2,000 mg) of standard gymnema extract, with the average increase being 800% greater. No other Gymnema product on the market even comes close, making GymnePURE® the premier insulin secretagogue available today.

But how does GymnePURE® stack up to the competition from a safety standpoint? This rarely talked about aspect of gymnema usage may be more important than you think, particularly in individuals with compromised beta cell viability or in those who regularly use GDA products. Located in the pancreas, beta cells are the cells responsible for secreting insulin into the bloodstream. When these cells are damaged through chronic/excessive insulin secretion (Type II diabetes, for example) or improper supplementation, they can partially or even totally lose their ability to release insulin into the bloodstream.

The safety difference between GymnePURE® and other gymnema extracts lies in its mechanism of action (M.O.A). Regular gymnema extracts possess a less than ideal M.O.A, as they stimulate insulin secretion by literally breaking down the beta cell walls, causing insulin to leak into the bloodstream. This unnatural method of inducing insulin secretion leads to subsequent beta cell wall exhaustion and eventually, death. You may want to think about this the next time you reach for your gymnema containing GDA product.

In contrast, GymnePURE® works by opening and closing the cell walls in a natural manner, thus preserving their integrity and future ability to perform vital functions. But this is not GymnePURE’s only MOA. It also works through signaling pathways in the presence of Ca and even in the absence of Ca. This three-fold mechanism of action is far superior to anything encountered with normal gymnema extracts, both from an effectiveness and safety standpoint. GymnePURE® accomplishes all this without activating AMPK, so you don’t need to wonder if your muscle building efforts are being compromised.

4-Hydroxyisoleucine: 4-Hydroxyisoleucine, otherwise known as 4-HIL, is a non-protein amino acid isolated from Fenugreek seeds. Although 4-HIL has been known about for some time now, it is almost never included in GDA’s at a meaningful dose (the last time I saw a properly dosed 4-HIL product was 12-15 years ago and it was the only ingredient in the product), and when it is listed on the label, it is always part of an undisclosed (i.e. ineffective) proprietary blend. This is due to its excessive cost, as a single 200 mg dose (the dose found in Insuligen) has a higher production cost than most GDA products do in their entirety. Although highly effective, this makes 4-HIL an impractical addition to many multi-faceted GDA products, unless the company is willing to abandon conventional profit margins in the pursuit of effectiveness.

Like GymnePURE®, 4-HIL does not activate AMPK, but directly activates pancreatic islets, causing insulin to be released into the bloodstream. In addition to its insulin secreting effects, 4-HIL also possess the ability to lower plasma glucose through non-insulin dependent pathways, while simultaneously improving HDL levels and lowering total cholesterol and triglycerides.

Beta-umbelliferone: Beta-umbelliferone, also referred to as 7-hydroxycoumarin, is an interesting compound with a plethora of beneficial effects. Never before used in a GDA product, umbelliferone is the parent compound from which the prescription medication, Warfarin, is derived. However, unlike warfarin, umbelliferone does not have any significant blood thinning properties, but instead acts as an insulin secretagogue, anti-oxidant, and anti-inflammatory agent.

Impressively, umbelliferone has been shown to possess insulinotropic effects comparable to the powerful prescription insulin secretagogue, glibenclamide, but without the AMPK activation that is so prevalent among GDA's in general. That is a very significant finding, as glibenclamide is one of the most effective and long-standing secretagogues used in medicine today. Even better, Umbelliferone does this without any harmful side effects; something that cannot be said of glibenclamide, which has numerous contraindications and potentially serious negative effects on the patientÂ’s health.

As a side benefit, umbelliferone also helps prevent/reverse inflammation induced liver injury, making it a powerful and natural liver protectant. This hepatoprotective effect is largely attributable to umbelliferone’s anti-inflammatory properties, which have been repeatedly demonstrated in clinical studies. Most notably, it has been shown to reduce hepatic TNF-a, IL-1β, and IL-6 levels. These inflammatory cytokines play a critical role in the progression of liver injury by provoking hepatocellular injury and death, while TNF-α and IL-1β act as sensitizing factors, amplifying hepatocyte damage by inciting hepatic leukocyte infiltration.

Ampalaya: More commonly known as Momordica Charantia or bitter pear, Ampalaya is a routinely used oral hypoglycemic agent capable of stimulating glucose uptake through multiple pathways. Acting as an insulin secretagogue, insulin sensitizer, and insulin mimetic, Ampalaya provides a number of benefits not found with secretagogues alone. In addition to its clinical efficacy, Ampalaya was selected for this very reason, as it activates AMPK just enough to provide a potent insulin sensitizing effects, but not so much that it impairs the growth process.

Although there are dozens of hypoglycemic agents found in Ampalaya, the most powerful of these include: charantin, polypeptide-p and to a lesser extent, vicine. Charantin functions as an insulin secretagogue and has been shown in clinical studies to produce a more powerful insulinotropic effect than the prescription secretagogue, tolbutamide. Polypeptide-p functions as a potent insulin mimetic, closely resembling insulin in both structure and effect. So comparable are its physiological effects to insulin that it can even be used as an insulin replacement in Type I diabetics. There are at least a dozen additional hypoglycemic agents found within Ampalaya, all of which contribute to the overall effects of this amazing plant.



Enhanced Bioavailability

When designing an GDA formula, one could decide to include only the most powerful ingredients available, but if they are poorly absorbed due to low bioavailability, it means very little. Therefore, it would behoove any supplement company to make sure that this aspect of product development is not overlooked. In many cases, the simple addition of one or more bioavailability enhancers is all that is required to greatly improve a product’s absorption into the bloodstream, thereby enabling the product to provide the results it was intended to.

For Insuligen, I have chosen to use a combination of 4 different compounds, all of which are backed by a mountain of clinical research. These include BioPerine (a trademarked version of piperine), ginger, cumin seed, and gallic acid. Each of these possesses a different mechanism of action and/or work synergistically with the others to further improve bioavailability. Mechanisms of action include p-glycoprotein inhibition, stimulation of gut amino acid transporters, inhibition of drug metabolizing enzymes, reduced production of intestinal glucuronic acid, and increased bile production and digestive motility.

By optimizing virtually every variable associated with the absorption process, you can rest assured that you are receiving maximum benefit from the compounds within Insuligen.



***IMPORTANT***

Insuligen: Glucose Dependent

When using Insuligen, it is very important to understand that its effects are almost entirely glucose dependent. What does this mean? It means that the substances within Insuligen only stimulate insulin secretion in response to the presence of elevated blood glucose levels…and the greater the elevation, the greater the insulinogenic response. In other words, the more carbs you eat, the better the product works, while those who eat little to no carbs will notice little to no results. Yes, its lipolytic and anti-lipogenic effects will still be present, as will a portion of its insulin sensitizing effects, but without adequate carb intake insulin secretion will be minimal to non-existent. Therefore, low-carb dieters need not apply. Insuligen was designed specifically for those interested in building muscle mass.

Given the fact that Insuligen is glucose-dependent, one should not expect to experience hypoglycemia when using it, regardless of the dose employed, because as soon as Insuligen has done its job (lowered BG levels back down into a normal range), insulin secretion will cease. This self-modulatory effect is exactly what we want out of a secretagogue, as it not only prevents the occurrence of hypoglycemia, but also helps prevent insulin resistance and potential fat gain.



Conclusion

As the 1st product of its kind, Insuligen’s arrival ushers in a new class of GDA’s—the muscle-building GDA. By foregoing AMPK activation as its primary M.O.A., Insuligen takes a step away from the anti-growth approach that typifies most GDA’s and instead chooses to rely on endogenous insulin production to power its effects.

By providing a more muscle-friendly GDA, Insuligen helps fill the gap left by the current roster of GDA products, which are more suited for fat-loss and/or recomping. As always, MA Labs is proud to introduce to you it’s newest release in the MA Labs line-up—Insuligen.



cool formula but not industry first.....Don't be like blackstone who "invented" the GDA category like 8 months ago. The members at AM are a bit more savvy to fall for it..

some OGs will remember PSlin....
 
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Don’t we want the carbs to not be blocked ?
 

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This is true that GymnePure was not used so far in GDAs however it’s s already sold as a stand-alone (250mg per cap) product.
Of course, but I said as a bodybuilding/fitness supp.
 

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]cool formula but not industry first[/B].....Don't be like blackstone who "invented" the GDA category like 8 months ago. The members at AM are a bit more savvy to fall for it..

some OGs will remember PSlin....

You Don't Think So? I Can Prove it. Can You?

Thank you, but as far as I can tell, it is an industry "first". Keep in mind I did not say it was the first GDA or something ridiculous like that. I said it was the first GDA that functions primarily as an insulin secretagogue and is not AMPK-based. AMPK suppresses muscle growth via inhibition of mTOR...and basically every product on the market today is LOADED with AMPK activators. A little AMPK activation is a good thing (from a growth standpoint), as it can indirectly assist with muscle growth, but excessive AMPK activation...or even moderate activation (particularly at catabolic times like the training window) will most certainly suppress muscle growth via inhibition of the mTOR pathway. In other words, AMPK-based GDA's are bad for people trying to make gains.

From what I have seen (and I have looked at over 150+ products), every other GDA on the market contains copius amounts of AMPK activators...or was comprised almost entirely of AMPK activators. That is where Insuligen differs from other GDA's...in its primary mechnaism of action. Insuligen functions primarily as an insulin secretagoge, not as an AMPK acitvator. These are two very differnet things from a functioinality standpoint. All GDA's are NOT equal in all aspects. There are differnet categories of GDA's (that the industry at large hasn't recognized yet, but which I am bringing to the forefront because people need to know).

AMPK-based GDA's are great for fat loss, but not muscle growth. On the other hand, Insuligen is superior for muscle growth, but not as good for fat loss.

So, until you can find me a product that is comprised almost entirely of insulin secretagogues with minimal to no AMPK activating compounds, I will reserve the right to call Insuligen an industry FIRST.
 

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Don’t we want the carbs to not be blocked ?
I don't understand what you're referring to...about carbs being blocked. Please explain. Thanks.
 

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Is there an AM discount code or no because it’s only a 1 time run?
You can always use the MA Labs dis**** code, which is: am20
 

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I googled GymnePure and the only info I found in relation to insuline leakage from beta cells is on the write up of the sites and products with financial interest in GymnePure and even then they are talking about studies run at king’s college of London but no reference to the studies. They all repeat the same sentence which is the following (with no actual references to the the studies): According to studies at Kings College in London* GymnePURE is a much safer MOA than standard Gymnema Sylvestre extracts which damage pancreatic beta cell walls by breaking down the cell walls thus a “flooding release of insulin” and causing subsequent exhaustion of cell wall.
That's where I got it from--the Kings College clinical studies (which I explicitly stated in the product description itself). In this study, when GymnePURE was compared against 4 other Gymnema extracts, it out-performed the other extracts by 800%, releasing 8X the amount of insulin. This study alos mentions the differnet pathways through which GymnePURE works, which then goes into the safety aspects. It is very common for developers of new compounds to fund their own studies. This doesn't necessarily make them unreliable, especially when the product actually receives patents. Gaspari would be a good example. Their Novadex XT studies were self-sponsored, but they were as legit as they come. That stuff was awesome--better than any other AI on the market from an HPTA recovery standpoint.

Keep in mind, GymnePURE has multiple patents. If there was no significant difference between GymnePURE and other Gymnema extracts, the company never would have had their multiple patents granted, as Gymnema is a DSHEA comliant, GRASS recognized plant-based product sold by a ton of companies. You can't patent an herbal extract like Gynnema...UNLESS it is altered in a way that makes it fundamentally differnet from a functionality/effects standpoint. In order to get a patent (especially multiple), you have to be able to prove that your product not only does what it claims, but that it works in a new and unique way. Otherwise, the patent application will be rejected. Way more patents (many which actually have validity behind them) get turned down than accepted. Anyway, yes, that is where I got it the information from.

Alex Kickel received the product about a week before anyone else and has been using it. He said "he absolutely F---'ing loves it" and talks about it at length in his latest podcast (Beast Fitness Radio). He said each dose provides results equivalent of 2-3 iu of Humalog.

I'll look for his podcast and post it here.
 

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So in theory potential fullness and vascularity from said product?
Anything which stimulates glucose uptake can increase muscle fullness, but the area where Insuligen differentiates itself from other GDA's is in its primary mechanism of action. Insuligen is an insulin secretagogue, whereas pretty much every other GDA currently available is AMPK-based. Both have their pros and cons.

AMPK-based GDA's are great for fat loss, but they suppress muscle growth via inhibition of mTOR. Insuligen, which is an insulin-based GDA, does not suppress muscle growth, but actually has pro-growth effects. However, it's fat loss effects are weaker than AMPK-based GDA's. There are some pro-fat loss effectd as well. Iit won't help much with fat loss (while mass-building), but it will help prevent fat gains while building muscle mass. However, it doesn't stimulate fat loss as potently as AMPK-based GDA's do, as that was not its primary purpose. Insuligen was designed to function like oral insulin (it is an insulin secretagogue with positive effects on growth, rather than negative effects on growth).
 
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That's where I got it from--the Kings College clinical studies (which I explicitly stated in the product description itself). In this study, when GymnePURE was compared against 4 other Gymnema extracts, it out-performed the other extracts by 800%, releasing 8X the amount of insulin. This study alos mentions the differnet pathways through which GymnePURE works, which then goes into the safety aspects. It is very common for developers of new compounds to fund their own studies. This doesn't necessarily make them unreliable, especially when they product actually receives patents. Gaspari would be a good example. Their Novadex XT studies were self-sponsored, but they were as legit as they come. That stuff was awesome--better than any other AI on the market from an HPTA recovery standpoint.

Keep in mind, GymnePURE has multiple patents. If there was no significant difference between GymnePURE and other Gymnema extracts, the comoany never would have had their multiple patents approved, as Gymnema is a DSHEA, GRASS compliant plant-pbased product sold by ton sof companies. You can't patent an herbal extract like Gynnema...UNLESS it is altered in a way that makes it fundementally differnet from a functionality/effects standpoint. In order to get a patent (especially multiple), you have to be able to prove that your product not only does what it claims, but that it works in a new and unique way. Otherwise, the patent application will be rejected. Way more patents (many which actually have validity behind them) get turned down than accepted. Anyway, Yes, that is where I got it from.

Alex Kickel received the product about a week before anyone else and has been using it. He said "he absolutely F---'ing loves it" and talks about it at length in his latest podcast (Beast Fitness Radio). He said each dose provides results equivalent of 3 iu of Humalog.

I'll look for his podcast and post it here.
I don’t really care if Alex Kickel or who ever else liked it or not. Or whatever the manufacturer of GymnePure put on their product write up. What I’m interested is the study they talk about and that can’t find any reference to it. They talk about the study but don’t give the reference to the study/ articles. Until I see the study I will remain skeptical in regard to safety superiority of GymnePure vs other Gymnema products. So if you have the study please post the reference If not please dont say that other gymnema break down the beta cell wall if no proof can be given.
 

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Thank you but here again he posted 7 studies but none are the one from king’s college or safety of Gymnepure vs other gymnema.
You lost me for a second, here. Alex Kickel's's Podcast doesn't have anything to do with your posts. He is not my employee. I figured I would post a link to his Podcast for anyone who wanted to hear his opinion and feedback on Insuligen. He's recommended it to over 50 people now. He loves it. As far as any refs he posted, I don't know anything about them. It's his show.

However, I already answered your question. Like I said above, please read the patents and Kings College study, as those would be a great first place to look. If you want extra detailed info on a singular, secondary aspect of the product (i.e. a breakdown of specific mechanisms of action on a more detailed level), you may need to do some digging, brother, as I still have over 20+ refences to post up, while simultaneously preparing for the imminent release (this week) of two, long overdue products. So, I really just don't have time to do further research for you. 20+ references is already a lot for a product (most products have zero references). I didn't have a problem referring you to the studies and patents, but anything beyond that and you'll have to take the reigns.
 
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You say you don’t have time but why should we waist our time and dig to find the reference of something you said? This reference maybe doesn’t even exist. It’s easy to say something and asking the others to find the related reference. You were the one here talking about the safety of regular gymnema and mentioning the study at Kings college so you should give the reference to this study.
 
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You do know his name is spelled Alex KIKEL

Not Kickel

If you even click on the link it states:
ALEX KIKEL, The Prep Coach

he may not be an employee but he must be an affiliate since he has his own coupon code:
(SPECIALITY SUPPLEMENTS) www.masupps.com___use discount code “alex20” to save off your order!

This way he gets money and kickback on each sale. He has done this time in and time out for all his sponsors over the years. He dropped lots of sponsors when he use to do the podcast with Austin Stout because they simply were not selling them, and it was not worth their time.

I don't know how much validity I put into Alex's statements. This is also a coach who will acquire new clients, and then never give them their plan. I have had several of my friends get burned hiring him as a coach and paid him for a year up front and then had to contact their banks to get their money back and dispute the charges.

He also tried to promote outside vendors (sponsors) on here multiple times and his training. Admin had to ban him because he continaully tried to repeat that practice even though he was told not to.

Its just as bad as all the 1st Phorm reps who push their products, and people buy them cause they trust the person and it gets them kickback. People buy those supplements and even if they have subpar results or don't get what is expected out of it then try and voice their opinion in public and they are called liars or "it just doesn't work for you".
 

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No surprise, they are all salesmen trying to push product to make money. Can't trust a word they say. I purchased once from them and didn't like it so I was called a liar through messenger, so I am out regardless.
 

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I don’t really care if Alex Kickel or who ever else liked it or not. Or whatever the manufacturer of GymnePure put on their product write up. What I’m interested is the study they talk about and that can’t find any reference to it. They talk about the study but don’t give the reference to the study/ articles. Until I see the study I will remain skeptical in regard to safety superiority of GymnePure vs other Gymnema products. So if you have the study please post the reference If not please dont say that other gymnema break down the beta cell wall if no proof can be given.
I've been nice to you this whole time, despite you not being the nicest to me and continuing to re-ask me the same questions over and over again, even after I answered you.

With that said, I already told you I didn't post the Alex Kickel podcast for you, so you either aren't reading my posts or you don't know how to read. I know it's not the later, so I am going with the former. Just to make it abundantly clear (since you missed it the last time), I will tell you a 3rd time. The Alex Kickel podcast was not posted specifically for you, but for anyone who might be interested in hearing what he has to say about it--both from an informational and feedback standpoint. It was posted for the BOARD members in general.

Secondly, if you don't want to wait for me to post refs (even though I said right from the start (before you even posted) that I would have to attach the refs to the description later on because I was pressed for time with the release of two new products), you can do so yourself. I told you what the study was and you can view the patents (which will breakdown the differences between GymnePURE and other gmnema extracts). If you have an issue with either of them or if the refs I post aren't detailed/reliable enough for you (90% of the refs are from Pubmed), there is nothing I can do about that. 95% of all the refs are rock solid. Maybe 5% are arguable. I think that's pretty good, especially considering the fact that most companies post zero refeences. in fact, most companies releaswe products that don;t work at all...or work so poorly they are not even worth using. AM is pretty fortunate, as it has some of the better supop companies.formulators as sposnors. Some of the best formulators/comopanies out there are the smaller guys...because they are often prioritizing effectuveness over profit. They know the only way they can compete with the bigger companies is to have lower profit margins so they can make better products. Insuligen costs almost $40 a bottle! It was not intentional, though. The price on one of the ingredients went up 250% half-way through production.
 

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You say you don’t have time but why should we waist our time and dig to find the reference of something you said? This reference maybe doesn’t even exist. It’s easy to say something and asking the others to find the related reference. You were the one here talking about the safety of regular gymnema and mentioning the study at Kings college so you should give the reference to this study.
You don't have to find anything. It's your choice. I will post the refs after my two new products are released. I'm not trying to be mean in saying the following, but personally, it doesn't really matter to me if you are skeptical or not. You are debating a secondary, minor aspect of the product that has nothing to due with its effectiveness/potency. I will look for the Kings College study and patents. I told you that. I need until after Friday because I am super pressed for time trying to get my two new products ready for release. As I stated above, 95% of all my refs are rock sold...and maybe 5% are arguable (I said 5% "might" be arguable; I'll know by Friday), but this 5% doesn't even have to do with the product's effectiveness. I'll take that any day.
 

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