In 1914, Zwicky chewed 5 g of kougoed resulting in nausea, analgesia
to the mouth, normal pulse, discomfort and stuffiness of the
head, and loss of appetite. On a separate occasion he swallowed
a decoction made from 15 g of kougoed, with similar results, but
including headache, and the local anaesthetic action was found to
be much weaker than cocaine (Watt and Breyer-Brandwijk, 1962).
Smith et al. (1996) reported the effect in two individuals of 2 g
of kougoed held in the mouth with a small quantity of alcohol.
A feeling of “tranquil mellowness” was experienced after 30 min,
with no impairment of motor function, and no hallucinations. On
a later occasion these same individuals took 1 g material, which on
this occasion the material included root. The subjects experienced
the same effect as before, but stronger. The effects of traditionally
prepared kougoed was documented by Smith et al. (1996), and a
wide range of effects were reported, including anxiolytic activity,
improved social intercourse, decreased self-consciousness, synergistic
effect with alcohol and with Cannabis, decreased substance
abuse in poly-substance abuser, as well as feelings of relaxation,
and a meditative state of mind. Three first-time users reported
clouding of consciousness with doses that were high enough to be
intoxicating. Ingestion of Sceletium gave pain relief from a bee-sting.
Gericke (2002) reports that when taken in intoxicating doses,
Sceletium tortuosum can cause euphoria, initially with stimulation,
followed by sedation, but the plant is not hallucinogenic, and no
severe adverse effects are known. Chronic use does not appear
to result in a withdrawal state. Tinctures of the plant are useful
clinically for treating anxiety, depression and stress.