Well there's lots of theories about M1T lethargy but nothing concrete. From SS's et al blood work we've seen factors like
1. Total testicular shutdown in as little as 48 hours
2. Persistent low blood sugar while on
3. Severe dip in cholesterol levels
4. Elevation of liver values
Personally, I think factors 1 and 2 are the most pertinent to the lethargy problem. I say this because anecdotally I used M1T about 4-5 times and used it differently every time. M1T solo cycles had the most severe sides, no doubt about it. M1T and 4AD cycles were a little less severe. M1t + 4AD and upping the amount of carbs consumed at every meal helped to alleviate most of the sides.
But the real winner has been M1T stacked with 4AD and daily 100iu HCG shots plus a lot of carbs/fat with every meal. I did this for my latest cycle and sides were pretty much non-existent, in fact I felt pretty damned good. I did gain a little fat with it but nothing terrible. The only side I felt was lurking was high blood pressure. Next time I'll add hawthorne, alliin/allicin and maybe arjuna...but I can only take so many more supps, lol.
Also, keep the M1T dose as low as possible. Fortunately, I do well on 5-10mg ed.