it really depends on the compound and what you are trying to do, I guess I should just start a new thread about dosing since most people seem to be asking. Ill try and give the reasons why one might be better over the other. If a mod wants to move this to a better thread or something please do.
First let me explain that I come from the schoool of thought of spreading out the dose as much as possible throughout the day so there are no high spikes of the compound in the blood. For me, this has always worked the best in gains as well as mood flucuations. Also I have had my shoulder replaced 3 times and ankle fused, so there is rarely a day where I can try and max out a specific lift. So i dont need a high peak in blood concentration to try and get a new Personal Best in a lift nor do i compete in lifting events.
High spikes are best for when you are trying to get a lot more done in the gym in lifting, aggresion, amount of weight lifted, etc. Also if you are taking a single compound by itself you probably will get more out of a single dose 1 hour prior to your workout then you would if you split it up throughout the day. Since you will have the highest concentration after that dose you are hoping that it will allow for a higher amount of weight lifted, or greater number of reps with increased recovery time inbetween sets. So if you are trying focus on a strength or a mass type workout building phase in your diet and you are using M14ADDiol for ex., i would take all 30mgs prior to workout.
Now if you are dieting (Ill give me reasons why), just looking to slowly improve week in week out or stacking compounds together I personally feel it is better to split the doses up during the day as much as possible. This way you have a constant level flow of hormones in the blood throughout the day. For dieting I believe certain hormones have a great effect on fatloss and feel that by having an even flow throughout the day it allows your body to be able to use those hormones for fatloss as much as possible. Where as if you spiked it with a single dose you may only get a short window of opportunity to effect the fatloss. Plus having hormone levels stable also allow for a more stable mood, you dont want highs and lows in your mood while on restricted cals and working out. High amounts of hormones can have a effect on mood (and i do not mean roid raging or anything like that). For ex. M1t seems to have about a 8 hour half life, if you look at some blood work, so after 8 hours if you didnt take another dose you could feel a lul or more lethargy then normal during that part of the day. That is not what you want to feel like if you are having 750 less cals per day, where only 50 of them are in carbs while doing 30mins of cardio. Also by stacking it with another compound you are given the chance to spread out another compound through the day so you may not want to spikes unless of course you are stacking something specific. (this is only for example) if you were using 20mg M5AA per day with 30mgs per day of M14ADD i would rather have the M5AA just pre workout and either split the m14add into two doses of 15 mgs 4 hours before workout and 4 hours after to help with recovery or the full 30 in the a.m. to get it into the blood until you would be taking the m5aa.
When ever i test a compound I always split the dose up into mutiple amounts, MDien i used 5 doses per day, starting at 250mcg per dose. I feel that is the best way to test it. So it really comes down to how well you know your body, what type of workout your are doing, what type of diet you are following and what goals you are looking for.
So let me try and recap this huge post, single compounds i would use alone in 1 single dose 1 hour prior to workout providing you are not currently dieting or under more stress then normal. If you know your body responds well to high blood concetrations then you want single dosing.
When stacking or dieting or under more stress then normal (holidays for some people) i would spread the dose out in 6-8 hours intervals. If you know your body does well on a constant throughout the day (like blood sugar) then you may want to try splitting up the doses.
For everyone who is trying out methyls, regardless of the taste or how much you hate it I would try giving an 8oz. glass of grapefruit juice first thing in the a.m. a try and see how it does. What is the worst thing that could happen it dosent help at all and you have to drink something sour for a week or 2. You may find out that even though it is nasty, you need less of the PH to get the same effect.