Daily Ibuprofen And Muscle gain.

[doggzj]

I have been taking ibuprofen daily due to doctors orders. I've read some random things relating it and reduced anabolism. Does anyone know more on this subject?

 

[Lean One]

Have you tried a search? :gotsearch

I remember Bobo putting up a studdy a while back on the topic.

 

[Haggerty]

It's a little trick most people still don't know about, but I've employed it for years now and it really does help. Aromatase activity decreases in a dose dependant fashion following treatment with an NSAID or COX inhibitor. Basically, if you take 200-400mg ibuprofen 2-4x daily, depending on how bad the gyno is, it takes less time to get rid of it. Try not to take more than 8 motrins/day and only do it for a few wks or month at the most, especially if you have any kidney issues. It's synergistic with nolva and other AI's too.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&li st_uids=15964185&query_hl=112

Dr. D's knowledge

 

[shootmeagain]

D's info is good, of course, but specific to a certain protocol.

I don't think that addresses what doggzj was asking.


Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis

T. A. Trappe1, F. White1, C. P. Lambert1, D. Cesar2, M. Hellerstein2, and W. J. Evans1

1 Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, Departments of Geriatrics and Physiology and Biophysics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205; and 2 Department of Nutritional Sciences, University of California, Berkeley, California 94720-3104

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 ± 3 yr, 180 ± 6 cm, 81 ± 6 kg, and 17 ± 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 ± 19% (P < 0.05) in PLA (0.058 ± 0.012%/h) and was unchanged (P > 0.05) in IBU (35 ± 21%; 0.021 ± 0.014%/h) and ACET (22 ± 23%; 0.010 ± 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.


Also --

http://www.findarticles.com/p/articles/mi_m0KGB/is_6_5/ai_n6110823

 

[jagleaso]

I would stay the hell away from NSAIDs at doses like 400mg 2-4x ed unless you have a burning desire to get ulcers, lol!

You will know what im talking about when your stool turns black.

 

[Wedgylx]

I would stay the hell away from NSAIDs at doses like 400mg 2-4x ed unless you have a burning desire to get ulcers, lol!

You will know what im talking about when your stool turns black.

I took 400mg 4-5X ED for 2-3 weeks when I broke my collarbone/pulled muscles in my neck. I didn't have any sides from it at all, but I'm aware ulceration and GI discomfort are very common with NSAID

 

[jagleaso]

I took 400mg 4-5X ED for 2-3 weeks when I broke my collarbone/pulled muscles in my neck. I didn't have any sides from it at all, but I'm aware ulceration and GI discomfort are very common with NSAID

Then you sir have a stronger stomach than I.

 

[Wedgylx]

Then you sir have a stronger stomach than I.

or maybe I just didnt notice the blood in my stool LOL

 

[jagleaso]

or maybe I just didnt notice the blood in my stool LOL

lol, Very true my friend.

 

[doggzj]

I've taken 200mg morning and evening since I made this post, and I haven't really noticed any disruption in my training or growth. Just figured I'd post since someone bumped this thread

 

[rockhard_4eva]

psoriatic arthritus. I've been taking 300 mg daily of flurbiprofen. Equal in about 10 extra strength advil. No stomache issues. Maintained my strength, except in joints with pain obviously.