Myostatin Question for PA, anybody else with knowledge
- 05-13-2007, 02:46 AM
- 05-13-2007, 06:42 AM
Thats Right Hey Im 215 Pounds 5ft6in I Dont Know Maybe I Did Something Wrong Maybe I Did Not Take It Long Enough I Know For A Fact My Shoulders And Traps Grew And My Energy Left I Started Getting Tired Real Fast And I Felt Like Crap When I Took The Stuff.i See People Thinking You Gonna Become This Monster Over Night While I Personally Beleive It Can Happen With Hard Work Its Just Gonna Take Time .maybe I Mix It Wrong Or Something I Used Bac Water I Dont Know Whos To Say That I Actually Block My Myostatin In Just 7 Weeks I Mean I Did See Some Growth Expecially In My Trap And Neck Area Just My Experience From The Injectable
05-13-2007, 06:57 AM
05-13-2007, 07:01 AM
I HAVE Seen From The Studying That I Have Done That Muscle Growth From Follistatin Is Alot Better Then The Antibody So Im Real Excited About This Folstaxan
The World Awaits Lol
05-13-2007, 07:12 AM
I Must Add This, I Read I Forget Where That Muscle That Dont Produce Myostatin Gets Tired Fast So Maybe I Did Get Some Form Of Surpression Keep In Mind It Was Only 7 Weeks
05-14-2007, 02:53 PM
05-14-2007, 07:50 PM
well its nothing new like i said before the biggest muscle growth i notice and its still quite visible today is my trap and shoulder muscle it stands out from the rest
05-14-2007, 10:09 PM
05-15-2007, 12:36 AM
05-18-2007, 08:09 AM
05-18-2007, 09:59 AM
06-01-2007, 08:20 PM
I have alwasy had the question in the back of my mind - when it comes to myostatin inhibition on matured muscle - will it have an effect?
I know that genetically altered mice - whether ACTIIRb knockout or Follistatin producing - are born with this and their muscles undergo hyperplasia and hypertrophy as they grow from infancy to maturity.
But what can be expected if you start inhibiting mysotatin on a matured muscle in terms of growth.
This study was recently published and while its not conclusive - it does show that a reduction in myostatin does increase muscle size in mature muscle - but as we had suspected - by way of fiber hypertrophy and not hyperplasia. Its positive but don't throw the GH/IGF-1 out just yet.
1: Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E985-91. Epub 2006 Dec 5.
Muscle growth after postdevelopmental myostatin gene knockout.Welle S, Bhatt K, Pinkert CA, Tawil R, Thornton CA.
Department of Medicine, University of Rochester, Rochester, NY, USA. [email protected] du
Constitutive myostatin gene knockout in mice causes excessive muscle growth during development. To examine the effect of knocking out the myostatin gene after muscle has matured, we generated mice in which myostatin exon 3 was flanked by loxP sequences (Mstn[f/f]) and crossed them with mice bearing a tamoxifen-inducible, ubiquitously expressed Cre recombinase transgene. At 4 mo of age, Mstn[f/f]/Cre+ mice that had not received tamoxifen had a 50-90% reduction in myostatin expression due to basal Cre activity but were not hypermuscular relative to Mstn[w/w]/Cre+ mice (homozygous for wild-type myostatin gene). Three months after tamoxifen treatment (initiated at 4 mo of age), muscle mass had not changed from the pretreatment level in Mstn[w/w]/Cre+ control mice. Tamoxifen administration to 4-mo-old Mstn[f/f]/Cre+ mice reduced myostatin mRNA expression to less than 1% of normal, which increased muscle mass approximately 25% over the following 3 mo in both male and female mice (P<0.005 vs. control). Fiber hypertrophy appeared to be sufficient to explain the increase in muscle mass. The pattern of expression of genes encoding the various myosin heavy-chain isoforms was unaffected by postdevelopmental myostatin knockout. We conclude that, even after developmental muscle growth has ceased, knockout of the myostatin gene induces a significant increase in muscle mass.
PMID: 17148752 [PubMed - indexed for MEDLINE]
06-04-2007, 09:07 PM
Carl, when are they releasing this stuff? Like 6 weeks ago or so they said it would be 6-8 weeks. Do you know when they are actually shipping this stuff?
06-05-2007, 05:38 AM
well i have been in contact with rick and he told me that they are on track for july 1st shipping possibly sooner if it helps i am planning on running a log on this stuff.
06-05-2007, 11:38 PM
Black747- That TLR product you used, what was it called exactly? Was it their anti-Myostatin polyclonal anti-body? Or was it something else? Also do you know if that product you used was human recombinant or mouse recombinant? Thanks bro.
06-06-2007, 05:34 AM
06-06-2007, 07:57 AM
06-06-2007, 04:42 PM
well it seems as if rick has push folstaxan back again just recieved and email stating it will be the middle or the end of july before shipping. I promise you all a detail log on this stuff as soon as it arrives at my doorstep. peace!!!!!!!!!!!!!!!
06-14-2007, 07:29 PM
Its all a big con boys mun
You can't find the abstracts, the site looks sh*t, you have to pay to be on the waiting list?!?!?!?! Ot's registered as follows:
Domain name: folstaxan.com
Celldyne Biopharma LLC
Richard Green ()
227 Adams Street
San Antonio, TX 78210
maps.google.com the zip, and then the street,
all the w's.san-antonio-texas.com is a B&B a few doors down,doesn't look to me like a place where a legit pharm company should be registered. In any case, it's residential. Either a massive con, or, if not, then definately it does't work and they want to cash in before everyone finds this out, by charging you to buy it?!
06-15-2007, 08:03 AM
How can you surmise that it doesn't work or is a scam from a whois look-up?
I'll be doing a followup interview with Dr. Carlon Colker at the time product is to begin being shipped in July. He's the one who authored the paper on the test subjects results. The product will be released in July as expected according to email from Rick Green. I think we should all just wait and see. If you're not comfortable with the way the site looks or the whois registry - don't buy it. Just wait. But bashing them isn't the other alternative.
Dr. Colker wouldn't be involved if it wasn't real. He has a sterling reputation in this industry and way too much to lose aligning himself with a fake product.
I understand your suspicions. I have them as well from time to time. For instance, about the possibility of you being a shill who just registered to make this single disparaging post about Folstaxan. To some that might look like a fake post by someone who has a vested interest in the products failure. I'm sure its not - but see how some things can appear?
06-15-2007, 08:17 AM
Here's the abstract I think you were looking for..
ABSORPTION PROFILE AND HORMONAL INFLUENCES OF Fertilized EGG YOLK INGESTION IN THE HUMAN
Journal of the American College of Nutrition, Volume 25, Number 5, October 2006
Colker, C. Peak Wellness, Inc. Greenwich, CT
Fertile egg yolks contain significant concentrations of follistatin. In an effort to identify whether this orally ingested source of naturally occurring follistatin is actually absorbed and pharmacokinetically active in the human model, this study was undertaken.
A male subject was chosen because the normal baseline male physiology does not regularly contain any measurable concentration of follistatin. Follistatin-rich fertile egg yolk powder properly processed to preserve active follistatin (FolstaxanTM) was obtained (Celldyne Biopharma, San Antonio, TX). After initial blood draw and subsequential oral Folstaxan dosing, serum follistatin levels were qualitatively and quantitatively) measured as an indicator of absorption. In addition, since we know follistatin is a negative modulator of myostatin, serum myostatin levels were qualitatively and quantitatively measured as an indication of hormonal influence and thus true pharmacokinetic activity. Testing utilized purchased follistatin and myostatin standardized for verification. Confirmations were run by ELISA and quantitations by Liquid Chromatography Tandem Mass Spectrometer with third degree fragmentation (Expertox, Deer Park, TX).
Results showed as predicted, a zero level of follistatin at baseline with a myostatin level of 46 pg/ml, 12 hours after FolstaxanTM dosing. Serum follistatin measured 57.1 pg/ml with a decline of myostatin to 34 pg/m1, 24 hours after the initial dosing, follistatin levels began to predictably drop from the time of initial dosing to 11.4 pg/ml. Yet myostatin continued to decline slightly with a 24-hour level of 31 pg/ml. These results clearly indicate that a fertile egg yolk powder properly processed to preserve active follistatin, when orally ingested, results in detectable serum follistatin. Furthermore, this resultant follistatin presence has significant pharmacokinetic activity is shown by the hormonal down regulation of serum follistatin.
06-15-2007, 02:42 PM
06-15-2007, 03:18 PM
remember some of the worst products has the best advertising so dont trash rick for that website he have insured me that this product is for real and i will say this again i am going to run a log on it.be patient.!!!!!!!!!!!!!!!!!!!!!
07-11-2007, 09:51 PM
alright i was imformed by rick that theres a toll free number 1-866 -750-5168 up and running for anyone who dont want to order folstaxan on the computer
07-12-2007, 09:22 AM
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