EvoMuse Epitome™ Writeup

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Ladies and gentlement I present to you; Epitome™

General Intro
Epitome is a brand new, cutting edge development in fat loss. It works in ways we've only previously been able to fantasize about. Epitome helps control appetite and accelerates fat burning by manipulation of the Leptin pathway. By increasing Leptin sensitivity and keeping Leptin levels within normal range, the brain and body self-adjust to drive your physique where it should be: Lean. Leptin signals will tell your body that it's not hungry while at the same time telling your brain to burn that fat!
With the addition of Queen Bee Acid, a component of Royal Jelly, we boost AMPk signals, literally causing the body to react as if you are smack dab in the middle of a heavy demanding workout, causing addition acceleration of fat loss. Epitome is exactly what it promises - the epitome of fat loss.

Leptin Overview
I want to start with a short and sweet Leptin overview, which will be new to some and a refresher to others. Leptin is a hormone that structurally belongs to the cytokine family made primarily in white adipose tissue (WAT), but it is also produced in other areas of the body in lesser amounts, like brown adipose tissue (BAT) and skeletal muscle, among others. It’s primary function, particularly for our purposes, is controlling hunger and satiety. When we have optimal Leptin levels in conjunction with optimal Leptin sensitivity, as our energy stores fill up, the “fed state” is signaled and we are no longer driven to eat. When this system becomes dysfunctional, like in obesity or calorie restriction, everything goes haywire and we end up with strong hunger signals even when the body doesn’t need calories.

Like most hormones and adipokines, and pretty much anything responsible for any amount of signaling in the body, we function best when it is at an “optimal” level, we don’t want it super high or super low.

A number of things control the synthesis, release, and sensitivity to Leptin, but there are two main factors to be concerned with. These are fat stores (cell size and number), and energy balance. The important thing to remember is that a calorie deficit causes Leptin to drop, and a calorie surplus causes Leptin to rise. Part of the reason why people tend to hit a wall after extended dieting is this drop in Leptin levels. One of the common ways people deal with this is by implementing regular cheat days where they eat a bunch of carbs and a huge calorie surplus. However, this method is not without drawbacks, and with proper supplementation (Epitome), this becomes unnecessary.

In obesity, we typically see elevated Leptin, which causes reduced sensitivity. The constant over-supply of Leptin causes the receptors to downregulate. So we’ve got plenty of this stuff around, but the body has no idea what to do with it. As an example, let’s say every morning you go into Starbucks to buy coffee. But every time you pull your wallet out, it’s just full of Jordanian Dinar instead of dollar bills. You’ve got like, 100,000 Dinar in there, which is possibly enough to buy the whole coffee shop, but the Baristas have no idea what to do with it so you leave sad and confused with no coffee.

When an individual is obese, or has an endomorphic phenotype (who have similar biochemistry to the obese), and they lose weight, they will experience a major drop in Leptin levels, typically below that optimal window. So take Person A, who is naturally a fairly lean 180lbs, and Person B, who is an endomorph that dieted down from 215 to 180, and Person B is going to have lower Leptin levels and messed up neuroendocrine signaling giving him a strong desire to overeat and get back to that original weight. Even the emotional response to eating is highly controlled by Leptin in the brain, so Person B is getting stronger physiological signals (hunger pangs/fatigue), as well as psychological signals (specific cravings, increased reward response to food). Also chalk up the reduced resting energy expenditure from low Leptin, and you’ve got a brutal combination.
 
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Unfortunately this is when the typical person, through their own accord or the advice of their nutrition guru, will often cut calories even more, because if you’re not losing weight, you must be eating too much right? This further caloric restriction drops Leptin even more, and the condition is exacerbated. Also worth noting, with Leptin being tightly linked to the anabolic hormonal cascade of the Fed State (increasing LH which boosts testosterone, increasing GH and T3, decreasing cortisol, etc.) at this point any weight you’re losing is likely to be a high percentage of muscle instead of fat.

Again, one method to attempt to fix this is with a “refeed”, but you’re still sacrificing fat loss during and after the refeed, and the psychological aspect to this type of binge behavior can be quite damaging to many people, making it difficult to stay on a diet. Particularly when Leptin is low and reward signaling is dramatically elevated from food.

This is where Epitome comes in, offering the following benefits to the endomorph:
Constant Fed State signaling. This allows you to employ a large drop in calories during acute fat loss phases, or gradually keep dropping them lower and lower during long-term fat loss phases without ever hitting a plateau.
Optimal Leptin levels and sensitivity
Reduced appetite and cravings
No refeeds necessary
Reduced muscle loss during dieting
Increased rate of fat oxidation
Immune system support (the immune system takes a hit due to reduced Leptin during calorie restriction)
Makes your body act like an ectomorph or mesomorph

Definition of terms

This is a list of terms that, if you scan through first, will better help you understand the ingredients and function. You may want to refer back to it as you read about the specifics of the formula.

SREBP
Sterol Regulatory Element Binding Proteins or SREBPs are proteins required for cellular uptake of fatty acids, as well as production of endogenous cholesterol and fatty acids.

SREBP-1a relates to cholesterol, and is regulated by the amount of sterol levels in the cell. This is one of the major reasons why when we eat less cholesterol, our body just produces more, and vice versa.

SREBP-1c relates to glucose, lipids and fatty acids, and is regulated by insulin.

AMPK
Adenosine monophosphate-activated protein kinase, or AMPK, is basically the cellular signaling equivalent of exercise. Once activated, it triggers fatty acid oxidation and the generation of ketone bodies, inhibits cholesterol synthesis and lipogenesis, stimulates skeletal muscle glucose uptake, and favorably modulates insulin secretion. Increasing AMPK activation can actually repair damaged insulin signaling.

Fat loss and fat gain are moderated by numerous complex mechanisms, and AMPk is a key player in this flux. Appropriate levels of AMPk activation are great for fat loss.

AMPK phosphorylates, and inhibits the aforementioned SREBP-1c (1). Without adequate AMPK activation, SREBP-1c reacts to glucose elevations causing lipogenesis and lipid accumulation.

When looking at fat loss research, data on Type II Diabetes is an interesting and highly relevant place to look, even for those lacking the clinical symptoms. One of the ways the drug Metformin works (most people with T2DM are prescribed this right off the bat), is through AMPK activation.

To reiterate, activation basically has the same effect as exercise, from a fat loss/metabolic perspective.

PTP1B
Protein-tyrosine phosphatase 1B (or PTP1B) is an enzyme found in the endoplasmic reticulum of cells. This enzyme relates to insulin signaling, in that, suppressing it improves insulin sensitivity. When mice have this enzyme knocked out, insulin sensitivity is enhanced and they become resistant to obesity (2). And what’s really cool about that, is that the enhanced insulin sensitivity and increased glucose disposal is tissue specific to skeletal muscle, not fat (3).

LPS
Lipopolysaccharides (or LPS), are molecules consisting of a bonded lipid and carbohydrate produced from bacteria in the body. These are also referred to as endotoxins. LPS act as potent immune stimulating signals, interacting with monocytes and macrophages. They interplay with many inflammatory cytokines like TNF-a, various interleukins and TGF-b (4).

In overweight and obese folks, LPS are consistently elevated due to bacterial imbalance of the gut microbiome. The inflammatory stress from LPS can contribute to intestinal permeability, also known as Leaky Gut Syndrome. This is a double-whammy, as the increased permeability allows LPS to freely enter the bloodstream and cause more problems.

cAMP
Cyclic adenosine monophosphate (or cAMP) is made from ATP, acting as a 2nd messenger for things like epinephrine and glucagon, which can’t pass through plasma membranes themselves. It is closely involved in regulating glucose and glycogen, as well as lipid metabolism.

Phenotype
Genetics + Environment = Phenotype

Genetics = what your parents gave you.
Environment = food, exercise, supplements, behavior psychology.

Endomorph
The classic round body type that has a hard time losing fat. The CICO (calories in/calories out) model of weight loss typically doesn’t get the job done for this person. You’re frequently hungry when you shouldn’t be. Diets work initially then you hit a wall after a short phase of progress. Getting motivated to exercise is challenging due to physiology as much as psychology (your body, through many intricate hormonal processes, makes you feel tired as to conserve energy, which then, downstream tells your brain to stay on the couch and eat more food).

This is highly genetically determined, however it can be either exacerbated or significantly improved by environment. Endomorphs can still be lean, if the environment is properly addressed. This rarely comes down to things like will power and working insanely hard, like The Biggest Loser would have you believe. It comes down to repairing broken signals in the body by adjusting your environment, which then gives you more will power and desire to do the work, and allows that work to actually pay off properly.
 
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Epitome Ingredients and Function
Betulinic Acid
Betulinic Acid (BA) is a triterpenoid derived from the bark of the White Birch tree. It also exists naturally in many types of foods, and exhibits several biological functions.

BA directly acts on SREBPs, resulting in some highly favorable effects. By inhibiting the maturation of SREBP, it decreases the body’s endogenous production of cholesterol and fatty acids. It has been shown, in vivo, to ameliorate diet-induced obesity by decreasing lipid content in the serum as well as at the tissue level, and by improving insulin sensitivity.

It also was found to reduce the size and improve stability of atherosclerotic plaques, also through the SREBP route (5,6). In addition to inhibiting the maturation of SREBP, it also knocks it out on multiple levels by suppressing mRNA expression, translocation to the nucleus, and target gene expression in hepatocytes (7).

Excessive fat (triglyceride) accumulation in the liver is a major problem for people with endomorphic tendencies. In fact, Non-Alcoholic Fatty Liver Disease (NAFLD, which is defined by excessive fat storage in the liver) is a rapidly increasing diagnosis that likely relates, at least in part, to climbing rates of obesity. As far as large scale data goes, the last estimate (which is surely pretty conservative now) was that about 20% of U.S. residents have NAFLD, which is associated with diabetes, insulin resistance and obesity (8). Point being, as an endomorph, the likelihood of your liver over-storing triglycerides is quite high, which can lead down a pretty unforgiving path, not only from an overall health & longevity perspective, but also due to the downstream signaling effects on appetite regulation and body composition. BA has been shown, in vivo, to suppress excessive triglyceride accumulation and lipogenesis in the liver. This is accomplished by SREBP suppression, as well as AMPK activation (7).

Now that we’re talking about the liver and AMPK (the exercise mimetic), BA has also been shown to have an inhibitory effect on liver glucose production through AMPK activation (9). Now, hepatic (liver) glucose production is a normal function that keeps blood glucose stable when you’re not shoving carbs in your mouth, so its not necessarily/inherently a bad thing. The problem arises in the endomorphic phenotype when this system becomes dysfunctional and the liver over-produces glucose causing hyperglycemia and/or above optimal fasting glucose levels. When fasting glucose is high, the body doesn’t have any urgency to use fatty acids as fuel, so fat burning, in the eyes of your body, becomes an unnecessary and useless endeavor. To illustrate this point, when two groups of insulin resistant mice were given a diet that should make them fat and sick, the ones receiving BA saw a decrease in blood glucose, triglycerides, and insulin resistance by 34%, 59%, and 38%, respectively (9).

Along these lines, another study looked at mice fed a fattening diet for 15 weeks. One group had BA added to their diet, the other did not. The BA group showed significantly decreased body weight, less abdominal fat accumulation, lower blood glucose, less plasma triglycerides and cholesterol, increased plasma Leptin, and an optimized ratio of amylase:lipase enzymes favoring fat metabolism over carbohydrate (10).

Oh but there’s more, so much more. BA is also a PTP1B inhibitor, which optimizes Leptin signaling and increases insulin sensitivity (11). It has been shown to modulate cAMP, resulting in a strong lipolytic boost in adipose tissue, while directly preventing absorption of lipids from the small intestine resulting in a pronounced anti-obesity effect (12).

In line with the inflammation/obesity link, some brand new research on Betulin demonstrates that it inhibits NF-kB, a protein complex that becomes activated in response to things like stress, elevated ROS, oxidation of LDL cholesterol, and various inflammatory cytokines (13). Elevated NF-kB causes a host of inflammatory related problems, and the Endomorphic Phenotype is more susceptible to this cascade.

To return the focus to Leptin, one of the major problems with potent Leptin sensitizers is that while they improve Leptin resistance, they tend to do this at the expense of lowering Leptin levels, which throws a figurative wrench in the Leptin associated fat loss effect. As a refresher, we will typically see elevated Leptin levels in the overweight and obese, but a decreased Leptin sensitivity. Weight loss in and of itself will drop Leptin levels, and coupled with a Leptin sensitizer, Leptin would likely drop below optimal levels. When this happens, you start to see a decrease in thyroid output, increased hunger, lower energy expenditure in skeletal muscle, and other problems.

Knowing this problematic limitation, researchers out of Yeungnam University in South Korea designed an experiment using a Leptin sensitizer in combination with a stimulant of endogenous Leptin to see if there was any synergy. They chose BA for their Leptin sensitizer, along with something called Orthosiphon Staminus (OS) as the Leptin stimulant, knowing that OS increases Leptin expression in vivo and in vitro.

Mice were given a fattening diet for 6 weeks, in conjunction with 2 weeks of BA, OS, both, or neither. The subjects receiving BA, OS, or neither, didn’t see a significant body weight reduction, but the combination of BA+OS significantly reduced bodyweight over the other groups suggesting a synergy in line with the proposed hypothesis between these two ingredients (14).

Now, keep in mind this was only two weeks worth of supplemental intervention, so its likely that more time on BA alone would have shown results in line with the previously mentioned studies. That being said, it’s pretty interesting that a positive effect on weight loss was seen so rapidly in the combination group. Which brings us to our next ingredient…
Orthosiphon Stamineus (ethanolic extract)
Orhosiphon Stamineus (OS) is a tropical herb, commonly consumed in Southeast Asia as a tea for it’s anti-inflammatory, analgesic (pain-reducing), and kidney health properties (15–17). On the general health front, it has also been shown to be a liver protecting agent, purportedly through it’s direct antioxidant capabilities in liver cells (17,18).

To revisit the inflammation-obesity connection, this interplay between inflammatory signaling and bodyfat storage is a self-perpetuating cycle that needs to be managed, particularly in Endomorphs. The collective data on OS is pretty clear about it’s anti-inflammatory effect, which seems to be mediated largely by it’s ability to block the negative effect of LPS, even when cells are directly stimulated with LPS (19,20,17). As you might recall, management of LPS is critical for proper immune function, and OS has been shown to additionally optimize this by favorably modulating the immune system through proliferation of peripheral blood mononuclear cells (PBMCs) (21).

Glucose control (fasting and post-prandial) is typically a problem for the overweight/obese/endomorph. OS has been shown to lower blood glucose without elevating insulin. It does this, at least in part, by inhibiting two enzymes, alpha-glucosidase and alpha-amylase (22,23).

OS hits most of the things in our Definition of Terms section at the beginning of the article pretty hard. It decreases the expression of SREBP-1c, giving it anti-adipogenic properties. It increases hormone sensitive lipase (HSL, a key player in fat burning) through the cAMP pathway. It hits AMPK from multiple angles; by directly increasing phosphorylation as well as upregulating something called carnitine palmitoyltransferase 1-a, which enhances fat oxidation through the AMPK pathway. It also inhibits glucose uptake into fat cells by decreasing phosphorylation of insulin receptor substrate (24).

Additionally, OS has been shown to be a mild diuretic and anorectic, supporting water loss and appetite control (17,25).

Throughout this writeup we have focused on obese/endomorph phenotypes, since these issues are a huge social problem approaching epidemic proportions. So, what about lean individuals (sub 12%), you ask? Well, as touched on earlier OS functions on the Leptin system in a very unique way - normalization. For the Obese/Endomorph, this means lowering levels to within normal, but for the truly lean (and my hats off to you), this would function to raise Leptin level also to within normal. No longer will you find yourself up at 2am sleep-eating some Little Debbie Zebra Cakes, or contemplating capital murder to get to a plate of pasta. For the lean individual, you should be able to maintain your leanness with a minimum of effort, or even consider attempting single digits (this will be made easier with the addition of Leptigen Basic, but that’s for another time.)

Queen Bee Acid
Queen Bee Acid (or QBA), also known as 10-dydroxy-2-decenoic acid, is a bioactive medium chain fat found in Royal Jelly. In the larvae stage, bees fed Royal Jelly grow into Queen Bees instead of worker bees. Queen Bees are much larger and live several years, while worker bees only live about six weeks (26). The growth promoting property of Royal Jelly likely comes from a protein called royalactin, which is not part of the lipid fraction where the QBA is found. The life extension property is likely found in the QBA however, as worms given QBA live about 12% longer (27). This may have something to do with improving cell membrane resistance to peroxidation, at least in part, but this hasn’t been tested in humans yet.

The main reason for the inclusion of QBA in the Epitome formula is that it appears to be a super AMPK activator. So again, with increased AMPK you get an exercise mimetic and increased fat oxidation. In addition, this boost in AMPK from QBA has been shown, in vitro and in vivo, to enhance glucose uptake in skeletal muscle independently of insulin for better nutrient partitioning (28).

QBA also has an interesting effect on the brain, in that it has been shown to increase neuron growth similar to endogenous BDNF and the omega-3 fatty acid DHA (29). Similar to Orthosiphon, QBA also acts as an anti-inflammatory through favorable modulation of LPS signaling (30). It also acts as an anti-inflammatory in a second way, through inhibition of something called Histone Deacetylase (HDAC), which is also inhibited by the ketone body b-hydroxybutyrate. HDAC inhibitors are also looked at for prevention and treatment of cancer, as well as mood stabilization.

Some other side-notes on general benefits, QBA has been shown to boost collagen production, help with skin aging, and reduce joint destruction in Rheumatoid Arthritis (31–33).

Conclusion

As you can see, Epitome will help eliminate the misery associated with dieting for the endomorph by supporting optimal Leptin levels and sensitivity, increasing fat oxidation through multiple angles as well as reducing inflammation and supporting the immune system. We are extremely excited to bring this to the market, and foresee it becoming a must-have staple for the endomorph dieter.
 
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Epitome was released for sale yesterday, and will begin shipping after Arnold Classic weekend, on Monday March 9th. Initial allocation for direct sale has already sold out 3 times, but I will be pulling a little more of retailer stock over this morning to support the customers who wanted to wait and read the writeup before deciding.

http://evolutionary-muse.myshopify.com/products/epitome-fat-loss-amplifier
 

vasu

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In case anyone's curious: 100,000 Jordanian Dinar is $141,163
 

vasu

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I'm on a keto diet and tend to just eat once a day (around 6-7pm, after work) .. it seems like Epitome is going to really help me out and ensure that things "keep going" during the fasted period between mega-meal.

I've never been a breakfast person, and gave up lunch because I just wasn't hungry so didn't see the need to make myself eat, and then just having 1 big meal for dinner helps me control and tabulate my daily calorie/nutrient breakdown. I like how my day is structured, but I've often worried that only eating once a day is screwing up metabolic rate, leptin signaling, etc.

  • 230 pounds (had gotten down to 185 from 250 a couple years back)
  • around 30-35% BF
  • keto diet
  • Intermittent fasting with 1 meal a day
  • End up eating 1200-1600 cals/day at a keto macronutrient ratio
I'm going to take and love Epitome no matter what, but after reading this writeup, it looks like it should be really great for someone like me right?
 
Depasi

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In case anyone's curious: 100,000 Jordanian Dinar is $141,163
I actually ran that through the Google currency converter before I wrote it...that's how seriously I take my analogies ;)
 
dsade

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I actually ran that through the Google currency converter before I wrote it...that's how seriously I take my analogies ;)
Here i was figuring it was about tree fiddy.
 
dsade

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I'm on a keto diet and tend to just eat once a day (around 6-7pm, after work) .. it seems like Epitome is going to really help me out and ensure that things "keep going" during the fasted period between mega-meal.

I've never been a breakfast person, and gave up lunch because I just wasn't hungry so didn't see the need to make myself eat, and then just having 1 big meal for dinner helps me control and tabulate my daily calorie/nutrient breakdown. I like how my day is structured, but I've often worried that only eating once a day is screwing up metabolic rate, leptin signaling, etc.

  • 230 pounds (had gotten down to 185 from 250 a couple years back)
  • around 30-35% BF
  • keto diet
  • Intermittent fasting with 1 meal a day
  • End up eating 1200-1600 cals/day at a keto macronutrient ratio
I'm going to take and love Epitome no matter what, but after reading this writeup, it looks like it should be really great for someone like me right?
So you have a single 1200- 1600 calorie meal at night? I would seriously consider a smaller meal during the day, but yeah Epitome would work. Might take a little longer to become apparent, as I would think your metabolism is pretty jacked up.
 

ma70

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I got your response in the other thread this morning. Whoo. Just ordered 2 Epitome and 1 Flawless IDRT. Great stuff!
 
dsade

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I got your response in the other thread this morning. Whoo. Just ordered 2 Epitome and 1 Flawless IDRT. Great stuff!
Look for the queen bee acid to make an appearance in a future formulation of the Flawless IDRT as well.
 
johnfaceman

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Have a couple ordered. I'm glad to see the inclusion of the QBA. I've been looking at it's benefits for a while now. Can't wait to get this in and see what Lipomorph(britev2)/Epitome can do for a ~12% endomorph who cant seem to keep sanity when dieting.
 

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So you have a single 1200- 1600 calorie meal at night? I would seriously consider a smaller meal during the day, but yeah Epitome would work. Might take a little longer to become apparent, as I would think your metabolism is pretty jacked up.
If i'm eating only once a day, it tends to be a little closer to 1200-1300 cals... sometimes if I do actually get hungry around lunch time or slightly after I'll have a snack and then the day ends up closer to 1600.

How significant do you think the smaller meal would have to be? Lately i've gotten into the habit of having cheese as a nice keto-y snack sometimes around lunch time ... sometimes closer to 3-4pmish .. It usually ends up being 250-500 calories depending on the cheese (triple cream brie, mmm). Or sometimes I'll just have an avocado for lunch.

When I do that, I tend to subtract some of all of those cals away from the nightly mega meal. Do you think the overall caloric intake is ok and just needs to be split up more?
 

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On epitome do you just eat at a slight reduction or maintenance calories when trying to sub 10%?
 
dsade

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Trying to go sub 10, your diet to reach it should stay the same (Marc can help with diets), but your results will be quicker and without the need for as many refeeds.
 

GNO

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Trying to go sub 10, your diet to reach it should stay the same (Marc can help with diets), but your results will be quicker and without the need for as many refeeds.
Sorry one more Q, can I run for greater than 8 weeks until results taper off depending on bf%?
 
dsade

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You can run it as long as you want.
 
cubs1987

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awesome write-up... still processing it all
 
dsade

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This is the easy one...unlike it's name, BASIC is where the hard science will kick in.
 
NoAddedHmones

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That was a great read, kudos Matt.

Looking forward to running this in the future.
 
cubs1987

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This is the easy one...unlike it's name, BASIC is where the hard science will kick in.
I know this may sound greedy but what's the ETA on BASIC? 1-2 mos?
 
dsade

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I know this may sound greedy but what's the ETA on BASIC? 1-2 mos?
Rebirth is first, then a whole lot of restock on things that are sold out (MyoSynergy, AMMO, Nerve Restore, Sleephoria, CardioTryx, Defuse). I would say by mid-summer for at least an initial batch.
 
bananaClip

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what about if my leptin is already within normal range and im not fat, 15%(male)
would epitome help someone whos not exactly on a diet?
im not restricting calories i dont even count but with work and gym im sure i burn a lot
but somehow i weigh around the same unless i specifically bulk or diet
what im asking is could epitome lean me down(bf %) with my current life style
ps - i ordered 3.. if not fat loss the reducing inflammation is good too
 
dsade

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what about if my leptin is already within normal range and im not fat, 15%(male)
would epitome help someone whos not exactly on a diet?
im not restricting calories i dont even count but with work and gym im sure i burn a lot
but somehow i weigh around the same unless i specifically bulk or diet
what im asking is could epitome lean me down(bf %) with my current life style
ps - i ordered 3.. if not fat loss the reducing inflammation is good too
Epitome really is mostly a Leptin normalizing/Sensitizing product. It will be MOST effective for >25% body fat, but will also be effective keeping Leptin levels up for sub 12%. At your level, the AMPk activation will help you get lower, but I would definitely combine it with an Adrenergic-Lipolytic and/or PPAR based fat burner.
 

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Did you end up picking loggers?
 

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Well then, in for 2. Looking to see how well this suppresses appetite.
 
enhanced

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I may have missed it, but would running the ec stack with this be beneficial?
 

ma70

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I may have missed it, but would running the ec stack with this be beneficial?
Epitome really is mostly a Leptin normalizing/Sensitizing product. It will be MOST effective for >25% body fat, but will also be effective keeping Leptin levels up for sub 12%. At your level, the AMPk activation will help you get lower, but I would definitely combine it with an Adrenergic-Lipolytic and/or PPAR based fat burner.
I guess EC counts as Adrenergic/Lipolytic, right?
 
Euch

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Where is everyone purchasing this? I'd love to try it. I already have a bottle of Lipomorph and need something to stack with it.
 
dsade

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I may have missed it, but would running the ec stack with this be beneficial?
Running EC is always beneficial. The reason I recommend not using Epitome when you are between 18-14% is because the Leptin dysfunction isn't really the primary fatloss pathway. Leptin levels are within normal, and Leptin sensitivity isn't generally an issue. While the AMPk activation will help, your primary ways to burn fat within that range is Adrenergic/Lipolytic and PPAR-mediated.
 
dsade

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Thanks dsade! Final question - Could this be stacked with Lipomorph and Slintensity?
It can be stacked with LipoMorph, but there won't be a huge amount of synergy. LipoMorph is effective in its own, different, way. You can definitely stack it with Slintensity.
 
mechka_grizli

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It can be stacked with LipoMorph, but there won't be a huge amount of synergy. LipoMorph is effective in its own, different, way. You can definitely stack it with Slintensity.
Several questions Dsade?

Whats your opinion on Lipomorph? Ive seen you and a few other formulaters speak highly of it.

Although there isnt alot of synergy between the two, how do you think the results will be with the two stacked together

If stacking the two, would you change the dosing?
 

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Im not an expert or anything. However, I believe that this would stack well with DCP. 2.0
 
dsade

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Several questions Dsade?

Whats your opinion on Lipomorph? Ive seen you and a few other formulaters speak highly of it.

Although there isnt alot of synergy between the two, how do you think the results will be with the two stacked together

If stacking the two, would you change the dosing?
I actually worked a bit with the LipoMorph designer and exchanged notes when I was working on BRITE. The products were to fit extremely well together, but BRITE's primary ingredient, TUNG oil, ended up causing some GI Distress in customers. I've gone ahead with the reformulation, pulling out the TUNG Oil and increasing the Bitter Melon Seed Oil, and as soon as capital allows the BRITE v2 will be released.

While there isn't direct synergy between the two (as in increasing potency beyond a 1+1=2), they will increase your fatloss when used together.
 
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what about if my leptin is already within normal range and im not fat, 15%(male)
would epitome help someone whos not exactly on a diet?
im not restricting calories i dont even count but with work and gym im sure i burn a lot
but somehow i weigh around the same unless i specifically bulk or diet
what im asking is could epitome lean me down(bf %) with my current life style
ps - i ordered 3.. if not fat loss the reducing inflammation is good too
At your current bf%, I'd definitely use something else and save that for when your bf% gets lower and leptin levels are off. What you're describing sounds to me like a good opportunity to use Defuse and/or Slintensity. It's not necessarily going to be a pure fat loss attack, but will certainly help things keep moving in the right direction if you're not counting calories and are still working out. That way you're just dosing before appropriate meals.

And yeah, DCP 2.0 would also be a solid one to add in. But I think the above makes more sense until you want to specifically focus on the numbers to push hard one way or the other.
 

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Well since no one's asked yet and it's bound to come up, I'll be the first jerk to ask:

Is there any advantage to taking higher doses and/or an initial loading phase for a week or something?
 
dsade

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Well since no one's asked yet and it's bound to come up, I'll be the first jerk to ask:

Is there any advantage to taking higher doses and/or an initial loading phase for a week or something?
No, you wouldn't really get extra benefit.
 
cubsfan815

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I couldn't wait. Popped first pill this morning.
 
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Any thoughts regarding possible synergy with pantethine with respect to leptin sensitivity, BDNF and LPL?
 
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dsade

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Any thoughts regarding possible synergy with pantethine with respect to leptin sensitivity, BDNF and LPL?
now there's something I haven't seen discussed in a while.

Let me pull my old Avant research on Pantethine.
 

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dsade What products would this specifically work well with?? DCP, UR Spray, etc
 
dsade

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dsade What products would this specifically work well with?? DCP, UR Spray, etc
Definitely add in some Fish Oil. Depending on BF level, would also work well with either Abliderate or Eviscerate.
 

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